Article
Immunology
Yung-Hsiang Chao, Chin-Hsiu Liu, Yu-An Pan, Fu-Shun Yen, Jeng-Yuan Chiou, James Cheng-Chung Wei
Summary: This population-based cohort study found that patients with a history of endometriosis have an increased risk of developing Sjogren's syndrome, especially within the first five years after diagnosis, and in the age group of 20-39.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Liao Tan, Jie Liu, Zhaoya Liu
Summary: This study investigates the association between periodontitis and the prevalence and mortality of prediabetes. The results indicate that periodontitis is positively associated with the occurrence and development of prediabetes.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, General & Internal
Tsung-Po Chen, Hui-Chieh Yu, Tai-Hsin Lin, Yu-Hsun Wang, Yu-Chao Chang
Summary: This population-based cohort study in Taiwan found an association between obesity and the development of chronic periodontitis (CP), with obese patients having a 1.12-fold increased risk of CP compared to non-obese patients. The risk was higher in patients aged 65 or older. Differences in CP risk between obesity and non-obesity groups were not observed by sex.
Article
Clinical Neurology
Mu-Hong Chen, Tai-Long Pan, Wei-Chen Lin, Kai-Lin Huang, Ju-Wei Hsu, Cheng-Ta Li, Shih-Jen Tsai, Tung-Ping Su, Tzeng-Ji Chen, Ya-Mei Bai
Summary: The study shows a bidirectional association between migraine and depression in probands and unaffected siblings, suggesting a familial coaggregation of these two conditions. Further research is needed to investigate the genetic and environmental etiologies for this coaggregation.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Multidisciplinary Sciences
Claire E. Hastie, David J. Lowe, Andrew McAuley, Nicholas L. Mills, Andrew J. Winter, Corri Black, Janet T. Scott, Catherine A. O'Donnell, David N. Blane, Susan Browne, Tracy R. Ibbotson, Jill P. Pell
Summary: Previous studies on long-COVID have been limited, and without comparison groups, it is difficult to differentiate disease progression from symptoms caused by other factors. The Long-COVID in Scotland Study (Long-CISS) conducted a cohort study in Scotland, comparing adults with laboratory-confirmed SARS-CoV-2 infection to PCR-negative adults. The study found that individuals with previous symptomatic infection had a higher prevalence of symptoms compared to those who were never infected, with altered taste, smell, and confusion improving over time, and late onset dry and productive cough, and hearing problems being more likely following SARS-CoV-2 infection.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Eun Hwa Kim, Sunghyun Nam, Chung Hyun Park, Yitak Kim, Myeongjee Lee, Joong Bae Ahn, Sang Joon Shin, Yu Rang Park, Hoi In Jung, Baek-Il Kim, Inkyung Jung, Han Sang Kim
Summary: This study aimed to investigate the association between chronic periodontitis and cancer risk. Using a large nationwide database, the study found that individuals with periodontitis had a higher risk of developing cancer compared to those without periodontitis. The study also identified significant associations between periodontitis and specific types of cancer, including stomach cancer, colon cancer, lung cancer, bladder cancer, thyroid cancer, and leukemia. However, there was no significant association between periodontitis and the development of secondary malignancy in cancer survivors.
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
Kuan-Ying Li, Mei-Chia Chou, James Cheng-Chung Wei, Mei-Chen Lin, Yao-Min Hung, Renin Chang
Summary: This study found an increased risk of stroke, particularly hemorrhagic stroke, among patients with leptospirosis. The risk was higher for males and individuals aged 18 to 39, with the highest risk in the first two years after diagnosis. Age served as an effect modifier in the association between leptospirosis and new-onset stroke risk.
Article
Clinical Neurology
Nelsan Pourhadi, Lina S. Morch, Ellen A. Holm, Christian T. Torp-Pedersen, Amani Meaidi
Summary: In women aged 50 to 60 years initiating systemic hormone therapy for the first time, cumulative dose of vaginal estradiol tablets was not significantly associated with dementia risk. The study results suggest that exposure to vaginal estradiol tablets was not significantly related to all-cause dementia or Alzheimer's disease only.
ALZHEIMERS & DEMENTIA
(2022)
Article
Clinical Neurology
S. Lubotzky-Gete, A. Ornoy, I Grotto, R. Calderon-Margalit
Summary: In a population-based historical cohort study conducted in Israel, it was found that postpartum depression (PPD) was associated with delays in child development across various domains, including language skills, personal social skills, fine motor skills, and gross motor skills. Future studies should validate these findings and intervention programs should be developed to minimize these gaps effectively.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Endocrinology & Metabolism
Yoo Hyun Um, Tae-Won Kim, Jong-Hyun Jeong, Seung-Chul Hong, Ho-Jun Seo, Kyung-Do Han
Summary: This study found a significant increase in the risk of insomnia in patients with diabetic retinopathy (DR). Men and younger age groups were more vulnerable to insomnia. Sex, age, DM duration, and chronic kidney disease (CKD) status interacted with DR status to further increase the risk of insomnia.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Clinical Neurology
Dun-Yu Hsu, Wu-Chien Chien, Chi-Hsiang Chung, Kuo-Chou Chiu, Tsung- Li, Ling-Yu Kung, Nian-Sheng Tzeng
Summary: This study aims to determine the risk of developing anxiety and/or depression among patients with lichen planus. Based on the analysis of the Taiwan National Health Insurance Research Database, the study found that patients with lichen planus have a higher incidence of anxiety and/or depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Svetlana Filatova, Subina Upadhyaya, Terhi Luntamo, Andre Sourander, Roshan Chudal
Summary: The study found a U-shaped relationship between parental age and offspring depression, with the highest risk of depression in offspring of fathers aged 50 plus years and mothers under 20 years.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Dermatology
Ming-Li Chen, Yueh-Han Ku, Hei-Tung Yip, James Cheng-Chung Wei
Summary: The study found a significantly decreased risk of psoriasis in patients who underwent tonsillectomy, especially among males and younger individuals. However, patients with rheumatoid arthritis had an increased risk of developing psoriasis.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sung-Hsiung Chen, Jui-Feng Chen, Yu-Tung Hung, Tzu-Ju Hsu, Ching-Chih Chiu, Shu-Jui Kuo
Summary: This study aimed to evaluate the systemic impact of periodontitis, previously considered a local disease, on cancer occurrence. We enrolled 683,854 participants, comparing cancer incidence among those with and without periodontitis and assessing the impact of periodontal treatment on cancer risk. Regardless of gender, age, Charlson comorbidity index, or the use of non-steroidal anti-inflammatory drugs, periodontitis patients had a lower overall cancer risk than controls. However, men with periodontitis had a higher risk of prostate cancer, and both men and women had a higher risk of thyroid cancer. Patients with periodontitis who received treatment showed a reduced cancer risk compared to untreated patients. Proper treatment for periodontitis may lower an individual's cancer risk more than if they did not have the disease at all, suggesting that periodontitis is a modifiable risk factor for cancer.
Article
Dentistry, Oral Surgery & Medicine
Jung-Hyun Park, Hyungwoo Lee, Jin-Woo Kim, Tae-Jin Song
Summary: This study aimed to investigate the association between changes in periodontal disease status and the risk of atrial fibrillation. The findings suggest that changes in periodontal disease status impact the risk of atrial fibrillation, and managing periodontal disease may help prevent atrial fibrillation.
Article
Oncology
Lee-Won Chong, Chia-Ling Tsai, Kou-Ching Yang, Chen-Chung Liao, Yi-Chao Hsu
MOLECULAR MEDICINE REPORTS
(2020)
Article
Environmental Sciences
Kuang-Hsi Chang, Stella Chin-Shaw Tsai, Chang-Yin Lee, Ruey-Hwang Chou, Hueng-Chuen Fan, Frank Cheau-Feng Lin, Cheng-Li Lin, Yi-Chao Hsu
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Medicine, General & Internal
Kuang-Hsi Chang, Yi-Chao Hsu, Ing-Ming Chiu, Lih-Chyang Chen, Chih-Chao Hsu, Chang-Yin Lee, Hueng-Chuen Fan, Hsuan-Ju Chen, Ruey-Hwang Chou
Article
Medicine, General & Internal
Hung-Lin Chen, Yi-Chao Hsu, Chang-Hsu Chen, Pei-Jen Wang, Cheng-Li Lin, Sheng-Han Cheng, Kuang-Hsi Chang
Article
Audiology & Speech-Language Pathology
Stella Chin-Shaw Tsai, Frank Cheau-Feng Lin, Kuang-Hsi Chang, Min-Chih Li, Ruey-Hwang Chou, Mei-Yue Huang, Yen-Chung Chen, Chien-Yu Kao, Ching-Chang Cheng, Hung-Ching Lin, Yi-Chao Hsu
Summary: MSCs can be isolated from different tissue origins and have the potential to ameliorate ototoxicity-induced hearing loss. In this study, skin-derived MSCs were found to significantly reduce the hearing threshold of mice with cisplatin-induced hearing loss. Neuropathological gene analyses revealed the mechanisms through which SMSCs could alleviate cochlear damage and hearing loss induced by cisplatin.
Article
Cell & Tissue Engineering
Huai-En Lu, Yu-Ling Pan, Hui-Wen Ko, Shih-Han Hsu, Cheng-Hao Wen, Yi-Chao Hsu
Summary: The production of ALDH2-pE487K iPSCs will be valuable for investigating the pathogenic mechanisms linking ALDH2 polymorphism to alcohol-related diseases.
STEM CELL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Stella Chin-Shaw Tsai, Kuender D. Yang, Kuang-Hsi Chang, Frank Cheau-Feng Lin, Ruey-Hwang Chou, Min-Chih Li, Ching-Chang Cheng, Chien-Yu Kao, Chie-Pein Chen, Hung-Ching Lin, Yi-Chao Hsu
Summary: The study demonstrated that UCMSC exosomes have protective effects in treating ototoxicity-induced hearing loss by promoting tissue remodeling and repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Hung-Lin Chen, Ruihong Zhang, Stella Chin-Shaw Tsai, Ruey-Hwang Chou, Yi-Chao Hsu, Hueng-Chuen Fan, Chih-Hsin Muo, Chung Y. Hsu, Kuang-Hsi Chang
Summary: The study found that children and teenagers in Taiwan exposed to SO2, CO, and NO2 have an increased risk of developmental delay. The adjusted odds ratios for developmental delay in comparison among the tertiles with respect to SO2, CO, and NO2 exposures were 1.12, 1.21, and 1.40, respectively.
Article
Audiology & Speech-Language Pathology
Yi-Feng Lin, Hung-Ching Lin, Chia-Ling Tsai, Yi-Chao Hsu
Summary: This study investigated the spectrum of GJB2 mutations in Taiwan and explored the genotype-phenotype correlations in patients with NSHL. The data revealed that GJB2 c.109G > A heterozygotes had poorer hearing compared to homozygotes, highlighting the complexity of GJB2 genetics. Further investigation is needed to understand the mechanism underlying the more severe phenotype in heterozygotes and whether it is caused by GJB2 heterozygotes or compound heterozygotes.
Article
Medicine, Research & Experimental
Stella Chin-Shaw Tsai, Yi-Chao Hsu, Jung-Nien Lai, Ruey-Hwang Chou, Hueng-Chuen Fan, Frank Cheau-Feng Lin, Ruihong Zhang, Cheng-Li Lin, Kuang-Hsi Chang
Summary: This study revealed an increased risk of SSNHL in residents with long-term exposure to air pollution, especially in those exposed to higher concentrations of CO, NO, and NO2. Additionally, patients exposed to moderate and high levels of PM2.5 also showed a significant higher risk of developing SSNHL. Further experimental and clinical studies are needed to verify these findings.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Environmental Sciences
Han-Jie Lin, Stella Chin-Shaw Tsai, Frank Cheau-Feng Lin, Yi-Chao Hsu, Shih-Wei Chen, Ruey-Hwang Chou, Cheng-Li Lin, Chung Y. Hsu, Kuang-Hsi Chang
Summary: Residents in Taiwan with long-term exposure to higher levels of air pollutants had a greater risk of periodontitis, with various air pollutants being associated with the risk of periodontitis.
Article
Cell Biology
Yi-Chao Hsu, Yu-Fen Chung, Mei-Shu Chen, Chi-Kuang Wang, Si-Tse Jiang, Ing-Ming Chiu
Summary: The F1A-CreER(T2) mouse line, driven by the Fgf1A promoter, can be used for time-dependent and lineage tracing of Fgf1A-expressing cells in vivo.
Article
Environmental Sciences
Kuang-Hsi Chang, Chieh-Lin Jerry Teng, Yi-Chao Hsu, Stella Chin-Shaw Tsai, Han-Jie Lin, Tsai-Ling Hsieh, Chih-Hsin Muo, Chung Y. Hsu, Ruey-Hwang Chou
Summary: This study assessed the environmental risk factors of benign brain tumors (BBT) by integrating patients' clinical data and daily air quality data. The results indicated that long-term exposure to air pollutants such as CO, NO2, and PM2.5 may be associated with an increased risk of BBT.
Article
Audiology & Speech-Language Pathology
Chao -Wen Chou, Yi-Chao Hsu
Summary: Of all the sensory systems in the human body, the auditory system is the most complex. Hearing loss is the most common form of sensory loss and can result from even minor damage or cell death in the inner ear. The auditory system relies on the sensory epithelium, the lateral wall, and auditory nerves for human hearing. Outer hair cells, inner hair cells, and supporting cells are the key functional cells in the sensory epithelium. Different cochlear regions process different sound frequencies, with the apex handling low frequencies and the basal region handling high frequencies. Hair cells can be damaged or destroyed by various factors, making them a primary target for treating sensorineural hearing loss.
Article
Multidisciplinary Sciences
Dian-Shiue Lee, Yu -Ling Pan, Yi-Chao Hsu
Summary: An improved mouse model of noise-induced hearing loss (NIHL) was developed and validated in this study. The model demonstrated significant hearing loss in mice exposed to loud noises for 6 hours per day for 5 consecutive days. Immunofluorescence staining confirmed damage to the outer hair cells. This study provides valuable insights for researchers and practitioners in understanding and treating NIHL.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2023)