Compound Library Screening Identified Cardiac Glycoside Digitoxin as an Effective Growth Inhibitor of Gefitinib-Resistant Non-Small Cell Lung Cancer via Downregulation of α-Tubulin and Inhibition of Microtubule Formation

A systems pharmacology approach to decipher the mechanism of danggui-shaoyao-san decoction for the treatment of neurodegenerative diseases

(2016) Yunxia Luo et al.   JOURNAL OF ETHNOPHARMACOLOGY

Cardenolide Aglycones Inhibit Tumor Necrosis Factor α-Induced Expression of Intercellular Adhesion Molecule-1 at the Translation Step by Blocking Na+/K+-ATPase

(2015) Yuji Okina et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Novel curcumin analogs to overcome EGFR–TKI lung adenocarcinoma drug resistance and reduce EGFR–TKI-induced GI adverse effects

(2015) Koji Wada et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins with Potent in Vitro and in Vivo Anticancer Activities

(2015) Derek C. Medellin et al.   JOURNAL OF MEDICINAL CHEMISTRY

The history and future of targeting cyclin-dependent kinases in cancer therapy

(2015) Uzma Asghar et al.   NATURE REVIEWS DRUG DISCOVERY

Digitoxin and its synthetic analog MonoD have potent antiproliferative effects on lung cancer cells and potentiate the effects of hydroxyurea and paclitaxel

(2015) JUAN SEBASTIAN YAKISICH et al.   ONCOLOGY REPORTS

Afatinib increases sensitivity to radiation in non-small cell lung cancer cells with acquired EGFR T790M mutation

(2015) Shirong Zhang et al.   Oncotarget

Inactivation of Src-to-Ezrin Pathway: A Possible Mechanism in the Ouabain-Mediated Inhibition of A549 Cell Migration

(2015) Hye Kyoung Shin et al.   Biomed Research International

Digoxin Suppresses Tumor Malignancy through Inhibiting Multiple Src-Related Signaling Pathways in Non-Small Cell Lung Cancer

(2015) Sheng-Yi Lin et al.   PLoS One

Cardiac glycoside ouabain induces autophagic cell death in non-small cell lung cancer cells via a JNK-dependent decrease of Bcl-2

(2014) Annalisa Trenti et al.   BIOCHEMICAL PHARMACOLOGY

Chk1-induced CCNB1 overexpression promotes cell proliferation and tumor growth in human colorectal cancer

(2014) Yifeng Fang et al.   CANCER BIOLOGY & THERAPY

Camptothecin sensitizes human hepatoma Hep3B cells to TRAIL-mediated apoptosis via ROS-dependent death receptor 5 upregulation with the involvement of MAPKs

(2014) Rajapaksha Gedara Prasad Tharanga Jayasooriya et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability

(2014) Guillermo Rodríguez-Berna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Reactive Oxygen Species, AMP-activated Protein Kinase, and the Transcription Cofactor p300 Regulate α-Tubulin Acetyltransferase-1 (αTAT-1/MEC-17)-dependent Microtubule Hyperacetylation during Cell Stress

(2014) Rafah Mackeh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evaluation of the antitumor effects of c-Myc-Max heterodimerization inhibitor 100258-F4 in ovarian cancer cells

(2014) Jiandong Wang et al.   Journal of Translational Medicine

Src mediates extracellular signal-regulated kinase 1/2 activation and autophagic cell death induced by cardiac glycosides in human non-small cell lung cancer cell lines

(2014) Yan Wang et al.   MOLECULAR CARCINOGENESIS

Celastrol Induces Apoptosis in Gefitinib-Resistant Non-Small Cell Lung Cancer Cells via Caspases-Dependent Pathways and Hsp90 Client Protein Degradation

(2014) Xing-Xing Fan et al.   MOLECULES

Anti-tubulins DEPendably induce apoptosis

(2014) Daniel P. Denning et al.   NATURE CELL BIOLOGY

Cyclin B1 Overexpression Induces Cell Death Independent of Mitotic Arrest

(2014) Joshua M. Eichhorn et al.   PLoS One

Inhibition of epidermal growth factor signaling by the cardiac glycoside ouabain in medulloblastoma

(2014) Daniel Wolle et al.   Cancer Medicine

AMPK attenuates microtubule proliferation in cardiac hypertrophy

(2013) John T. Fassett et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK

(2013) Y Storozhuk et al.   BRITISH JOURNAL OF CANCER

AMP-activated protein kinase (AMPK) beyond metabolism

(2013) Toran Sanli et al.   CANCER BIOLOGY & THERAPY

Checkpoint kinase 1 in DNA damage response and cell cycle regulation

(2013) Mallikarjun Patil et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Digoxin Downregulates NDRG1 and VEGF through the Inhibition of HIF-1α under Hypoxic Conditions in Human Lung Adenocarcinoma A549 Cells

(2013) Dong Wei et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulation of the DNA Damage Response by Cyclin-Dependent Kinases

(2013) Camilla Trovesi et al.   JOURNAL OF MOLECULAR BIOLOGY

Nanoparticle albumin-bound paclitaxel for second-line treatment of metastatic urothelial carcinoma: a single group, multicentre, phase 2 study

(2013) Yoo-Joung Ko et al.   LANCET ONCOLOGY

Clinical perspective of afatinib in non-small cell lung cancer

(2013) Xiaofeng Chen et al.   LUNG CANCER

Inhibition of cell migration by ouabain in the A549 human lung cancer cell line

(2013) NING LIU et al.   Oncology Letters

Posttranslational Acetylation of α-Tubulin Constrains Protofilament Number in Native Microtubules

(2012) Juan G. Cueva et al.   CURRENT BIOLOGY

Sustained Antidiabetic Effects of a Berberine-Containing Chinese Herbal Medicine Through Regulation of Hepatic Gene Expression

(2012) H.-L. Zhao et al.   DIABETES

The anti-inflammatory effects of sanguinarine and its modulation of inflammatory mediators from peritoneal macrophages

(2012) Xiaofeng Niu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cardiac glycosides induce autophagy in human non-small cell lung cancer cells through regulation of dual signaling pathways

(2012) Yan Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Beyond ATM: The protein kinase landscape of the DNA damage response

(2011) Ariel Bensimon et al.   FEBS LETTERS

Impact of arsenic trioxide in the treatment of acute promyelocytic leukemia

(2011) E Lengfelder et al.   LEUKEMIA

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

Spectrum of Oncogenic Driver Mutations in Lung Adenocarcinomas from East Asian Never Smokers

(2011) Chenguang Li et al.   PLoS One

Digitoxin and a synthetic monosaccharide analog inhibit cell viability in lung cancer cells

(2011) Hosam A. Elbaz et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Reciprocal and Complementary Role of MET Amplification and EGFR T790M Mutation in Acquired Resistance to Kinase Inhibitors in Lung Cancer

(2010) K. Suda et al.   CLINICAL CANCER RESEARCH

Metformin: Taking away the candy for cancer?

(2010) Mathilde Jalving et al.   EUROPEAN JOURNAL OF CANCER

Structure and function of polarity-inducing kinase family MARK/Par-1 within the branch of AMPK/Snf1-related kinases

(2010) A. Marx et al.   FASEB JOURNAL

Stereotactic Body Radiotherapy (SBRT) for Operable Stage I Non–Small-Cell Lung Cancer: Can SBRT Be Comparable to Surgery?

(2010) Hiroshi Onishi et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Cellular Stress Responses: A Balancing Act

(2010) Feng Chen et al.   MOLECULAR CELL

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

LKB1 and AMP-activated protein kinase control of mTOR signalling and growth

(2009) R. J. Shaw   Acta Physiologica

Odoroside A and ouabain inhibit Na+/K+-ATPase and prevent NF-κB-inducible protein expression by blocking Na+-dependent amino acid transport

(2009) Yohei Takada et al.   BIOCHEMICAL PHARMACOLOGY

Frequency of and variables associated with the EGFR mutation and its subtypes

(2009) Tomoaki Tanaka et al.   INTERNATIONAL JOURNAL OF CANCER

Motor-dependent microtubule disassembly driven by tubulin tyrosination

(2009) Leticia Peris et al.   JOURNAL OF CELL BIOLOGY