Recent advances in transition-metal-catalyzed reactions of alkynes with isoxazoles

α-Imino Gold Carbenes from 1,2,4-Oxadiazoles: Atom-Economical Access to Fully Substituted 4-Aminoimidazoles

(2017) Zhongyi Zeng et al.   ORGANIC LETTERS

Gold-Catalyzed Formal [3 + 2] Cycloaddition of Ynamides with 4,5-Dihydro-1,2,4-oxadiazoles: Synthesis of Functionalized 4-Aminoimidazoles

(2017) Wei Xu et al.   ORGANIC LETTERS

Reversal of Regioselectivity in Catalytic Arene-Ynamide Cyclization: Direct Synthesis of Valuable Azepino[4,5-b]indoles and β-Carbolines and DFT Calculations

(2017) Long Li et al.   ACS Catalysis

Copper nitrate-mediated chemo- and regioselective annulation from two different alkynes: a direct route to isoxazoles

(2017) Yingying Li et al.   Organic Chemistry Frontiers

Site-selective Cp*Rh(iii)-catalyzed C–H amination of indolines with anthranils

(2017) Neeraj Kumar Mishra et al.   Organic Chemistry Frontiers

Rh(iii)-Catalyzed direct C-7 amination of indolines with anthranils

(2017) Haoyi Li et al.   Organic Chemistry Frontiers

Recent Advances in Gold-Catalyzed N- and O-Functionalizations of Alkynes with Nitrones, Nitroso, Nitro and Nitroxy Species

(2016) Deepak B. Huple et al.   ADVANCED SYNTHESIS & CATALYSIS

Development of Gold-catalyzed [4+1] and [2+2+1]/[4+2] Annulations between Propiolate Derivatives and Isoxazoles

(2016) Rajkumar Lalji Sahani et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Gold-Catalyzed Synthesis of Quinolines from Propargyl Silyl Ethers and Anthranils through the Umpolung of a Gold Carbene Carbon

(2016) Hongming Jin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly Site Selective Formal [5+2] and [4+2] Annulations of Isoxazoles with Heterosubstituted Alkynes by Platinum Catalysis: Rapid Access to Functionalized 1,3-Oxazepines and 2,5-Dihydropyridines

(2016) Wen-Bo Shen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Anthranil: An Aminating Reagent Leading to Bifunctionality for Both C(sp3)−H and C(sp2)−H under Rhodium(III) Catalysis

(2016) Songjie Yu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dioxazoles, a new mild nitrene transfer reagent in gold catalysis: highly efficient synthesis of functionalized oxazoles

(2016) Ming Chen et al.   CHEMICAL COMMUNICATIONS

Gold-catalysed reactions of diynes

(2016) Abdullah M. Asiri et al.   CHEMICAL SOCIETY REVIEWS

Au-Catalysed oxidative cyclisation

(2016) Zhitong Zheng et al.   CHEMICAL SOCIETY REVIEWS

Gold-catalyzed transformations of α-diazocarbonyl compounds: selectivity and diversity

(2016) Lu Liu et al.   CHEMICAL SOCIETY REVIEWS

Gold catalysis in total synthesis – recent achievements

(2016) Daniel Pflästerer et al.   CHEMICAL SOCIETY REVIEWS

Rh-Catalyzed Direct Amination of Unactivated C(sp3 )−H bond with Anthranils Under Mild Conditions

(2016) Conghui Tang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Switchable Synthesis of Pyrroles and Pyrazines via Rh(II)-Catalyzed Reaction of 1,2,3-Triazoles with Isoxazoles: Experimental and DFT Evidence for the 1,4-Diazahexatriene Intermediate

(2016) Nikolai V. Rostovskii et al.   JOURNAL OF ORGANIC CHEMISTRY

Recent progress towards gold-catalyzed synthesis of N-containing tricyclic compounds based on ynamides

(2016) Fei Pan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Gold-Catalyzed Direct Assembly of Aryl-Annulated Carbazoles from 2-Alkynyl Arylazides and Alkynes

(2016) Nan Li et al.   ORGANIC LETTERS

Cooperative Co(III)/Cu(II)-Catalyzed C–N/N–N Coupling of Imidates with Anthranils: Access to 1H-Indazoles via C–H Activation

(2016) Lei Li et al.   ORGANIC LETTERS

Gold-Catalyzed Intermolecular Ynamide Amination-Initiated Aza-Nazarov Cyclization: Access to Functionalized 2-Aminopyrroles

(2016) Chao Shu et al.   ORGANIC LETTERS

Access to Structurally Diverse Quinoline-Fused Heterocycles via Rhodium(III)-Catalyzed C–C/C–N Coupling of Bifunctional Substrates

(2016) Songjie Yu et al.   ORGANIC LETTERS

Tandem Rh(III)-Catalyzed C–H Amination/Annulation Reactions: Synthesis of Indoloquinoline Derivatives in Water

(2016) Liangliang Shi et al.   ORGANIC LETTERS

Rh-Catalyzed N–O Bond Cleavage of Anthranil: A C–H Amination Reagent for Simultaneous Incorporation of Amine and a Functional Group

(2016) Miancheng Zou et al.   ORGANIC LETTERS

Rh(II)-Catalyzed Transannulation of N-Sulfonyl-1,2,3-Triazoles with 2,1-Benzisoxazoles or 1,2-Benzisoxazoles

(2016) Xiaoqiang Lei et al.   ORGANIC LETTERS

Catalytic Ynamide Oxidation Strategy for the Preparation of α-Functionalized Amides

(2016) Fei Pan et al.   ACS Catalysis

A zinc-catalyzed oxidative reaction of ynamides with phenols and thiophenols: highly site-selective synthesis of versatile α-aryloxy amides and α-arylthio amides

(2016) Peng-Peng Ruan et al.   Organic Chemistry Frontiers

Synthesis of fused isoquinolines via gold-catalyzed tandem alkyne amination/intramolecular O–H insertion

(2016) Yuan Pan et al.   Organic Chemistry Frontiers

Recent Developments in the Synthesis and Reactivity of Isoxazoles: Metal Catalysis and Beyond

(2015) Feng Hu et al.   ADVANCED SYNTHESIS & CATALYSIS

Zinc-Catalyzed Alkyne Oxidation/CH Functionalization: Highly Site-Selective Synthesis of Versatile Isoquinolones and β-Carbolines

(2015) Long Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Gold-Catalyzed CH Annulation of Anthranils with Alkynes: A Facile, Flexible, and Atom-Economical Synthesis of Unprotected 7-Acylindoles

(2015) Hongming Jin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Jadomycins, put a bigger ring in it: isolation of seven- to ten-membered ring analogues

(2015) Camilo F. Martinez-Farina et al.   CHEMICAL COMMUNICATIONS

Gold(I)-Catalyzed Activation of Alkynes for the Construction of Molecular Complexity

(2015) Ruth Dorel et al.   CHEMICAL REVIEWS

Gold-catalyzed cyclopropanation reactions using a carbenoid precursor toolbox

(2015) Deyun Qian et al.   CHEMICAL SOCIETY REVIEWS

Gold Carbene or Carbenoid: Is There a Difference?

(2015) Yahui Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Atom-Economic Synthesis of Fully Substituted 2-Aminopyrroles via Gold-Catalyzed Formal [3+2] Cycloaddition between Ynamides and Isoxazoles

(2015) Xin-Yu Xiao et al.   Chemistry-An Asian Journal

Facile and efficient synthesis of [1,4]oxazino[3,2-b]indoles and 1H-pyrazino[2,3-b]indoles through gold-catalyzed cascade cyclization of (azido)ynamides

(2015) Cang-Hai Shen et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Generation of α-Imino Gold Carbenes through Gold-Catalyzed Intermolecular Reaction of Azides with Ynamides

(2015) Chao Shu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rhodium(II)-Catalyzed Formal [3 + 2] Cycloaddition of N-Sulfonyl-1,2,3-triazoles with Isoxazoles: Entry to Polysubstituted 3-Aminopyrroles

(2015) Xiaoqiang Lei et al.   ORGANIC LETTERS

Atom-economic generation of gold carbenes: gold-catalyzed formal [3+2] cycloaddition between ynamides and isoxazoles

(2015) Ai-Hua Zhou et al.   Chemical Science

Nucleophilic Nitrenoids Through π-Acid Catalysis: Providing a Common Basis for Rapid Access into Diverse Nitrogen Heterocycles

(2015) Paul W. Davies et al.   Asian Journal of Organic Chemistry

Gold carbene chemistry from diazo compounds

(2015) Fang Wei et al.   Science Bulletin

Catalytic Access to α-Oxo Gold Carbenes by N–O Bond Oxidants

(2014) Hyun-Suk Yeom et al.   ACCOUNTS OF CHEMICAL RESEARCH

A Non-Diazo Approach to α-Oxo Gold Carbenes via Gold-Catalyzed Alkyne Oxidation

(2014) Liming Zhang   ACCOUNTS OF CHEMICAL RESEARCH

Dual Gold Catalysis

(2014) A. Stephen K. Hashmi   ACCOUNTS OF CHEMICAL RESEARCH

Molecular Complexity from Polyunsaturated Substrates: The Gold Catalysis Approach

(2014) Louis Fensterbank et al.   ACCOUNTS OF CHEMICAL RESEARCH

Gold-Catalyzed Synthesis of Functionalized Pyridines by Using 2H-Azirines as Synthetic Equivalents of Alkenyl Nitrenes

(2014) Agnes Prechter et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Gold-catalyzed intermolecular oxidation of o-alkynylbiaryls: an easy and practical access to functionalized fluorenes

(2014) Fei Pan et al.   CHEMICAL COMMUNICATIONS

A Photochemical One-Pot Three-Component Synthesis of Tetrasubstituted Imidazoles

(2014) Stefan Pusch et al.   ORGANIC LETTERS

Facile Synthesis of Disubstituted Isoxazoles from Homopropargylic Alcohol via C═N Bond Formation

(2014) Pin Gao et al.   ORGANIC LETTERS

Gold-Catalyzed Cascade Cyclization of (Azido)ynamides: An Efficient Strategy for the Construction of Indoloquinolines

(2014) Yusuke Tokimizu et al.   ORGANIC LETTERS

Gold-Catalyzed Intermolecular Nitrene Transfer from 2H-Azirines to Ynamides: A Direct Approach to Polysubstituted Pyrroles

(2014) Lei Zhu et al.   ORGANIC LETTERS

Generation of gold carbenes in water: efficient intermolecular trapping of the α-oxo gold carbenoids by indoles and anilines

(2014) Long Li et al.   Chemical Science

Synthesis of novel [3,1]-benzothiazepine and [3,1]-benzoxazepine derivatives with antitumoral activity

(2014) Walter R. Martínez et al.   RSC Advances

Ynamides in Ring Forming Transformations

(2013) Xiao-Na Wang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Gold-Catalyzed Rearrangements and Beyond

(2013) Carla Obradors et al.   ACCOUNTS OF CHEMICAL RESEARCH

Intriguing mechanistic labyrinths in gold(i) catalysis

(2013) Carla Obradors et al.   CHEMICAL COMMUNICATIONS

Transition Metal-Mediated Synthesis of Monocyclic Aromatic Heterocycles

(2013) Anton V. Gulevich et al.   CHEMICAL REVIEWS

Design, Synthesis, and Pharmacological Characterization of N- and O-Substituted 5,6,7,8-Tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol Analogues: Novel 5-HT2A/5-HT2C Receptor Agonists with Pro-Cognitive Properties

(2013) Anders A. Jensen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Exquisite Selectivity for Human Toll-Like Receptor 8 in Substituted Furo[2,3-c]quinolines

(2013) Hari Prasad Kokatla et al.   JOURNAL OF MEDICINAL CHEMISTRY

Heterocycle–Heterocycle Strategies: (2-Nitrophenyl)isoxazole Precursors to 4-Aminoquinolines, 1H-Indoles, and Quinolin-4(1H)-ones

(2013) Keith C. Coffman et al.   ORGANIC LETTERS

Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus

(2013) Jun Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gold-Catalyzed One-Step Construction of 2,3-Dihydro-1H-Pyrrolizines with an Electron-Withdrawing group in the 5-position: A Formal Synthesis of 7-Methoxymitosene

(2012) Ze-Yi Yan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pd-mediated functionalization of polysubstituted pyrroles: Their evaluation as potential inhibitors of PDE4

(2012) T. Bhaskar Kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of Highly Potent and Selective α4β2-Nicotinic Acetylcholine Receptor (nAChR) Partial Agonists Containing an Isoxazolylpyridine Ether Scaffold that Demonstrate Antidepressant-like Activity. Part II

(2012) Li-Fang Yu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Bicyclic Imidazoles via [2 + 3] Cycloaddition between Nitriles and Regioselectively Generated α-Imino Gold Carbene Intermediates

(2012) Yuanjing Xiao et al.   ORGANIC LETTERS

Gold-Catalyzed Transformation of 2-Alkynyl Arylazides: Efficient Access to the Valuable Pseudoindoxyl and Indolyl Frameworks

(2011) Alexander Wetzel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Umpolung Reactivity of Indole through Gold Catalysis

(2011) Biao Lu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Photocycloaddition of aromatic and aliphatic aldehydes to isoxazoles: Cycloaddition reactivity and stability studies

(2011) Axel G Griesbeck et al.   Beilstein Journal of Organic Chemistry

Identification of Novel Malarial Cysteine Protease Inhibitors Using Structure-Based Virtual Screening of a Focused Cysteine Protease Inhibitor Library

(2011) Falgun Shah et al.   Journal of Chemical Information and Modeling

From Fragment Screening to In Vivo Efficacy: Optimization of a Series of 2-Aminoquinolines as Potent Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1)

(2011) Yuan Cheng et al.   JOURNAL OF MEDICINAL CHEMISTRY

3,5-Dimethylisoxazoles Act As Acetyl-lysine-mimetic Bromodomain Ligands

(2011) David S. Hewings et al.   JOURNAL OF MEDICINAL CHEMISTRY

One-Pot Multicomponent Synthesis of Diversely Substituted 2-Aminopyrroles. A Short General Synthesis of Rigidins A, B, C, and D

(2011) Liliya V. Frolova et al.   ORGANIC LETTERS

An efficient synthesis of 2-aminopyrroles from enaminone–amidine adduct and phenacyl/benzyl/heteroalkyl-halides

(2011) Hitesh B. Jalani et al.   TETRAHEDRON LETTERS

Identification of Metabotropic Glutamate Receptor Subtype 5 Potentiators Using Virtual High-Throughput Screening

(2010) Ralf Mueller et al.   ACS Chemical Neuroscience

Ynamides: Versatile Tools in Organic Synthesis

(2010) Gwilherm Evano et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Modifications of C-2 on the pyrroloquinoline template aimed at the development of potent herpesvirus antivirals with improved aqueous solubility

(2010) James A. Nieman et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors

(2010) Michael B. Wallace et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Ynamides: A Modern Functional Group for the New Millennium

(2010) Kyle A. DeKorver et al.   CHEMICAL REVIEWS

A Versatile Iron-Catalyzed Protocol for the One-Pot Synthesis of Isoxazoles or Isoxazolines from the Same Propargylic Alcohols

(2010) Olivier Debleds et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Medicinal Chemist’s Guide to Molecular Interactions

(2010) Caterina Bissantz et al.   JOURNAL OF MEDICINAL CHEMISTRY

N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte fatty-acid binding protein (A-FABP) inhibitors

(2009) Tjeerd Barf et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Efficient and Regioselective One-Pot Synthesis of 3-Substituted and 3,5-Disubstituted Isoxazoles

(2009) Shibing Tang et al.   ORGANIC LETTERS

5-(4-Chlorophenyl)-5,6-dihydro-1,3-oxazepin-7(4H)-one derivatives as lipophilic cyclic analogues of baclofen: Design, synthesis, and neuropharmacological evaluation

(2008) Atef A. Abdel-Hafez et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Coinage Metal-Assisted Synthesis of Heterocycles

(2008) Nitin T. Patil et al.   CHEMICAL REVIEWS

2-Acylhydrazino-5-arylpyrrole derivatives: Synthesis and antifungal activity evaluation

(2008) Valentina Onnis et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

One-Pot Synthesis of Highly Functionalized Pyridines via a Rhodium Carbenoid Induced Ring Expansion of Isoxazoles

(2008) James R. Manning et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Boom in the development of non-peptidic β-secretase (BACE1) inhibitors for the treatment of Alzheimer's disease

(2008) Romano Silvestri   MEDICINAL RESEARCH REVIEWS