LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase
Published 2015 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase
Authors
Keywords
-
Journal
Nature Communications
Volume 6, Issue 1, Pages -
Publisher
Springer Nature
Online
2015-09-14
DOI
10.1038/ncomms9255
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The G2019S LRRK2 mutation increases myeloid cell chemotactic responses and enhances LRRK2 binding to actin-regulatory proteins
- (2015) Mark S. Moehle et al. HUMAN MOLECULAR GENETICS
- Migration of neutrophils targeting amyloid plaques in Alzheimer's disease mouse model
- (2014) Sung Hoon Baik et al. NEUROBIOLOGY OF AGING
- Suppression of miR-155 Expression in IFN-γ-Treated Astrocytes and Microglia by DJ-1: A Possible Mechanism for Maintaining SOCS1 Expression
- (2014) Jong-hyeon Kim et al. Experimental Neurobiology
- Homeostatic and injury-induced microglia behavior in the aging brain
- (2013) Jasmin K. Hefendehl et al. AGING CELL
- Mitoxantrone Targets the ATP-binding Site of FAK, Binds the FAK Kinase Domain and Decreases FAK, Pyk-2, c-Src, and IGF-1R In Vitro Kinase Activities
- (2013) Vita M. Golubovskaya et al. Anti-Cancer Agents in Medicinal Chemistry
- Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies
- (2013) Paul Davies et al. BIOCHEMICAL JOURNAL
- Pink1 deficiency attenuates astrocyte proliferation through mitochondrial dysfunction, reduced akt and increased p38 mapk activation, and downregulation of egfr
- (2013) Insup Choi et al. GLIA
- DJ-1 Associates with lipid rafts by palmitoylation and regulates lipid rafts-dependent endocytosis in astrocytes
- (2013) Kwang Soo Kim et al. HUMAN MOLECULAR GENETICS
- Leucine-rich repeat kinase 2 functionally interacts with microtubules and kinase-dependently modulates cell migration
- (2013) Mareike Caesar et al. NEUROBIOLOGY OF DISEASE
- DJ-1 facilitates the interaction between STAT1 and its phosphatase, SHP-1, in brain microglia and astrocytes: A novel anti-inflammatory function of DJ-1
- (2013) Jong-hyeon Kim et al. NEUROBIOLOGY OF DISEASE
- Brain Inflammation and Microglia: Facts and Misconceptions
- (2013) Hey-Kyeong Jeong et al. Experimental Neurobiology
- GSK2578215A; A potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor
- (2012) Alastair D. Reith et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Reciprocal Regulation between Resting Microglial Dynamics and Neuronal Activity In Vivo
- (2012) Ying Li et al. DEVELOPMENTAL CELL
- Mutant huntingtin impairs immune cell migration in Huntington disease
- (2012) Wanda Kwan et al. JOURNAL OF CLINICAL INVESTIGATION
- LRRK2 Inhibition Attenuates Microglial Inflammatory Responses
- (2012) M. S. Moehle et al. JOURNAL OF NEUROSCIENCE
- Impaired Inflammatory Responses in Murine Lrrk2-Knockdown Brain Microglia
- (2012) Beomsue Kim et al. PLoS One
- Leucine-rich repeat kinase 2 (LRRK2) as a potential therapeutic target in Parkinson's disease
- (2012) Byoung Dae Lee et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Chemoproteomics-Based Design of Potent LRRK2-Selective Lead Compounds That Attenuate Parkinson’s Disease-Related Toxicity in Human Neurons
- (2011) Nigel Ramsden et al. ACS Chemical Biology
- Rac1 Protein Rescues Neurite Retraction Caused by G2019S Leucine-rich Repeat Kinase 2 (LRRK2)
- (2011) Diane Chan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- FAK phosphorylation at Tyr-925 regulates cross-talk between focal adhesion turnover and cell protrusion
- (2011) Therese B. Deramaudt et al. MOLECULAR BIOLOGY OF THE CELL
- Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2
- (2011) Xianming Deng et al. Nature Chemical Biology
- Age-related alterations in the dynamic behavior of microglia
- (2010) Mausam R. Damani et al. AGING CELL
- A QUICK Screen for Lrrk2 Interaction Partners – Leucine-rich Repeat Kinase 2 is Involved in Actin Cytoskeleton Dynamics
- (2010) Andrea Meixner et al. MOLECULAR & CELLULAR PROTEOMICS
- Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease
- (2010) Byoung Dae Lee et al. NATURE MEDICINE
- Inflammatory Responses Are Not Sufficient to Cause Delayed Neuronal Death in ATP-Induced Acute Brain Injury
- (2010) Hey-Kyeong Jeong et al. PLoS One
- Identification and Characterization of a Leucine-Rich Repeat Kinase 2 (LRRK2) Consensus Phosphorylation Motif
- (2010) Pooja P. Pungaliya et al. PLoS One
- Parkinson's Disease and Low Frequency Alleles Found Together ThroughoutLRRK2
- (2009) Coro Paisán-Ruiz et al. ANNALS OF HUMAN GENETICS
- Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease
- (2009) R. Jeremy Nichols et al. BIOCHEMICAL JOURNAL
- Microglia processes block the spread of damage in the brain and require functional chloride channels
- (2009) Dustin J. Hines et al. GLIA
- Phosphorylation of Ezrin/Radixin/Moesin Proteins by LRRK2 Promotes the Rearrangement of Actin Cytoskeleton in Neuronal Morphogenesis
- (2009) L. Parisiadou et al. JOURNAL OF NEUROSCIENCE
- FAK Phosphorylation by ERK Primes Ras-Induced Tyrosine Dephosphorylation of FAK Mediated by PIN1 and PTP-PEST
- (2009) Yanhua Zheng et al. MOLECULAR CELL
- Mutant LRRK2 R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease
- (2009) Yanping Li et al. NATURE NEUROSCIENCE
- A Small Molecule Inhibitor, 1,2,4,5-Benzenetetraamine Tetrahydrochloride, Targeting the Y397 Site of Focal Adhesion Kinase Decreases Tumor Growth
- (2008) Vita M. Golubovskaya et al. JOURNAL OF MEDICINAL CHEMISTRY
- Nuclear FAK Promotes Cell Proliferation and Survival through FERM-Enhanced p53 Degradation
- (2008) Ssang-Taek Lim et al. MOLECULAR CELL
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now