Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization
Published 2013 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization
Authors
Keywords
-
Journal
Nature Chemical Biology
Volume 9, Issue 7, Pages 428-436
Publisher
Springer Nature
Online
2013-05-20
DOI
10.1038/nchembio.1257
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling
- (2012) Michael Röring et al. EMBO JOURNAL
- Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)
- (2012) Jeffrey M. Axten et al. JOURNAL OF MEDICINAL CHEMISTRY
- Kinase-Impaired BRAF Mutations in Lung Cancer Confer Sensitivity to Dasatinib
- (2012) B. Sen et al. Science Translational Medicine
- The Evolution of Protein Kinase Inhibitors from Antagonists to Agonists of Cellular Signaling
- (2011) Arvin C. Dar et al. Annual Review of Biochemistry
- Mutant BRAF Melanomas—Dependence and Resistance
- (2011) Poulikos I. Poulikakos et al. CANCER CELL
- Nilotinib and MEK Inhibitors Induce Synthetic Lethality through Paradoxical Activation of RAF in Drug-Resistant Chronic Myeloid Leukemia
- (2011) Leisl M. Packer et al. CANCER CELL
- RAF Inhibitor-Induced KSR1/B-RAF Binding and Its Effects on ERK Cascade Signaling
- (2011) Melissa M. McKay et al. CURRENT BIOLOGY
- RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
- (2011) Poulikos I. Poulikakos et al. NATURE
- Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity
- (2011) Theonie Anastassiadis et al. NATURE BIOTECHNOLOGY
- Resistance to BRAF Inhibition in Melanomas
- (2011) David B. Solit et al. NEW ENGLAND JOURNAL OF MEDICINE
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Multiplexing of Multicolor Bioluminescence Resonance Energy Transfer
- (2010) Billy Breton et al. BIOPHYSICAL JOURNAL
- Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF
- (2010) Sonja J. Heidorn et al. CELL
- RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
- (2010) Poulikos I. Poulikakos et al. NATURE
- RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
- (2010) Georgia Hatzivassiliou et al. NATURE
- Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
- (2010) Gideon Bollag et al. NATURE
- The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner
- (2010) E. W. Joseph et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Gatekeeper Mutations Mediate Resistance to BRAF-Targeted Therapies
- (2010) S. Whittaker et al. Science Translational Medicine
- Defining the conserved internal architecture of a protein kinase
- (2009) Alexandr P. Kornev et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Impact of Feedback Phosphorylation and Raf Heterodimerization on Normal and Mutant B-Raf Signaling
- (2009) D. A. Ritt et al. MOLECULAR AND CELLULAR BIOLOGY
- A dimerization-dependent mechanism drives RAF catalytic activation
- (2009) Thanashan Rajakulendran et al. NATURE
- The BRET technology and its application to screening assays
- (2008) Johan Bacart et al. Biotechnology Journal
- Fluorescence-based methods in the study of protein–protein interactions in living cells
- (2008) Francisco Ciruela CURRENT OPINION IN BIOTECHNOLOGY
- Therapeutic strategies for inhibiting oncogenic BRAF signaling
- (2008) Ensar Halilovic et al. CURRENT OPINION IN PHARMACOLOGY
- The unfolded protein response signals through high-order assembly of Ire1
- (2008) Alexei V. Korennykh et al. NATURE
- Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
- (2008) J. Tsai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now