NADPH oxidase: its potential role in promotion of pulmonary arterial hypertension

Non-muscle myosin light chain promotes endothelial progenitor cells senescence and dysfunction in pulmonary hypertensive rats through up-regulation of NADPH oxidase

(2016) Bin Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inhibition of histone deacetylase reduces transcription of NADPH oxidases and ROS production and ameliorates pulmonary arterial hypertension

(2016) Feng Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement

(2015) Sebastian Altenhöfer et al.   ANTIOXIDANTS & REDOX SIGNALING

Nuclear cardiac myosin light chain 2 modulates NADPH oxidase 2 expression in myocardium: a novel function beyond muscle contraction

(2015) Yi-Shuai Zhang et al.   BASIC RESEARCH IN CARDIOLOGY

Current Treatment Approaches to Pulmonary Arterial Hypertension

(2015) Steeve Provencher et al.   CANADIAN JOURNAL OF CARDIOLOGY

Right Ventricular Adaptation and Failure in Pulmonary Arterial Hypertension

(2015) John J. Ryan et al.   CANADIAN JOURNAL OF CARDIOLOGY

High-glucose-increased expression and activation of NADPH oxidase in human vascular smooth muscle cells is mediated by 4-hydroxynonenal-activated PPARα and PPARβ/δ

(2015) Adrian Manea et al.   CELL AND TISSUE RESEARCH

Targeting mitochondrial reactive oxygen species to modulate hypoxia-induced pulmonary hypertension

(2015) Sherry E. Adesina et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dysfunctional Endothelial Progenitor Cells in Cardiovascular Diseases

(2015) Jun Peng et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Management of Pulmonary Arterial Hypertension

(2015) Vallerie V. McLaughlin et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Inhibition of myosin light chain kinase reduces NADPH oxidase-mediated oxidative injury in rat brain following cerebral ischemia/reperfusion

(2015) Hong-Feng Zhang et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Effects of chrysin (5,7-dihydroxyflavone) on vascular remodeling in hypoxia-induced pulmonary hypertension in rats

(2015) Xian-Wei Li et al.   Chinese Medicine

NADPH Oxidase 4 Is Expressed in Pulmonary Artery Adventitia and Contributes to Hypertensive Vascular Remodeling

(2014) Scott A. Barman et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The Effects of High Glucose Levels on Reactive Oxygen Species-Induced Apoptosis and Involved Signaling in Human Vascular Endothelial Cells

(2014) Qian Hou et al.   Cardiovascular Toxicology

Pulmonary Arterial Hypertension

(2014) Yen-Chun Lai et al.   CIRCULATION RESEARCH

Nox family NADPH oxidases: Molecular mechanisms of activation

(2014) Ralf P. Brandes et al.   FREE RADICAL BIOLOGY AND MEDICINE

Increased Reactive Oxygen Species, Metabolic Maladaptation, and Autophagy Contribute to Pulmonary Arterial Hypertension–Induced Ventricular Hypertrophy and Diastolic Heart Failure

(2014) Dhawjbahadur K. Rawat et al.   HYPERTENSION

Inhibition of NOX/VPO1 Pathway and Inflammatory Reaction by Trimethoxystilbene in Prevention of Cardiovascular Remodeling in Hypoxia-induced Pulmonary Hypertensive Rats

(2014) Bin Liu et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Oxidative stress augments pulmonary hypertension in chronically hypoxic mice overexpressing the oxidized LDL receptor

(2013) Sayoko Ogura et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Nox-derived ROS are acutely activated in pressure overload pulmonary hypertension: indications for a seminal role for mitochondrial Nox4

(2013) Giovanna Frazziano et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Nox Enzymes and New Thinking on Reactive Oxygen: A Double-Edged Sword Revisited

(2013) J. David Lambeth et al.   Annual Review of Pathology-Mechanisms of Disease

Function of NADPH Oxidase 1 in Pulmonary Arterial Smooth Muscle Cells After Monocrotaline-Induced Pulmonary Vascular Remodeling

(2013) Florian Veit et al.   ANTIOXIDANTS & REDOX SIGNALING

The Quest for Selective Nox Inhibitors and Therapeutics: Challenges, Triumphs and Pitfalls

(2013) Eugenia Cifuentes-Pagano et al.   ANTIOXIDANTS & REDOX SIGNALING

NADPH Oxidases in Vascular Pathology

(2013) Anna Konior et al.   ANTIOXIDANTS & REDOX SIGNALING

Deficiency of NOX1/Nicotinamide Adenine Dinucleotide Phosphate, Reduced Form Oxidase Leads to Pulmonary Vascular Remodeling

(2013) Kazumi Iwata et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mammalian Target of Rapamycin Complex 2 (mTORC2) Coordinates Pulmonary Artery Smooth Muscle Cell Metabolism, Proliferation, and Survival in Pulmonary Arterial Hypertension

(2013) Dmitry A. Goncharov et al.   CIRCULATION

Hypoxia downregulates PPARγ via an ERK1/2–NF-κB–Nox4-dependent mechanism in human pulmonary artery smooth muscle cells

(2013) Xianghuai Lu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inhibition of Phosphodiesterase-1 Attenuates Cold-Induced Pulmonary Hypertension

(2013) Patrick Crosswhite et al.   HYPERTENSION

Selective Recapitulation of Conserved and Nonconserved Regions of Putative NOXA1 Protein Activation Domain Confers Isoform-specific Inhibition of Nox1 Oxidase and Attenuation of Endothelial Cell Migration

(2013) Daniel J. Ranayhossaini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNA-25-dependent up-regulation of NADPH oxidase 4 (NOX4) mediates hypercholesterolemia-induced oxidative/nitrative stress and subsequent dysfunction in the heart

(2013) Zoltán V. Varga et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Reactive oxygen species as therapeutic targets in pulmonary hypertension

(2013) Véronique Freund-Michel et al.   Therapeutic Advances in Respiratory Disease

NADPH oxidase-derived ROS and the regulation of pulmonary vessel tone

(2012) G. Frazziano et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

NADPH oxidase inhibitors: a decade of discovery from Nox2ds to HTS

(2012) Eugenia Cifuentes-Pagano et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Biochemistry, Physiology, and Pathophysiology of NADPH Oxidases in the Cardiovascular System

(2012) Bernard Lassègue et al.   CIRCULATION RESEARCH

Reactive oxygen and nitrogen species in pulmonary hypertension

(2012) Diana M. Tabima et al.   FREE RADICAL BIOLOGY AND MEDICINE

Resveratrol downregulates acute pulmonary thromboembolism-induced pulmonary artery hypertension via p38 mitogen-activated protein kinase and monocyte chemoattractant protein-1 signaling in rats

(2012) Chen Chun et al.   LIFE SCIENCES

Apocynin improves oxygenation and increases eNOS in persistent pulmonary hypertension of the newborn

(2011) Stephen Wedgwood et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Role of endothelial Nox2 NADPH oxidase in angiotensin II-induced hypertension and vasomotor dysfunction

(2011) Colin E. Murdoch et al.   BASIC RESEARCH IN CARDIOLOGY

Involvement of vascular peroxidase 1 in angiotensin II-induced vascular smooth muscle cell proliferation

(2011) Ruizheng Shi et al.   CARDIOVASCULAR RESEARCH

The E-loop Is Involved in Hydrogen Peroxide Formation by the NADPH Oxidase Nox4

(2011) Ina Takac et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NADPH Oxidase-Mediated Redox Signaling: Roles in Cellular Stress Response, Stress Tolerance, and Tissue Repair

(2011) F. Jiang et al.   PHARMACOLOGICAL REVIEWS

Suppression of NADPH oxidase 2 substantially restores glucose-induced dysfunction of pancreatic NIT-1 cells

(2010) Huiping Yuan et al.   FEBS Journal

Nox4 B-loop Creates an Interface between the Transmembrane and Dehydrogenase Domains

(2010) Heather M. Jackson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small-Molecule NOX Inhibitors: ROS-Generating NADPH Oxidases as Therapeutic Targets

(2009) Vincent Jaquet et al.   ANTIOXIDANTS & REDOX SIGNALING

Resveratrol inhibits right ventricular hypertrophy induced by monocrotaline in rats

(2009) Dan-Li Yang et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Resveratrol Prevents Monocrotaline-Induced Pulmonary Hypertension in Rats

(2009) Anna Csiszar et al.   HYPERTENSION

Is Resveratrol the Magic Bullet for Pulmonary Hypertension?

(2009) Louis G. Chicoine et al.   HYPERTENSION

Reactive Oxygen Generated by NADPH Oxidase 1 (Nox1) Contributes to Cell Invasion by Regulating Matrix Metalloprotease-9 Production and Cell Migration

(2009) Masahiro Shinohara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NOX4 mediates hypoxia-induced proliferation of human pulmonary artery smooth muscle cells: the role of autocrine production of transforming growth factor-β1 and insulin-like growth factor binding protein-3

(2008) Saleh Ismail et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Role of NADPH Oxidase in Chronic Intermittent Hypoxia-Induced Pulmonary Hypertension in Mice

(2008) Rachel E. Nisbet et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Redox Regulation of Cell Survival

(2008) Dunyaporn Trachootham et al.   ANTIOXIDANTS & REDOX SIGNALING

Endothelial cell dysfunction and cross talk between endothelium and smooth muscle cells in pulmonary arterial hypertension

(2008) Marc Humbert et al.   VASCULAR PHARMACOLOGY

Contribution of xanthine oxidase-derived superoxide to chronic hypoxic pulmonary hypertension in neonatal rats

(2007) Robert P. Jankov et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY