Amikacin: Uses, Resistance, and Prospects for Inhibition

Nebulized Versus IV Amikacin as Adjunctive Antibiotic for Hospital and Ventilator-Acquired Pneumonia Postcardiac Surgeries

(2018) Nehal A. Hassan et al.   CRITICAL CARE MEDICINE

Inhibition of aminoglycoside 6′- N -acetyltransferase type Ib-mediated amikacin resistance by zinc complexed with clioquinol, an ionophore active against tumors and neurodegenerative diseases

(2018) Kevin Chiem et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Mechanism and evidence of nonsense suppression therapy for genetic eye disorders

(2017) Rose Richardson et al.   EXPERIMENTAL EYE RESEARCH

Intrathecal or intraventricular administration of colistin, vancomycin and amikacin for central nervous system infections in neurosurgical patients in an intensive care unit

(2017) Angeliki Tsimogianni et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

In-vitro activity of several antimicrobial agents against methicillin-resistant Staphylococcus aureus (MRSA) isolates expressing aminoglycoside-modifying enzymes: potency of plazomicin alone and in combination with other agents

(2017) María Carmen López Díaz et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Once-daily dosing of amikacin for treatment of Mycobacterium abscessus lung disease

(2017) H. Lee et al.   INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE

Acinetobacter baumannii transfers the blaNDM-1 gene via outer membrane vesicles

(2017) Somdatta Chatterjee et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

In vitro activity of plazomicin against β-lactamase-producing carbapenem-resistant Enterobacteriaceae (CRE)

(2017) Yunliang Zhang et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Plazomicin activity against polymyxin-resistant Enterobacteriaceae, including MCR-1-producing isolates

(2017) Valérie Denervaud-Tendon et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Estimation of once-daily amikacin dose in critically ill adults

(2017) Martin Šíma et al.   JOURNAL OF CHEMOTHERAPY

Making sense of antisense oligonucleotides: A narrative review

(2017) Neelam Goyal et al.   MUSCLE & NERVE

A systematic meta-analysis on the efficacy of pre-clinically tested nephroprotectants at preventing aminoglycoside nephrotoxicity

(2017) Laura Vicente-Vicente et al.   TOXICOLOGY

d-Tubocurarine and Berbamine: Alkaloids That Are Permeant Blockers of the Hair Cell's Mechano-Electrical Transducer Channel and Protect from Aminoglycoside Toxicity

(2017) Nerissa K. Kirkwood et al.   Frontiers in Cellular Neuroscience

Antimicrobial Activity, AME Resistance, and A-Site Binding Studies of Anthraquinone–Neomycin Conjugates

(2017) Natalya N. Degtyareva et al.   ACS Infectious Diseases

Combating Enhanced Intracellular Survival (Eis)-Mediated Kanamycin Resistance of Mycobacterium tuberculosis by Novel Pyrrolo[1,5-a]pyrazine-Based Eis Inhibitors

(2017) Atefeh Garzan et al.   ACS Infectious Diseases

Pulmonary Deposition and Elimination of Liposomal Amikacin for Inhalation and Effect on Macrophage Function after Administration in Rats

(2016) Vladimir Malinin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pharmacodynamics of Aerosolized Fosfomycin and Amikacin against Resistant Clinical Isolates of Pseudomonas aeruginosa and Klebsiella pneumoniae in a Hollow-Fiber Infection Model: Experimental Basis for Combination Therapy

(2016) Fekade Bruck Sime et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Molecular Diversity and Plasmid Analysis of KPC-Producing Escherichia coli

(2016) Kalyan D. Chavda et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bacterial GCN5-Related N-Acetyltransferases: From Resistance to Regulation

(2016) Lorenza Favrot et al.   BIOCHEMISTRY

Expanding Aminoglycoside Resistance Enzyme Regiospecificity by Mutation and Truncation

(2016) Selina Y. L. Holbrook et al.   BIOCHEMISTRY

Natural antisense RNAs as mRNA regulatory elements in bacteria: a review on function and applications

(2016) Fatemeh Saberi et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Amikacin in Critically Ill Patients: A Review of Population Pharmacokinetic Studies

(2016) Amélie Marsot et al.   CLINICAL PHARMACOKINETICS

Antisense antimicrobial therapeutics

(2016) Erin K Sully et al.   CURRENT OPINION IN MICROBIOLOGY

Amikacin use and therapeutic drug monitoring in adults: do dose regimens and drug exposures affect either outcome or adverse events? A systematic review

(2016) Abi Jenkins et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Sulfonamide-Based Inhibitors of Aminoglycoside Acetyltransferase Eis Abolish Resistance to Kanamycin in Mycobacterium tuberculosis

(2016) Atefeh Garzan et al.   JOURNAL OF MEDICINAL CHEMISTRY

New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues

(2016) Louis Zimmermann et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Novel 6′-N-Aminoglycoside Acetyltransferase, AAC(6′)-Ial, from a Clinical Isolate ofSerratia marcescens

(2016) Tatsuya Tada et al.   Microbial Drug Resistance

Aminoglycoside-induced nephrotoxicity in children

(2016) Stephen J McWilliam et al.   PEDIATRIC NEPHROLOGY

Antibiotic Binding Drives Catalytic Activation of Aminoglycoside Kinase APH(2″)-Ia

(2016) Shane J. Caldwell et al.   STRUCTURE

A review of patents (2011–2015) towards combating resistance to and toxicity of aminoglycosides

(2016) Nishad Thamban Chandrika et al.   MedChemComm

Identification of an inhibitor of the aminoglycoside 6′-N-acetyltransferase type Ib [AAC(6′)-Ib] by glide molecular docking

(2016) Kevin Chiem et al.   MedChemComm

Mechanisms of resistance to aminoglycoside antibiotics: overview and perspectives

(2016) Sylvie Garneau-Tsodikova et al.   MedChemComm

Mechanisms of Evolution in High-Consequence Drug Resistance Plasmids

(2016) Susu He et al.   mBio

Discovery and Optimization of Two Eis Inhibitor Families as Kanamycin Adjuvants against Drug-Resistant M. tuberculosis

(2016) Atefeh Garzan et al.   ACS Medicinal Chemistry Letters

External guide sequence technology: a path to development of novel antimicrobial therapeutics

(2015) Carol Davies-Sala et al.   Annals of the New York Academy of Sciences

Optimizing the Initial Amikacin Dosage in Adults

(2015) Bryan P. White et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Can Plazomicin Alone or in Combination Be a Therapeutic Option against Carbapenem-Resistant Acinetobacter baumannii?

(2015) Cristina García-Salguero et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibition of Aminoglycoside 6′-N-Acetyltransferase Type Ib-Mediated Amikacin Resistance in Klebsiella pneumoniae by Zinc and Copper Pyrithione

(2015) Kevin Chiem et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibition of AAC(6′)-Ib-Mediated Resistance to Amikacin in Acinetobacter baumannii by an Antisense Peptide-Conjugated 2′,4′-Bridged Nucleic Acid-NC-DNA Hybrid Oligomer

(2015) Christina Lopez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Characterization of Tn6238with a New Allele ofaac(6′)-Ib-cr

(2015) María P. Quiroga et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibition of Aminoglycoside Acetyltransferase Resistance Enzymes by Metal Salts

(2015) Yijia Li et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Amphiphilic Tobramycin Analogues as Antibacterial and Antifungal Agents

(2015) Sanjib K. Shrestha et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In vitro activity of the next-generation aminoglycoside plazomicin alone and in combination with colistin, meropenem, fosfomycin or tigecycline against carbapenemase-producing Enterobacteriaceae strains

(2015) Iciar Rodríguez-Avial et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

New plasmid-mediated aminoglycoside 6′-N-acetyltransferase, AAC(6′)-Ian, and ESBL, TLA-3, from aSerratia marcescensclinical isolate

(2015) Wanchun Jin et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Structure–Activity Relationships for Antibacterial to Antifungal Conversion of Kanamycin to Amphiphilic Analogues

(2015) Marina Fosso et al.   JOURNAL OF ORGANIC CHEMISTRY

Insertion Sequence IS 26 Reorganizes Plasmids in Clinically Isolated Multidrug-Resistant Bacteria by Replicative Transposition

(2015) Susu He et al.   mBio

Synthesis and Biological Activity of Mono- and Di-N-acylated Aminoglycosides

(2015) Nishad Thamban Chandrika et al.   ACS Medicinal Chemistry Letters

Mechanisms of antibiotic resistance

(2015) Jun Lin et al.   Frontiers in Microbiology

Identification of a Novel 6′-N-Aminoglycoside Acetyltransferase, AAC(6′)-Iak, from a Multidrug-Resistant Clinical Isolate of Stenotrophomonas maltophilia

(2014) Tatsuya Tada et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Complete Nucleotide Sequence ofcfr-Carrying IncX4 Plasmid pSD11 from Escherichia coli

(2014) Jian Sun et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vitro Activity of Plazomicin against 5,015 Gram-Negative and Gram-Positive Clinical Isolates Obtained from Patients in Canadian Hospitals as Part of the CANWARD Study, 2011-2012

(2014) A. Walkty et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibition of Aminoglycoside 6′-N-Acetyltransferase Type Ib by Zinc: Reversal of Amikacin Resistance in Acinetobacter baumannii and Escherichia coli by a Zinc Ionophore

(2014) David L. Lin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Aminoglycoside-induced ototoxicity

(2014) Jerome A. Leis et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Biological metals and metal-targeting compounds in major neurodegenerative diseases

(2014) Kevin J. Barnham et al.   CHEMICAL SOCIETY REVIEWS

Singly Modified Amikacin and Tobramycin Derivatives Show Increased rRNA A-Site Binding and Higher Potency against Resistant Bacteria

(2014) Richard J. Fair et al.   ChemMedChem

A Random Sequential Mechanism of Aminoglycoside Acetylation by Mycobacterium tuberculosis Eis Protein

(2014) Oleg V. Tsodikov et al.   PLoS One

Molecular dissection of the evolution of carbapenem-resistant multilocus sequence type 258Klebsiella pneumoniae

(2014) Frank R. DeLeo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mycobacterial endocarditis: a comprehensive review

(2014) Shi-Min Yuan   Revista Brasileira de Cirurgia Cardiovascular

Carbapenemase-producing Klebsiella pneumoniae: molecular and genetic decoding

(2014) Liang Chen et al.   TRENDS IN MICROBIOLOGY

Structure of the phosphotransferase domain of the bifunctional aminoglycoside-resistance enzyme AAC(6′)-Ie-APH(2′′)-Ia

(2014) Clyde A. Smith et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structure of the bifunctional aminoglycoside-resistance enzyme AAC(6′)-Ie-APH(2′′)-Ia revealed by crystallographic and small-angle X-ray scattering analysis

(2014) Clyde A. Smith et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Complete Nucleotide Sequence of ablaKPC-Harboring IncI2 Plasmid and Its Dissemination in New Jersey and New York Hospitals

(2013) Liang Chen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibitors of the aminoglycoside 6′-N-acetyltransferase type Ib [AAC(6′)-Ib] identified by in silico molecular docking

(2013) David L. Lin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Aminoglycosides

(2013) Justin Jackson et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Mycobacterium tuberculosis rrs A1401G mutation correlates with high-level resistance to kanamycin, amikacin, and capreomycin in clinical isolates from mainland China

(2013) Qinglin Du et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

High abundance and diversity of antimicrobial resistance determinants among early vancomycin-resistant Enterococcus faecium in Poland

(2013) E. Sadowy et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Strategies to overcome the action of aminoglycoside-modifying enzymes for treating resistant bacterial infections

(2013) Kristin J Labby et al.   Future Medicinal Chemistry

High-copy bacterial plasmids diffuse in the nucleoid-free space, replicate stochastically and are randomly partitioned at cell division

(2013) R. Reyes-Lamothe et al.   NUCLEIC ACIDS RESEARCH

Identification and Characterization of a Novel aac(6′)-Iag Associated with the blaIMP-1–Integron in a Multidrug-Resistant Pseudomonas aeruginosa

(2013) Kanao Kobayashi et al.   PLoS One

Rise and dissemination of aminoglycoside resistance: the aac(6′)-Ib paradigm

(2013) María S. Ramirez et al.   Frontiers in Microbiology

(Non-)translational medicine: targeting bacterial RNA

(2013) Adam M. Dinan et al.   Frontiers in Genetics

Novel 6′-N-Aminoglycoside Acetyltransferase AAC(6′)-Iaj from a Clinical Isolate of Pseudomonas aeruginosa

(2012) Tatsuya Tada et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Combination Therapy for Treatment of Infections with Gram-Negative Bacteria

(2012) P. D. Tamma et al.   CLINICAL MICROBIOLOGY REVIEWS

Suppression of premature termination codons as a therapeutic approach

(2012) Kim M. Keeling et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Development of Aminoglycoside Antibiotics Effective Against Resistant Bacterial Strains

(2012) Lin Yang et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

A carbapenem-resistant Klebsiella pneumoniae epidemic clone in Jerusalem: sequence type 512 carrying a plasmid encoding aac(6')-Ib

(2012) G. Warburg et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

qnr, aac(6′)-Ib-cr and qepA genes in Escherichia coli and Klebsiella spp.: genetic environments and plasmid and chromosomal location

(2012) Elena Ruiz et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Activity of Plazomicin (ACHN-490) against MDR clinical isolates ofKlebsiella pneumoniae, Escherichia coli, andEnterobacterspp. from Athens, Greece

(2012) Irene Galani et al.   JOURNAL OF CHEMOTHERAPY

2-Deoxystreptamine-containing aminoglycoside antibiotics: Recent advances in the characterization and manipulation of their biosynthetic pathways

(2012) Sung Ryeol Park et al.   NATURAL PRODUCT REPORTS

Quantification of Amikacin in Bronchial Epithelial Lining Fluid in Neonates

(2011) C. Tayman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Horizontal Transfer of the OXA-24 Carbapenemase Gene via Outer Membrane Vesicles: a New Mechanism of Dissemination of Carbapenem Resistance Genes in Acinetobacter baumannii

(2011) Carlos Rumbo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identification and Characterization of Inhibitors of the Aminoglycoside Resistance Acetyltransferase Eis from Mycobacterium tuberculosis

(2011) Keith D. Green et al.   ChemMedChem

Mutations in the rrs A1401G Gene and Phenotypic Resistance to Amikacin and Capreomycin in Mycobacterium tuberculosis

(2011) Frederick A. Sirgel et al.   Microbial Drug Resistance

Aminoglycoside Resistance Rates, Phenotypes, and Mechanisms of Gram-Negative Bacteria from Infected Patients in Upper Egypt

(2011) Gamal F. Gad et al.   PLoS One

Unusual regioversatility of acetyltransferase Eis, a cause of drug resistance in XDR-TB

(2011) W. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding and overcoming aminoglycoside resistance caused by N-6′-acetyltransferase

(2011) Kenward Vong et al.   MedChemComm

Bacterial Antisense RNAs: How Many Are There, and What Are They Doing?

(2010) Maureen Kiley Thomason et al.   Annual Review of Genetics

Synthesis and Spectrum of the Neoglycoside ACHN-490

(2010) J. B. Aggen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Future of Aminoglycosides: The End or Renaissance?

(2010) Jacob L. Houghton  et al.   CHEMBIOCHEM

Clioquinol: Review of its Mechanisms of Action and Clinical Uses in Neurodegenerative Disorders

(2010) Silvio R. Bareggi et al.   CNS Neuroscience & Therapeutics

Combating evolution with intelligent design: the neoglycoside ACHN-490

(2010) Eliana S Armstrong et al.   CURRENT OPINION IN MICROBIOLOGY

Aminoglycoside modifying enzymes

(2010) Maria S. Ramirez et al.   DRUG RESISTANCE UPDATES

New aminoglycoside antibiotics

(2010) Paola Dozzo et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Nocardiosis: Updated Clinical Review and Experience at a Tertiary Center

(2010) J. Ambrosioni et al.   INFECTION

Best drug treatment for multidrug-resistant and extensively drug-resistant tuberculosis

(2010) José A Caminero et al.   LANCET INFECTIOUS DISEASES

Inhibition of gene expression by RNase P

(2010) Eirik Wasmuth Lundblad et al.   New Biotechnology

Side effects of aminoglycosides on the kidney, ear and balance in cystic fibrosis

(2010) A. Prayle et al.   THORAX

Antibiotics that target protein synthesis

(2010) Lisa S. McCoy et al.   Wiley Interdisciplinary Reviews-RNA

Management of Aminoglycosides in the Intensive Care Unit

(2010) Elizabeth A. Radigan et al.   JOURNAL OF INTENSIVE CARE MEDICINE

In Vivo Antibacterial Activity of Vertilmicin, a New Aminoglycoside Antibiotic

(2009) X.-F. You et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

High Level of Cross-Resistance between Kanamycin, Amikacin, and Capreomycin among Mycobacterium tuberculosis Isolates from Georgia and a Close Relation with Mutations in the rrs Gene

(2009) L. Jugheli et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A blaVEB-1 Variant, blaVEB-6, Associated with Repeated Elements in a Complex Genetic Structure

(2009) Z. Zong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Complete Nucleotide Sequences of Plasmids pEK204, pEK499, and pEK516, Encoding CTX-M Enzymes in Three Major Escherichia coli Lineages from the United Kingdom, All Belonging to the International O25:H4-ST131 Clone

(2009) N. Woodford et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The bifunctional enzymes of antibiotic resistance

(2009) Weilie Zhang et al.   CURRENT OPINION IN MICROBIOLOGY

Individualised dosing of amikacin in neonates: a pharmacokinetic/pharmacodynamic analysis

(2009) Catherine M. T. Sherwin et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

mwr Xer site-specific recombination is hypersensitive to DNA supercoiling

(2009) Sonia Trigueros et al.   NUCLEIC ACIDS RESEARCH

In Vitro Antibacterial Activity of Vertilmicin and Its Susceptibility to Modifications by the Recombinant AAC(6')-APH(2'') Enzyme

(2008) C.-R. Li et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The KQ Element, a Complex Genetic Region Conferring Transferable Resistance to Carbapenems, Aminoglycosides, and Fluoroquinolones in Klebsiella pneumoniae

(2008) L. B. Rice et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

NMR-Guided Fragment-Based Approach for the Design of AAC(6′)-Ib Ligands

(2008) Thomas Lombès et al.   CHEMBIOCHEM

Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

(2008) Helen W. Boucher et al.   CLINICAL INFECTIOUS DISEASES

Inhaled aminoglycosides in cancer patients with ventilator-associated Gram-negative bacterial pneumonia: safety and feasibility in the era of escalating drug resistance

(2008) D. E. Ghannam et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Insights into functional modulation of catalytic RNA activity

(2008) Anastassios Vourekas et al.   IUBMB LIFE

Tackling antibiotic resistance: a dose of common antisense?

(2008) N. Woodford et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Functional characterization of Tn1331 gene cassettes

(2008) M. S. Ramirez et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Cleavage of RNA oligonucleotides by aminoglycosides

(2008) Matthew J. Belousoff et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Aminoglycoside induced ototoxicity

(2008) O’neil W. Guthrie   TOXICOLOGY

Paromomycin

(2008) Robert N. Davidson et al.   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE