The enantioselective addition of 1-fluoro-1-nitro(phenylsulfonyl)methane to isatin-derived ketimines

Nucleophilic monofluoroalkylation with fluorinated phosphonium salt toward carbonyl and imine compounds

(2017) Xian-Liang Zeng et al.   JOURNAL OF FLUORINE CHEMISTRY

Quinine-Based Trifunctional Organocatalyst for Tandem Aza-Henry Reaction-Cyclization: Asymmetric Synthesis of Spiroxindole-Pyrrolidine/Piperidines

(2017) Saumen Hajra et al.   ORGANIC LETTERS

Asymmetric Catalytic 1,2-Hydroperoxidation of Isatin-Derived Ketimine with Hydrogen Peroxide in the Crowding Environment of PEGs

(2017) Wengang Guo et al.   ORGANIC LETTERS

Effective asymmetric vinylogous Mannich reaction of isatin imines with α,α-dicyanoolefins in the presence of a simple chiral amide phosphonium bifunctional phase transfer catalyst

(2017) Cang Cheng et al.   Organic Chemistry Frontiers

Organocatalytic Enantioselective Alkylation of Pyrazol-3-ones with Isatin-Derived Ketimines: Stereocontrolled Construction of Vicinal Tetrasubstituted Stereocenters

(2016) Fares Ibrahim Amr et al.   ADVANCED SYNTHESIS & CATALYSIS

Recent Developments in the Stereoselective Synthesis of Nitrogen-Containing Heterocycles usingN-Acylimines as Reactive Substrates

(2016) Enrico Marcantoni et al.   ADVANCED SYNTHESIS & CATALYSIS

Asymmetric synthesis of 3,3′-pyrrolidinyl-dispirooxindoles via a one-pot organocatalytic Mannich/deprotection/aza-Michael sequence

(2016) Kun Zhao et al.   CHEMICAL COMMUNICATIONS

The enantioselective construction of chiral spirooxindole-based 4-thiazolidinone via asymmetric catalytic formal [3+2] annulation using a bifunctional catalyst

(2016) Ping Cheng et al.   CHEMICAL COMMUNICATIONS

Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas

(2016) Yu Zhou et al.   CHEMICAL REVIEWS

Organocatalytic Enantioselective Synthesis of Pyrazoles Bearing a Quaternary Stereocenter

(2016) Carlos Vila et al.   Chemistry-An Asian Journal

Asymmetric [3+2] annulations of 1,4-di-thiane-2,5-diol and oxindole ketimines

(2016) Bo-Xu Feng et al.   TETRAHEDRON LETTERS

Organocatalytic Enantioselective Friedel–Crafts Aminoalkylation of Indoles in the Carbocyclic Ring

(2016) Marc Montesinos-Magraner et al.   ACS Catalysis

Organocatalytic enantioselective Mukaiyama–Mannich reaction of fluorinated enol silyl ethers and cyclic N-sulfonyl ketimines

(2016) Jin-Sheng Yu et al.   Organic Chemistry Frontiers

Catalytic Enantioselective Construction of Quaternary Stereocenters: Assembly of Key Building Blocks for the Synthesis of Biologically Active Molecules

(2015) Yiyang Liu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Stereoselective Organocatalytic Synthesis of Oxindoles with Adjacent Tetrasubstituted Stereocenters

(2015) Oliver D. Engl et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic Asymmetric Addition of Naphthols and Electron-Rich Phenols to Isatin-Derived Ketimines: Highly Enantioselective Construction of Tetrasubstituted Stereocenters

(2015) Marc Montesinos-Magraner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regio- and Enantioselective Aza-Diels-Alder Reactions of 3-Vinylindoles: A Concise Synthesis of the Antimalarial Spiroindolone NITD609

(2015) Haifeng Zheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An Organocatalytic Mannich/Denitration Reaction for the Asymmetric Synthesis of 3-Ethylacetate-Substitued 3-Amino-2-Oxindoles: Formal Synthesis of AG-041R

(2015) Kun Zhao et al.   CHEMISTRY-A EUROPEAN JOURNAL

Modular Catalytic Synthesis of 3-Amino-3-aryl-2-oxindoles: Rh Catalysis with Isatin-DerivedN-Boc-Protected Ketimines

(2015) Carolina S. Marques et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Applications of Fluorine in Medicinal Chemistry

(2015) Eric P. Gillis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Construction of Vicinal Tetrasubstituted Stereocenters with a C–F Bond through a Catalytic Enantioselective Detrifluoroacetylative Mannich Reaction

(2015) Xihong Liu et al.   JOURNAL OF ORGANIC CHEMISTRY

Catalytic Asymmetric Construction of Vicinal Tetrasubstituted Stereocenters by the Mannich Reaction of Linear α-Substituted Monothiomalonates with Isatin N-Boc Ketimines

(2015) Teng Liu et al.   JOURNAL OF ORGANIC CHEMISTRY

Maleimide as an efficient nucleophilic partner in the aza-Morita–Baylis–Hillman reaction: synthesis of chiral 3-substituted-3-aminooxindoles

(2015) Akshay Kumar et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A highly efficient Mukaiyama–Mannich reaction of N-Boc isatin ketimines and other active cyclic ketimines using difluoroenol silyl ethers catalyzed by Ph3PAuOTf

(2015) Jin-Sheng Yu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

An enantioselective organocatalyzed aza-Morita–Baylis–Hillman reaction of isatin-derived ketimines with acrolein

(2015) Yasushi Yoshida et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Organocatalytic Enantioselective Peroxidation of Ketimines Derived from Isatins

(2015) Shuichi Nakamura et al.   ORGANIC LETTERS

PyBidine–NiCl2-Catalyzed Asymmetric Addition of Alcohols and Peroxides to Isatin-Derived Ketimines

(2015) Takayoshi Arai et al.   ORGANIC LETTERS

An Organocatalytic Asymmetric Friedel–Crafts Addition/Fluorination Sequence: Construction of Oxindole–Pyrazolone Conjugates Bearing Vicinal Tetrasubstituted Stereocenters

(2015) Xiaoze Bao et al.   ORGANIC LETTERS

Asymmetric addition of 3-substituted benzofuran-2-ones to isatin N-Boc ketimines catalyzed by chiral biscinchona alkaloid catalyst

(2015) Yi Zhu et al.   TETRAHEDRON

Good Partnership between Sulfur and Fluorine: Sulfur-Based Fluorination and Fluoroalkylation Reagents for Organic Synthesis

(2014) Chuanfa Ni et al.   CHEMICAL REVIEWS

Highly Diastereoselective Reaction of α-Diazoesters with Aryl Alcohols and Isatin Imines: Rapid Access to Oxindole-Derived α-Alkoxy-β-amino Acid Derivatives with Two Adjacent Quaternary Carbon Centers

(2014) Tamilselvan Rajasekaran et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Organocatalyzed Enantioselective Mannich Reaction of Pyrazoleamides with Isatin-Derived Ketimines

(2014) Tian-Ze Li et al.   JOURNAL OF ORGANIC CHEMISTRY

All-Carbon Quaternary Stereogenic Centers in Acyclic Systems through the Creation of Several C–C Bonds per Chemical Step

(2014) Ilan Marek et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic enantioselective synthesis of quaternary carbon stereocentres

(2014) Kyle W. Quasdorf et al.   NATURE

Enantioselective aza-Morita–Baylis–Hillman reaction between acrylates and N-Boc isatin ketimines: asymmetric construction of chiral 3-substituted-3-aminooxindoles

(2014) Xuan Zhao et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Highly enantioselective synthesis of bisoxindoles with two vicinal quaternary stereocenters via Lewis base mediated addition of oxindoles to isatin-derived ketimines

(2014) Zhongkai Tang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Organocatalytic Enantioselective Addition of Thiols to Ketimines Derived from Isatins

(2014) Shuichi Nakamura et al.   ORGANIC LETTERS

Bis(imidazolidine)pyridine-NiCl2 Catalyst for Nitro-Mannich Reaction of Isatin-Derived N-Boc Ketimines: Asymmetric Synthesis of Chiral 3-Substituted 3-Amino-2-oxindoles

(2014) Takayoshi Arai et al.   ORGANIC LETTERS

N-Hydroxymethyl derivatives of α-amino aldehydes used for the stereoselective syntheses of β-amino-α-hydroxy acids

(2014) Youngran Seo et al.   TETRAHEDRON-ASYMMETRY

Organocatalytic direct asymmetric vinylogous Mannich reaction of γ-butenolides with isatin-derived ketimines

(2014) Yunlong Guo et al.   RSC Advances

Organocatalytic enantioselective aza-Henry reaction of ketimines derived from isatins: access to optically active 3-amino-2-oxindoles

(2014) Akshay Kumar et al.   RSC Advances

An Organocatalytic Addition of Nitromethane to Activated Ketimines

(2014) Yu-Hui Wang et al.   Asian Journal of Organic Chemistry

Enantioselective methodologies using N-carbamoyl-imines

(2013) Jan Vesely et al.   CHEMICAL SOCIETY REVIEWS

Direct Synthesis of Diverse β-Fluoroethylamines by a Multicomponent Protocol

(2013) G. K. Surya Prakash et al.   CHEMISTRY-A EUROPEAN JOURNAL

Catalytic Enantioselective Allylation of Ketimines by Using Palladium Pincer Complexes with Chiral Bis(imidazoline)s

(2013) Shuichi Nakamura et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enantioselective Squaramide-Catalysed Domino Mannich-Cyclization Reaction of Isatin Imines

(2013) Xi-Bo Wang et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

The Construction of All-Carbon Quaternary Stereocenters by Use of Pd-Catalyzed Asymmetric Allylic Alkylation Reactions in Total Synthesis

(2013) Allen Y. Hong et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Asymmetric catalytic aza-Morita–Baylis–Hillman reaction for the synthesis of 3-substituted-3-aminooxindoles with chiral quaternary carbon centers

(2013) Fang-Le Hu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

First example of quinine-squaramide catalyzed enantioselective addition of diphenyl phosphite to ketimines derived from isatins

(2013) Jimil George et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Rhodium-catalyzed three-component reaction of 3-diazooxindoles with indoles and isatin-derived ketimines: a facile and versatile approach to functionalized 3,3′,3′′-trisindoles

(2013) Liang-Yong Mei et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Highly Enantioselective Monofluoromethylation of C2-Arylindoles Using FBSM under Chiral Phase-Transfer Catalysis

(2013) Kohei Matsuzaki et al.   ORGANIC LETTERS

Catalytic enantioselective addition of alcohols to isatin-derived N-Boc ketimines

(2013) Tian-Ze Li et al.   TETRAHEDRON

Organocatalytic alkynylation of densely functionalized monofluorinated derivatives: C(sp3)–C(sp) coupling

(2013) Martin Kamlar et al.   TETRAHEDRON LETTERS

Asymmetric Conjugate Addition of 1-Fluoro-1-nitro(phenylsulfonyl)methane to Chalcones Catalyzed by Binaphthyl-Derived Organocatalyst

(2012) Hyoung-Wook Moon et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Organocatalytic asymmetric cyanation of isatin derived N-Boc ketoimines

(2012) Yun-Lin Liu et al.   CHEMICAL COMMUNICATIONS

Enantioselective Synthesis of AG-041R by using N-Heteroarenesulfonyl Cinchona Alkaloid Amides as Organocatalysts

(2012) Noriyuki Hara et al.   CHEMISTRY-A EUROPEAN JOURNAL

DIAD-mediated metal-free cross dehydrogenative coupling between tertiary amines and α-fluorinated sulfones

(2012) Weizhou Huang et al.   NEW JOURNAL OF CHEMISTRY

Rhodium-Catalyzed Asymmetric Formal Cycloadditions of Racemic Butadiene Monoxide with Imines

(2012) Zhaoqun Liu et al.   ORGANIC LETTERS

Synthesis of N-Alkoxycarbonyl Ketimines Derived from Isatins and Their Application in Enantioselective Synthesis of 3-Aminooxindoles

(2012) Wenjin Yan et al.   ORGANIC LETTERS

Stereoselective Construction of Quaternary Carbon Stereocenters via a Semipinacol Rearrangement Strategy

(2011) Baomin Wang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Construction of Asymmetric Quaternary Carbon Centers with High Enantioselectivity

(2011) Masaki Shimizu   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Allylic Monofluoromethylation and Methylation of Morita-Baylis-Hillman Carbonates with FBSM and BSM by Cooperative Cinchona Alkaloid/FeCl2 Catalysis

(2011) Tatsuya Furukawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nucleophilic Fluoromethylation of Aldehydes with Fluorobis(phenylsulfonyl)methane: The Importance of Strong Li-O Coordination and Fluorine Substitution for CC Bond Formation

(2011) Xiao Shen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Potent and selective oxindole-based vasopressin 1b receptor antagonists with improved pharmacokinetic properties

(2011) Thorsten Oost et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Enantioselective synthesis of all-carbon quaternary stereogenic centers in acyclic systems

(2011) Jaya Prakash Das et al.   CHEMICAL COMMUNICATIONS

Highly Enantio- and Diastereoselective Synthesis of β-Methyl-γ-monofluoromethyl-Substituted Alcohols

(2011) Wenguo Yang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enantioselective Organocatalytic Synthesis of Fluorinated Molecules

(2011) Guillem Valero et al.   CHEMISTRY-A EUROPEAN JOURNAL

Identification of Thiazolidinones Spiro-Fused to Indolin-2-ones as Potent and Selective Inhibitors of theMycobacterium tuberculosisProtein Tyrosine Phosphatase B

(2010) Viktor V. Vintonyak et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metal-catalyzed asymmetric conjugate addition reaction: formation of quaternary stereocenters

(2010) Christine Hawner et al.   CHEMICAL COMMUNICATIONS

Highly Diastereoselective Synthesis of α-Difluoromethyl Amines from N-tert-Butylsulfinyl Ketimines and Difluoromethyl Phenyl Sulfone

(2010) Jun Liu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Highly Enantioselective Addition of 1-Fluoro-1-nitro(phenylsulfonyl)methane to α,β-Unsaturated Aldehydes

(2010) Martin Kamlar et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Fluorine in health care: Organofluorine containing blockbuster drugs

(2010) David O’Hagan   JOURNAL OF FLUORINE CHEMISTRY

Spiroindolones, a Potent Compound Class for the Treatment of Malaria

(2010) M. Rottmann et al.   SCIENCE

Enantioselective Synthesis of α-Fluorinated β-Amino Acid Derivatives by an Asymmetric Mannich Reaction and Selective Deacylation/Decarboxylation Reactions

(2009) Yuanhang Pan et al.   CHEMISTRY-A EUROPEAN JOURNAL

Formal Highly Enantioselective Organocatalytic Addition of Fluoromethyl Anion to α,β-Unsaturated Aldehydes

(2009) Andrea-Nekane Alba et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enantioselective Organocatalytic Conjugate Addition of Fluorocarbon Nucleophiles to α,β-Unsaturated Aldehydes

(2009) Farman Ullah et al.   CHEMISTRY-A EUROPEAN JOURNAL

 -Fluoro- -nitro(phenylsulfonyl)methane as a fluoromethyl pronucleophile: Efficient stereoselective Michael addition to chalcones

(2009) G. K. S. Prakash et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Catalytic Enantioselective Michael Addition of 1-Fluorobis(phenylsulfonyl)methane to α,β-Unsaturated Ketones Catalyzed by Cinchona Alkaloids

(2008) Tatsuya Furukawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficient 1,4-addition of α-substituted fluoro(phenylsulfonyl)methane derivatives to α,β-unsaturated compounds

(2008) G K Surya Prakash et al.   Beilstein Journal of Organic Chemistry

The Many Roles for Fluorine in Medicinal Chemistry

(2008) William K. Hagmann   JOURNAL OF MEDICINAL CHEMISTRY

Nucleophilic Fluoroalkylation of α,β-Enones, Arynes, and Activated Alkynes with Fluorinated Sulfones: Probing the Hard/Soft Nature of Fluorinated Carbanions

(2008) Chuanfa Ni et al.   JOURNAL OF ORGANIC CHEMISTRY

Stereoselective Monofluoromethylation ofN-tert-Butylsulfinyl Ketimines Using Pregenerated Fluoro(phenylsulfonyl)methyl Anion

(2008) Jun Liu et al.   ORGANIC LETTERS

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS