Article
Integrative & Complementary Medicine
Dai-yan Zhang, Wen-qing Cui, Ling Hou, Jing Yang, Li-yang Lyu, Ze-yu Wang, Ke-Gang Linghu, Wen-bin He, Hua Yu, Yuan-jia Hu
Summary: This study aims to expand potential targets and verify drug-herb interactions using the node2vec algorithm. The results show that node2vec algorithm performs the best among all algorithms and successfully identifies potential interactions between 32 herbal chemicals and drug targets.
Article
Chemistry, Multidisciplinary
Feng Zhang, Wei Liu, Jian Huang, Qi-long Chen, Dan-dan Wang, Li-wei Zou, Yong-fang Zhao, Wei-dong Zhang, Jian-guang Xu, Hong-zhuan Chen, Guang-bo Ge
Summary: Jingyin granules, an antiviral herbal medicine, are commonly used to treat viral infections. Research shows that the herbal extract of Jingyin granules can inhibit human drug-metabolizing enzymes and modulate the plasma exposure and half-life of certain drugs.
ACTA PHARMACOLOGICA SINICA
(2022)
Review
Pharmacology & Pharmacy
Dallas J. J. Smith, Huichang Bi, Josias Hamman, Xiaochao Ma, Constance Mitchell, Kumbukani Nyirenda, Tsitsi Monera-Penduka, Hellen Oketch-Rabah, Mary F. F. Paine, Syril Pettit, Wihan Pheiffer, Richard B. B. Van Breemen, Michelle Embry
Summary: The COVID-19 pandemic has led to the development of new anti-viral drugs that effectively reduce fatality and hospitalization rates in high-risk COVID-19 patients. Currently, nirmatrelvir/ritonavir (Paxlovid (TM)) combination is recommended for COVID-19 treatment. However, the ritonavir component interacts with CYP3A, which raises concerns about potential interactions with other drugs metabolized by CYP3A.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Food Science & Technology
Feng Zhang, Jian Huang, Wei Liu, Chao-Ran Wang, Yan-Fang Liu, Dong-Zhu Tu, Xin-Miao Liang, Ling Yang, Wei-Dong Zhang, Hong-Zhuan Chen, Guang-Bo Ge
Summary: The study found that Qingfei Paidu decoction can inhibit multiple drug-metabolizing enzymes, with a significant inhibitory effect on CYP3A. In vivo experiments showed that co-administration of QPD with lopinavir could prolong the half-life of lopinavir and increase its AUC, and further investigations revealed that Fructus Aurantii Immaturus in QPD may cause significant loss of CYP3A activity.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
Guru Raghavendra Valicherla, Phillip Graebing, Junmei Zhang, Ruohui Zheng, Jeremy Nuttall, Peter Silvera, Lisa Cencia Rohan
Summary: The study found that the concomitant use of DPV and MIC may increase the exposure of DPV in women, as MIC inhibits the metabolism of DPV by CYP1A1 and CYP3A4 enzymes.
Review
Pharmacology & Pharmacy
Young Hee Choi, Young-Won Chin
Summary: Studies have shown that metabolic enzyme and/or transporter-mediated pharmacokinetic changes in a drug caused by concomitant herbal products may affect efficacy and toxicity, but discrepancies between predictive data and clinical significance still exist, adding to confusion regarding the use of herbal products and drug combinations.
Review
Biochemistry & Molecular Biology
Wenhao Cheng, Kexin Xia, Siyang Wu, Yingfei Li
Summary: Herb medicine has a long history and is still used worldwide. The interaction between herb and drugs has attracted more attention due to the development of complementary medicine. This review provides a comprehensive summary of the mechanisms and results of herb-pharmacokinetic interactions in the last ten years, aiming to promote the rational and safe clinical use of herbs and drugs.
CURRENT DRUG METABOLISM
(2023)
Article
Chemistry, Analytical
Chun-Hao Chang, Wen-Ya Peng, Wan-Hsin Lee, Tung-Yi Lin, Muh-Hwa Yang, Jeffrey W. Dalley, Tung-Hu Tsai
Summary: The aim of this study was to investigate the effects of herbal drug interactions on the biotransformation of molnupiravir and its metabolite NHC in the blood and brain. The results showed that molnupiravir was rapidly metabolized to NHC and penetrated into the brain.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Food Science & Technology
Ren-Jong Liang, Shu-Hao Hsu, Tien-Yu Chang, Tzu-Yi Chiang, Hong-Jaan Wang, Yune-Fang Ueng
Summary: Herb-drug interactions have become increasingly important in modern healthcare, especially in the treatment of cardiovascular disease. This review summarizes 55 herb-drug interactions and discusses their potential mechanisms. Due to the complexity of traditional Chinese medicines, a better understanding and management of these interactions is needed.
JOURNAL OF FOOD AND DRUG ANALYSIS
(2022)
Article
Plant Sciences
Islam Husain, Olivia R. Dale, Katherine Martin, Bill J. Gurley, Sebastian J. Adams, Bharathi Avula, Amar G. Chittiboyina, Ikhlas A. Khan, Shabana I. Khan
Summary: The popularity and consumption of herbal products have increased significantly in the past three decades, however, chronic consumption of these products may lead to herb-drug interactions (HDIs) and result in adverse health outcomes. Therefore, it is essential to evaluate the potential HDIs of commonly used herbal plants.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Mayang Kusuma Dewi, Anis Yohana Chaerunisaa, Muhaimin Muhaimin, I. Made Joni
Summary: Phytochemicals or secondary metabolites are substances produced by plants that have shown various biological activities, providing a scientific basis for the use of herbs in traditional medicine. Although herbal medicines are considered to be safe and cost-effective, they have disadvantages such as low solubility, stability, and bioavailability. In recent years, nanotechnology-based herbal drug formulations have gained attention for their enhanced activity and potential in overcoming these issues.
Article
Medicine, Research & Experimental
Weiyi Cao, Qiaoning Yang, Wantong Zhang, Yonggang Xu, Shuge Wang, Yi Wu, Yang Zhao, Zhongning Guo, Rui Li, Rui Gao
Summary: This study found a pharmacokinetic drug-drug interaction between aspirin and salvianolate, with no difference in pharmacodynamics between the A + S and AP groups, but the combination group showed superior P2Y12 expression compared to the SV group.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biotechnology & Applied Microbiology
Abdul Arif Khan, HariOm Singh
Summary: Adipocytes play a crucial role in lipid and sugar metabolism. Genetic variations in patients with HIV may lead to different responses to antiretroviral therapy and contribute to HIV-associated lipodystrophy syndrome (HALS). This study examines the impact of genes related to lipid metabolism, drug transport, and transcription factors on metabolic complications and HALS.
JOURNAL OF GENE MEDICINE
(2023)
Article
Plant Sciences
Tingting Qiang, Yiping Li, Keyan Wang, Wenyong Lin, Zhenchao Niu, Dan Wang, Xiaolong Wang
Summary: Suxiao jiuxin pill (SJP) is a Chinese medical drug used for the treatment of coronary heart disease and angina. It has been found to inhibit the activity of certain CYP450 enzymes, especially CYP1A2, 2B6, 2C19, and 3A4, while also showing inhibitory effects on human OATP1B1 and BCRP. Potential herb-drug interactions should be considered when using SJP in combination with other drugs.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Neurosciences
Tram T. Le, Sarah R. McGrath, Pius S. Fasinu
Summary: The use of herbal products as complementary medicine alongside prescription neuropsychiatric drugs is common, but it can lead to herb-drug interactions that may jeopardize the success of pharmacotherapy. This study identified 13 commonly used herbal products that have clinically relevant interactions with prescription drugs used in the management of neuropsychiatric disorders, emphasizing the importance of caution in herb-drug co-medication.
CURRENT NEUROPHARMACOLOGY
(2022)