The possible factors affecting microglial activation in cases of obesity with cognitive dysfunction

Novel GLP-1R/GIPR co-agonist “twincretin” is neuroprotective in cell and rodent models of mild traumatic brain injury

(2017) Ian A. Tamargo et al.   EXPERIMENTAL NEUROLOGY

Hypothalamic lipid-laden astrocytes induce microglia migration and activation

(2017) Yoon-Hee Kwon et al.   FEBS LETTERS

Mineralocorticoid receptor associates with pro-inflammatory bias in the hippocampus of spontaneously hypertensive rats

(2017) M. E. Brocca et al.   JOURNAL OF NEUROENDOCRINOLOGY

Identification of a fatty acid binding protein4-UCP2 axis regulating microglial mediated neuroinflammation

(2017) Cayla M. Duffy et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Diet-driven microbiota dysbiosis is associated with vagal remodeling and obesity

(2017) Tanusree Sen et al.   PHYSIOLOGY & BEHAVIOR

Pathological α-synuclein exacerbates the progression of Parkinson’s disease through microglial activation

(2017) Qiu-Shuang Zhang et al.   TOXICOLOGY LETTERS

Quercetin Protects Obesity-Induced Hypothalamic Inflammation by Reducing Microglia-Mediated Inflammatory Responses via HO-1 Induction

(2017) Jihyeon Yang et al.   Nutrients

Deficiency of PTP1B Attenuates Hypothalamic Inflammation via Activation of the JAK2-STAT3 Pathway in Microglia

(2017) Taku Tsunekawa et al.   EBioMedicine

Serum- and glucocorticoid-inducible kinases in microglia

(2016) Koichi Inoue et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dietary obesity reversibly induces synaptic stripping by microglia and impairs hippocampal plasticity

(2016) Shuai Hao et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglia show altered morphology and reduced arborization in human brain during aging and Alzheimer's disease

(2016) Danielle S. Davies et al.   BRAIN PATHOLOGY

Inhibiting Microglia Expansion Prevents Diet-Induced Hypothalamic and Peripheral Inflammation

(2016) Caroline André et al.   DIABETES

FGF21 improves cognition by restored synaptic plasticity, dendritic spine density, brain mitochondrial function and cell apoptosis in obese-insulin resistant male rats

(2016) Piangkwan Sa-nguanmoo et al.   HORMONES AND BEHAVIOR

Blood–brain barrier breakdown promotes macrophage infiltration and cognitive impairment in leptin receptor-deficient mice

(2016) Alexis M Stranahan et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Association of Serum hs-CRP Levels With the Presence of Obesity, Diabetes Mellitus, and Other Cardiovascular Risk Factors

(2016) Mahmoud Ebrahimi et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Oxytocin inhibits lipopolysaccharide-induced inflammation in microglial cells and attenuates microglial activation in lipopolysaccharide-treated mice

(2016) Lin Yuan et al.   Journal of Neuroinflammation

Anti-Inflammatory Modulation of Microglia via CD163-Targeted Glucocorticoids Protects Dopaminergic Neurons in the 6-OHDA Parkinson's Disease Model

(2016) Noemie Tentillier et al.   JOURNAL OF NEUROSCIENCE

Deletion of Suppressor of Cytokine Signaling 3 from Forebrain Neurons Delays Infertility and Onset of Hypothalamic Leptin Resistance in Response to a High Caloric Diet

(2016) H. J. L. McEwen et al.   JOURNAL OF NEUROSCIENCE

Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants

(2016)   LANCET

Targeting CCR3 to Reduce Amyloid-β Production, Tau Hyperphosphorylation, and Synaptic Loss in a Mouse Model of Alzheimer’s Disease

(2016) Chunyan Zhu et al.   MOLECULAR NEUROBIOLOGY

Expression and processing analyses of wild type and p.R47H TREM2 variant in Alzheimer’s disease brains

(2016) Li Ma et al.   Molecular Neurodegeneration

Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects

(2016) H-J Kim et al.   MOLECULAR PSYCHIATRY

Influence of weight reduction on blood levels of C-reactive protein, tumor necrosis factor-α, interleukin-6, and oxylipins in obese subjects

(2016) Katharina Möller et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

A Novel Microfluidic Cell Co-culture Platform for the Study of the Molecular Mechanisms of Parkinson's Disease and Other Synucleinopathies

(2016) João T. S. Fernandes et al.   Frontiers in Neuroscience

Vagus Nerve Stimulation Improves Cardiac Function by Preventing Mitochondrial Dysfunction in Obese-Insulin Resistant Rats

(2016) Bencharunan Samniang et al.   Scientific Reports

Vagus Nerve Stimulation Exerts the Neuroprotective Effects in Obese-Insulin Resistant Rats, Leading to the Improvement of Cognitive Function

(2016) Titikorn Chunchai et al.   Scientific Reports

A Stereological Analysis of NPY, POMC, Orexin, GFAP Astrocyte, and Iba1 Microglia Cell Number and Volume in Diet-Induced Obese Male Mice

(2015) Moyra B. Lemus et al.   ENDOCRINOLOGY

New insights in leptin resistance mechanisms in mice

(2015) Eglantine Balland et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Sequential activation of microglia and astrocyte cytokine expression precedes increased iba-1 or GFAP immunoreactivity following systemic immune challenge

(2015) Diana M. Norden et al.   GLIA

Obesity accelerates cognitive decline by aggravating mitochondrial dysfunction, insulin resistance and synaptic dysfunction under estrogen-deprived conditions

(2015) Wasana Pratchayasakul et al.   HORMONES AND BEHAVIOR

Corticosterone mediates the synaptic and behavioral effects of chronic stress at rat hippocampal temporoammonic synapses

(2015) Mark D. Kvarta et al.   JOURNAL OF NEUROPHYSIOLOGY

Novel Molecular Insights into Classical and Alternative Activation States of Microglia as Revealed by Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC)-based Proteomics

(2015) Harris Bell-Temin et al.   MOLECULAR & CELLULAR PROTEOMICS

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

M1 and M2 immune activation in Parkinson’s Disease: Foe and ally?

(2015) M.S. Moehle et al.   NEUROSCIENCE

Fluoxetine and S-citalopram inhibit M1 activation and promote M2 activation of microglia in vitro

(2015) F. Su et al.   NEUROSCIENCE

Leptin resistance in diet-induced obesity: the role of hypothalamic inflammation

(2015) K. C. G. de Git et al.   Obesity Reviews

Obesity diminishes synaptic markers, alters microglial morphology, and impairs cognitive function

(2015) Miriam E. Bocarsly et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternatively activated microglia and macrophages in the central nervous system

(2015) Rafael Franco et al.   PROGRESS IN NEUROBIOLOGY

Origin of Microglia: Current Concepts and Past Controversies

(2015) Florent Ginhoux et al.   Cold Spring Harbor Perspectives in Biology

Age-Related Onset of Obesity Corresponds with Metabolic Dysregulation and Altered Microglia Morphology in Mice Deficient for Ifitm Proteins

(2015) Yin Shen Wee et al.   PLoS One

Microglia Development and Function

(2014) Debasis Nayak et al.   Annual Review of Immunology

DPP-4 Inhibitor and PPARγ Agonist Restore the Loss of CA1 Dendritic Spines in Obese Insulin-resistant Rats

(2014) Jirapas Sripetchwandee et al.   ARCHIVES OF MEDICAL RESEARCH

Tumour necrosis factor alpha-induced neuronal loss is mediated by microglial phagocytosis

(2014) Urte Neniskyte et al.   FEBS LETTERS

Glucocorticoid sensitization of microglia in a genetic mouse model of obesity and diabetes

(2014) Aditi Dey et al.   JOURNAL OF NEUROIMMUNOLOGY

Obesity Elicits Interleukin 1-Mediated Deficits in Hippocampal Synaptic Plasticity

(2014) J. R. Erion et al.   JOURNAL OF NEUROSCIENCE

Obesity induces neuroinflammation mediated by altered expression of the renin–angiotensin system in mouse forebrain nuclei

(2014) Annette D. de Kloet et al.   PHYSIOLOGY & BEHAVIOR

The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain

(2014) Marc-André Bellavance et al.   Frontiers in Immunology

Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro

(2013) Vibol Chhor et al.   BRAIN BEHAVIOR AND IMMUNITY

Obesity induced by a high-fat diet is associated with increased immune cell entry into the central nervous system

(2013) Laura B. Buckman et al.   BRAIN BEHAVIOR AND IMMUNITY

Hormones and diet, but not body weight, control hypothalamic microglial activity

(2013) Yuanqing Gao et al.   GLIA

Diet-Induced Obesity Suppresses Expression of Many Proteins at the Blood–Brain Barrier

(2013) Suidong Ouyang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Exposure to the Saturated Free Fatty Acid Palmitate Alters BV-2 Microglia Inflammatory Response

(2013) Linda M. Tracy et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Angiotensin Type 1a Receptors in the Paraventricular Nucleus of the Hypothalamus Protect against Diet-Induced Obesity

(2013) A. D. de Kloet et al.   JOURNAL OF NEUROSCIENCE

Layer V cortical neurons require microglial support for survival during postnatal development

(2013) Masaki Ueno et al.   NATURE NEUROSCIENCE

Microglia: New Roles for the Synaptic Stripper

(2013) Helmut Kettenmann et al.   NEURON

Critical Role of Regulator G-Protein Signaling 10 (RGS10) in Modulating Macrophage M1/M2 Activation

(2013) Jae-Kyung Lee et al.   PLoS One

Origin and differentiation of microglia

(2013) Florent Ginhoux et al.   Frontiers in Cellular Neuroscience

Exendin-4 induced glucagon-like peptide-1 receptor activation reverses behavioral impairments of mild traumatic brain injury in mice

(2012) Lital Rachmany et al.   AGE

High-fat-diet exposure induces IgG accumulation in hypothalamic microglia

(2012) C.-X. Yi et al.   Disease Models & Mechanisms

DPP4-inhibitor improves neuronal insulin receptor function, brain mitochondrial function and cognitive function in rats with insulin resistance induced by high-fat diet consumption

(2012) Noppamas Pipatpiboon et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Blood-Borne Metabolic Factors in Obesity Exacerbate Injury-Induced Gliosis

(2012) Hung Hsuchou et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

GLP-1 secretion by microglial cells and decreased CNS expression in obesity

(2012) Camilla Kappe et al.   Journal of Neuroinflammation

Effects of metformin on learning and memory behaviors and brain mitochondrial functions in high fat diet induced insulin resistant rats

(2012) Hiranya Pintana et al.   LIFE SCIENCES

Brain-derived neurotrophic factor from microglia: a molecular substrate for neuropathic pain

(2012) Tuan Trang et al.   Neuron Glia Biology

Exercise protects against high-fat diet-induced hypothalamic inflammation

(2012) Chun-Xia Yi et al.   PHYSIOLOGY & BEHAVIOR

High Fat Diet-Induced Gut Microbiota Exacerbates Inflammation and Obesity in Mice via the TLR4 Signaling Pathway

(2012) Kyung-Ah Kim et al.   PLoS One

Microglia: actively surveying and shaping neuronal circuit structure and function

(2012) Hiroaki Wake et al.   TRENDS IN NEUROSCIENCES

Brain inflammation is induced by co-morbidities and risk factors for stroke

(2011) Caroline Drake et al.   BRAIN BEHAVIOR AND IMMUNITY

Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases

(2011) Joshua A. Smith et al.   BRAIN RESEARCH BULLETIN

Saturated fatty acids activate microglia via Toll-like receptor 4/NF-κB signalling

(2011) Zhen Wang et al.   BRITISH JOURNAL OF NUTRITION

A High-Fat/High-Cholesterol Diet Inhibits Growth of Fetal Hippocampal Transplants via Increased Inflammation

(2011) L. R. Freeman et al.   CELL TRANSPLANTATION

PPARγ Agonist Improves Neuronal Insulin Receptor Function in Hippocampus and Brain Mitochondria Function in Rats with Insulin Resistance Induced by Long Term High-Fat Diets

(2011) Noppamas Pipatpiboon et al.   ENDOCRINOLOGY

Effects of high-fat diet on insulin receptor function in rat hippocampus and the level of neuronal corticosterone

(2011) Wasana Pratchayasakul et al.   LIFE SCIENCES

B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies

(2011) Daniel A Winer et al.   NATURE MEDICINE

Consumption of a high-fat diet induces central insulin resistance independent of adiposity

(2011) Deborah J. Clegg et al.   PHYSIOLOGY & BEHAVIOR

Inflammasome is a central player in the induction of obesity and insulin resistance

(2011) R. Stienstra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Central administration of interleukin-4 exacerbates hypothalamic inflammation and weight gain during high-fat feeding

(2010) Shinsuke Oh-I et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Changes in Melanocortin Expression and Inflammatory Pathways in Fetal Offspring of Nonhuman Primates Fed a High-Fat Diet

(2010) B. E. Grayson et al.   ENDOCRINOLOGY

Obesity and Free Fatty Acids

(2008) Guenther Boden   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats

(2008) Alexis M. Stranahan et al.   HIPPOCAMPUS

Comparative Study on High Fat Diet-induced 4-Hydroxy-2E-nonenal Adducts in the Hippocampal CA1 Region of C57BL/6N and C3H/HeN Mice

(2008) In Koo Hwang et al.   NEUROCHEMICAL RESEARCH