Neonatal Immune Adaptation of the Gut and Its Role during Infections

Lipoproteins Are Critical TLR2 Activating Toxins in Group B Streptococcal Sepsis

(2014) Philipp Henneke et al.   JOURNAL OF IMMUNOLOGY

Enterocyte-Derived TAK1 Signaling Prevents Epithelium Apoptosis and the Development of Ileitis and Colitis

(2014) R. Kajino-Sakamoto et al.   JOURNAL OF IMMUNOLOGY

Postnatal amniotic fluid intake reduces gut inflammatory responses and necrotizing enterocolitis in preterm neonates

(2013) Jayda Siggers et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Distortions in Development of Intestinal Microbiota Associated with Late Onset Sepsis in Preterm Infants

(2013) Volker Mai et al.   PLoS One

Gut microbial colonisation in premature neonates predicts neonatal sepsis

(2012) Juliette C Madan et al.   Archives of Disease in Childhood-Fetal and Neonatal Edition

Protective effects of lactoferrin chimera and bovine lactoferrin in a mouse model of enterohaemorrhagic Escherichia coli O157:H7 infection1This article is part of a Special Issue entitled Lactoferrin and has undergone the Journal's usual peer review process.

(2012) Héctor Flores-Villaseñor et al.   Biochemistry and Cell Biology

Intestinal Commensal Microbes as Immune Modulators

(2012) Ivaylo I. Ivanov et al.   Cell Host & Microbe

Enterocyte Microvillus-Derived Vesicles Detoxify Bacterial Products and Regulate Epithelial-Microbial Interactions

(2012) David A. Shifrin et al.   CURRENT BIOLOGY

Microbiota and innate immunity in intestinal inflammation and neoplasia

(2012) Elke Cario   CURRENT OPINION IN GASTROENTEROLOGY

MicroRNA-146a-mediated downregulation of IRAK1 protects mouse and human small intestine against ischemia/reperfusion injury

(2012) Cécilia Chassin et al.   EMBO Molecular Medicine

Intestinal Epithelial Toll-Like Receptor 4 Regulates Goblet Cell Development and Is Required for Necrotizing Enterocolitis in Mice

(2012) Chhinder P. Sodhi et al.   GASTROENTEROLOGY

Activation of the NLRP3 Inflammasome by Group B Streptococci

(2012) A. Costa et al.   JOURNAL OF IMMUNOLOGY

Human Milk Mucin 1 and Mucin 4 Inhibit Salmonella enterica Serovar Typhimurium Invasion of Human Intestinal Epithelial Cells In Vitro

(2012) Bo Liu et al.   JOURNAL OF NUTRITION

Targeted deletion of MyD88 in intestinal epithelial cells results in compromised antibacterial immunity associated with downregulation of polymeric immunoglobulin receptor, mucin-2 and antibacterial peptides

(2012) A L Frantz et al.   Mucosal Immunology

Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine

(2012) Jeremiah R. McDole et al.   NATURE

Functional interactions between the gut microbiota and host metabolism

(2012) Valentina Tremaroli et al.   NATURE

Lethal inflammasome activation by a multidrug-resistant pathobiont upon antibiotic disruption of the microbiota

(2012) Janelle S Ayres et al.   NATURE MEDICINE

Staphylococcus epidermidis biofilms induce lower complement activation in neonates as compared with adults

(2012) Hildegunn N. Granslo et al.   PEDIATRIC RESEARCH

Lineage Tracing Reveals Lgr5+ Stem Cell Activity in Mouse Intestinal Adenomas

(2012) A. G. Schepers et al.   SCIENCE

The Early Settlers: Intestinal Microbiology in Early Life

(2012) Petra A.M.J. Scholtens et al.   Annual Review of Food Science and Technology

Immunology and probiotic impact of the newborn and young children intestinal microflora

(2011) Eugenia Bezirtzoglou et al.   ANAEROBE

Function of the CysD domain of the gel-forming MUC2 mucin

(2011) Daniel Ambort et al.   BIOCHEMICAL JOURNAL

Fetal lipopolysaccharide exposure modulates diet-dependent gut maturation and sensitivity to necrotising enterocolitis in pre-term pigs

(2011) Malene S. Cilieborg et al.   BRITISH JOURNAL OF NUTRITION

Bacteroides in the Infant Gut Consume Milk Oligosaccharides via Mucus-Utilization Pathways

(2011) Angela Marcobal et al.   Cell Host & Microbe

Establishment of intestinal homeostasis during the neonatal period

(2011) Silvia Stockinger et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The potter’s wheel: the host’s role in sculpting its microbiota

(2011) Charles L. Bevins et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Tumor necrosis factor-α promoter −308 G/A polymorphism and susceptibility to sepsis in very-low-birth-weight infants

(2011) Christoph Härtel et al.   CRITICAL CARE MEDICINE

Role of mucus layers in gut infection and inflammation

(2011) Gunnar C Hansson   CURRENT OPINION IN MICROBIOLOGY

Cell dynamics in fetal intestinal epithelium: implications for intestinal growth and morphogenesis

(2011) A. S. Grosse et al.   DEVELOPMENT

Intestinal development and differentiation

(2011) Taeko K. Noah et al.   EXPERIMENTAL CELL RESEARCH

Transcytosis ofListeria monocytogenesacross the intestinal barrier upon specific targeting of goblet cell accessible E-cadherin

(2011) Georgios Nikitas et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NO Is a Macrophage Autonomous Modifier of the Cytokine Response to Streptococcal Single-Stranded RNA

(2011) S. D. Deshmukh et al.   JOURNAL OF IMMUNOLOGY

Serum mannose-binding lectin (MBL) gene polymorphism and low MBL levels are associated with neonatal sepsis and pneumonia

(2011) H Özkan et al.   Journal of Perinatology

On the growth and form of the gut

(2011) Thierry Savin et al.   NATURE

Bifidobacteria can protect from enteropathogenic infection through production of acetate

(2011) Shinji Fukuda et al.   NATURE

Intestinal homeostasis and its breakdown in inflammatory bowel disease

(2011) Kevin J. Maloy et al.   NATURE

Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut

(2011) Natalia Shulzhenko et al.   NATURE MEDICINE

Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis

(2011) Charles L. Bevins et al.   NATURE REVIEWS MICROBIOLOGY

Early Onset Neonatal Sepsis: The Burden of Group B Streptococcal and E. coli Disease Continues

(2011) B. J. Stoll et al.   PEDIATRICS

IFN-  determines the intestinal epithelial antiviral host defense

(2011) J. Pott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The transcriptional repressor Blimp1/Prdm1 regulates postnatal reprogramming of intestinal enterocytes

(2011) J. Harper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Antibacterial Lectin RegIII  Promotes the Spatial Segregation of Microbiota and Host in the Intestine

(2011) S. Vaishnava et al.   SCIENCE

The Toll-Like Receptor 2 Pathway Establishes Colonization by a Commensal of the Human Microbiota

(2011) J. L. Round et al.   SCIENCE

Blimp1 regulates the transition of neonatal to adult intestinal epithelium

(2011) Vanesa Muncan et al.   Nature Communications

The Enteropathogenic E. coli (EPEC) Tir Effector Inhibits NF-κB Activity by Targeting TNFα Receptor-Associated Factors

(2011) Marie-Hélène Ruchaud-Sparagano et al.   PLoS Pathogens

Development of gut microbiota in infants not exposed to medical interventions

(2010) MERETE EGGESBø et al.   APMIS

Defensins play a crucial role in protecting mice against oral Shigella flexneri infection

(2010) Doo-Hee Shim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Homeostasis and Inflammation in the Intestine

(2010) Wendy S. Garrett et al.   CELL

miR-146a Mediates Protective Innate Immune Tolerance in the Neonate Intestine

(2010) Cécilia Chassin et al.   Cell Host & Microbe

New Concepts of Microbial Translocation in the Neonatal Intestine: Mechanisms and Prevention

(2010) Michael P. Sherman   CLINICS IN PERINATOLOGY

Macrophages recognize streptococci through bacterial single-stranded RNA

(2010) Sachin D Deshmukh et al.   EMBO REPORTS

Nod1 and Nod2 Regulation of Inflammation in the Salmonella Colitis Model

(2010) K. Geddes et al.   INFECTION AND IMMUNITY

RIG-I/MDA5/MAVS Are Required To Signal a Protective IFN Response in Rotavirus-Infected Intestinal Epithelium

(2010) A. H. Broquet et al.   JOURNAL OF IMMUNOLOGY

Cytokines in Human Milk

(2010) Roberto Garofalo   JOURNAL OF PEDIATRICS

Control of intestinal Nod2-mediated peptidoglycan recognition by epithelium-associated lymphocytes

(2010) C U Duerr et al.   Mucosal Immunology

Role of Polymorphic Variants as Genetic Modulators of Infection in Neonatal Sepsis

(2010) Asmaa Abu-Maziad et al.   PEDIATRIC RESEARCH

Bacteria Penetrate the Inner Mucus Layer before Inflammation in the Dextran Sulfate Colitis Model

(2010) Malin E. V. Johansson et al.   PLoS One

Molecular basis for peptidoglycan recognition by a bactericidal lectin

(2010) Rebecca E. Lehotzky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions

(2010) M. E. V. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Succession of microbial consortia in the developing infant gut microbiome

(2010) J. E. Koenig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns

(2010) M. G. Dominguez-Bello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potential role of the intestinal microbiota of the mother in neonatal immune education

(2010) Anne Donnet-Hughes et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species

(2010) K. Atarashi et al.   SCIENCE

Potentiation of Epithelial Innate Host Responses by Intercellular Communication

(2010) Tamas Dolowschiak et al.   PLoS Pathogens

The Microbiota Mediates Pathogen Clearance from the Gut Lumen after Non-Typhoidal Salmonella Diarrhea

(2010) Kathrin Endt et al.   PLoS Pathogens

Epidemiology and risk factors for early onset sepsis among very-low-birthweight infants

(2009) Gil Klinger et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Bile high-mobility group box 1 contributes to gut barrier dysfunction in experimental endotoxemia

(2009) Runkuan Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

Lactoferrin as a Natural Immune Modulator

(2009) Jeffrey Actor et al.   CURRENT PHARMACEUTICAL DESIGN

The Key Role of Segmented Filamentous Bacteria in the Coordinated Maturation of Gut Helper T Cell Responses

(2009) Valérie Gaboriau-Routhiau et al.   IMMUNITY

Role of p38 and Early Growth Response Factor 1 in the Macrophage Response to Group B Streptococcus

(2009) S. Kenzel et al.   INFECTION AND IMMUNITY

miR-584 mediates post-transcriptional expression of lactoferrin receptor in Caco-2 cells and in mouse small intestine during the perinatal period

(2009) Y. Liao et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Enteric defensins are essential regulators of intestinal microbial ecology

(2009) Nita H Salzman et al.   NATURE IMMUNOLOGY

Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism

(2009) E. Slack et al.   SCIENCE

Bacterial Community Variation in Human Body Habitats Across Space and Time

(2009) E. K. Costello et al.   SCIENCE

AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense

(2009) Yuping Lai et al.   TRENDS IN IMMUNOLOGY

O-Antigen Delays Lipopolysaccharide Recognition and Impairs Antibacterial Host Defense in Murine Intestinal Epithelial Cells

(2009) Claudia U. Duerr et al.   PLoS Pathogens

Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium

(2008) Laurens G. van der Flier et al.   Annual Review of Physiology

Effect of lactoferrin on enteric pathogens

(2008) T OCHOA et al.   BIOCHIMIE

Defective innate immunity predisposes murine neonates to poor sepsis outcome but is reversed by TLR agonists

(2008) J. L. Wynn et al.   BLOOD

Postnatal changes in the expression of genes for cryptdins 1–6 and the role of luminal bacteria in cryptdin gene expression in mouse small intestine

(2008) Ryo Inoue et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Intestinal Deletion of Pofut1 in the Mouse Inactivates Notch Signaling and Causes Enterocolitis

(2008) Sandra Guilmeau et al.   GASTROENTEROLOGY

Developmental switch of intestinal antimicrobial peptide expression

(2008) Sandrine Ménard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human recombinant lactoferrin acts synergistically with antimicrobials commonly used in neonatal practice against coagulase-negative staphylococci and Candida albicans causing neonatal sepsis

(2008) M. P. Venkatesh et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Potential of immunomodulatory agents for prevention and treatment of neonatal sepsis

(2008) J L Wynn et al.   Journal of Perinatology

Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis

(2008) Djahida Bouskra et al.   NATURE

A core gut microbiome in obese and lean twins

(2008) Peter J. Turnbaugh et al.   NATURE

RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46+ cells

(2008) Stephanie L Sanos et al.   NATURE IMMUNOLOGY

Microbial Prevalence, Diversity and Abundance in Amniotic Fluid During Preterm Labor: A Molecular and Culture-Based Investigation

(2008) Daniel B. DiGiulio et al.   PLoS One

The genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome

(2008) D. A. Sela et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

(2008) M. E. V. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA