Time-resolved Phosphoproteome Analysis of Paradoxical RAF Activation Reveals Novel Targets of ERK

Phosphorylation acts positively and negatively to regulate MRTF-A subcellular localisation and activity

(2016) Richard Panayiotou et al.   eLife

BRAF Mutants Evade ERK-Dependent Feedback by Different Mechanisms that Determine Their Sensitivity to Pharmacologic Inhibition

(2015) Zhan Yao et al.   CANCER CELL

Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

(2015) Fa-Xing Yu et al.   CELL

Myocardin-related transcription factors are required for cardiac development and function

(2015) Mayssa H. Mokalled et al.   DEVELOPMENTAL BIOLOGY

cAMP-induced actin cytoskeleton remodelling inhibits MKL1-dependent expression of the chemotactic and pro-proliferative factor, CCN1

(2015) Aparna Duggirala et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis

(2015) Yu Sun et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

A Phosphoproteomic Comparison of B-RAFV600Eand MKK1/2 Inhibitors in Melanoma Cells

(2015) Scott A. Stuart et al.   MOLECULAR & CELLULAR PROTEOMICS

Phosphoproteome dynamics of Saccharomyces cerevisiae under heat shock and cold stress

(2015) E. Kanshin et al.   Molecular Systems Biology

The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies

(2015) Luping Lin et al.   NATURE GENETICS

Regulation of RAF protein kinases in ERK signalling

(2015) Hugo Lavoie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Filamin A interacts with the coactivator MKL1 to promote the activity of the transcription factor SRF and cell migration

(2015) Philipp Kircher et al.   Science Signaling

A Cell-Signaling Network Temporally Resolves Specific versus Promiscuous Phosphorylation

(2015) Evgeny Kanshin et al.   Cell Reports

Filamin A interacts with the coactivator MKL1 to promote the activity of the transcription factor SRF and cell migration

(2015) Philipp Kircher et al.   Science Signaling

Design, synthesis and biological evaluation of novel 5-phenyl-1H-pyrazole derivatives as potential BRAFV600E inhibitors

(2014) Shu-Fu Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Phosphorylation of nucleoporin Tpr governs its differential localization and is required for its mitotic function

(2014) K. Rajanala et al.   JOURNAL OF CELL SCIENCE

Protein interaction switches coordinate Raf-1 and MST2/Hippo signalling

(2014) David Romano et al.   NATURE CELL BIOLOGY

KinomeXplorer: an integrated platform for kinome biology studies

(2014) Heiko Horn et al.   NATURE METHODS

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation

(2014) Neroshan Thevakumaran et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

COSMIC: exploring the world's knowledge of somatic mutations in human cancer

(2014) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

The BioGRID interaction database: 2015 update

(2014) Andrew Chatr-aryamontri et al.   NUCLEIC ACIDS RESEARCH

STRING v10: protein–protein interaction networks, integrated over the tree of life

(2014) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3

(2014) J. A. Galan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transient α-helices in the disordered RPEL motifs of the serum response factor coactivator MKL1

(2014) Mineyuki Mizuguchi et al.   Scientific Reports

The RASopathies

(2013) Katherine A. Rauen   Annual Review of Genomics and Human Genetics

Displacement of N/Q-rich Peptides on TiO2 Beads Enhances the Depth and Coverage of Yeast Phosphoproteome Analyses

(2013) Evgeny Kanshin et al.   JOURNAL OF PROTEOME RESEARCH

Comparison of Alternative MS/MS and Bioinformatics Approaches for Confident Phosphorylation Site Localization

(2013) Heike Wiese et al.   JOURNAL OF PROTEOME RESEARCH

Lamin A/C and emerin regulate MKL1–SRF activity by modulating actin dynamics

(2013) Chin Yee Ho et al.   NATURE

Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization

(2013) Hugo Lavoie et al.   Nature Chemical Biology

Molecular basis of MAP kinase regulation

(2013) Wolfgang Peti et al.   PROTEIN SCIENCE

Induction of megakaryocyte differentiation drives nuclear accumulation and transcriptional function of MKL1 via actin polymerization and RhoA activation

(2012) E. C. Smith et al.   BLOOD

The role of BRAF V600 mutation in melanoma

(2012) Paolo A Ascierto et al.   Journal of Translational Medicine

Increased BRAF Heterodimerization Is the Common Pathogenic Mechanism for Noonan Syndrome-Associated RAF1 Mutants

(2012) X. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

New and continuing developments at PROSITE

(2012) Christian J. A. Sigrist et al.   NUCLEIC ACIDS RESEARCH

STRING v9.1: protein-protein interaction networks, with increased coverage and integration

(2012) Andrea Franceschini et al.   NUCLEIC ACIDS RESEARCH

Sample preparation and analytical strategies for large-scale phosphoproteomics experiments

(2012) Evgeny Kanshin et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Sensing actin dynamics: Structural basis for G-actin-sensitive nuclear import of MAL

(2011) Hidemi Hirano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment

(2011) Jürgen Cox et al.   JOURNAL OF PROTEOME RESEARCH

Combination therapy with vemurafenib (PLX4032/RG7204) and metformin in melanoma cell lines with distinct driver mutations

(2011) Franziska Niehr et al.   Journal of Translational Medicine

LMO7 Mediates Cell-Specific Activation of the Rho-Myocardin-Related Transcription Factor-Serum Response Factor Pathway and Plays an Important Role in Breast Cancer Cell Migration

(2011) Q. Hu et al.   MOLECULAR AND CELLULAR BIOLOGY

Large-Scale Discovery of ERK2 Substrates Identifies ERK-Mediated Transcriptional Regulation by ETV3

(2011) S. M. Carlson et al.   Science Signaling

Structure of a Pentavalent G-Actin*MRTF-A Complex Reveals How G-Actin Controls Nucleocytoplasmic Shuttling of a Transcriptional Coactivator

(2011) S. Mouilleron et al.   Science Signaling

Cytoscape 2.8: new features for data integration and network visualization

(2010) M. E. Smoot et al.   BIOINFORMATICS

A simple and fast method to determine the parameters for fuzzy c–means cluster analysis

(2010) Veit Schwämmle et al.   BIOINFORMATICS

RG7204 (PLX4032), a Selective BRAFV600E Inhibitor, Displays Potent Antitumor Activity in Preclinical Melanoma Models

(2010) H. Yang et al.   CANCER RESEARCH

Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF

(2010) Sonja J. Heidorn et al.   CELL

Mechanistic principles of RAF kinase signaling

(2010) Christian M. Udell et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Structural insights into the YAP and TEAD complex

(2010) Z. Li et al.   GENES & DEVELOPMENT

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF -TRCP

(2010) B. Zhao et al.   GENES & DEVELOPMENT

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

(2010) Poulikos I. Poulikakos et al.   NATURE

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

(2010) Georgia Hatzivassiliou et al.   NATURE

The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner

(2010) E. W. Joseph et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global analysis of the yeast osmotic stress response by quantitative proteomics

(2009) Boumediene Soufi et al.   Molecular BioSystems

A dimerization-dependent mechanism drives RAF catalytic activation

(2009) Thanashan Rajakulendran et al.   NATURE

Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis

(2009) Souhila Medjkane et al.   NATURE CELL BIOLOGY

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Phosphoproteomics reveals new ERK MAP kinase targets and links ERK to nucleoporin-mediated nuclear transport

(2009) Hidetaka Kosako et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Myocardin is required for cardiomyocyte survival and maintenance of heart function

(2009) J. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular basis for G-actin binding to RPEL motifs from the serum response factor coactivator MAL

(2008) Stephane Mouilleron et al.   EMBO JOURNAL

TEAD mediates YAP-dependent gene induction and growth control

(2008) B. Zhao et al.   GENES & DEVELOPMENT

Prevention of Amino Acid Conversion in SILAC Experiments with Embryonic Stem Cells

(2008) Sean C. Bendall et al.   MOLECULAR & CELLULAR PROTEOMICS

Serum-Induced Phosphorylation of the Serum Response Factor Coactivator MKL1 by the Extracellular Signal-Regulated Kinase 1/2 Pathway Inhibits Its Nuclear Localization

(2008) S. Muehlich et al.   MOLECULAR AND CELLULAR BIOLOGY

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH