Hydroxytyrosol Induces Apoptosis and Cell Cycle Arrest and Suppresses Multiple Oncogenic Signaling Pathways in Prostate Cancer Cells

Cancer statistics, 2016

(2016) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Metabolic disposition and biological significance of simple phenols of dietary origin: hydroxytyrosol and tyrosol

(2016) Jose Rodríguez-Morató et al.   DRUG METABOLISM REVIEWS

The bounty of nature for changing the cancer landscape

(2016) Aamir Ahmad et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Food-based natural products for cancer management: Is the whole greater than the sum of the parts?

(2016) Suleman S. Hussain et al.   SEMINARS IN CANCER BIOLOGY

Inhibition of AKT promotes FOXO3a-dependent apoptosis in prostate cancer

(2016) T P Das et al.   Cell Death & Disease

High doses of hydroxytyrosol induce apoptosis in papillary and follicular thyroid cancer cells

(2016) G. Toteda et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Dietary Polyphenols in Prevention and Treatment of Prostate Cancer

(2015) Rahul Lall et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hydroxytyrosol-Derived Compounds: A Basis for the Creation of New Pharmacological Agents for Cancer Prevention and Therapy

(2015) Roberta Bernini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Extravirgin olive oil up-regulates CB1 tumor suppressor gene in human colon cancer cells and in rat colon via epigenetic mechanisms

(2015) Andrea Di Francesco et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Hydroxytyrosol, a product from olive oil, reduces colon cancer growth by enhancing epidermal growth factor receptor degradation

(2015) Erika Terzuoli et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Hydroxytyrosol inhibits chemokine C-C motif ligand 5 mediated aged quiescent fibroblast-induced stimulation of breast cancer cell proliferation

(2014) Ehab H. Sarsour et al.   AGE

Hydroxytyrosol, a natural molecule from olive oil, suppresses the growth of human hepatocellular carcinoma cells via inactivating AKT and nuclear factor-kappa B pathways

(2014) Baolei Zhao et al.   CANCER LETTERS

Beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: focus on protection against cardiovascular and metabolic diseases

(2014) Stefania Bulotta et al.   Journal of Translational Medicine

Inhibition of NF-kappa B signaling restores responsiveness of castrate-resistant prostate cancer cells to anti-androgen treatment by decreasing androgen receptor-variant expression

(2014) R Jin et al.   ONCOGENE

Hydroxytyrosol induces apoptosis in human colon cancer cells through ROS generation

(2014) Lijuan Sun et al.   Food & Function

The Multifaceted Roles of STAT3 Signaling in the Progression of Prostate Cancer

(2014) Jennifer Bishop et al.   Cancers

Hydroxytyrosol Promotes Superoxide Production and Defects in Autophagy Leading to Anti-proliferation and Apoptosis on Human Prostate Cancer Cells

(2013) Cheng Luo et al.   CURRENT CANCER DRUG TARGETS

Naturally Occurring Hydroxytyrosol: Synthesis and Anticancer Potential

(2013) R. Bernini et al.   CURRENT MEDICINAL CHEMISTRY

Enhanced chemopreventive activity of hydroxytyrosol on HL60 and HL60R cells by chemical conversion into thio derivatives

(2013) Maria Vittoria Sepporta et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Olive oil compounds inhibit vascular endothelial growth factor receptor-2 phosphorylation

(2013) Sylvie Lamy et al.   EXPERIMENTAL CELL RESEARCH

Selective Cytotoxic Activity of New Lipophilic Hydroxytyrosol Alkyl Ether Derivatives

(2013) José Manuel Calderón-Montaño et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Epigenetic regulation of miRNA-cancer stem cells nexus by nutraceuticals

(2013) Aamir Ahmad et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Plant polyphenol induced cell death in human cancer cells involves mobilization of intracellular copper ions and reactive oxygen species generation: A mechanism for cancer chemopreventive action

(2013) Husain Yar Khan et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Oleuropein and hydroxytyrosol activate GPER/ GPR30-dependent pathways leading to apoptosis of ER-negative SKBR3 breast cancer cells

(2013) Adele Chimento et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Hydroxytyrosol attenuates tunicamycin-induced endoplasmic reticulum stress in human hepatocarcinoma cells

(2013) Elena Giordano et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Oleuropein, a Secoiridoid Derived from Olive Tree, Inhibits the Proliferation of Human Colorectal Cancer Cell Through Downregulation of HIF-1α

(2013) Ana Cárdeno et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Hydroxytyrosol is not genotoxic in vitro

(2013) David Auñon-Calles et al.   PHARMACOLOGICAL RESEARCH

Modulation of signaling pathways in prostate cancer by green tea polyphenols

(2012) Naghma Khan et al.   BIOCHEMICAL PHARMACOLOGY

Identification of the factors responsible for the in vitro pro-oxidant and cytotoxic activities of the olive polyphenols oleuropein and hydroxytyrosol

(2012) Elena M. Odiatou et al.   CANCER LETTERS

Direct Liquid Chromatography Method for the Simultaneous Quantification of Hydroxytyrosol and Tyrosol in Red Wines

(2011) Zulema Piñeiro et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Synthesis of a novel ester of hydroxytyrosol and α-lipoic acid exhibiting an antiproliferative effect on human colon cancer HT-29 cells

(2010) Roberta Bernini et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Hydroxytyrosol rich extract from olive leaves modulates cell cycle progression in MCF-7 human breast cancer cells

(2010) Zouhaier Bouallagui et al.   FOOD AND CHEMICAL TOXICOLOGY

NF-κB Regulates Androgen Receptor Expression and Prostate Cancer Growth

(2009) Liying Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

Hydroxytyrosol inhibits the proliferation of human colon adenocarcinoma cells through inhibition of ERK1/2 and cyclin D1

(2009) Giulia Corona et al.   MOLECULAR NUTRITION & FOOD RESEARCH