PERK Integrates Oncogenic Signaling and Cell Survival During Cancer Development

MALAT1 long non-coding RNA in cancer

(2016) Rei Yoshimoto et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Carfilzomib: A second-generation proteasome inhibitor for the treatment of multiple myeloma

(2015) A. McBride et al.   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

Type I interferons mediate pancreatic toxicities of PERK inhibition

(2015) Qiujing Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic Reticulum Stress-Activated Cell Reprogramming in Oncogenesis

(2015) E. Chevet et al.   Cancer Discovery

PERK silence inhibits glioma cell growth under low glucose stress by blockage of p-AKT and subsequent HK2's mitochondria translocation

(2015) Xu Hou et al.   Scientific Reports

The Malat1 long non-coding RNA is upregulated by signalling through the PERK axis of unfolded protein response during flavivirus infection

(2015) Sankar Bhattacharyya et al.   Scientific Reports

Oncogenic BRAF induces chronic ER stress condition resulting in increased basal autophagy and apoptotic resistance of cutaneous melanoma

(2014) M Corazzari et al.   CELL DEATH AND DIFFERENTIATION

Hypoxic regulation of the PERK/ATF4/LAMP3-arm of the unfolded protein response in head and neck squamous cell carcinoma

(2014) Anika Nagelkerke et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Targeting ER stress–induced autophagy overcomes BRAF inhibitor resistance in melanoma

(2014) Xiao-Hong Ma et al.   JOURNAL OF CLINICAL INVESTIGATION

VEGF Signals through ATF6 and PERK to Promote Endothelial Cell Survival and Angiogenesis in the Absence of ER Stress

(2014) Evdoxia Karali et al.   MOLECULAR CELL

Epithelial-to-Mesenchymal Transition Activates PERK-eIF2  and Sensitizes Cells to Endoplasmic Reticulum Stress

(2014) Y.-x. Feng et al.   Cancer Discovery

miRNA signature of unfolded protein response in H9c2 rat cardiomyoblasts

(2014) Danielle E Read et al.   Cell and Bioscience

De-Differentiation Confers Multidrug Resistance Via Noncanonical PERK-Nrf2 Signaling

(2014) Catherine A. Del Vecchio et al.   PLOS BIOLOGY

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Suppression of miRNA-708 by Polycomb Group Promotes Metastases by Calcium-Induced Cell Migration

(2013) Seongho Ryu et al.   CANCER CELL

Characterization of a Novel PERK Kinase Inhibitor with Antitumor and Antiangiogenic Activity

(2013) C. Atkins et al.   CANCER RESEARCH

Hypoxic Activation of the PERK/eIF2  Arm of the Unfolded Protein Response Promotes Metastasis through Induction of LAMP3

(2013) H. Mujcic et al.   CLINICAL CANCER RESEARCH

ER stress potentiates insulin resistance through PERK-mediated FOXO phosphorylation

(2013) W. Zhang et al.   GENES & DEVELOPMENT

p53 and Translation Attenuation Regulate Distinct Cell Cycle Checkpoints during Endoplasmic Reticulum (ER) Stress

(2013) Sally E. Thomas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

(2013) Wafa B’chir et al.   NUCLEIC ACIDS RESEARCH

Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development

(2013) Jeffrey M. Axten et al.   ACS Medicinal Chemistry Letters

The next generation proteasome inhibitors carfilzomib and oprozomib activate prosurvival autophagy via induction of the unfolded protein response and ATF4

(2012) Yan Zang et al.   Autophagy

The PERK-eIF2α phosphorylation arm is a pro-survival pathway of BCR-ABL signaling and confers resistance to imatinib treatment in chronic myeloid leukemia cells

(2012) Monika Kusio-Kobialka et al.   CELL CYCLE

Lipid metabolism in cancer

(2012) Claudio R. Santos et al.   FEBS Journal

MicroRNA-30c-2* limits expression of proadaptive factor XBP1 in the unfolded protein response

(2012) Andrew E. Byrd et al.   JOURNAL OF CELL BIOLOGY

ER stress–mediated autophagy promotes Myc-dependent transformation and tumor growth

(2012) Lori S. Hart et al.   JOURNAL OF CLINICAL INVESTIGATION

Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)

(2012) Jeffrey M. Axten et al.   JOURNAL OF MEDICINAL CHEMISTRY

PERK Is Required in the Adult Pancreas and Is Essential for Maintenance of Glucose Homeostasis

(2012) Y. Gao et al.   MOLECULAR AND CELLULAR BIOLOGY

PERK Utilizes Intrinsic Lipid Kinase Activity To Generate Phosphatidic Acid, Mediate Akt Activation, and Promote Adipocyte Differentiation

(2012) E. Bobrovnikova-Marjon et al.   MOLECULAR AND CELLULAR BIOLOGY

miR-211 Is a Prosurvival MicroRNA that Regulates chop Expression in a PERK-Dependent Manner

(2012) Nilesh S. Chitnis et al.   MOLECULAR CELL

The ER stress transducer IRE1β is required for airway epithelial mucin production

(2012) M B Martino et al.   Mucosal Immunology

Perk-dependent repression of miR-106b-25 cluster is required for ER stress-induced apoptosis

(2012) S Gupta et al.   Cell Death & Disease

Principles and Current Strategies for Targeting Autophagy for Cancer Treatment

(2011) R. K. Amaravadi et al.   CLINICAL CANCER RESEARCH

A CHOP-regulated microRNA controls rhodopsin expression

(2011) Shannon Behrman et al.   JOURNAL OF CELL BIOLOGY

The Unfolded Protein Response: Integrating Stress Signals Through the Stress Sensor IRE1α

(2011) Claudio Hetz et al.   PHYSIOLOGICAL REVIEWS

Endoplasmic Reticulum Stress Induces G2 Cell-Cycle Arrest via mRNA Translation of the p53 Isoform p53/47

(2010) Karima Bourougaa et al.   MOLECULAR CELL

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

(2010) Keith T. Flaherty et al.   NEW ENGLAND JOURNAL OF MEDICINE

PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage

(2010) E Bobrovnikova-Marjon et al.   ONCOGENE

Identification of the miR-106b 25 MicroRNA Cluster as a Proto-Oncogenic PTEN-Targeting Intron That Cooperates with Its Host Gene MCM7 in Transformation

(2010) L. Poliseno et al.   Science Signaling

PERK in beta cell biology and insulin biogenesis

(2010) Douglas R. Cavener et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Quantitative Metabolome Profiling of Colon and Stomach Cancer Microenvironment by Capillary Electrophoresis Time-of-Flight Mass Spectrometry

(2009) A. Hirayama et al.   CANCER RESEARCH

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

(2009) Kasper M.A. Rouschop et al.   JOURNAL OF CLINICAL INVESTIGATION

Dysregulation of unfolded protein response partially underlies proapoptotic activity of bortezomib in multiple myeloma cells

(2009) Hongjuan Dong et al.   LEUKEMIA & LYMPHOMA

Long non-coding RNAs: insights into functions

(2009) Tim R. Mercer et al.   NATURE REVIEWS GENETICS

Hypoxic activation of the unfolded protein response (UPR) induces expression of the metastasis-associated gene LAMP3

(2009) Hilda Mujcic et al.   RADIOTHERAPY AND ONCOLOGY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

(2008) X.-J. Wang et al.   CARCINOGENESIS

How IRE1 Reacts to ER Stress

(2008) David Ron et al.   CELL

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Getting to the Root of miRNA-Mediated Gene Silencing

(2008) Ana Eulalio et al.   CELL

Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

(2008) Inki Kim et al.   NATURE REVIEWS DRUG DISCOVERY

PERK-dependent regulation of IAP translation during ER stress

(2008) R B Hamanaka et al.   ONCOGENE

PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation

(2008) E. Bobrovnikova-Marjon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATF6 -Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo

(2008) D. M. Schewe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA