Hellebrin and its aglycone form hellebrigenin display similar in vitro growth inhibitory effects in cancer cells and binding profiles to the alpha subunits of the Na+/K+-ATPase

Cardiotonic Steroids-Mediated Targeting of the Na+/K+-ATPase to Combat Chemoresistant Cancers

(2012) T. Mijatovic et al.   CURRENT MEDICINAL CHEMISTRY

Approaches Targeting KV10.1 Open a Novel Window for Cancer Diagnosis and Therapy

(2012) L.A. Pardo et al.   CURRENT MEDICINAL CHEMISTRY

Bufadienolide compounds sensitize human breast cancer cells to TRAIL-induced apoptosis via inhibition of STAT3/Mcl-1 pathway

(2011) Yinhui Dong et al.   APOPTOSIS

Stochastic Receptor Expression Determines Cell Fate upon Interferon Treatment

(2011) D. Levin et al.   MOLECULAR AND CELLULAR BIOLOGY

Bufadienolides and their antitumor activity

(2011) Huimin Gao et al.   NATURAL PRODUCT REPORTS

A Novel Two-Stage, Transdisciplinary Study Identifies Digoxin as a Possible Drug for Prostate Cancer Treatment

(2011) Elizabeth A. Platz et al.   Cancer Discovery

UNBS1450, a steroid cardiac glycoside inducing apoptotic cell death in human leukemia cells

(2010) Tom Juncker et al.   BIOCHEMICAL PHARMACOLOGY

Increase in ouabain-sensitive K+-ATPase activity in hepatocellular carcinoma by overexpression of Na+,K+-ATPase α3-isoform

(2010) Kazuto Shibuya et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Targeting of eEF1A with Amaryllidaceae isocarbostyrils as a strategy to combat melanomas

(2010) Gwendoline Van Goietsenoven et al.   FASEB JOURNAL

Selectivity of Digitalis Glycosides for Isoforms of Human Na,K-ATPase

(2010) Adriana Katz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of mitochondrial dysfunction in cardiac glycoside toxicity

(2010) Ting Liu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Digitalis and Na/Ca exchange: Old dog learns new mitochondrial tricks

(2010) Donald M. Bers   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Rapid Structural Identification of Cytotoxic Bufadienolide Sulfates in Toad Venom fromBufo melanosticusby LC-DAD-MSnand LC-SPE-NMR

(2010) Huimin Gao et al.   JOURNAL OF NATURAL PRODUCTS

The Na+/K+-ATPase is the Achilles Heel of multi-drug-resistant cancer cells

(2009) Tatjana Mijatovic et al.   CANCER LETTERS

Cardiac Glycosides Inhibit p53 Synthesis by a Mechanism Relieved by Src or MAPK Inhibition

(2009) Z. Wang et al.   CANCER RESEARCH

Inhibition of the Sodium Potassium Adenosine Triphosphatase Pump Sensitizes Cancer Cells to Anoikis and Prevents Distant Tumor Formation

(2009) C. D. Simpson et al.   CANCER RESEARCH

Changes in Sodium Pump Expression Dictate the Effects of Ouabain on Cell Growth

(2009) Jiang Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The sodium pump α1 sub-unit: a disease progression-related target for metastatic melanoma treatment

(2009) Véronique Mathieu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Evaluation of current methods used to analyze the expression profiles of ATP-binding cassette transporters yields an improved drug-discovery database

(2009) J. N. Orina et al.   MOLECULAR CANCER THERAPEUTICS

Oleandrin-mediated inhibition of human tumor cell proliferation: Importance of Na,K-ATPase   subunits as drug targets

(2009) P. Yang et al.   MOLECULAR CANCER THERAPEUTICS

TARGETING THE α 1 SUBUNIT OF THE SODIUM PUMP TO COMBAT GLIOBLASTOMA CELLS

(2009) Florence Lefranc et al.   NEUROSURGERY

Novel therapeutic applications of cardiac glycosides

(2008) Ioannis Prassas et al.   NATURE REVIEWS DRUG DISCOVERY

Digoxin and other cardiac glycosides inhibit HIF-1  synthesis and block tumor growth

(2008) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence of galectin-1 involvement in glioma chemoresistance☆

(2008) Marie Le Mercier et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY