Na/K Pump and Beyond: Na/K-ATPase as a Modulator of Apoptosis and Autophagy

Lung Adenocarcinoma in Never Smokers: Problems of Primary Prevention from Aspects of Susceptible Genes and Carcinogens

(2016) ISAO OKAZAKI et al.   ANTICANCER RESEARCH

Plant-derived cardiac glycosides: Role in heart ailments and cancer management

(2016) Seema Patel   BIOMEDICINE & PHARMACOTHERAPY

Cancer statistics, 2016

(2016) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Brain metastasis in lung cancer: Building a molecular and systems-level understanding to improve outcomes

(2016) Johnathan D. Ebben et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cardiac glycosides and breast cancer risk: A systematic review and meta-analysis of observational studies

(2016) Reema A. Karasneh et al.   INTERNATIONAL JOURNAL OF CANCER

New and emerging targeted treatments in advanced non-small-cell lung cancer

(2016) Fred R Hirsch et al.   LANCET

Compound Library Screening Identified Cardiac Glycoside Digitoxin as an Effective Growth Inhibitor of Gefitinib-Resistant Non-Small Cell Lung Cancer via Downregulation of α-Tubulin and Inhibition of Microtubule Formation

(2016) Yi-Ze Zhang et al.   MOLECULES

Digoxin: The good and the bad

(2016) Oliver J. Ziff et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Temozolomide-perillyl alcohol conjugate induced reactive oxygen species accumulation contributes to its cytotoxicity against non-small cell lung cancer

(2016) Xingguo Song et al.   Scientific Reports

Cardiac glycosides display selective efficacy for STK11 mutant lung cancer

(2016) Nayoung Kim et al.   Scientific Reports

Regulation of Cardiac Remodeling by Cardiac Na+/K+-ATPase Isoforms

(2016) Lijun Liu et al.   Frontiers in Physiology

Omega-9 Oleic Acid Induces Fatty Acid Oxidation and Decreases Organ Dysfunction and Mortality in Experimental Sepsis

(2016) Cassiano Felippe Gonçalves-de-Albuquerque et al.   PLoS One

Interaction between Na-K-ATPase and Bcl-2 proteins BclXL and Bak

(2015) Peter K. Lauf et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Ion dependence of Na-K-ATPase-mediated epithelial cell adhesion and migration

(2015) Sona Lakshme Balasubramaniam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Targeting Na+/K+-translocating adenosine triphosphatase in cancer treatment

(2015) Cameron T. Durlacher et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Cytotoxicity of cardiotonic steroids in sensitive and multidrug-resistant leukemia cells and the link with Na+/K+-ATPase

(2015) Maen Zeino et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Acute Respiratory Distress Syndrome: Role of Oleic Acid-Triggered Lung Injury and Inflammation

(2015) Cassiano Felippe Gonçalves-de-Albuquerque et al.   MEDIATORS OF INFLAMMATION

Na/K-ATPase as a target for anticancer drugs: studies with perillyl alcohol

(2015) Diogo Gomes Garcia et al.   Molecular Cancer

Targeting the genetic alterations of the PI3K–AKT–mTOR pathway: Its potential use in the treatment of bladder cancers

(2015) Nadine Houédé et al.   PHARMACOLOGY & THERAPEUTICS

Structures and characterization of digoxin- and bufalin-bound Na+,K+-ATPase compared with the ouabain-bound complex

(2015) Mette Laursen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endogenous acetylcholine increases alveolar epithelial fluid transport via activation of alveolar epithelial Na,K-ATPase in mice

(2015) Xia Li et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

TXA9, a cardiac glycoside from Streptocaulon juventas, exerts a potent anti-tumor activity against human non-small cell lung cancer cells in vitro and in vivo

(2015) Rui Xue et al.   STEROIDS

Molecular pathways and therapeutic targets in lung cancer

(2015) Emma Shtivelman et al.   Oncotarget

Steroidal Cardiac Na+/K+ ATPase Inhibitors Exhibit Strong Anti-Cancer Potential in vitro and in Prostate and Lung Cancer Xenografts in vivo

(2014) Konstantinos Dimas et al.   Anti-Cancer Agents in Medicinal Chemistry

Cardiac glycoside ouabain induces autophagic cell death in non-small cell lung cancer cells via a JNK-dependent decrease of Bcl-2

(2014) Annalisa Trenti et al.   BIOCHEMICAL PHARMACOLOGY

Structural determinants for the ouabain-stimulated increase in Na–K ATPase activity

(2014) Syed J. Khundmiri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Inhibition of Na+/K+-ATPase induces hybrid cell death and enhanced sensitivity to chemotherapy in human glioblastoma cells

(2014) Dongdong Chen et al.   BMC CANCER

Autosis and autophagic cell death: the dark side of autophagy

(2014) Y Liu et al.   CELL DEATH AND DIFFERENTIATION

Epigenetic silencing of Na,K-ATPase β1subunit geneATP1B1by methylation in clear cell renal cell carcinoma

(2014) Ponniah Selvakumar et al.   Epigenetics

Bufalin Induces the Interplay between Apoptosis and Autophagy in Glioma Cells through Endoplasmic Reticulum Stress

(2014) Shuying Shen et al.   International Journal of Biological Sciences

Src mediates extracellular signal-regulated kinase 1/2 activation and autophagic cell death induced by cardiac glycosides in human non-small cell lung cancer cell lines

(2014) Yan Wang et al.   MOLECULAR CARCINOGENESIS

Novel concepts of acute lung injury and alveolar-capillary barrier dysfunction

(2013) Susanne Herold et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Monosaccharide digitoxin derivative sensitize human non-small cell lung cancer cells to anoikis through Mcl-1 proteasomal degradation

(2013) Varisa Pongrakhananon et al.   BIOCHEMICAL PHARMACOLOGY

4-Bromo-2-(piperidin-1-yl)thiazol-5-yl-phenyl methanone (12b) inhibits Na+/K+-ATPase and Ras oncogene activity in cancer cells

(2013) Florence Lefranc et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Anticancer Effects of Bufalin on Human Hepatocellular Carcinoma HepG2 Cells: Roles of Apoptosis and Autophagy

(2013) Qing Miao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Expression of Mutant α1 Na/K-ATPase Defective in Conformational Transition Attenuates Src-mediated Signal Transduction

(2013) Qiqi Ye et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oleic acid inhibits lung Na/K-ATPase in mice and induces injury with lipid body formation in leukocytes and eicosanoid production

(2013) Cassiano Gonçalves-de-Albuquerque et al.   Journal of Inflammation-London

Ouabain-Induced Alterations of the Apical Junctional Complex Involve α1 and β1 Na,K-ATPase Downregulation and ERK1/2 Activation Independent of Caveolae in Colorectal Cancer Cells

(2013) Waldemir Fernandes de Souza et al.   JOURNAL OF MEMBRANE BIOLOGY

Hellebrin and its aglycone form hellebrigenin display similar in vitro growth inhibitory effects in cancer cells and binding profiles to the alpha subunits of the Na+/K+-ATPase

(2013) Laetitia Moreno Y Banuls et al.   Molecular Cancer

Cardiotonic Steroids-Mediated Na+/K+-ATPase Targeting Could Circumvent Various Chemoresistance Pathways

(2013) Tatjana Mijatovic et al.   PLANTA MEDICA

Hypoxia and Hypoxia Mimetics Decrease Aquaporin 5 (AQP5) Expression through Both Hypoxia Inducible Factor-1α and Proteasome-Mediated Pathways

(2013) Jitesh D. Kawedia et al.   PLoS One

Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia

(2013) Y. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ouabain downregulates Mcl-1 and sensitizes lung cancer cells to TRAIL-induced apoptosis

(2012) Pithi Chanvorachote et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Na,K-ATPase activity modulates Src activation: A role for ATP/ADP ratio

(2012) Karl M. Weigand et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Quiescence and γH2AX in neuroblastoma are regulated by ouabain/Na,K-ATPase

(2012) H Hiyoshi et al.   BRITISH JOURNAL OF CANCER

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Na+,K+-ATPase as a docking station: protein–protein complexes of the Na+,K+-ATPase

(2012) Linda Reinhard et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Modulators of Na/K-ATPase: a patent review

(2012) Hua-Yu Leo Wang et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Cardiac glycosides induce autophagy in human non-small cell lung cancer cells through regulation of dual signaling pathways

(2012) Yan Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Bufalin Induces Lung Cancer Cell Apoptosis via the Inhibition of PI3K/Akt Pathway

(2012) Zhitu Zhu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Assembling the puzzle of anti-cancer mechanisms triggered by cardiac glycosides

(2012) Claudia Cerella et al.   MITOCHONDRION

Cellular location and expression of Na+, K+-ATPase α subunits affect the anti-proliferative activity of oleandrin

(2012) Peiying Yang et al.   MOLECULAR CARCINOGENESIS

The second sodium pump: from the function to the gene

(2012) Miguel A. Rocafull et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Lung Cancer: Epidemiology, Etiology, and Prevention

(2011) Charles S. Dela Cruz et al.   CLINICS IN CHEST MEDICINE

FXYD Proteins Stabilize Na,K-ATPase

(2011) Neeraj Kumar Mishra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Na+, K+-ATPase: Functions in the nervous system and involvement in neurologic disease

(2011) E. E. Benarroch   NEUROLOGY

Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors

(2011) L. V. Sequist et al.   Science Translational Medicine

Digitoxin and a synthetic monosaccharide analog inhibit cell viability in lung cancer cells

(2011) Hosam A. Elbaz et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The Physiological Significance of the Cardiotonic Steroid/Ouabain-Binding Site of the Na,K-ATPase

(2010) Jerry B Lingrel   Annual Review of Physiology

Targeting the Na+/K+-ATPase α1 Subunit of Hepatoma HepG2 Cell Line to Induce Apoptosis and Cell Cycle Arresting

(2010) Zhong-Wei Xu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The Na+, K+-ATPase: more than just a sodium pump

(2010) G. Scheiner-Bobis   CARDIOVASCULAR RESEARCH

Cardioprotection induced by Na+/K+-ATPase activation involves extracellular signal-regulated kinase 1/2 and phosphoinositide 3-kinase/Akt pathway

(2010) J. Zheng et al.   CARDIOVASCULAR RESEARCH

Selectivity of Digitalis Glycosides for Isoforms of Human Na,K-ATPase

(2010) Adriana Katz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alterations of Na+/K+-ATPase function in caveolin-1 knockout cardiac fibroblasts

(2010) Luis E.M. Quintas et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The Na+/K+-ATPase is the Achilles Heel of multi-drug-resistant cancer cells

(2009) Tatjana Mijatovic et al.   CANCER LETTERS

Inhibition of the Sodium Potassium Adenosine Triphosphatase Pump Sensitizes Cancer Cells to Anoikis and Prevents Distant Tumor Formation

(2009) C. D. Simpson et al.   CANCER RESEARCH

The sodium pump α1 sub-unit: a disease progression-related target for metastatic melanoma treatment

(2009) Véronique Mathieu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Oleandrin-mediated inhibition of human tumor cell proliferation: Importance of Na,K-ATPase   subunits as drug targets

(2009) P. Yang et al.   MOLECULAR CANCER THERAPEUTICS

TARGETING THE α 1 SUBUNIT OF THE SODIUM PUMP TO COMBAT GLIOBLASTOMA CELLS

(2009) Florence Lefranc et al.   NEUROSURGERY

Crystal structure of the sodium-potassium pump (Na+,K+-ATPase) with bound potassium and ouabain

(2009) H. Ogawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional roles of Na,K-ATPase subunits

(2008) Käthi Geering   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Na+/K+-ATPase α subunits as new targets in anticancer therapy

(2008) Tatjana Mijatovic et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Cardiac Glycosides as Novel Cancer Therapeutic Agents

(2008) R. A. Newman et al.   MOLECULAR INTERVENTIONS

Lung Cancer

(2008) Roy S. Herbst et al.   NEW ENGLAND JOURNAL OF MEDICINE

Na,K-Adenosine Triphosphatase α1-Subunit Predicts Survival of Renal Clear Cell Carcinoma

(2007) David B. Seligson et al.   JOURNAL OF UROLOGY