A PERK–miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival

Induction of Therapeutic Senescence in Vemurafenib-Resistant Melanoma by Extended Inhibition of CDK4/6

(2016) A. Yoshida et al.   CANCER RESEARCH

PERK Integrates Oncogenic Signaling and Cell Survival During Cancer Development

(2016) Yiwen Bu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

PERK Is a Haploinsufficient Tumor Suppressor: Gene Dose Determines Tumor-Suppressive Versus Tumor Promoting Properties of PERK in Melanoma

(2016) Dariusz Pytel et al.   PLoS Genetics

The Circadian Protein BMAL1 Regulates Translation in Response to S6K1-Mediated Phosphorylation

(2015) Jonathan O. Lipton et al.   CELL

MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells

(2015) Brian J. Altman et al.   Cell Metabolism

Tumor progression and the different faces of the PERK kinase

(2015) D Pytel et al.   ONCOGENE

PRMT5 Is Required for Lymphomagenesis Triggered by Multiple Oncogenic Drivers

(2015) Y. Li et al.   Cancer Discovery

Reprogramming of the Circadian Clock by Nutritional Challenge

(2013) Kristin L. Eckel-Mahan et al.   CELL

Online Survival Analysis Software to Assess the Prognostic Value of Biomarkers Using Transcriptomic Data in Non-Small-Cell Lung Cancer

(2013) Balázs Győrffy et al.   PLoS One

ER stress–mediated autophagy promotes Myc-dependent transformation and tumor growth

(2012) Lori S. Hart et al.   JOURNAL OF CLINICAL INVESTIGATION

Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)

(2012) Jeffrey M. Axten et al.   JOURNAL OF MEDICINAL CHEMISTRY

PERK Is Required in the Adult Pancreas and Is Essential for Maintenance of Glucose Homeostasis

(2012) Y. Gao et al.   MOLECULAR AND CELLULAR BIOLOGY

miR-211 Is a Prosurvival MicroRNA that Regulates chop Expression in a PERK-Dependent Manner

(2012) Nilesh S. Chitnis et al.   MOLECULAR CELL

Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK

(2012) A Avivar-Valderas et al.   ONCOGENE

Anti-tumorigenic effects of Type 1 interferon are subdued by integrated stress responses

(2012) S Bhattacharya et al.   ONCOGENE

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

(2011) Jake E. Delmore et al.   CELL

The Cell Biology of the Unfolded Protein Response

(2011) J. Alan Diehl et al.   GASTROENTEROLOGY

Cell-autonomous circadian clock of hepatocytes drives rhythms in transcription and polyamine synthesis

(2011) A. Atwood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Cyclin D1/CDK4 Kinase Regulates CUL4 Expression and Triggers Neoplastic Growth via Activation of the PRMT5 Methyltransferase

(2010) Priya Aggarwal et al.   CANCER CELL

PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage

(2010) E Bobrovnikova-Marjon et al.   ONCOGENE

Circadian Integration of Metabolism and Energetics

(2010) J. Bass et al.   SCIENCE

The Role of Myc-Induced Protein Synthesis in Cancer

(2009) D. Ruggero   CANCER RESEARCH

Network Features of the Mammalian Circadian Clock

(2009) Julie E Baggs et al.   PLOS BIOLOGY

Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency

(2008) Maria Barna et al.   NATURE

N-myc augments death and attenuates protective effects of Bcl-2 in trophically stressed neuroblastoma cells

(2008) A Ushmorov et al.   ONCOGENE