The transcriptome of lung tumor-infiltrating dendritic cells reveals a tumor-supporting phenotype and a microRNA signature with negative impact on clinical outcome

Tumor-derived factors modulating dendritic cell function

(2016) Jinbao Zong et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Expansion and Activation of CD103 + Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition

(2016) Hélène Salmon et al.   IMMUNITY

Immune checkpoint therapy for non-small-cell lung cancer: an update

(2016) Bing Xia et al.   Immunotherapy

Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): a multicentre, open-label, phase 2 randomised controlled trial

(2016) Louis Fehrenbacher et al.   LANCET

The Non–Small Cell Lung Cancer Immune Contexture. A Major Determinant of Tumor Characteristics and Patient Outcome

(2015) Romain Remark et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis

(2015) Juan R. Cubillos-Ruiz et al.   CELL

GM-CSF Mouse Bone Marrow Cultures Comprise a Heterogeneous Population of CD11c+MHCII+ Macrophages and Dendritic Cells

(2015) Julie Helft et al.   IMMUNITY

Benzyl butyl phthalate increases the chemoresistance to doxorubicin/cyclophosphamide by increasing breast cancer-associated dendritic cell-derived CXCL1/GROα and S100A8/A9

(2015) YA-LING HSU et al.   ONCOLOGY REPORTS

A systematic analysis of predicted MiR-31-targets identifies a diagnostic and prognostic signature for lung cancer

(2014) Wen Gao et al.   BIOMEDICINE & PHARMACOTHERAPY

Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity

(2014) Miranda L. Broz et al.   CANCER CELL

ISMARA: automated modeling of genomic signals as a democracy of regulatory motifs

(2014) P. J. Balwierz et al.   GENOME RESEARCH

Lung tumours reprogram pulmonary dendritic cell immunogenicity at the microRNA level

(2014) Lotte Pyfferoen et al.   INTERNATIONAL JOURNAL OF CANCER

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

(2014) Muhammad Zaeem Noman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Myeloid expression of angiotensin-converting enzyme facilitates myeloid maturation and inhibits the development of myeloid-derived suppressor cells

(2014) Xiao Z Shen et al.   LABORATORY INVESTIGATION

XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

(2014) Xi Chen et al.   NATURE

Intravital imaging reveals distinct responses of depleting dynamic tumor-associated macrophage and dendritic cell subpopulations

(2014) Marja Lohela et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cellular and molecular origin of tumor-associated macrophages

(2014) R. A. Franklin et al.   SCIENCE

Prognostic role of microRNA-31 in various cancers: a meta-analysis

(2014) Shuwei Wang et al.   TUMOR BIOLOGY

MicroRNA-31 inhibits cisplatin-induced apoptosis in non-small cell lung cancer cells by regulating the drug transporter ABCB9

(2013) Zhuo Dong et al.   CANCER LETTERS

Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

(2013) J. Goc et al.   CANCER RESEARCH

MicroRNA-31 Predicts the Presence of Lymph Node Metastases and Survival in Patients with Lung Adenocarcinoma

(2013) W. Meng et al.   CLINICAL CANCER RESEARCH

Chronic hypoxia reprograms human immature dendritic cells by inducing a proinflammatory phenotype and TREM-1 expression

(2013) Daniele Pierobon et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Conventional and Monocyte-Derived CD11b+ Dendritic Cells Initiate and Maintain T Helper 2 Cell-Mediated Immunity to House Dust Mite Allergen

(2013) Maud Plantinga et al.   IMMUNITY

MicroRNA-31-5p modulates cell cycle by targeting human mutL homolog 1 in human cancer cells

(2013) Zhiwei Zhong et al.   TUMOR BIOLOGY

Primary tumours modulate innate immune signalling to create pre-metastatic vascular hyperpermeability foci

(2013) Sachie Hiratsuka et al.   Nature Communications

CD14+S100A9+Monocytic Myeloid-derived Suppressor Cells and Their Clinical Relevance in Non–Small Cell Lung Cancer

(2012) Po-Hao Feng et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Immunostimulatory conventional dendritic cells evolve into regulatory macrophage-like cells

(2012) J. Diao et al.   BLOOD

The hypoxic environment reprograms the cytokine/chemokine expression profile of human mature dendritic cells

(2012) Fabiola Blengio et al.   IMMUNOBIOLOGY

Adenosine and cAMP signalling skew human dendritic cell differentiation towards a tolerogenic phenotype with defective CD8+T-cell priming capacity

(2012) John Challier et al.   IMMUNOLOGY

Silencing IDO in dendritic cells: A novel approach to enhance cancer immunotherapy in a murine breast cancer model

(2012) Xiufen Zheng et al.   INTERNATIONAL JOURNAL OF CANCER

The Outgrowth of Micrometastases Is Enabled by the Formation of Filopodium-like Protrusions

(2012) Tsukasa Shibue et al.   Cancer Discovery

Inhibition of PPAR  in myeloid-lineage cells induces systemic inflammation, immunosuppression, and tumorigenesis

(2011) L. Wu et al.   BLOOD

Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: identification of TREM-1 as a novel hypoxic marker in vitro and in vivo

(2010) M. C. Bosco et al.   BLOOD

Knockout of the Tumor Suppressor Gene Gprc5a in Mice Leads to NF- B Activation in Airway Epithelium and Promotes Lung Inflammation and Tumorigenesis

(2010) J. Deng et al.   Cancer Prevention Research

miR-31 Ablates Expression of the HIF Regulatory Factor FIH to Activate the HIF Pathway in Head and Neck Carcinoma

(2010) C.-J. Liu et al.   CANCER RESEARCH

Lipid accumulation and dendritic cell dysfunction in cancer

(2010) Donna L Herber et al.   NATURE MEDICINE

Tumor-Infiltrating Regulatory Dendritic Cells Inhibit CD8+ T Cell Function via L-Arginine Metabolism

(2009) L. A. Norian et al.   CANCER RESEARCH

Lung vascular endothelial growth factor expression induces local myeloid dendritic cell activation

(2009) Svetlana P. Chapoval et al.   CLINICAL IMMUNOLOGY

MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer

(2009) P. Olson et al.   GENES & DEVELOPMENT

Modeling and quantification of cancer cell invasion through collagen type I matrices

(2009) Olivier De Wever et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Ly6Clow Monocytes Differentiate into Dendritic Cells and Cross-Tolerize T Cells through PDL-1

(2009) Y. Peng et al.   JOURNAL OF IMMUNOLOGY

Tumor-Educated CD11b high Ia low Regulatory Dendritic Cells Suppress T Cell Response through Arginase I

(2009) Qiuyan Liu et al.   JOURNAL OF IMMUNOLOGY

A novel and universal method for microRNA RT-qPCR data normalization

(2009) Pieter Mestdagh et al.   GENOME BIOLOGY

Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein

(2008) Pingyan Cheng et al.   JOURNAL OF EXPERIMENTAL MEDICINE

High-throughput stem-loop RT-qPCR miRNA expression profiling using minute amounts of input RNA

(2008) Pieter Mestdagh et al.   NUCLEIC ACIDS RESEARCH