New factors in mammalian DNA repair—the chromatin connection

NRAGE is involved in homologous recombination repair to resist the DNA-damaging chemotherapy and composes a ternary complex with RNF8–BARD1 to promote cell survival in squamous esophageal tumorigenesis

(2016) Q Yang et al.   CELL DEATH AND DIFFERENTIATION

PACS-2 mediates the ATM and NF-κB-dependent induction of anti-apoptotic Bcl-xL in response to DNA damage

(2016) J Barroso-González et al.   CELL DEATH AND DIFFERENTIATION

Splicing controls the ubiquitin response during DNA double-strand break repair

(2016) C Pederiva et al.   CELL DEATH AND DIFFERENTIATION

Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans

(2016) Z Li et al.   CELL DEATH AND DIFFERENTIATION

Zfp281 Coordinates Opposing Functions of Tet1 and Tet2 in Pluripotent States

(2016) Miguel Fidalgo et al.   Cell Stem Cell

The C2H2-ZF transcription factor Zfp335 recognizes two consensus motifs using separate zinc finger arrays

(2016) Brenda Yuyuan Han et al.   GENES & DEVELOPMENT

Synthetic lethality between PAXX and XLF in mammalian development

(2016) Gabriel Balmus et al.   GENES & DEVELOPMENT

The role of ADP-ribosylation in regulating DNA interstrand crosslink repair

(2016) Alasdair R. Gunn et al.   JOURNAL OF CELL SCIENCE

PARP1 Links CHD2-Mediated Chromatin Expansion and H3.3 Deposition to DNA Repair by Non-homologous End-Joining

(2016) Martijn S. Luijsterburg et al.   MOLECULAR CELL

HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity

(2016) Ian Gibbs-Seymour et al.   MOLECULAR CELL

53BP1 Integrates DNA Repair and p53-Dependent Cell Fate Decisions via Distinct Mechanisms

(2016) Raquel Cuella-Martin et al.   MOLECULAR CELL

Sliding sleeves of XRCC4–XLF bridge DNA and connect fragments of broken DNA

(2016) Ineke Brouwer et al.   NATURE

The structural basis of modified nucleosome recognition by 53BP1

(2016) Marcus D. Wilson et al.   NATURE

EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome

(2016) Dejiu Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

53BP1 fosters fidelity of homology-directed DNA repair

(2016) Fena Ochs et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A permissive chromatin state regulated by ZFP281-AFF3 in controlling the imprinted Meg3 polycistron

(2016) Yan Wang et al.   NUCLEIC ACIDS RESEARCH

NF-κB-HOTAIR axis links DNA damage response, chemoresistance and cellular senescence in ovarian cancer

(2016) A R Özeş et al.   ONCOGENE

MMSET/WHSC1 enhances DNA damage repair leading to an increase in resistance to chemotherapeutic agents

(2016) M Y Shah et al.   ONCOGENE

BET bromodomain inhibitors synergize with ATR inhibitors to induce DNA damage, apoptosis, senescence-associated secretory pathway and ER stress in Myc-induced lymphoma cells

(2016) S V Muralidharan et al.   ONCOGENE

Rad54 and Mus81 cooperation promotes DNA damage repair and restrains chromosome missegregation

(2016) S El Ghamrasni et al.   ONCOGENE

PAXX and XLF DNA repair factors are functionally redundant in joining DNA breaks in a G1-arrested progenitor B-cell line

(2016) Vipul Kumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repair Pathway Choices and Consequences at the Double-Strand Break

(2016) Raphael Ceccaldi et al.   TRENDS IN CELL BIOLOGY

Attenuated DNA damage repair delays therapy-related myeloid neoplasms in a mouse model

(2016) Kit I Tong et al.   Cell Death & Disease

DNA-PK-mediated phosphorylation of EZH2 regulates the DNA damage-induced apoptosis to maintain T-cell genomic integrity

(2016) Y Wang et al.   Cell Death & Disease

Targeting the epigenetics of the DNA damage response in breast cancer

(2016) M F Montenegro et al.   Cell Death & Disease

EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome

(2016) Dejiu Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

53BP1 fosters fidelity of homology-directed DNA repair

(2016) Fena Ochs et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination

(2016) Chloé Lescale et al.   Cell Reports

NOTCH1 Inhibits Activation of ATM by Impairing the Formation of an ATM-FOXO3a-KAT5/Tip60 Complex

(2016) Marek Adamowicz et al.   Cell Reports

Cow’s milk allergy in Dutch children: an epigenetic pilot survey

(2016) Nicole C. M. Petrus et al.   Clinical and Translational Allergy

DNA repair and aging: the impact of the p53 family

(2015) Sara Nicolai et al.   Aging-US

TRIM28 as a novel transcriptional elongation factor

(2015) Heeyoun Bunch et al.   BMC MOLECULAR BIOLOGY

DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis

(2015) Jonathan F. Goodwin et al.   CANCER CELL

DNA damage-induced ephrin-B2 reverse signaling promotes chemoresistance and drives EMT in colorectal carcinoma harboring mutant p53

(2015) S K Alam et al.   CELL DEATH AND DIFFERENTIATION

XLS (c9orf142) is a new component of mammalian DNA double-stranded break repair

(2015) A Craxton et al.   CELL DEATH AND DIFFERENTIATION

Next generation limb development and evolution: old questions, new perspectives

(2015) Aimée Zuniga   DEVELOPMENT

Spatiotemporal regulation of posttranslational modifications in the DNA damage response

(2015) N. P. Dantuma et al.   EMBO JOURNAL

Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage

(2015) Tina Thorslund et al.   NATURE

ZNF281 contributes to the DNA damage response by controlling the expression of XRCC2 and XRCC4

(2015) M Pieraccioli et al.   ONCOGENE

PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair

(2015) T. Ochi et al.   SCIENCE

Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins

(2015) Rohit Prakash et al.   Cold Spring Harbor Perspectives in Biology

Downregulation of the cancer susceptibility protein WRAP53β in epithelial ovarian cancer leads to defective DNA repair and poor clinical outcome

(2015) E Hedström et al.   Cell Death & Disease

Targeting neddylation induces DNA damage and checkpoint activation and sensitizes chronic lymphocytic leukemia B cells to alkylating agents

(2015) C Paiva et al.   Cell Death & Disease

LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair

(2015) Xue-Song Liu et al.   Nature Communications

Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway

(2015) Mengtan Xing et al.   Nature Communications

A Systematic Analysis of Factors Localized to Damaged Chromatin Reveals PARP-Dependent Recruitment of Transcription Factors

(2015) Lior Izhar et al.   Cell Reports

Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks

(2015) Pierre Caron et al.   Cell Reports

ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis

(2014) P. Goggolidou et al.   DEVELOPMENT

Nonhomologous end joining: A good solution for bad ends

(2014) Crystal A. Waters et al.   DNA REPAIR

Function of transcription factors at DNA lesions in DNA repair

(2014) Michal Malewicz et al.   EXPERIMENTAL CELL RESEARCH

Poly(ADP-ribose) polymerases in double-strand break repair: Focus on PARP1, PARP2 and PARP3

(2014) Carole Beck et al.   EXPERIMENTAL CELL RESEARCH

Deep Vertebrate Roots for Mammalian Zinc Finger Transcription Factor Subfamilies

(2014) Hui Liu et al.   Genome Biology and Evolution

ZNF281/ZBP-99: a new player in epithelial–mesenchymal transition, stemness, and cancer

(2014) Stefanie Hahn et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The fidelity of the ligation step determines how ends are resolved during nonhomologous end joining

(2014) Crystal A. Waters et al.   Nature Communications

Chromatin Remodeling at DNA Double-Strand Breaks

(2013) Brendan D. Price et al.   CELL

SNAIL and miR-34a feed-forward regulation of ZNF281/ZBP99 promotes epithelial-mesenchymal transition

(2013) Stefanie Hahn et al.   EMBO JOURNAL

A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair

(2013) Sébastien Britton et al.   JOURNAL OF CELL BIOLOGY

KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling

(2013) Abderrahmane Kaidi et al.   NATURE

53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark

(2013) Amélie Fradet-Turcotte et al.   NATURE

The ATM protein kinase: regulating the cellular response to genotoxic stress and more

(2013) Yosef Shiloh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Double-strand break repair: 53BP1 comes into focus

(2013) Stephanie Panier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nucleolin mediates nucleosome disruption critical for DNA double-strand break repair

(2013) M. Goldstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Genome-wide Map of CTCF Multivalency Redefines the CTCF Code

(2013) Hirotaka Nakahashi et al.   Cell Reports

The Interaction of CtIP and Nbs1 Connects CDK and ATM to Regulate HR–Mediated Double-Strand Break Repair

(2013) Hailong Wang et al.   PLoS Genetics

APLF promotes the assembly and activity of non-homologous end joining protein complexes

(2012) Gabrielle J Grundy et al.   EMBO JOURNAL

The DNA Damage- and Transcription-Associated Protein Paxip1 Controls Thymocyte Development and Emigration

(2012) Elsa Callen et al.   IMMUNITY

Histone H2A.Z Controls a Critical Chromatin Remodeling Step Required for DNA Double-Strand Break Repair

(2012) Ye Xu et al.   MOLECULAR CELL

New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs

(2012) Bryan A. Gibson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Bivalent recognition of nucleosomes by the tandem PHD fingers of the CHD4 ATPase is required for CHD4-mediated repression

(2012) C. A. Musselman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zfp281 mediates Nanog autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming

(2012) M. Fidalgo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional and Nontranscriptional Functions of E2F1 in Response to DNA Damage

(2011) A. K. Biswas et al.   CANCER RESEARCH

MiR-203 controls proliferation, migration and invasive potential of prostate cancer cell lines

(2011) Giuditta Viticchiè et al.   CELL CYCLE

Essential role for DNA-PK-mediated phosphorylation of NR4A nuclear orphan receptors in DNA double-strand break repair

(2011) M. Malewicz et al.   GENES & DEVELOPMENT

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

(2011) S. E. Polo et al.   GENES & DEVELOPMENT

PARP regulates nonhomologous end joining through retention of Ku at double-strand breaks

(2011) C. Anne-Marie Couto et al.   JOURNAL OF CELL BIOLOGY

DNA Repair Factor APLF Is a Histone Chaperone

(2011) Pawan Vinod Mehrotra et al.   MOLECULAR CELL

PARP-3 and APLF Function Together to Accelerate Nonhomologous End-Joining

(2011) Stuart L. Rulten et al.   MOLECULAR CELL

More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance

(2011) Jiri Lukas et al.   NATURE CELL BIOLOGY

Zfp281 Functions as a Transcriptional Repressor for Pluripotency of Mouse Embryonic Stem Cells

(2011) Miguel Fidalgo et al.   STEM CELLS

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4

(2010) Sophie E Polo et al.   EMBO JOURNAL

ATM modulates transcription in response to histone deacetylase inhibition as part of its DNA damage response

(2010) Eun Ryoung Jang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks

(2010) Shan Zha et al.   NATURE

53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair

(2010) Angela T. Noon et al.   NATURE CELL BIOLOGY

Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining

(2010) Kyle M Miller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genome-Wide Promoter Analysis of the SOX4 Transcriptional Network in Prostate Cancer Cells

(2009) C. D. Scharer et al.   CANCER RESEARCH

A census of human transcription factors: function, expression and evolution

(2009) Juan M. Vaquerizas et al.   NATURE REVIEWS GENETICS

Poly(ADP-ribose)-Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1

(2009) D. Ahel et al.   SCIENCE

Mutations to Ku reveal differences in human somatic cell lines

(2008) Kazi R. Fattah et al.   DNA REPAIR

Lymphocyte-Specific Compensation for XLF/Cernunnos End-Joining Functions in V(D)J Recombination

(2008) Gang Li et al.   MOLECULAR CELL

Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins

(2008) Ivan Ahel et al.   NATURE