Vaccine nanoparticles for protection against HIV infection

Role of nanotechnology in HIV/AIDS vaccine development

(2016) Ying Liu et al.   ADVANCED DRUG DELIVERY REVIEWS

Recent advances in RNAi-based strategies for therapy and prevention of HIV-1/AIDS

(2016) Manjunath N. Swamy et al.   ADVANCED DRUG DELIVERY REVIEWS

Broadly Neutralizing Antibodies to HIV and Their Role in Vaccine Design

(2016) Dennis R. Burton et al.   Annual Review of Immunology

Directing vaccine immune responses to mucosa by nanosized particulate carriers encapsulating NOD ligands

(2016) Vincent Pavot et al.   BIOMATERIALS

The safety and efficacy of Onivyde (irinotecan liposome injection) for the treatment of metastatic pancreatic cancer following gemcitabine-based therapy

(2016) Frank C. Passero et al.   Expert Review of Anticancer Therapy

Enhancing dendritic cell activation and HIV vaccine effectiveness through nanoparticle vaccination

(2016) Joshua J. Glass et al.   Expert Review of Vaccines

The Density Code for the Development of a Vaccine?

(2016) Wei Cheng   JOURNAL OF PHARMACEUTICAL SCIENCES

LFA-1 Engagement Triggers T Cell Polarization at the HIV-1 Virological Synapse

(2016) Shimona Starling et al.   JOURNAL OF VIROLOGY

Generation of Long-Lived Bone Marrow Plasma Cells Secreting Antibodies Specific for the HIV-1 gp41 Membrane-Proximal External Region in the Absence of Polyreactivity

(2016) Luke R. Donius et al.   JOURNAL OF VIROLOGY

Rationally Designed Immunogens Targeting HIV-1 gp120 V1V2 Induce Distinct Conformation-Specific Antibody Responses in Rabbits

(2016) Xunqing Jiang et al.   JOURNAL OF VIROLOGY

Design of a hyperstable 60-subunit protein icosahedron

(2016) Yang Hsia et al.   NATURE

The coming of age of de novo protein design

(2016) Po-Ssu Huang et al.   NATURE

Broadly Neutralizing Antibodies for HIV-1 Prevention or Immunotherapy

(2016) Marina Caskey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice

(2016) D. Sok et al.   SCIENCE

Accurate design of megadalton-scale two-component icosahedral protein complexes

(2016) J. B. Bale et al.   SCIENCE

Presenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles

(2016) Linling He et al.   Nature Communications

High-Density Array of Well-Ordered HIV-1 Spikes on Synthetic Liposomal Nanoparticles Efficiently Activate B Cells

(2016) Jidnyasa Ingale et al.   Cell Reports

Nanoparticulate STING agonists are potent lymph node–targeted vaccine adjuvants

(2015) Melissa C. Hanson et al.   JOURNAL OF CLINICAL INVESTIGATION

Cationic liposome–hyaluronic acid hybrid nanoparticles for intranasal vaccination with subunit antigens

(2015) Yuchen Fan et al.   JOURNAL OF CONTROLLED RELEASE

Success and failure of the cellular immune response against HIV-1

(2015) Stephen A Migueles et al.   NATURE IMMUNOLOGY

Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity

(2015) Kwinten Sliepen et al.   Retrovirology

Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen

(2015) J. G. Jardine et al.   SCIENCE

HIV-1 neutralizing antibodies induced by native-like envelope trimers

(2015) R. W. Sanders et al.   SCIENCE

Liposomal vaccines incorporating molecular adjuvants and intrastructural T-cell help promote the immunogenicity of HIV membrane-proximal external region peptides

(2015) Melissa C. Hanson et al.   VACCINE

Design of Lipid Nanocapsule Delivery Vehicles for Multivalent Display of Recombinant Env Trimers in HIV Vaccination

(2014) Sharmila Pejawar-Gaddy et al.   BIOCONJUGATE CHEMISTRY

The prevalence of IgG and IgA against adenoviruses in serum of children aged 11-26 months, hospitalised in the Clinical Paediatric Hospital in Warsaw, Poland

(2014) Zuzanna Trojnar et al.   Central European Journal of Immunology

Chemically Modified Peptides Based on the Membrane-Proximal External Region of the HIV-1 Envelope Induce High-Titer, Epitope-Specific Nonneutralizing Antibodies in Rabbits

(2014) Vincent J. Venditto et al.   Clinical and Vaccine Immunology

Biomaterials for Nanoparticle Vaccine Delivery Systems

(2014) Preety Sahdev et al.   PHARMACEUTICAL RESEARCH

Multimeric Scaffolds Displaying the HIV-1 Envelope MPER Induce MPER-Specific Antibodies and Cross-Neutralizing Antibodies when Co-Immunized with gp160 DNA

(2014) Shelly J. Krebs et al.   PLoS One

CCR5 Gene Disruption via Lentiviral Vectors Expressing Cas9 and Single Guided RNA Renders Cells Resistant to HIV-1 Infection

(2014) Weiming Wang et al.   PLoS One

Immunogenicity of Membrane-bound HIV-1 gp41 Membrane-proximal External Region (MPER) Segments Is Dominated by Residue Accessibility and Modulated by Stereochemistry

(2013) Mikyung Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cleavage strongly influences whether soluble HIV-1 envelope glycoprotein trimers adopt a native-like conformation

(2013) R. P. Ringe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer

(2013) J.-P. Julien et al.   SCIENCE

Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer

(2013) D. Lyumkis et al.   SCIENCE

Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors

(2013) J. Jardine et al.   SCIENCE

Generation of Effector Memory T Cell-Based Mucosal and Systemic Immunity with Pulmonary Nanoparticle Vaccination

(2013) A. V. Li et al.   Science Translational Medicine

Modulation of HIV peptide antigen specific cellular immune response by synthetic α- and β-defensin peptides

(2013) Teena Mohan et al.   VACCINE

Nonreplicating vectors in HIV vaccines

(2013) Jennifer A. Johnson et al.   Current Opinion in HIV and AIDS

A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but Not Non-Neutralizing Antibodies

(2013) Rogier W. Sanders et al.   PLoS Pathogens

Self-Healing Microencapsulation of Biomacromolecules without Organic Solvents

(2012) Samuel E. Reinhold et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multivalent glycoconjugates as anti-pathogenic agents

(2012) Anna Bernardi et al.   CHEMICAL SOCIETY REVIEWS

Rational Design of Membrane Proximal External Region Lipopeptides Containing Chemical Modifications for HIV-1 Vaccination

(2012) Vincent J. Venditto et al.   Clinical and Vaccine Immunology

Active self-healing encapsulation of vaccine antigens in PLGA microspheres

(2012) Kashappa-Goud H. Desai et al.   JOURNAL OF CONTROLLED RELEASE

Surface-Engineered Gold Nanorods: Promising DNA Vaccine Adjuvant for HIV-1 Treatment

(2012) Ligeng Xu et al.   NANO LETTERS

Large intestine–targeted, nanoparticle-releasing oral vaccine to control genitorectal viral infection

(2012) Qing Zhu et al.   NATURE MEDICINE

Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial

(2012) Barton F. Haynes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Merck Ad5/HIV induces broad innate immune activation that predicts CD8+ T-cell responses but is attenuated by preexisting Ad5 immunity

(2012) D. E. Zak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction

(2012) J. J. Moon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Solution NMR Study of the Interactions of Oligomannosides and the Anti-HIV-1 2G12 Antibody Reveals Distinct Binding Modes for Branched Ligands*

(2011) Pedro M. Enríquez-Navas et al.   CHEMISTRY-A EUROPEAN JOURNAL

Gold Nanoparticles Coated with Oligomannosides of HIV-1 Glycoprotein gp120 Mimic the Carbohydrate Epitope of Antibody 2G12

(2011) Marco Marradi et al.   JOURNAL OF MOLECULAR BIOLOGY

Programming the magnitude and persistence of antibody responses with innate immunity

(2011) Sudhir Pai Kasturi et al.   NATURE

Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses

(2011) James J. Moon et al.   NATURE MATERIALS

Antibody mechanics on a membrane-bound HIV segment essential for GP41-targeted viral neutralization

(2011) Mikyung Kim et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Emerging nanotechnology approaches for HIV/AIDS treatment and prevention

(2010) Tewodros Mamo et al.   Nanomedicine

HIV vaccines: lessons learned and the way forward

(2010) Jerome H Kim et al.   Current Opinion in HIV and AIDS

Neutralizing antibodies induced by liposomal HIV-1 glycoprotein 41 peptide simultaneously bind to both the 2F5 or 4E10 epitope and lipid epitopes

(2009) Gary R Matyas et al.   AIDS

The development of antiretroviral therapy and its impact on the HIV-1/AIDS pandemic

(2009) Samuel Broder   ANTIVIRAL RESEARCH

RNAi-mediated CCR5 Silencing by LFA-1-targeted Nanoparticles Prevents HIV Infection in BLT Mice

(2009) Sang-Soo Kim et al.   MOLECULAR THERAPY

Long-Term Control of HIV byCCR5Delta32/Delta32 Stem-Cell Transplantation

(2009) Gero Hütter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand

(2009) Supachai Rerks-Ngarm et al.   NEW ENGLAND JOURNAL OF MEDICINE

Adenovirus vector vaccination induces expansion of memory CD4 T cells with a mucosal homing phenotype that are readily susceptible to HIV-1

(2009) A. Benlahrech et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broadly neutralizing anti-HIV-1 antibodies disrupt a hinge-related function of gp41 at the membrane interface

(2009) L. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 Broadly Neutralizing Antibody Extracts Its Epitope from a Kinked gp41 Ectodomain Region on the Viral Membrane

(2008) Zhen-Yu J. Sun et al.   IMMUNITY

Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial

(2008) Susan P Buchbinder et al.   LANCET