Interleukin 33: an innate alarm for adaptive responses beyond Th2 immunity-emerging roles in obesity, intestinal inflammation, and cancer

The helminth T2 RNase ω1 promotes metabolic homeostasis in an IL-33– and group 2 innate lymphoid cell–dependent mechanism

(2016) Emily Hams et al.   FASEB JOURNAL

Eosinophil-specific deletion of IκBα in mice reveals a critical role of NF-κB–induced Bcl-x L for inhibition of apoptosis

(2015) Christian Schwartz et al.   BLOOD

A Distinct Function of Regulatory T Cells in Tissue Protection

(2015) Nicholas Arpaia et al.   CELL

Activated Type 2 Innate Lymphoid Cells Regulate Beige Fat Biogenesis

(2015) Min-Woo Lee et al.   CELL

IL-33 Promotes Gastric Cancer Cell Invasion and Migration Via ST2–ERK1/2 Pathway

(2015) Xi-Xiang Yu et al.   DIGESTIVE DISEASES AND SCIENCES

The “Big Bang” in obese fat: Events initiating obesity-induced adipose tissue inflammation

(2015) Felix M. Wensveen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-33 isoforms: their future as vaccine adjuvants?

(2015) Daniel O Villarreal et al.   Expert Review of Vaccines

Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation

(2015) Ari B. Molofsky et al.   IMMUNITY

Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation

(2015) Ari B. Molofsky et al.   IMMUNITY

Proteolytic Processing of Interleukin-1 Family Cytokines: Variations on a Common Theme

(2015) Inna S. Afonina et al.   IMMUNITY

The Interleukin-33-p38 Kinase Axis Confers Memory T Helper 2 Cell Pathogenicity in the Airway

(2015) Yusuke Endo et al.   IMMUNITY

IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms

(2015) Lukas F. Mager et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-33 Reverses an Obesity-Induced Deficit in Visceral Adipose Tissue ST2+T Regulatory Cells and Ameliorates Adipose Tissue Inflammation and Insulin Resistance

(2015) Jonathan M. Han et al.   JOURNAL OF IMMUNOLOGY

Circulating IL-33 level is associated with the progression of lung cancer

(2015) Myung Shin Kim et al.   LUNG CANCER

Interleukin-33 predicts poor prognosis and promotes ovarian cancer cell growth and metastasis through regulating ERK and JNK signaling pathways

(2015) Xiaoguang Tong et al.   Molecular Oncology

Group 2 innate lymphoid cells license dendritic cells to potentiate memory TH2 cell responses

(2015) Timotheus Y F Halim et al.   NATURE IMMUNOLOGY

Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells

(2015) Claudia U Duerr et al.   NATURE IMMUNOLOGY

Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses

(2015) Kazuyo Moro et al.   NATURE IMMUNOLOGY

The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue–resident regulatory T cells

(2015) Ajithkumar Vasanthakumar et al.   NATURE IMMUNOLOGY

IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin–EGFR interactions

(2015) Laurel A. Monticelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-33 activates tumor stroma to promote intestinal polyposis

(2015) Rebecca L. Maywald et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T-bet– and STAT4–dependent IL-33 receptor expression directly promotes antiviral Th1 cell responses

(2015) Claudia Baumann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation

(2015) E. Suzanne Cohen et al.   Nature Communications

The role of IL-33 and mast cells in allergy and inflammation

(2015) Rohit Saluja et al.   Clinical and Translational Allergy

Expression of interleukin-33 is correlated with poor prognosis of patients with squamous cell carcinoma of the tongue

(2014) Kazuya Ishikawa et al.   AURIS NASUS LARYNX

Alarmin IL-33 Acts as an Immunoadjuvant to Enhance Antigen-Specific Tumor Immunity

(2014) Daniel O. Villarreal et al.   CANCER RESEARCH

Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat

(2014) Yifu Qiu et al.   CELL

IgE and IL-33−mediated triggering of human basophils inhibits TLR4−induced monocyte activation

(2014) Felice Rivellese et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Chitin Activates Parallel Immune Modules that Direct Distinct Inflammatory Responses via Innate Lymphoid Type 2 and γδ T Cells

(2014) Steven J. Van Dyken et al.   IMMUNITY

Innate Lymphoid Cells in Inflammation and Immunity

(2014) Andrew N.J. McKenzie et al.   IMMUNITY

MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4+ T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion

(2014) Christopher J. Oliphant et al.   IMMUNITY

IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice

(2014) Dong Li et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Altered subcellular localization of IL-33 leads to non-resolving lethal inflammation

(2014) Juliana Bessa et al.   JOURNAL OF AUTOIMMUNITY

IL-10-producing regulatory B cells induced by IL-33 (BregIL-33) effectively attenuate mucosal inflammatory responses in the gut

(2014) Susanne Sattler et al.   JOURNAL OF AUTOIMMUNITY

Tumoral Expression of IL-33 Inhibits Tumor Growth and Modifies the Tumor Microenvironment through CD8+T and NK Cells

(2014) Xin Gao et al.   JOURNAL OF IMMUNOLOGY

IL-33 Is an Unconventional Alarmin That Stimulates IL-2 Secretion by Dendritic Cells To Selectively Expand IL-33R/ST2+Regulatory T Cells

(2014) Benjamin M. Matta et al.   JOURNAL OF IMMUNOLOGY

Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity

(2014) Jonathan R. Brestoff et al.   NATURE

The alarmin IL-33 promotes regulatory T-cell function in the intestine

(2014) Chris Schiering et al.   NATURE

Interleukin-33/ST2 axis promotes epithelial cell transformation and breast tumorigenesis via upregulation of COT activity

(2014) J Y Kim et al.   ONCOGENE

Central domain of IL-33 is cleaved by mast cell proteases for potent activation of group-2 innate lymphoid cells

(2014) E. Lefrancais et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of interleukin-13 in fibrosis, particularly systemic sclerosis

(2013) Steven O'Reilly   BIOFACTORS

Transgenic expression of IL-33 activates CD8+ T cells and NK cells and inhibits tumor growth and metastasis in mice

(2013) Kun Gao et al.   CANCER LETTERS

Amphiregulin Enhances Regulatory T Cell-Suppressive Function via the Epidermal Growth Factor Receptor

(2013) Dietmar M.W. Zaiss et al.   IMMUNITY

Interleukin-33/ST2 axis promotes breast cancer growth and metastases by facilitating intratumoral accumulation of immunosuppressive and innate lymphoid cells

(2013) Ivan P. Jovanovic et al.   INTERNATIONAL JOURNAL OF CANCER

Mast Cell Chymase Degrades the Alarmins Heat Shock Protein 70, Biglycan, HMGB1, and Interleukin-33 (IL-33) and Limits Danger-induced Inflammation

(2013) Ananya Roy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Long-term IL-33–producing epithelial progenitor cells in chronic obstructive lung disease

(2013) Derek E. Byers et al.   JOURNAL OF CLINICAL INVESTIGATION

Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages

(2013) Ari B. Molofsky et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-33 Markedly Activates Murine Eosinophils by an NF- B-Dependent Mechanism Differentially Dependent upon an IL-4-Driven Autoinflammatory Loop

(2013) C. Bouffi et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: IL-25 Elicits Innate Lymphoid Type 2 and Type II NKT Cells That Regulate Obesity in Mice

(2013) E. Hams et al.   JOURNAL OF IMMUNOLOGY

Type 2 innate lymphoid cells control eosinophil homeostasis

(2013) Jesse C. Nussbaum et al.   NATURE

Macrophages as IL-25/IL-33-Responsive Cells Play an Important Role in the Induction of Type 2 Immunity

(2013) Zhonghan Yang et al.   PLoS One

Structural insights into the interaction of IL-33 with its receptors

(2013) X. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-33 attenuates development and perpetuation of chronic intestinal inflammation

(2012) Philipp Gro et al.   INFLAMMATORY BOWEL DISEASES

Contradictory Functions (Activation/Termination) of Neutrophil Proteinase 3 Enzyme (PR3) in Interleukin-33 Biological Activity

(2012) Suyoung Bae et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endogenous IL-33 Is Highly Expressed in Mouse Epithelial Barrier Tissues, Lymphoid Organs, Brain, Embryos, and Inflamed Tissues: In Situ Analysis Using a Novel Il-33-LacZ Gene Trap Reporter Strain

(2012) M. Pichery et al.   JOURNAL OF IMMUNOLOGY

Mast cell chymase modulates IL-33 levels and controls allergic sensitization in dust-mite induced airway inflammation

(2012) I Waern et al.   Mucosal Immunology

IL-33 drives biphasic IL-13 production for noncanonical Type 2 immunity against hookworms

(2012) L.-Y. Hung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice

(2012) K. Yasuda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G

(2012) E. Lefrancais et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Alarmin Interleukin-33 Drives Protective Antiviral CD8+ T Cell Responses

(2012) W. V. Bonilla et al.   SCIENCE

IL-33 synergizes with TCR and IL-12 signaling to promote the effector function of CD8+T cells

(2011) Qianting Yang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-33-activated dendritic cells are critical for allergic airway inflammation

(2011) Anne-Gaëlle Besnard et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

An Essential Role of the Transcription Factor GATA-3 for the Function of Regulatory T Cells

(2011) Yunqi Wang et al.   IMMUNITY

The Danger Signal, Extracellular ATP, Is a Sensor for an Airborne Allergen and Triggers IL-33 Release and Innate Th2-Type Responses

(2011) Hideaki Kouzaki et al.   JOURNAL OF IMMUNOLOGY

IL-33 Activates B1 Cells and Exacerbates Contact Sensitivity

(2011) M. Komai-Koma et al.   JOURNAL OF IMMUNOLOGY

The Dual Function Cytokine IL-33 Interacts with the Transcription Factor NF- B To Dampen NF- B-Stimulated Gene Transcription

(2011) S. Ali et al.   JOURNAL OF IMMUNOLOGY

Mast Cells as Sensors of Cell Injury through IL-33 Recognition

(2011) M. Enoksson et al.   JOURNAL OF IMMUNOLOGY

Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus

(2011) Laurel A Monticelli et al.   NATURE IMMUNOLOGY

Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity

(2011) Ya-Jen Chang et al.   NATURE IMMUNOLOGY

Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis

(2011) D. Wu et al.   SCIENCE

Alternatively activated macrophages inhibit T-cell proliferation by Stat6-dependent expression of PD-L2

(2010) S. Huber et al.   BLOOD

Automated comparative protein structure modeling with SWISS-MODEL and Swiss-PdbViewer: A historical perspective

(2010) Nicolas Guex et al.   ELECTROPHORESIS

Characterization of ST2 transgenic mice with resistance to IL-33

(2010) Hiromi Ohto-Ozaki et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-33, a recently identified interleukin-1 gene family member, is expressed in human adipocytes

(2009) I. Stuart Wood et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The pro-Th2 cytokine IL-33 directly interacts with invariant NKT and NK cells to induce IFN-γ production

(2009) Elvire Bourgeois et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases

(2009) Alexander U. Lüthi et al.   IMMUNITY

IL-33–activated dendritic cells induce an atypical TH2-type response

(2009) Matthew A. Rank et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Interleukin-33 Is Biologically Active Independently of Caspase-1 Cleavage

(2009) Dominique Talabot-Ayer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Functional IL-13 Receptor Is Expressed on Polarized Murine CD4+ Th17 Cells and IL-13 Signaling Attenuates Th17 Cytokine Production

(2009) D. C. Newcomb et al.   JOURNAL OF IMMUNOLOGY

The Essential Role of Single Ig IL-1 Receptor-Related Molecule/Toll IL-1R8 in Regulation of Th2 Immune Response

(2009) K. Bulek et al.   JOURNAL OF IMMUNOLOGY

IL-33 Activates Unprimed Murine Basophils Directly In Vitro and Induces Their In Vivo Expansion Indirectly by Promoting Hematopoietic Growth Factor Production

(2009) E. Schneider et al.   JOURNAL OF IMMUNOLOGY

IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38α-dependent pathway

(2009) Kelly M. Kroeger et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells

(2009) Kazuyo Moro et al.   NATURE

The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1

(2009) C. Cayrol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of IL-33 and Its Interaction with the ST2 and IL-1RAcP Receptors—Insight into Heterotrimeric IL-1 Signaling Complexes

(2009) Andreas Lingel et al.   STRUCTURE

Molecular mimicry between IL-33 and KSHV for attachment to chromatin through the H2A–H2B acidic pocket

(2008) Lucie Roussel et al.   EMBO REPORTS

IL-33 amplifies both Th1- and Th2-type responses through its activity on human basophils, allergen-reactive Th2 cells, iNKT and NK Cells

(2008) M. D. Smithgall et al.   INTERNATIONAL IMMUNOLOGY

The IL-1-Like Cytokine IL-33 Is Constitutively Expressed in the Nucleus of Endothelial Cells and Epithelial Cells In Vivo: A Novel ‘Alarmin’?

(2008) Christine Moussion et al.   PLoS One