Vitamin B6 Reduces Neurochemical and Long-Term Cognitive Alterations After Polymicrobial Sepsis: Involvement of the Kynurenine Pathway Modulation

Vitamin B6 Prevents IL-1β Protein Production by Inhibiting NLRP3 Inflammasome Activation

(2016) Peipei Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kynurenine metabolic balance is disrupted in the hippocampus following peripheral lipopolysaccharide challenge

(2016) Jennifer M. Parrott et al.   Journal of Neuroinflammation

Indoleamine 2,3-dioxygenase-dependent neurotoxic kynurenine metabolism mediates inflammation-induced deficit in recognition memory

(2015) Jillian M. Heisler et al.   BRAIN BEHAVIOR AND IMMUNITY

Disrupted Tryptophan Metabolism Induced Cognitive Impairment in a Mouse Model of Sepsis-associated Encephalopathy

(2015) Rong Gao et al.   INFLAMMATION

Neurodevelopmental and Behavioral Outcomes in Children With Sepsis-Associated Encephalopathy Admitted to Pediatric Intensive Care Unit

(2015) Jasmine Kaur et al.   JOURNAL OF CHILD NEUROLOGY

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(2015) Monique Michels et al.   MOLECULAR MEDICINE

Lowered Levels of Carbonyl Proteins after Vitamin B Supplementation in Patients with Mild Cognitive Impairment and Alzheimer's Disease

(2015) Paulus S. Rommer et al.   Neurodegenerative Diseases

The kynurenine pathway and neurodegenerative disease

(2015) Daniel C. Maddison et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Vitamin B6 prevents cognitive impairment in experimental pneumococcal meningitis

(2014) Tatiana Barichello et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Low Pyridoxine Concentrations Enhance Lipopolysaccharide-Stimulated Gene Expression of Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in RAW264.7 Cells

(2014) Hiroaki KANOUCHI   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Structural and mechanistic insights into the kynurenine aminotransferase-mediated excretion of kynurenic acid

(2014) Ken Okada et al.   JOURNAL OF STRUCTURAL BIOLOGY

Effects of Organoselenium Compounds on Early and Late Brain Biochemical Alterations in Sepsis-Survivor Rats

(2014) Fernanda Silvestre et al.   NEUROTOXICITY RESEARCH

Kynurenines with Neuroactive and Redox Properties: Relevance to Aging and Brain Diseases

(2014) Jazmin Reyes Ocampo et al.   Oxidative Medicine and Cellular Longevity

Metabolomic Derangements Are Associated with Mortality in Critically Ill Adult Patients

(2014) Angela J. Rogers et al.   PLoS One

Vitamin B6 Supplementation Improves Oxidative Stress and Enhances Serum Paraoxonase/Arylesterase Activities in Streptozotocin-Induced Diabetic Rats

(2014) Sibel Taş et al.   TheScientificWorldJOURNAL

Kynurenines in CNS disease: regulation by inflammatory cytokines

(2014) Brian M. Campbell et al.   Frontiers in Neuroscience

The kynurenine pathway as a therapeutic target in cognitive and neurodegenerative disorders

(2013) Trevor W Stone et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sepsis Is Associated With Altered Cerebral Microcirculation and Tissue Hypoxia in Experimental Peritonitis*

(2013) Fabio Silvio Taccone et al.   CRITICAL CARE MEDICINE

Sepsis-induced brain dysfunction

(2013) Nicolas Adam et al.   Expert Review of Anti-Infective Therapy

Intracerebroventricular administration of lipopolysaccharide induces indoleamine-2,3-dioxygenase-dependent depression-like behaviors

(2013) Marcus A Lawson et al.   Journal of Neuroinflammation

Matrix Metalloproteinase-2 and Metalloproteinase-9 Activities are Associated with Blood–Brain Barrier Dysfunction in an Animal Model of Severe Sepsis

(2013) Felipe Dal-Pizzol et al.   MOLECULAR NEUROBIOLOGY

Effect of diet on serotonergic neurotransmission in depression

(2013) Faisal Shabbir et al.   NEUROCHEMISTRY INTERNATIONAL

Higher Plasma Pyridoxal Phosphate Is Associated with Increased Antioxidant Enzyme Activities in Critically Ill Surgical Patients

(2013) Chien-Hsiang Cheng et al.   Biomed Research International

Understanding brain dysfunction in sepsis

(2013) Romain Sonneville et al.   Annals of Intensive Care

Indoleamine 2,3-dioxygenase inhibition attenuates lipopolysaccharide induced persistent microglial activation and depressive-like complications in fractalkine receptor (CX3CR1)-deficient mice

(2012) Angela W. Corona et al.   BRAIN BEHAVIOR AND IMMUNITY

Deferoxamine inhibits iron induced hippocampal tau phosphorylation in the Alzheimer transgenic mouse brain

(2012) Chuang Guo et al.   NEUROCHEMISTRY INTERNATIONAL

Higher plasma pyridoxal 5′-phosphate is associated with better blood glucose responses in critically ill surgical patients with inadequate vitamin B-6 status

(2011) Chen-Tai Hou et al.   CLINICAL NUTRITION

Tryptophan metabolism to kynurenine is a potential novel contributor to hypotension in human sepsis*

(2011) Dechaboon Changsirivathanathamrong et al.   CRITICAL CARE MEDICINE

NOS-1-derived NO is an essential triggering signal for the development of systemic inflammatory responses

(2011) Danielle Duma et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Traffic of leukocytes and cytokine up-regulation in the central nervous system in sepsis

(2011) Clarissa M. Comim et al.   INTENSIVE CARE MEDICINE

Neuro-oxidative-nitrosative stress in sepsis

(2011) Ronan MG Berg et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Endotoxin-activated microglia injure brain derived endothelial cells via NF-κB, JAK-STAT and JNK stress kinase pathways

(2011) Rachid Kacimi et al.   Journal of Inflammation-London

Low Plasma Vitamin B-6 Status Affects Metabolism through the Kynurenine Pathway in Cardiovascular Patients with Systemic Inflammation

(2011) Øivind Midttun et al.   JOURNAL OF NUTRITION

On the antioxidant properties of kynurenic acid: Free radical scavenging activity and inhibition of oxidative stress

(2011) R. Lugo-Huitrón et al.   NEUROTOXICOLOGY AND TERATOLOGY

Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis

(2010) Theodore J. Iwashyna et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Enhanced Indoleamine 2,3‐Dioxygenase Activity in Patients with Severe Sepsis and Septic Shock

(2010) Pierre Tattevin et al.   JOURNAL OF INFECTIOUS DISEASES

SEPSIS, LEUKOCYTES, AND NITRIC OXIDE (NO)

(2010) Carl F. Fortin et al.   SHOCK

Mitochondria and reactive oxygen species

(2009) Alicia J. Kowaltowski et al.   FREE RADICAL BIOLOGY AND MEDICINE

Quality of life after septic illness

(2009) Andrea Lazosky et al.   JOURNAL OF CRITICAL CARE

Vitamin B6: A Long Known Compound of Surprising Complexity

(2009) Sutton Mooney et al.   MOLECULES

Tryptophan 2,3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice

(2009) Masaaki Kanai et al.   Molecular Brain

Reactive oxygen species generation is modulated by mitochondrial kinases: Correlation with mitochondrial antioxidant peroxidases in rat tissues

(2008) Ana Paula S.A. Santiago et al.   BIOCHIMIE

Time-dependent behavioral recovery after sepsis in rats

(2008) Lisiane Tuon et al.   INTENSIVE CARE MEDICINE

Mitochondrial respiratory chain and creatine kinase activities in rat brain after sepsis induced by cecal ligation and perforation

(2008) Clarissa M. Comim et al.   MITOCHONDRION

Role of Brain Inflammation in Epileptogenesis

(2008) Jieun Choi et al.   YONSEI MEDICAL JOURNAL