Proteomic identification of ERP29 as a key chemoresistant factor activated by the aggregating p53 mutant Arg282Trp

A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas

(2016) Alice Soragni et al.   CANCER CELL

Multi-omics reveals global effects of mutant p53 gain-of-function

(2016) Dawid Walerych et al.   CELL CYCLE

Mutant p53 Gain of Function and Chemoresistance: The Role of Mutant p53 in Response to Clinical Chemotherapy

(2016) Chao He et al.   CHEMOTHERAPY

Targeting mutant p53 in cancer: a long road to precision therapy

(2016) Fiamma Mantovani et al.   FEBS Journal

Expression of GRP78, Master Regulator of the Unfolded Protein Response, Increases Chemoresistance in Pancreatic Ductal Adenocarcinoma

(2016) J. B. Gifford et al.   MOLECULAR CANCER THERAPEUTICS

Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer

(2016) Dawid Walerych et al.   NATURE CELL BIOLOGY

Gain-of-function miRNA signature by mutant p53 associates with poor cancer outcome

(2016) Yao Zhang et al.   Oncotarget

Degradation of Redox-Sensitive Proteins including Peroxiredoxins and DJ-1 is Promoted by Oxidation-induced Conformational Changes and Ubiquitination

(2016) In-Kang Song et al.   Scientific Reports

Regulation of Cellular Metabolism and Hypoxia by p53

(2016) Timothy J. Humpton et al.   Cold Spring Harbor Perspectives in Medicine

B cell regulation of the anti-tumor response and role in carcinogenesis

(2016) Marc Schwartz et al.   Journal for ImmunoTherapy of Cancer

Aggregation tendencies in the p53 family are modulated by backbone hydrogen bonds

(2016) Elio A. Cino et al.   Scientific Reports

Novel role of PELP1 in regulating chemotherapy response in mutant p53-expressing triple negative breast cancer cells

(2015) Samaya R. Krishnan et al.   BREAST CANCER RESEARCH AND TREATMENT

JASPAR 2016: a major expansion and update of the open-access database of transcription factor binding profiles

(2015) Anthony Mathelier et al.   NUCLEIC ACIDS RESEARCH

Proteome-wide analysis of mutant p53 targets in breast cancer identifies new levels of gain-of-function that influence PARP, PCNA, and MCM4

(2015) Alla Polotskaia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic reticulum protein 29 (ERp29) confers radioresistance through the DNA repair gene, O6-methylguanine DNA-methyltransferase, in breast cancer cells

(2015) Shaohua Chen et al.   Scientific Reports

Friend or foe: Endoplasmic reticulum protein 29 (ERp29) in epithelial cancer

(2015) Shaohua Chen et al.   FEBS Open Bio

Mutant p53: One, No One, and One Hundred Thousand

(2015) Dawid Walerych et al.   Frontiers in Oncology

Proteomic Analysis of INS-1 Rat Insulinoma Cells: ER Stress Effects and the Protective Role of Exenatide, a GLP-1 Receptor Agonist

(2015) Mi-Kyung Kim et al.   PLoS One

Mutant p53 uses p63 as a molecular chaperone to alter gene expression and induce a pro-invasive secretome

(2015) Paul M. Neilsen et al.   Oncotarget

Mutant p53 gain of function can be at the root of dedifferentiation of human osteosarcoma MG63 cells into 3AB-OS cancer stem cells

(2014) Riccardo Di Fiore et al.   BONE

Gain-of-function of mutant p53: mutant p53 enhances cancer progression by inhibiting KLF17 expression in invasive breast carcinoma cells

(2014) Amjad Ali et al.   CANCER LETTERS

The evolution of thymic lymphomas in p53 knockout mice

(2014) Crissy Dudgeon et al.   GENES & DEVELOPMENT

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Gain-of-Function Mutant p53 Promotes Cell Growth and Cancer Cell Metabolism via Inhibition of AMPK Activation

(2014) Ge Zhou et al.   MOLECULAR CELL

UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein–DNA interactions

(2014) Maxwell A. Hume et al.   NUCLEIC ACIDS RESEARCH

p53 protein aggregation promotes platinum resistance in ovarian cancer

(2014) Y Yang-Hartwich et al.   ONCOGENE

Prion-like aggregation of mutant p53 in cancer

(2014) Jerson L. Silva et al.   TRENDS IN BIOCHEMICAL SCIENCES

A gain-of-function mutant p53–HSF1 feed forward circuit governs adaptation of cancer cells to proteotoxic stress

(2014) D Li et al.   Cell Death & Disease

Unequal prognostic potentials of p53 gain-of-function mutations in human cancers associate with drug-metabolizing activity

(2014) J Xu et al.   Cell Death & Disease

Heterogeneity of Li-Fraumeni Syndrome links to unequal gain-of-function effects of p53 mutations

(2014) Jie Xu et al.   Scientific Reports

Gain of Function of Mutant TP53 in Glioblastoma: Prognosis and Response to Temozolomide

(2013) Xiang Wang et al.   ANNALS OF SURGICAL ONCOLOGY

ERp29 deficiency affects sensitivity to apoptosis via impairment of the ATF6–CHOP pathway of stress response

(2013) Irina Hirsch et al.   APOPTOSIS

Induction of the Unfolded Protein Response Drives Enhanced Metabolism and Chemoresistance in Glioma Cells

(2013) Laura M. Epple et al.   PLoS One

Allele specific gain-of-function activity of p53 mutants in lung cancer cells

(2012) Catherine A. Vaughan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dual role of p53 amyloid formation in cancer; loss of function and gain of toxicity

(2012) Cristian A. Lasagna-Reeves et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Overexpression of WW domain-containing oxidoreductase WOX1 preferentially induces apoptosis in human glioblastoma cells harboring mutant p53

(2012) Ming-Fu Chiang et al.   BIOMEDICINE & PHARMACOTHERAPY

Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion

(2012) Cynthia R Coffill et al.   EMBO REPORTS

Mutant p53 cooperates with ETS2 to promote etoposide resistance

(2012) P. M. Do et al.   GENES & DEVELOPMENT

Mutant p53: one name, many proteins

(2012) W. A. Freed-Pastor et al.   GENES & DEVELOPMENT

Mutant p53 Aggregates into Prion-like Amyloid Oligomers and Fibrils

(2012) Ana P. D. Ano Bom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53 mutations in cancer

(2012) Patricia A. J. Muller et al.   NATURE CELL BIOLOGY

DREME: motif discovery in transcription factor ChIP-seq data

(2011) Timothy L. Bailey   BIOINFORMATICS

Gain-of-function mutant p53 but not p53 deletion promotes head and neck cancer progression in response to oncogenic K-ras

(2011) Sergio Acin et al.   JOURNAL OF PATHOLOGY

Inhibiting ERp29 expression enhances radiosensitivity in human nasopharyngeal carcinoma cell lines

(2011) Lin Qi et al.   MEDICAL ONCOLOGY

Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

(2011) Jie Xu et al.   Nature Chemical Biology

The role of p53 in glucose metabolism

(2010) Eric C Cheung et al.   CURRENT OPINION IN CELL BIOLOGY

Unfolded protein response activation contributes to chemoresistance in hepatocellular carcinoma

(2010) Feras Y. Al-Rawashdeh et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Over-expression of ERp29 attenuates doxorubicin-induced cell apoptosis through up-regulation of Hsp27 in breast cancer cells

(2010) Daohai Zhang et al.   EXPERIMENTAL CELL RESEARCH

Co-localization of mutant p53 and amyloid-like protein aggregates in breast tumors

(2010) Claudia B. Levy et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

ERp29 Restricts Connexin43 Oligomerization in the Endoplasmic Reticulum

(2009) Shamie Das et al.   MOLECULAR BIOLOGY OF THE CELL

Mutant p53 Gain-of-Function in Cancer

(2009) M. Oren et al.   Cold Spring Harbor Perspectives in Biology

Gal-3is stimulated by gain-of-functionp53mutations and modulates chemoresistance in anaplastic thyroid carcinomas

(2008) Luca Lavra et al.   JOURNAL OF PATHOLOGY