EMT: Present and future in clinical oncology

Clinical significance of altering epithelial–mesenchymal transition in metastatic lymph nodes of gastric cancer

(2017) Keishi Okubo et al.   Gastric Cancer

Epigenetics of epithelial-to-mesenchymal transition in pancreatic carcinoma

(2017) Max M. Träger et al.   INTERNATIONAL JOURNAL OF CANCER

Circulating tumor cells: clinical validity and utility

(2017) Luc Cabel et al.   International Journal of Clinical Oncology

Triple-amiRNA VEGFRs inhibition in pancreatic cancer improves the efficacy of chemotherapy through EMT regulation

(2017) Jianfei Huang et al.   JOURNAL OF CONTROLLED RELEASE

Effect of dasatinib on EMT-mediated-mechanism of resistance against EGFR inhibitors in lung cancer cells

(2017) Yuichi Sesumi et al.   LUNG CANCER

The epithelial to mesenchymal transition (EMT) and cancer stem cells: implication for treatment resistance in pancreatic cancer

(2017) Pingting Zhou et al.   Molecular Cancer

Tumor cell dormancy

(2017) Roger R. Gomis et al.   Molecular Oncology

Oligonucleotide therapies for disorders of the nervous system

(2017) Olga Khorkova et al.   NATURE BIOTECHNOLOGY

The EMT-activator Zeb1 is a key factor for cell plasticity and promotes metastasis in pancreatic cancer

(2017) Angela M. Krebs et al.   NATURE CELL BIOLOGY

miR-34a inhibits pancreatic cancer progression through Snail1-mediated epithelial–mesenchymal transition and the Notch signaling pathway

(2017) Yan Tang et al.   Scientific Reports

A critical role of platelet TGF-β release in podoplanin-mediated tumour invasion and metastasis

(2017) Ai Takemoto et al.   Scientific Reports

Mechanism of c-Met and EGFR tyrosine kinase inhibitor resistance through epithelial mesenchymal transition in non-small cell lung cancer

(2016) Ichwaku Rastogi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeted drug delivery to circulating tumor cells via platelet membrane-functionalized particles

(2016) Jiahe Li et al.   BIOMATERIALS

Reinforcing B16F10/GPI-IL-21 vaccine efficacy against melanoma by injecting mice with shZEB1 plasmid or miR200c agomir

(2016) Xiaoying Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Metastasis: new functional implications of platelets and megakaryocytes

(2016) Raphael Leblanc et al.   BLOOD

EMT, cell plasticity and metastasis

(2016) Christine L. Chaffer et al.   CANCER AND METASTASIS REVIEWS

In Vivo Visualization and Characterization of Epithelial–Mesenchymal Transition in Breast Tumors

(2016) Zhen Zhao et al.   CANCER RESEARCH

Snail1-Dependent Activation of Cancer-Associated Fibroblast Controls Epithelial Tumor Cell Invasion and Metastasis

(2016) Lorena Alba-Castellón et al.   CANCER RESEARCH

EMT: 2016

(2016) M. Angela Nieto et al.   CELL

Epigenetic regulation of epithelial–mesenchymal transition

(2016) Lidong Sun et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Development and validation of a multiplex methylation specific PCR-coupled liquid bead array for liquid biopsy analysis

(2016) C. Parisi et al.   CLINICA CHIMICA ACTA

Pooled Analysis of the Prognostic Relevance of Circulating Tumor Cells in Primary Breast Cancer

(2016) W. J. Janni et al.   CLINICAL CANCER RESEARCH

Epithelial–mesenchymal transition (EMT) and metastasis: yes, no, maybe?

(2016) Maren Diepenbruck et al.   CURRENT OPINION IN CELL BIOLOGY

Aspirin, platelets, and cancer: The point of view of the internist

(2016) F. Santilli et al.   European Journal of Internal Medicine

Distinctive properties of metastasis-initiating cells

(2016) Toni Celià-Terrassa et al.   GENES & DEVELOPMENT

Phase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors

(2016) Muhammad S. Beg et al.   INVESTIGATIONAL NEW DRUGS

Genetic engineering of platelets to neutralize circulating tumor cells

(2016) Jiahe Li et al.   JOURNAL OF CONTROLLED RELEASE

Epithelial-mesenchymal plasticity in circulating tumor cells

(2016) Catherine Alix-Panabières et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications

(2016) Silvia Juliana Serrano-Gomez et al.   Molecular Cancer

Epithelial-mesenchymal transition in tumor metastasis

(2016) Kay T. Yeung et al.   Molecular Oncology

Targeting Epithelial–Mesenchymal Transition (EMT) to Overcome Drug Resistance in Cancer

(2016) Bowen Du et al.   MOLECULES

Mechanism of early dissemination and metastasis in Her2+ mammary cancer

(2016) Kathryn L. Harper et al.   NATURE

Epithelial–mesenchymal transition: a new target in anticancer drug discovery

(2016) Fabrizio Marcucci et al.   NATURE REVIEWS DRUG DISCOVERY

Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways

(2016) J A Somarelli et al.   ONCOGENE

Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters

(2016) Kevin J. Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emodin Inhibits Migration and Invasion of Human Endometrial Stromal Cells by Facilitating the Mesenchymal–Epithelial Transition Through Targeting ILK

(2016) Qiaomei Zheng et al.   Reproductive Sciences

Plasticity between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity

(2016) Evelyne Beerling et al.   Cell Reports

Emodin Inhibits the Epithelial to Mesenchymal Transition of Epithelial Ovarian Cancer Cells via ILK/GSK-3β/Slug Signaling Pathway

(2016) Jingjing Lu et al.   Biomed Research International

Preclinical Efficacy and Safety Assessment of Artemisinin-Chemotherapeutic Agent Conjugates for Ovarian Cancer

(2016) Xiaoguang Li et al.   EBioMedicine

Role of EMT in Metastasis and Therapy Resistance

(2016) Bethany Smith et al.   Journal of Clinical Medicine

Glycosylation in Cancer: Interplay between Multidrug Resistance and Epithelial-to-Mesenchymal Transition?

(2016) Leonardo Marques da Fonseca et al.   Frontiers in Oncology

A Novel High-Throughput 3D Screening System for EMT Inhibitors: A Pilot Screening Discovered the EMT Inhibitory Activity of CDK2 Inhibitor SU9516

(2016) Kazuya Arai et al.   PLoS One

Prognostic Value of EMT-inducing Transcription Factors (EMT-TFs) in Metastatic Breast Cancer: A Systematic Review and Meta-analysis

(2016) Saber Imani et al.   Scientific Reports

SMO Gene Amplification and Activation of the Hedgehog Pathway as Novel Mechanisms of Resistance to Anti-Epidermal Growth Factor Receptor Drugs in Human Lung Cancer

(2015) C. M. Della Corte et al.   CLINICAL CANCER RESEARCH

Pretreatment microRNA Expression Impacting on Epithelial-to-Mesenchymal Transition Predicts Intrinsic Radiosensitivity in Head and Neck Cancer Cell Lines and Patients

(2015) M. C. de Jong et al.   CLINICAL CANCER RESEARCH

ZEB1-associated drug resistance in cancer cells is reversed by the class I HDAC inhibitor mocetinostat

(2015) S. Meidhof et al.   EMBO Molecular Medicine

The role of CD29-ILK-Akt signaling-mediated epithelial–mesenchymal transition of liver epithelial cells and chemoresistance and radioresistance in hepatocellular carcinoma cells

(2015) Xiaorong Jiang et al.   MEDICAL ONCOLOGY

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer

(2015) Xiaofeng Zheng et al.   NATURE

Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance

(2015) Kari R. Fischer et al.   NATURE

Distinct EMT programs control normal mammary stem cells and tumour-initiating cells

(2015) Xin Ye et al.   NATURE

A microfluidic device for label-free, physical capture of circulating tumor cell clusters

(2015) A Fatih Sarioglu et al.   NATURE METHODS

OVOL guides the epithelial-hybrid-mesenchymal transition

(2015) Dongya Jia et al.   Oncotarget

A novel embryonic plasticity gene signature that predicts metastatic competence and clinical outcome

(2015) Rama Soundararajan et al.   Scientific Reports

An Ovol2-Zeb1 Mutual Inhibitory Circuit Governs Bidirectional and Multi-step Transition between Epithelial and Mesenchymal States

(2015) Tian Hong et al.   PLoS Computational Biology

Epithelial to Mesenchymal Transition in a Clinical Perspective

(2015) Jennifer Pasquier et al.   Journal of Oncology

The Regulatory Role of MicroRNAs in EMT and Cancer

(2015) Apostolos Zaravinos   Journal of Oncology

Clinical Implications of Circulating Tumor Cells of Breast Cancer Patients: Role of Epithelial–Mesenchymal Plasticity

(2015) Linda M. McInnes et al.   Frontiers in Oncology

Classification of Circulating Tumor Cells by Epithelial-Mesenchymal Transition Markers

(2015) Shiyang Wu et al.   PLoS One

Overcoming EMT-associated resistance to anti-cancer drugs via Src/FAK pathway inhibition

(2015) Catherine Wilson et al.   Oncotarget

Epithelial to Mesenchymal Transition is Associated with Shorter Disease-Free Survival in Hepatocellular Carcinoma

(2014) Suguru Yamada et al.   ANNALS OF SURGICAL ONCOLOGY

Metformin inhibits epithelial–mesenchymal transition in prostate cancer cells: Involvement of the tumor suppressor miR30a and its target gene SOX4

(2014) Jing Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Transient SNAIL1 Expression Is Necessary for Metastatic Competence in Breast Cancer

(2014) H. D. Tran et al.   CANCER RESEARCH

Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis

(2014) Nicola Aceto et al.   CELL

Mammary Morphogenesis and Regeneration Require the Inhibition of EMT at Terminal End Buds by Ovol2 Transcriptional Repressor

(2014) Kazuhide Watanabe et al.   DEVELOPMENTAL CELL

Epithelial-mesenchymal transition spectrum quantification and its efficacy in deciphering survival and drug responses of cancer patients

(2014) T. Z. Tan et al.   EMBO Molecular Medicine

Prognostic role of Twist or Snail in various carcinomas: a systematic review and meta-analysis

(2014) Ping Zhang et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Zeb1 and Snail1 engage miR-200f transcriptional and epigenetic regulation during EMT

(2014) Antonio Díaz-López et al.   INTERNATIONAL JOURNAL OF CANCER

A multimarker panel for circulating tumor cells detection predicts patient outcome and therapy response in metastatic colorectal cancer

(2014) Jorge Barbazán et al.   INTERNATIONAL JOURNAL OF CANCER

Clinical validity of circulating tumour cells in patients with metastatic breast cancer: a pooled analysis of individual patient data

(2014) François-Clément Bidard et al.   LANCET ONCOLOGY

Molecular profiling of circulating tumor cells links plasticity to the metastatic process in endometrial cancer

(2014) Lorena Alonso-Alconada et al.   Molecular Cancer

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut

(2014) Maia Chanrion et al.   Nature Communications

MicroRNAs as therapeutic targets in human cancers

(2014) Maitri Y. Shah et al.   Wiley Interdisciplinary Reviews-RNA

Metformin: A Rising Star to Fight the Epithelial Mesenchymal Transition in Oncology

(2013) Guislaine Barriere et al.   Anti-Cancer Agents in Medicinal Chemistry

MiR-200, a new star miRNA in human cancer

(2013) Xiangling Feng et al.   CANCER LETTERS

A Randomized Phase II Trial Investigating the Effect of Platelet Function Inhibition on Circulating Tumor Cells in Patients With Metastatic Breast Cancer

(2013) Ryan P. Roop et al.   Clinical Breast Cancer

Emodin represses TWIST1-induced epithelial–mesenchymal transitions in head and neck squamous cell carcinoma cells by inhibiting the β-catenin and Akt pathways

(2013) Tzong-Der Way et al.   EUROPEAN JOURNAL OF CANCER

A core microRNA signature associated with inducers of the epithelial-to-mesenchymal transition

(2013) Juan Díaz-Martín et al.   JOURNAL OF PATHOLOGY

The epigenetics of epithelial-mesenchymal plasticity in cancer

(2013) Wai Leong Tam et al.   NATURE MEDICINE

Circulating tumor cells: Advances in isolation and analysis, and challenges for clinical applications

(2013) Ramdane Harouaka et al.   PHARMACOLOGY & THERAPEUTICS

Sorafenib Inhibits Epithelial-Mesenchymal Transition through an Epigenetic-Based Mechanism in Human Lung Epithelial Cells

(2013) Juyong Zhang et al.   PLoS One

Prognostic Significance of Circulating Tumor Cells in Non-Small-Cell Lung Cancer Patients: A Meta-Analysis

(2013) Jianwei Huang et al.   PLoS One

Epithelial Plasticity: A Common Theme in Embryonic and Cancer Cells

(2013) M. A. Nieto   SCIENCE

Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition

(2013) M. Yu et al.   SCIENCE

Epithelial–mesenchymal transition markers expressed in circulating tumor cells in hepatocellular carcinoma patients with different stages of disease

(2013) Y-M Li et al.   Cell Death & Disease

TGF-β-Id1 Signaling Opposes Twist1 and Promotes Metastatic Colonization via a Mesenchymal-to-Epithelial Transition

(2013) Marko Stankic et al.   Cell Reports

Epithelial-mesenchymal transition - activating transcription factors - multifunctional regulators in cancer

(2013) Minal Garg   World Journal of Stem Cells

Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1

(2012) Oscar H. Ocaña et al.   CANCER CELL

Spatiotemporal Regulation of Epithelial-Mesenchymal Transition Is Essential for Squamous Cell Carcinoma Metastasis

(2012) Jeff H. Tsai et al.   CANCER CELL

EMT and MET in Metastasis: Where Are the Cancer Stem Cells?

(2012) Thomas Brabletz   CANCER CELL

Clusterin Mediates TGF- -Induced Epithelial-Mesenchymal Transition and Metastasis via Twist1 in Prostate Cancer Cells

(2012) M. Shiota et al.   CANCER RESEARCH

EMT and Dissemination Precede Pancreatic Tumor Formation

(2012) Andrew D. Rhim et al.   CELL

Tumor-derived secretory clusterin induces epithelial–mesenchymal transition and facilitates hepatocellular carcinoma metastasis

(2012) Cun Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Insights into cancer metastasis from a clinicopathologic perspective: Epithelial-Mesenchymal Transition is not a necessary step

(2012) Michael Herman Chui   INTERNATIONAL JOURNAL OF CANCER

Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells

(2012) Toni Celià-Terrassa et al.   JOURNAL OF CLINICAL INVESTIGATION

The epithelial–mesenchymal transition under control: Global programs to regulate epithelial plasticity

(2012) M. Angela Nieto et al.   SEMINARS IN CANCER BIOLOGY

EMT Inducers Catalyze Malignant Transformation of Mammary Epithelial Cells and Drive Tumorigenesis towards Claudin-Low Tumors in Transgenic Mice

(2012) Anne-Pierre Morel et al.   PLoS Genetics

Metastatic Progression of Prostate Cancer and E-Cadherin

(2011) Aaron P. Putzke et al.   AMERICAN JOURNAL OF PATHOLOGY

The Ins and Outs of the Epithelial to Mesenchymal Transition in Health and Disease

(2011) M. Angela Nieto   Annual Review of Cell and Developmental Biology

Chemoresistance to 5-fluorouracil induces epithelial–mesenchymal transition via up-regulation of Snail in MCF7 human breast cancer cells

(2011) Weijia Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis

(2011) Myriam Labelle et al.   CANCER CELL

Abstract 1467: AB-16B5, a therapeutic monoclonal antibody against human clusterin that blocks the epithelial-to-mesenchymal transition

(2011) Gilles Tremblay et al.   CANCER RESEARCH

Vimentin in cancer and its potential as a molecular target for cancer therapy

(2011) Arun Satelli et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A Phase I Pharmacokinetic and Pharmacodynamic Study of Dalotuzumab (MK-0646), an Anti-Insulin-like Growth Factor-1 Receptor Monoclonal Antibody, in Patients with Advanced Solid Tumors

(2011) F. Atzori et al.   CLINICAL CANCER RESEARCH

Nuclear Snail1 and nuclear ZEB1 protein expression in invasive and intraductal human breast carcinomas

(2011) Joseph Geradts et al.   HUMAN PATHOLOGY

Circulating Tumor Cells from Patients with Advanced Prostate and Breast Cancer Display Both Epithelial and Mesenchymal Markers

(2011) A. J. Armstrong et al.   MOLECULAR CANCER RESEARCH

Cancer theory faces doubts

(2011) Heidi Ledford   NATURE

Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization

(2011) Manav Korpal et al.   NATURE MEDICINE

Transcription factors that mediate epithelial–mesenchymal transition lead to multidrug resistance by upregulating ABC transporters

(2011) M Saxena et al.   Cell Death & Disease

Epithelial-mesenchymal transition gene signature to predict clinical outcome of hepatocellular carcinoma

(2010) Jongmin Kim et al.   CANCER SCIENCE

Regulation of Excision Repair Cross-Complementation Group 1 by Snail Contributes to Cisplatin Resistance in Head and Neck Cancer

(2010) D. S.-S. Hsu et al.   CLINICAL CANCER RESEARCH

The ZEB/miR-200 feedback loop—a motor of cellular plasticity in development and cancer?

(2010) Simone Brabletz et al.   EMBO REPORTS

Micro-RNA signature of the epithelial-mesenchymal transition in endometrial carcinosarcoma

(2010) María Ángeles Castilla et al.   JOURNAL OF PATHOLOGY

Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes

(2010) J. H. Taube et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Embryonic stem cell markers expression in cancers

(2009) Matthieu Schoenhals et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

E-cadherin, β-catenin, and ZEB1 in malignant progression of cancer

(2009) Otto Schmalhofer et al.   CANCER AND METASTASIS REVIEWS

Characterization of a Naturally Occurring Breast Cancer Subset Enriched in Epithelial-to-Mesenchymal Transition and Stem Cell Characteristics

(2009) B. T. Hennessy et al.   CANCER RESEARCH

Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening

(2009) Piyush B. Gupta et al.   CELL

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Hedgehog Target Genes: Mechanisms of Carcinogenesis Induced by Aberrant Hedgehog Signaling Activation

(2009) Y. Katoh et al.   CURRENT MOLECULAR MEDICINE

Mesenchymal cells reactivate Snail1 expression to drive three-dimensional invasion programs

(2009) R. Grant Rowe et al.   JOURNAL OF CELL BIOLOGY

Biomarkers for epithelial-mesenchymal transitions

(2009) Michael Zeisberg et al.   JOURNAL OF CLINICAL INVESTIGATION

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Metformin in Breast Cancer: Time for Action

(2009) Pamela J. Goodwin et al.   JOURNAL OF CLINICAL ONCOLOGY

The morphological and molecular features of the epithelial-to-mesenchymal transition

(2009) Gema Moreno-Bueno et al.   Nature Protocols

Snail and Slug Mediate Radioresistance and Chemoresistance by Antagonizing p53-Mediated Apoptosis and Acquiring a Stem-Like Phenotype in Ovarian Cancer Cells

(2009) Nawneet K. Kurrey et al.   STEM CELLS

Epithelial-Mesenchymal Transition in Breast Cancer Relates to the Basal-like Phenotype

(2008) D. Sarrio et al.   CANCER RESEARCH

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis

(2008) Jing Yang et al.   DEVELOPMENTAL CELL

Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition

(2008) Anne-Pierre Morel et al.   PLoS One