Distinctive genomic signature of neural and intestinal organoids from familial Parkinson's disease patient-derived induced pluripotent stem cells

Biomarker Discovery by Modeling Behçet's Disease with Patient-Specific Human Induced Pluripotent Stem Cells

(2017) Mi-Young Son et al.   STEM CELLS AND DEVELOPMENT

Three-dimensional models for studying development and disease: moving on from organisms to organs-on-a-chip and organoids

(2016) E. L. Jackson et al.   Integrative Biology

Organoids as an in vitro model of human development and disease

(2016) Aliya Fatehullah et al.   NATURE CELL BIOLOGY

Integrative analysis of genes and miRNA alterations in human embryonic stem cells-derived neural cells after exposure to silver nanoparticles

(2016) Jung-Hwa Oh et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Biochemical and molecular characterization of novel mutations in GLB1 and NEU1 in patient cells with lysosomal storage disorders

(2015) Jae Eun Kwak et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Parkinson's Disease-Associated Mutation LRRK2-G2019S Impairs Synaptic Plasticity in Mouse Hippocampus

(2015) E. S. Sweet et al.   JOURNAL OF NEUROSCIENCE

A novel human model of the neurodegenerative disease GM1 gangliosidosis using induced pluripotent stem cells demonstrates inflammasome activation

(2015) Mi-Young Son et al.   JOURNAL OF PATHOLOGY

Novel TRAIL sensitizerTaraxacum officinaleF.H. Wigg enhances TRAIL-induced apoptosis in Huh7 cells

(2015) Ji-Yong Yoon et al.   MOLECULAR CARCINOGENESIS

Proteomic and network analysis of proteins regulated by REX1 in human embryonic stem cells

(2015) Mi-Young Son et al.   PROTEOMICS

LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase

(2015) Insup Choi et al.   Nature Communications

Direct regulation of E-cadherin by targeted histone methylation of TALE-SET fusion protein in cancer cells

(2015) Hyun-Soo Cho et al.   Oncotarget

Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21WAF1/CIP1 expression

(2015) Dong Hwan Ho et al.   Molecular Brain

Structural alterations of the intestinal epithelial barrier in Parkinson’s disease

(2015) Thomas Clairembault et al.   Acta Neuropathologica Communications

LRRK2 and neuroinflammation: partners in crime in Parkinson’s disease?

(2014) Isabella Russo et al.   Journal of Neuroinflammation

Peptidoglycan recognition protein genes and risk of Parkinson's disease

(2014) Samuel M. Goldman et al.   MOVEMENT DISORDERS

Three-dimensional organotypic culture: experimental models of mammalian biology and disease

(2014) Eliah R. Shamir et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations

(2014) Vinay K. Godena et al.   Nature Communications

LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex

(2014) Maria D. Cirnaru et al.   Frontiers in Molecular Neuroscience

Gene expression profile in fibroblasts of Huntington's disease patients and controls

(2013) Eleonora Marchina et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Advances in Cellular Models to Explore the Pathophysiology of Amyotrophic Lateral Sclerosis

(2013) C. Veyrat-Durebex et al.   MOLECULAR NEUROBIOLOGY

LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: Reversal by gene correction

(2013) Laurie H. Sanders et al.   NEUROBIOLOGY OF DISEASE

LRRK2 Affects Vesicle Trafficking, Neurotransmitter Extracellular Level and Membrane Receptor Localization

(2013) Rossana Migheli et al.   PLoS One

Unveiling the critical role of REX1 in the regulation of human stem cell pluripotency

(2013) Mi-Young Son et al.   STEM CELLS

Accumulation of Alpha-synuclein Causes Colonic Dysmotility Independently of Enteric Nervous Damage in the Early Stage of Parkinson's Disease (Neurogastroenterol Motil 2012;24:e425-e436)

(2013) Yong Sung Kim   Journal of Neurogastroenterology and Motility

An emerging role for LRRK2 in the immune system

(2012) Nicolas Dzamko et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1

(2012) X. Wang et al.   HUMAN MOLECULAR GENETICS

Cardioprotective molecules are enriched in beating cardiomyocytes derived from human embryonic stem cells

(2012) Jung-Il Chae et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Parkinson’s disease and immune system: is the culprit LRRKing in the periphery?

(2012) Elisa Greggio et al.   Journal of Neuroinflammation

LRRK2 Inhibition Attenuates Microglial Inflammatory Responses

(2012) M. S. Moehle et al.   JOURNAL OF NEUROSCIENCE

Colonic inflammation in Parkinson's disease

(2012) David Devos et al.   NEUROBIOLOGY OF DISEASE

Genome-Wide Gene Expression Analysis in Cancer Cells Reveals 3D Growth to Affect ECM and Processes Associated with Cell Adhesion but Not DNA Repair

(2012) Oliver Zschenker et al.   PLoS One

Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson's Disease

(2012) O. Cooper et al.   Science Translational Medicine

Concise Review: The Relevance of Human Stem Cell-Derived Organoid Models for Epithelial Translational Medicine

(2012) Robert E. Hynds et al.   STEM CELLS

LRRK2 in Transcription and Translation Regulation: Relevance for Parkinson’s Disease

(2012) Véronique Dorval et al.   Frontiers in Neurology

The Human Brain in a Dish: The Promise of iPSC-Derived Neurons

(2011) Ricardo Dolmetsch et al.   CELL

LRRK2 Mutant iPSC-Derived DA Neurons Demonstrate Increased Susceptibility to Oxidative Stress

(2011) Ha Nam Nguyen et al.   Cell Stem Cell

Synaptic vesicle trafficking and Parkinson's disease

(2011) Giovanni Esposito et al.   Developmental Neurobiology

LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice

(2011) Martin C. Herzig et al.   HUMAN MOLECULAR GENETICS

Gastrointestinal Dysfunction in a Parkinson’s Disease Rat Model and the Changes of Dopaminergic, Nitric Oxidergic, and Cholinergic Neurotransmitters in Myenteric Plexus

(2011) Hong Can Zhu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

LRRK2 Controls Synaptic Vesicle Storage and Mobilization within the Recycling Pool

(2011) G. Piccoli et al.   JOURNAL OF NEUROSCIENCE

Microarray expression analysis in idiopathic and LRRK2-associated Parkinson's disease

(2011) Teresa Botta-Orfila et al.   NEUROBIOLOGY OF DISEASE

Mouse models for LRRK2 Parkinson's disease

(2011) Qing Xu et al.   PARKINSONISM & RELATED DISORDERS

Pathogenic LRRK2 Mutations Do Not Alter Gene Expression in Cell Model Systems or Human Brain Tissue

(2011) Michael J. Devine et al.   PLoS One

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

(2010) Jason R. Spence et al.   NATURE

Transcriptional profile of Parkinson blood mononuclear cells with LRRK2 mutation

(2010) Eugénie Mutez et al.   NEUROBIOLOGY OF AGING

Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

(2010) B. Winner et al.   NEUROBIOLOGY OF DISEASE

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of  -synuclein, and apoptotic cell death in aged mice

(2010) Y. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide association study reveals genetic risk underlying Parkinson's disease

(2009) Javier Simón-Sánchez et al.   NATURE GENETICS

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention

(2009) Malú G. Tansey et al.   NEUROBIOLOGY OF DISEASE

Cytoskeleton-associated proteins are enriched in human embryonic-stem cell-derived neuroectodermal spheres

(2009) Jung-Il Chae et al.   PROTEOMICS

LRRK2 regulates synaptic vesicle endocytosis

(2008) Narae Shin et al.   EXPERIMENTAL CELL RESEARCH

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS