Phytotherapeutics: The Emerging Role of Intestinal and Hepatocellular Transporters in Drug Interactions with Botanical Supplements

Significance of Resveratrol in Clinical Management of Chronic Diseases

(2017) Awais Wahab et al.   MOLECULES

Inhibitory mechanism against oxidative stress of caffeic acid

(2016) Farhan Ahmed Khan et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

Cranberry Juice Ingestion and Clinical Drug-Drug Interaction Potentials; Review of Case Studies and Perspectives

(2016) Nuggehally R Srinivas   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

A comprehensive overview of hepatoprotective natural compounds: mechanism of action and clinical perspectives

(2015) Robert Domitrović et al.   ARCHIVES OF TOXICOLOGY

Hepatotoxicity of herbal and dietary supplements: an update

(2015) Felix Stickel et al.   ARCHIVES OF TOXICOLOGY

Pharmacokinetic Interactions Between Herbal Medicines and Prescribed Drugs: Focus on Drug Metabolic Enzymes and Transporters

(2015) Qiang Meng et al.   CURRENT DRUG METABOLISM

Exploring the Nutraceutical Potential of Polyphenols from Black, Green and White Tea Infusions – An Overview

(2015) Gian Tenore et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Herbal hepatotoxicity: current status, examples, and challenges

(2015) Carlemi Calitz et al.   Expert Opinion on Drug Metabolism & Toxicology

Amanita phalloides poisoning: Mechanisms of toxicity and treatment

(2015) Juliana Garcia et al.   FOOD AND CHEMICAL TOXICOLOGY

Herbal Products and the Liver: A Review of Adverse Effects and Mechanisms

(2015) Leonard B. Seeff et al.   GASTROENTEROLOGY

Current Status of Herbal Medicines in Chronic Liver Disease Therapy: The Biological Effects, Molecular Targets and Future Prospects

(2015) Ming Hong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Enhancement effect of resveratrol on the intestinal absorption of bestatin by regulating PEPT1, MDR1 and MRP2 in vivo and in vitro

(2015) Yongming Jia et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Enzyme- and transporter-mediated beverage-drug interactions: An update on fruit juices and green tea

(2015) Guohua An et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Possible molecular targets for therapeutic applications of caffeic acid phenethyl ester in inflammation and cancer

(2015) Ghulam Murtaza et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

Curcumin Affects Phase II Disposition of Resveratrol Through Inhibiting Efflux Transporters MRP2 and BCRP

(2015) Shufan Ge et al.   PHARMACEUTICAL RESEARCH

Multiple ABC Transporters Efflux Baicalin

(2015) Bernadett Kalapos-Kovács et al.   PHYTOTHERAPY RESEARCH

Pharmacological Studies of Artichoke Leaf Extract and Their Health Benefits

(2015) Maryem Ben Salem et al.   PLANT FOODS FOR HUMAN NUTRITION

A Lead-In with Silibinin Prior to Triple-Therapy Translates into Favorable Treatment Outcomes in Difficult-To-Treat HIV/Hepatitis C Coinfected Patients

(2015) Dominique L. Braun et al.   PLoS One

Boldine enhances bile production in rats via osmotic and Farnesoid X receptor dependent mechanisms

(2015) Jolana Cermanova et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Effects of anthocyans on the expression of organic anion transporting polypeptides (SLCOs/OATPs) in primary human hepatocytes

(2015) Juliane Riha et al.   Food & Function

Resveratrol overcomes gefitinib resistance by increasing the intracellular gefitinib concentration and triggering apoptosis, autophagy and senescence in PC9/G NSCLC cells

(2015) Yinsong Zhu et al.   Scientific Reports

Regulation of Multidrug Resistance Proteins by Genistein in a Hepatocarcinoma Cell Line: Impact on Sorafenib Cytotoxicity

(2015) Juan Pablo Rigalli et al.   PLoS One

Green Tea Ingestion Greatly Reduces Plasma Concentrations of Nadolol in Healthy Subjects

(2014) S Misaka et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Intestinal lipid absorption and lipoprotein formation

(2014) M. Mahmood Hussain   CURRENT OPINION IN LIPIDOLOGY

Traditional Medicines in the World: Where to Go Next?

(2014) Si-Yuan Pan et al.   Evidence-based Complementary and Alternative Medicine

Historical Perspective of Traditional Indigenous Medical Practices: The Current Renaissance and Conservation of Herbal Resources

(2014) Si-Yuan Pan et al.   Evidence-based Complementary and Alternative Medicine

Drug interactions with phytotherapeutics in oncology

(2014) Walter Emil Haefeli et al.   Expert Opinion on Drug Metabolism & Toxicology

Effects of Anthocyanidins and Anthocyanins on the Expression and Catalytic Activities of CYP2A6, CYP2B6, CYP2C9, and CYP3A4 in Primary Human Hepatocytes and Human Liver Microsomes

(2014) Alzbeta Srovnalova et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

ATP-binding cassette transporters in liver

(2013) Katrin Wlcek et al.   BIOFACTORS

Green Tea Extract Affects the Cytochrome P450 3A Activity and Pharmacokinetics of Simvastatin in Rats

(2013) Shingen Misaka et al.   Drug Metabolism and Pharmacokinetics

The effects of flavonoids on the ABC transporters: consequences for the pharmacokinetics of substrate drugs

(2013) Yan Li et al.   Expert Opinion on Drug Metabolism & Toxicology

Multidrug and toxin extrusion family SLC47: Physiological, pharmacokinetic and toxicokinetic importance of MATE1 and MATE2-K

(2013) Hideyuki Motohashi et al.   MOLECULAR ASPECTS OF MEDICINE

The SLC2 (GLUT) family of membrane transporters

(2013) Mike Mueckler et al.   MOLECULAR ASPECTS OF MEDICINE

Glucose transport families SLC5 and SLC50

(2013) Ernest M. Wright   MOLECULAR ASPECTS OF MEDICINE

Breast Cancer Resistance Protein-Mediated Efflux of Luteolin Glucuronides in HeLa Cells Overexpressing UDP-Glucuronosyltransferase 1A9

(2013) Lan Tang et al.   PHARMACEUTICAL RESEARCH

One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease

(2013) João Tomé-Carneiro et al.   PHARMACOLOGICAL RESEARCH

Hypericum perforatum: Pharmacokinetic, Mechanism of Action, Tolerability, and Clinical Drug-Drug Interactions

(2013) Emilio Russo et al.   PHYTOTHERAPY RESEARCH

Inhibitory effect of anthocyanidins on hepatic glutathione S-transferase, UDP-glucuronosyltransferase and carbonyl reductase activities in rat and human

(2013) Barbora Szotáková et al.   XENOBIOTICA

The bioavailability and distribution of trans-resveratrol are constrained by ABC transporters

(2012) Joana M. Planas et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Study on the Influence of Silymarin Pretreatment on Metabolism and Disposition of Metronidazole

(2012) Kandhagatla Rajnarayana et al.   ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH

Repeated dosing of piperine induced gene expression of P-glycoprotein via stimulated pregnane-X-receptor activity and altered pharmacokinetics of diltiazem in rats

(2012) Fu Qiang et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Apple juice greatly reduces systemic exposure to atenolol

(2012) Hyewon Jeon et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Herb-drug interactions: an overview of systematic reviews

(2012) Paul Posadzki et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Fruit Juices as Perpetrators of Drug Interactions: The Role of Organic Anion–Transporting Polypeptides

(2012) M J Dolton et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Herb-drug Interactions Involving Drug Metabolizing Enzymes and Transporters

(2012) Chang-Xiao Liu et al.   CURRENT DRUG METABOLISM

The Role of ABC and SLC Transporters in the Pharmacokinetics of Dietary and Herbal Phytochemicals and their Interactions with Xenobiotics

(2012) Yan Li et al.   CURRENT DRUG METABOLISM

The role of amino acid transporters in nutrition

(2012) Nadège Poncet et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

An update on the ability of St. John's wort to affect the metabolism of other drugs

(2012) Roja Rahimi et al.   Expert Opinion on Drug Metabolism & Toxicology

Major Active Components in Grapefruit, Orange, and Apple Juices Responsible for OATP2B1-Mediated Drug Interactions

(2012) Yoshiyuki Shirasaka et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Drug transport by Organic Anion Transporters (OATs)

(2012) Gerhard Burckhardt   PHARMACOLOGY & THERAPEUTICS

Botanical-Drug Interactions: A Scientific Perspective

(2012) Manuela de Lima Toccafondo Vieira et al.   PLANTA MEDICA

Inhibition of ABCG2/BCRP transporter by soy isoflavones genistein and daidzein: Effect on plasma and milk levels of danofloxacin in sheep

(2012) Miriam Perez et al.   VETERINARY JOURNAL

Warfarin-Cranberry Juice Interaction

(2011) Gale L Hamann et al.   ANNALS OF PHARMACOTHERAPY

Intravenous silibinin as ‘rescue treatment’ for on-treatment non-responders to pegylated interferon/ribavirin combination therapy

(2011) Karoline Rutter et al.   ANTIVIRAL THERAPY

Serum concentrations and clinical effects of atorvastatin in patients taking grapefruit juice daily

(2011) Patrick Reddy et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Resveratrol enhances the cytotoxic profile of docetaxel and doxorubicin in solid tumour cell lines in vitro

(2011) A. M. Al-Abd et al.   CELL PROLIFERATION

Interactions of Green Tea Catechins with Organic Anion-Transporting Polypeptides

(2011) M. Roth et al.   DRUG METABOLISM AND DISPOSITION

Intestinal OATP1A2 inhibition as a potential mechanism for the effect of grapefruit juice on aliskiren pharmacokinetics in healthy subjects

(2011) Sam Rebello et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

The emerging role of transport systems in liver function tests

(2011) Bruno Stieger et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The effect of grapefruit juice on drug disposition

(2011) Michael J Hanley et al.   Expert Opinion on Drug Metabolism & Toxicology

Interaction of St John’s wort (Hypericum perforatum) with clozapine

(2011) Annelies C.P. Van Strater et al.   INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY

Influence ofPanax ginsengon Cytochrome P450 (CYP)3A and P-glycoprotein (P-gp) Activity in Healthy Participants

(2011) Christine Y. Malati et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Differential Effect of Grapefruit Juice on Intestinal Absorption of Statins Due to Inhibition of Organic Anion Transporting Polypeptide and/or P-glycoprotein

(2011) Yoshiyuki Shirasaka et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Pharmacogenetics of drug transporters in the enterohepatic circulation

(2011) Bruno Stieger et al.   PHARMACOGENOMICS

Silybin and the liver: From basic research to clinical practice

(2011) Carmela Loguercio   WORLD JOURNAL OF GASTROENTEROLOGY

Getting the mOST from OST: Role of organic solute transporter, OSTα-OSTβ, in bile acid and steroid metabolism

(2010) Paul A. Dawson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Orange and apple juice greatly reduce the plasma concentrations of the OATP2B1 substrate aliskiren

(2010) Tuija Tapaninen et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Resveratrol Modulates Drug- and Carcinogen-Metabolizing Enzymes in a Healthy Volunteer Study

(2010) H.-H. S. Chow et al.   Cancer Prevention Research

Clinical Pharmacology of Resveratrol and Its Metabolites in Colorectal Cancer Patients

(2010) K. R. Patel et al.   CANCER RESEARCH

Disposition Pathways and Pharmacokinetics of Herbal Medicines in Humans

(2010) S.-M. He et al.   CURRENT MEDICINAL CHEMISTRY

Garlic Flavonoids and Organosulfur Compounds: Impact on the Hepatic Pharmacokinetics of Saquinavir and Darunavir

(2010) Katja Berginc et al.   Drug Metabolism and Pharmacokinetics

Inhibitory Effects of Herbal Extracts on Breast Cancer Resistance Protein (BCRP) and Structure-Inhibitory Potency Relationship of Isoflavonoids

(2010) Hirofumi Tamaki et al.   Drug Metabolism and Pharmacokinetics

Grapefruit-Drug Interactions

(2010) Kay Seden et al.   DRUGS

Garlic extract induces intestinal P-glycoprotein, but exhibits no effect on intestinal and hepatic CYP3A4 in humans

(2010) Jacek Hajda et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Efficacy and tolerability of Hypericum extract for the treatment of mild to moderate depression

(2010) Siegfried Kasper et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Lessons Learned from Herbal Medicinal Products: The Example of St. John’s Wort⊥

(2010) Adolf Nahrstedt et al.   JOURNAL OF NATURAL PRODUCTS

The effects of the SLCO2B1 c.1457C>T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans

(2010) Junko Imanaga et al.   Pharmacogenetics and Genomics

Genetic Determinants of Drug-induced Cholestasis and Intrahepatic Cholestasis of Pregnancy

(2010) Christiane Pauli-Magnus et al.   SEMINARS IN LIVER DISEASE

Herb–Drug Interactions with St John’s Wort (Hypericum perforatum): an Update on Clinical Observations

(2009) Francesca Borrelli et al.   AAPS Journal

Aged Garlic Extract Stimulates P-Glycoprotein and Multidrug Resistance Associated Protein 2 Mediated Effluxes

(2009) Katja Berginc et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Berry anthocyanins and anthocyanidins exhibit distinct affinities for the efflux transporters BCRP and MDR1

(2009) A Dreiseitel et al.   BRITISH JOURNAL OF PHARMACOLOGY

Short-term effect of quercetin on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein, in healthy volunteers

(2009) Kyoung-Ah Kim et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Effect of silymarin on the pharmacokinetics of losartan and its active metabolite E-3174 in healthy Chinese volunteers

(2009) Yang Han et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Rapid Suppression of Hepatitis C Viremia Induced by Intravenous Silibinin Plus Ribavirin

(2009) Michael Biermer et al.   GASTROENTEROLOGY

Targeted Metabolomics Identifies Glucuronides of Dietary Phytoestrogens as a Major Class of MRP3 Substrates In Vivo

(2009) Koen van de Wetering et al.   GASTROENTEROLOGY

Effect of continuous silymarin administration on oral talinolol pharmacokinetics in healthy volunteers

(2009) Y. Han et al.   XENOBIOTICA

Effect ofSchisandra chinensisextract andGinkgo bilobaextract on the pharmacokinetics of talinolol in healthy volunteers

(2009) L. Fan et al.   XENOBIOTICA

In vitro Inhibition of CYP3A4 Metabolism and P-Glycoprotein-Mediated Transport by Trade Herbal Products

(2008) Bent H. Hellum et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Inhibition of P-glycoprotein and multidrug resistance protein 1 by dietary phytochemicals

(2008) Tomohiro Nabekura et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Knollenblätterpilzvergiftung

(2008) M Ganzert et al.   DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT

Silibinin Is a Potent Antiviral Agent in Patients With Chronic Hepatitis C Not Responding to Pegylated Interferon/Ribavirin Therapy

(2008) Peter Ferenci et al.   GASTROENTEROLOGY

Quantification of free and protein-boundtrans-resveratrol metabolites and identification oftrans-resveratrol-C/O-conjugated diglucuronides – Two novel resveratrol metabolites in human plasma

(2008) Alexander Burkon et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Intestinal Breast Cancer Resistance Protein (BCRP)/Bcrp1 and Multidrug Resistance Protein 3 (MRP3)/Mrp3 Are Involved in the Pharmacokinetics of Resveratrol

(2008) K. van de Wetering et al.   MOLECULAR PHARMACOLOGY

Echinacea purpureaand P-glycoprotein drug transport in Caco-2 cells

(2008) Torstein Schrøder Hansen et al.   PHYTOTHERAPY RESEARCH

P-Glycoprotein Inhibitory Activity of Lipophilic Constituents of Echinacea pallida Roots in a Human Proximal Tubular Cell Line

(2008) Nadia Romiti et al.   PLANTA MEDICA

An Updated Systematic Review with Meta-Analysis for the Clinical Evidence of Silymarin

(2008) R. Saller et al.   FORSCHENDE KOMPLEMENTARMEDIZIN