The role of muscle-specific tyrosine kinase (MuSK) and mystery of MuSK myasthenia gravis

The search for new antigenic targets in myasthenia gravis

(2012) Judith Cossins et al.   Annals of the New York Academy of Sciences

Muscle-specific kinase myasthenia gravis IgG4 autoantibodies cause severe neuromuscular junction dysfunction in mice

(2012) Rinse Klooster et al.   BRAIN

Signaling and aging at the neuromuscular synapse: lessons learnt from neuromuscular diseases

(2012) Anna Rostedt Punga et al.   CURRENT OPINION IN PHARMACOLOGY

Muscle specific kinase autoantibodies cause synaptic failure through progressive wastage of postsynaptic acetylcholine receptors

(2012) Marco Morsch et al.   EXPERIMENTAL NEUROLOGY

Passive and active immunization models of MuSK-Ab positive myasthenia: Electrophysiological evidence for pre and postsynaptic defects

(2012) Stuart Viegas et al.   EXPERIMENTAL NEUROLOGY

Structural basis of agrin-LRP4-MuSK signaling

(2012) Y. Zong et al.   GENES & DEVELOPMENT

Divalent and monovalent autoantibodies cause dysfunction of MuSK by distinct mechanisms in a rabbit model of myasthenia gravis

(2012) Shuuichi Mori et al.   JOURNAL OF NEUROIMMUNOLOGY

Lrp4 is a retrograde signal for presynaptic differentiation at neuromuscular synapses

(2012) Norihiro Yumoto et al.   NATURE

Distinct Roles of Muscle and Motoneuron LRP4 in Neuromuscular Junction Formation

(2012) Haitao Wu et al.   NEURON

Antibodies against Muscle-Specific Kinase Impair Both Presynaptic and Postsynaptic Functions in a Murine Model of Myasthenia Gravis

(2011) Shuuichi Mori et al.   AMERICAN JOURNAL OF PATHOLOGY

Antibodies to Low Density Lipoprotein Receptor-Related Protein 4 in Seronegative Myasthenia Gravis

(2011) David P. Richman   ARCHIVES OF NEUROLOGY

Autoantibodies to Lipoprotein-Related Protein 4 in Patients With Double-Seronegative Myasthenia Gravis

(2011) John S. Tzartos   ARCHIVES OF NEUROLOGY

SnapShot: Neuromuscular Junction

(2011) Steven J. Burden   CELL

Agrin Binds to the N-terminal Region of Lrp4 Protein and Stimulates Association between Lrp4 and the First Immunoglobulin-like Domain in Muscle-specific Kinase (MuSK)

(2011) Wei Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-LRP4 autoantibodies in AChR- and MuSK-antibody-negative myasthenia gravis

(2011) Alexandra Pevzner et al.   JOURNAL OF NEUROLOGY

Anti-musk antibody myasthenia gravis: Clinical findings and response to treatment in two large cohorts

(2011) Jeffrey T. Guptill et al.   MUSCLE & NERVE

Autoantibodies to low-density lipoprotein receptor-related protein 4 in myasthenia gravis

(2010) Osamu Higuchi et al.   ANNALS OF NEUROLOGY

Antibody effector mechanisms in myasthenia gravis—Pathogenesis at the neuromuscular junction

(2010) Alejandro M. Gomez et al.   AUTOIMMUNITY

A systematic review of population based epidemiological studies in Myasthenia Gravis

(2010) Aisling S Carr et al.   BMC Neurology

Update on muscle-specific tyrosine kinase antibody positive myasthenia gravis

(2010) Jeffrey T Guptill et al.   CURRENT OPINION IN NEUROLOGY

To build a synapse: signaling pathways in neuromuscular junction assembly

(2010) H. Wu et al.   DEVELOPMENT

Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L

(2010) P. T. Hallock et al.   GENES & DEVELOPMENT

Patient autoantibodies deplete postsynaptic muscle-specific kinase leading to disassembly of the ACh receptor scaffold and myasthenia gravis in mice

(2010) R. N. Cole et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Cytoplasmic Adaptor Protein Dok7 Activates the Receptor Tyrosine Kinase MuSK via Dimerization

(2010) Elisa Bergamin et al.   MOLECULAR CELL

Pre- and postsynaptic neuromuscular junction abnormalities in musk myasthenia

(2010) Erik H. Niks et al.   MUSCLE & NERVE

The Effect of Plasma From Muscle-Specific Tyrosine Kinase Myasthenia Patients on Regenerating Endplates

(2009) W. Pascale ter Beek et al.   AMERICAN JOURNAL OF PATHOLOGY

Muscle-Specific Receptor Tyrosine Kinase Antibody Positive Myasthenia Gravis Current Status

(2009) Shin Joong Oh   Journal of Clinical Neurology

MuSK-antibody-positive myasthenia gravis in a South Asian population

(2009) Thashi Chang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Anti-MuSK patient antibodies disrupt the mouse neuromuscular junction

(2008) Rebecca N. Cole et al.   ANNALS OF NEUROLOGY

Myasthenia Gravis Experimentally Induced with Muscle-specific Kinase

(2008) Kazuhiro Shigemoto et al.   Annals of the New York Academy of Sciences

Response to Therapy in Myasthenia Gravis with Anti-MuSK Antibodies

(2008) Amelia Evoli et al.   Annals of the New York Academy of Sciences

Lrp4 Is a Receptor for Agrin and Forms a Complex with MuSK

(2008) Natalie Kim et al.   CELL

Muscle-Specific Receptor Tyrosine Kinase Endocytosis in Acetylcholine Receptor Clustering in Response to Agrin

(2008) D. Zhu et al.   JOURNAL OF NEUROSCIENCE

LRP4 Serves as a Coreceptor of Agrin

(2008) Bin Zhang et al.   NEURON