Activation of TREK-1 by morphine results in analgesia without adverse side effects

The Nav1.9 channel regulates colonic motility in mice

(2013) Carine Copel et al.   Frontiers in Neuroscience

Relative contribution of SKCa and TREK1 channels in purinergic and nitrergic neuromuscular transmission in the rat colon

(2012) V. Gil et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Synthesis and Evaluation of Aryl-Naloxamide Opiate Analgesics Targeting Truncated Exon 11-Associated μ Opioid Receptor (MOR-1) Splice Variants

(2012) Susruta Majumdar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Behavioral characterization of mice lacking Trek channels

(2012) Kelsey Mirkovic et al.   Frontiers in Behavioral Neuroscience

Molecular regulations governing TREK and TRAAK channel functions

(2011) Jacques Noël et al.   Channels

Multiple Targets of  -Opioid Receptor-Mediated Presynaptic Inhibition at Primary Afferent A - and C-Fibers

(2011) B. Heinke et al.   JOURNAL OF NEUROSCIENCE

Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects

(2011) S. Majumdar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The delta opioid receptor: an evolving target for the treatment of brain disorders

(2011) Amynah A. Pradhan et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Delta and Kappa Opioid Receptors as Suitable Drug Targets for Pain

(2009) Todd W. Vanderah   CLINICAL JOURNAL OF PAIN

The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception

(2009) Jacques Noël et al.   EMBO JOURNAL

Novel opioid antagonists for opioid-induced bowel dysfunction and postoperative ileus

(2009) Gerhild Becker et al.   LANCET

GABAB Receptor Activation Inhibits Neuronal Excitability and Spatial Learning in the Entorhinal Cortex by Activating TREK-2 K+ Channels

(2009) Pan-Yue Deng et al.   NEURON

Opioids and the control of respiration

(2008) K.T.S. Pattinson   BRITISH JOURNAL OF ANAESTHESIA

Patterns of Abuse Among Unintentional Pharmaceutical Overdose Fatalities

(2008) Aron J. Hall   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Absence and Rescue of Morphine Withdrawal in GIRK/Kir3 Knock-out Mice

(2008) H. G. Cruz et al.   JOURNAL OF NEUROSCIENCE

Deletion of the Glutamate Receptor 5 Subunit of Kainate Receptors Affects the Development of Morphine Tolerance

(2008) J. J. Bogulavsky et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Distinct Expression of Synaptic NR2A and NR2B in the Central Nervous System and Impaired Morphine Tolerance and Physical Dependence in Mice Deficient in Postsynaptic Density-93 Protein

(2008) Wen-Jinn Liaw et al.   Molecular Pain

Methylnaltrexone for Opioid-Induced Constipation in Advanced Illness

(2008) Jay Thomas et al.   NEW ENGLAND JOURNAL OF MEDICINE

Alvimopan, a peripherally acting mu-opioid receptor (PAM-OR) antagonist for the treatment of opioid-induced bowel dysfunction: Results from a randomized, double-blind, placebo-controlled, dose-finding study in subjects taking opioids for chronic non-cancer pain

(2008) Lynn Webster et al.   PAIN

The Prevalence, Severity, and Impact of Opioid-Induced Bowel Dysfunction: Results of a US and European Patient Survey (PROBE 1)

(2008) Timothy J. Bell et al.   PAIN MEDICINE

mGlu4 potentiation of K2P2.1 is dependant on C-terminal dephosphorylation

(2007) Stuart M. Cain et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Group III metabotropic glutamate receptors inhibit hyperalgesia in animal models of inflammation and neuropathic pain

(2007) Cyril Goudet et al.   PAIN