p53 protein aggregation promotes platinum resistance in ovarian cancer

Prion-like aggregation of mutant p53 in cancer

(2014) Jerson L. Silva et al.   TRENDS IN BIOCHEMICAL SCIENCES

Expanding the prion concept to cancer biology: dominant-negative effect of aggregates of mutant p53 tumour suppressor

(2013) Jerson L. Silva et al.   BIOSCIENCE REPORTS

Poor survival with wild-type TP53 ovarian cancer?

(2013) Kwong-Kwok Wong et al.   GYNECOLOGIC ONCOLOGY

p53 Aggregates Penetrate Cells and Induce the Co-Aggregation of Intracellular p53

(2013) Karolyn J. Forget et al.   PLoS One

Phenotypic modifications in ovarian cancer stem cells following Paclitaxel treatment

(2013) Vinicius Craveiro et al.   Cancer Medicine

Dual role of p53 amyloid formation in cancer; loss of function and gain of toxicity

(2012) Cristian A. Lasagna-Reeves et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mutant p53: one name, many proteins

(2012) W. A. Freed-Pastor et al.   GENES & DEVELOPMENT

Mutant p53 Aggregates into Prion-like Amyloid Oligomers and Fibrils

(2012) Ana P. D. Ano Bom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition

(2012) R. Wilcken et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-like Aggregates Sequester Numerous Metastable Proteins with Essential Cellular Functions

(2011) Heidi Olzscha et al.   CELL

Molecular phenotyping of human ovarian cancer stem cells unravels the mechanisms for repair and chemoresistance

(2011) Ayesha B. Alvero et al.   CELL CYCLE

Stem Cell Pathways Contribute to Clinical Chemoresistance in Ovarian Cancer

(2011) A. D. Steg et al.   CLINICAL CANCER RESEARCH

Ovarian Cancer Stem Cell-Like Side Populations Are Enriched Following Chemotherapy and Overexpress EZH2

(2011) S. Rizzo et al.   MOLECULAR CANCER THERAPEUTICS

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

Hidden order revealed

(2011) Michael E. Flatté   Nature Physics

High-Level Expression of Wild-Type p53 in Melanoma Cells is Frequently Associated with Inactivity in p53 Reporter Gene Assays

(2011) Roland Houben et al.   PLoS One

Molecular mechanism of Thioflavin-T binding to amyloid fibrils

(2010) Matthew Biancalana et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Co-localization of mutant p53 and amyloid-like protein aggregates in breast tumors

(2010) Claudia B. Levy et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Autophagy gone awry in neurodegenerative diseases

(2010) Esther Wong et al.   NATURE NEUROSCIENCE

Protein aggregation diseases: pathogenicity and therapeutic perspectives

(2010) Adriano Aguzzi et al.   NATURE REVIEWS DRUG DISCOVERY

Pluripotency factors Lin28 and Oct4 identify a sub-population of stem cell-like cells in ovarian cancer

(2010) S Peng et al.   ONCOGENE

cDNA sequencing improves the detection of P53 missense mutations in colorectal cancer

(2009) Malgorzata Szybka et al.   BMC CANCER

Pathogenesis of ovarian cancer: clues from selected overexpressed genes

(2009) Ie-Ming Shih et al.   Future Oncology

Proteomics identifies multipotent and low oncogenic risk stem cells of the spleen

(2009) Francisco Dieguez-Acuña et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Screening for Ovarian Cancer

(2009) Daniel L. Clarke-Pearson   NEW ENGLAND JOURNAL OF MEDICINE

Stem-Like Ovarian Cancer Cells Can Serve as Tumor Vascular Progenitors

(2009) Ayesha B. Alvero et al.   STEM CELLS

The (1–63) Region of the p53 Transactivation Domain Aggregates In Vitro into Cytotoxic Amyloid Assemblies

(2008) Stefania Rigacci et al.   BIOPHYSICAL JOURNAL

Regulation of IKKβ by miR-199a affects NF-κB activity in ovarian cancer cells

(2008) R Chen et al.   ONCOGENE