Identification of an inhibitor of the aminoglycoside 6′-N-acetyltransferase type Ib [AAC(6′)-Ib] by glide molecular docking

Inhibition of Aminoglycoside 6′-N-Acetyltransferase Type Ib-Mediated Amikacin Resistance in Klebsiella pneumoniae by Zinc and Copper Pyrithione

(2015) Kevin Chiem et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibition of Aminoglycoside Acetyltransferase Resistance Enzymes by Metal Salts

(2015) Yijia Li et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Beware of docking!

(2015) Yu-Chian Chen   TRENDS IN PHARMACOLOGICAL SCIENCES

Inhibition of Aminoglycoside 6′-N-Acetyltransferase Type Ib by Zinc: Reversal of Amikacin Resistance in Acinetobacter baumannii and Escherichia coli by a Zinc Ionophore

(2014) David L. Lin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

New β-Lactamase Inhibitors: a Therapeutic Renaissance in an MDR World

(2013) Sarah M. Drawz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibitors of the aminoglycoside 6′-N-acetyltransferase type Ib [AAC(6′)-Ib] identified by in silico molecular docking

(2013) David L. Lin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Aminoglycosides

(2013) Justin Jackson et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Aminoglycoside therapy in infectious diseases

(2013) Panagiotis Poulikakos et al.   EXPERT OPINION ON PHARMACOTHERAPY

Strategies to overcome the action of aminoglycoside-modifying enzymes for treating resistant bacterial infections

(2013) Kristin J Labby et al.   Future Medicinal Chemistry

Automated Docking with Protein Flexibility in the Design of Femtomolar “Click Chemistry” Inhibitors of Acetylcholinesterase

(2013) Garrett M. Morris et al.   Journal of Chemical Information and Modeling

Aminopurine derivatives as putative SopE inhibitors

(2013) Gizem Ozbuyukkaya et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Extra precision docking, free energy calculation and molecular dynamics simulation studies of CDK2 inhibitors

(2013) Sunil Kumar Tripathi et al.   JOURNAL OF THEORETICAL BIOLOGY

Novel β-lactamase inhibitors: a therapeutic hope against the scourge of multidrug resistance

(2013) Richard R. Watkins et al.   Frontiers in Microbiology

Rise and dissemination of aminoglycoside resistance: the aac(6′)-Ib paradigm

(2013) María S. Ramirez et al.   Frontiers in Microbiology

Inhibitors of Aminoglycoside Resistance Activated in Cells

(2012) Kenward Vong et al.   ACS Chemical Biology

A carbapenem-resistant Klebsiella pneumoniae epidemic clone in Jerusalem: sequence type 512 carrying a plasmid encoding aac(6')-Ib

(2012) G. Warburg et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

ZINC: A Free Tool to Discover Chemistry for Biology

(2012) John J. Irwin et al.   Journal of Chemical Information and Modeling

Identification and Characterization of Inhibitors of the Aminoglycoside Resistance Acetyltransferase Eis from Mycobacterium tuberculosis

(2011) Keith D. Green et al.   ChemMedChem

Current use of aminoglycosides: indications, pharmacokinetics and monitoring for toxicity

(2011) M. L. Avent et al.   INTERNAL MEDICINE JOURNAL

Understanding and overcoming aminoglycoside resistance caused by N-6′-acetyltransferase

(2011) Kenward Vong et al.   MedChemComm

Aminoglycoside modifying enzymes

(2010) Maria S. Ramirez et al.   DRUG RESISTANCE UPDATES

Fidelity at the Molecular Level: Lessons from Protein Synthesis

(2009) Hani S. Zaher et al.   CELL

Synthesis of a Phosphonate-Linked Aminoglycoside-Coenzyme A Bisubstrate and Use in Mechanistic Studies of an Enzyme Involved in Aminoglycoside Resistance

(2009) Feng Gao et al.   CHEMISTRY-A EUROPEAN JOURNAL

Mechanistic and Structural Analysis of AminoglycosideN-Acetyltransferase AAC(6′)-Ib and Its Bifunctional, Fluoroquinolone-Active AAC(6′)-Ib-cr Variant†‡

(2008) Matthew W. Vetting et al.   BIOCHEMISTRY

Synthesis and use of sulfonamide-, sulfoxide-, or sulfone-containing aminoglycoside–CoA bisubstrates as mechanistic probes for aminoglycoside N-6′-acetyltransferase

(2008) Feng Gao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

NMR-Guided Fragment-Based Approach for the Design of AAC(6′)-Ib Ligands

(2008) Thomas Lombès et al.   CHEMBIOCHEM

Enzyme structural plasticity and the emergence of broad-spectrum antibiotic resistance

(2008) Frédérique Maurice et al.   EMBO REPORTS

3D-QSAR CoMFA and CoMSIA Study on Benzodipyrazoles as Cyclin Dependent Kinase 2 Inhibitors

(2008) Nigus Dessalew et al.   Medicinal Chemistry

Kinetic and Structural Analysis of Bisubstrate Inhibition of theSalmonella entericaAminoglycoside 6‘-N-Acetyltransferase†,‡

(2007) Maria L. B. Magalhães et al.   BIOCHEMISTRY