Roles of the Hippo pathway in lung development and tumorigenesis

Yes-Associated Protein 1 Promotes Adenocarcinoma Growth and Metastasis through Activation of the Receptor Tyrosine Kinase Axl

(2017) Z-L. Cui et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

YAP1 acts as oncogenic target of 11q22 amplification in multiple cancer subtypes.

(2015) Erica Lorenzetto et al.   Oncotarget

Hippo pathway in mammary gland development and breast cancer

(2014) P. Shi et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Hippo signaling in epithelial stem cells

(2014) M.-X. Yin et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Mesenchymal stem cells in lung cancer tumor microenvironment: their biological properties, influence on tumor growth and therapeutic implications

(2014) Renwang Liu et al.   CANCER LETTERS

VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex

(2014) Wenjing Zhang et al.   CELL RESEARCH

An Integrative Analysis of the Tumorigenic Role of TAZ in Human Non-Small Cell Lung Cancer

(2014) S. Noguchi et al.   CLINICAL CANCER RESEARCH

The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease

(2014) X. Varelas   DEVELOPMENT

The Hippo Pathway Effector Yap Controls Patterning and Differentiation of Airway Epithelial Progenitors

(2014) John E. Mahoney et al.   DEVELOPMENTAL CELL

Yap Tunes Airway Epithelial Size and Architecture by Regulating the Identity, Maintenance, and Self-Renewal of Stem Cells

(2014) Rui Zhao et al.   DEVELOPMENTAL CELL

Tumor-propagating cells and Yap/Taz activity contribute to lung tumor progression and metastasis

(2014) A. N. Lau et al.   EMBO JOURNAL

RASSF1A–LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2

(2014) Dafni-Eleftheria Pefani et al.   NATURE CELL BIOLOGY

Expression of LATS1 contributes to good prognosis and can negatively regulate YAP oncoprotein in non-small-cell lung cancer

(2014) Xu-Yong Lin et al.   TUMOR BIOLOGY

YAP inhibits squamous transdifferentiation of Lkb1-deficient lung adenocarcinoma through ZEB2-dependent DNp63 repression

(2014) Yijun Gao et al.   Nature Communications

Transcriptome meta-analysis of lung cancer reveals recurrent aberrations in NRG1 and Hippo pathway genes

(2014) Saravana M. Dhanasekaran et al.   Nature Communications

The Hippo Transducer TAZ Interacts with the SWI/SNF Complex to Regulate Breast Epithelial Lineage Commitment

(2014) Adam Skibinski et al.   Cell Reports

NKX2-1/TTF-1: An Enigmatic Oncogene that Functions as a Double-Edged Sword for Cancer Cell Survival and Progression

(2013) Tomoya Yamaguchi et al.   CANCER CELL

Mst1 overexpression inhibited the growth of human non-small cell lung cancer in vitro and in vivo

(2013) C M Xu et al.   CANCER GENE THERAPY

BMP4 is a novel transcriptional target and mediator of mammary cell migration downstream of the Hippo pathway component TAZ

(2013) Dulcie Lai et al.   CELLULAR SIGNALLING

Molecular Pathways: YAP and TAZ Take Center Stage in Organ Growth and Tumorigenesis

(2013) S. Piccolo et al.   CLINICAL CANCER RESEARCH

Yes-Associated Protein Up-regulates Jagged-1 and Activates the NOTCH Pathway in Human Hepatocellular Carcinoma

(2013) Darjus Felix Tschaharganeh et al.   GASTROENTEROLOGY

The Hippo pathway: regulators and regulations

(2013) F.-X. Yu et al.   GENES & DEVELOPMENT

Evidence for a Tumor Suppressor Role for the Large Tumor Suppressor Genes LATS1 and LATS2 in Human Cancer

(2013) Tian Yu et al.   GENETICS

Therapy-induced enrichment of putative lung cancer stem-like cells

(2013) Daniela P. Freitas et al.   INTERNATIONAL JOURNAL OF CANCER

A genetic screen identifies an LKB1–MARK signalling axis controlling the Hippo–YAP pathway

(2013) Morvarid Mohseni et al.   NATURE CELL BIOLOGY

The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

(2013) Randy Johnson et al.   NATURE REVIEWS DRUG DISCOVERY

Hippo-Foxa2 signaling pathway plays a role in peripheral lung maturation and surfactant homeostasis

(2013) C. Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angiomotin'g YAP into the Nucleus for Cell Proliferation and Cancer Development

(2013) W. Hong   Science Signaling

MicroRNA-135b promotes lung cancer metastasis by regulating multiple targets in the Hippo pathway and LZTS1

(2013) Ching-Wen Lin et al.   Nature Communications

Lung cancer stem cells: a biological and clinical perspective

(2013) Ana Koren et al.   CELLULAR ONCOLOGY

Integration of mechanical and chemical signals by YAP and TAZ transcription coactivators

(2013) Xiaocan Guo et al.   Cell and Bioscience

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

(2012) Fa-Xing Yu et al.   CELL

Prognostic Significance of TAZ Expression in Resected Non-Small Cell Lung Cancer

(2012) Mian Xie et al.   Journal of Thoracic Oncology

Transduction of mechanical and cytoskeletal cues by YAP and TAZ

(2012) Georg Halder et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The YAP and TAZ transcription co-activators: Key downstream effectors of the mammalian Hippo pathway

(2012) Wanjin Hong et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Integration of intercellular signaling through the Hippo pathway

(2012) Kenneth D. Irvine   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Taxol Resistance in Breast Cancer Cells Is Mediated by the Hippo Pathway Component TAZ and Its Downstream Transcriptional Targets Cyr61 and CTGF

(2011) D. Lai et al.   CANCER RESEARCH

SnapShot: The Hippo Signaling Pathway

(2011) Caroline Badouel et al.   CELL

The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

(2011) Michelangelo Cordenonsi et al.   CELL

Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development

(2011) Y. Mao et al.   DEVELOPMENT

The Human Adenocarcinoma-associated Gene,AGR2, Induces Expression ofAmphiregulinthrough Hippo Pathway Co-activatorYAP1Activation

(2011) Aiwen Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal

(2011) Bin Zhao et al.   NATURE CELL BIOLOGY

TAZ is a novel oncogene in non-small cell lung cancer

(2011) Z Zhou et al.   ONCOGENE

LKB1 in lung cancerigenesis: a serine/threonine kinase as tumor suppressor

(2011) Yijun Gao et al.   Protein & Cell

Overexpression of yes-associated protein contributes to progression and poor prognosis of non-small-cell lung cancer

(2010) Yang Wang et al.   CANCER SCIENCE

The prognostic value of RASSF1A promoter hypermethylation in non-small cell lung carcinoma: a systematic review and meta-analysis

(2010) Jun Wang et al.   CARCINOGENESIS

LATS tumor suppressor: A new governor of cellular homeostasis

(2010) Stacy Visser et al.   CELL CYCLE

The Hippo Signaling Pathway in Development and Cancer

(2010) Duojia Pan   DEVELOPMENTAL CELL

Differential expression of Yes-associated protein is correlated with expression of cell cycle markers and pathologic TNM staging in non–small-cell lung carcinoma☆

(2010) Jin Man Kim et al.   HUMAN PATHOLOGY

MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors

(2010) Xi Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeted Therapies for Non-Small Cell Lung Cancer: An Evolving Landscape

(2010) S. K. Pal et al.   MOLECULAR CANCER THERAPEUTICS

The molecular pathology of cancer

(2010) Timothy J. R. Harris et al.   Nature Reviews Clinical Oncology

Transcriptional Coactivator with PDZ-binding Motif Is Essential for Normal Alveolarization in Mice

(2009) Akihisa Mitani et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

ATM Regulates a RASSF1A-Dependent DNA Damage Response

(2009) Garth Hamilton et al.   CURRENT BIOLOGY

Pathogenesis of lung cancer signalling pathways: roadmap for therapies

(2009) E. Brambilla et al.   EUROPEAN RESPIRATORY JOURNAL

Identification of LATS transcriptional targets in HeLa cells using whole human genome oligonucleotide microarray

(2009) Stacy Visser et al.   GENE

Advances in Target Therapy for Lung Cancer

(2009) T. Mitsudomi   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Negative Regulation of YAP by LATS1 Underscores Evolutionary Conservation of the Drosophila Hippo Pathway

(2008) J. Zhang et al.   CANCER RESEARCH

The TEAD/TEF Family Protein Scalloped Mediates Transcriptional Output of the Hippo Growth-Regulatory Pathway

(2008) Shian Wu et al.   DEVELOPMENTAL CELL

LATS2 tumour specific mutations and down-regulation of the gene in non-small cell carcinoma

(2008) Mojca Stražišar et al.   LUNG CANCER

TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway

(2008) Q.-Y. Lei et al.   MOLECULAR AND CELLULAR BIOLOGY

TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

(2008) Xaralabos Varelas et al.   NATURE CELL BIOLOGY