Effect of a toggle switch mutation in TM6 of the human adenosine A3receptor on Gi protein-dependent signalling and Gi-independent receptor internalization

The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors

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Molecular signatures of G-protein-coupled receptors

(2013) A. J. Venkatakrishnan et al.   NATURE

Conformational biosensors reveal GPCR signalling from endosomes

(2013) Roshanak Irannejad et al.   NATURE

Structure-Function of the G Protein–Coupled Receptor Superfamily

(2012) Vsevolod Katritch et al.   Annual Review of Pharmacology and Toxicology

Fragment Screening at Adenosine-A3 Receptors in Living Cells Using a Fluorescence-Based Binding Assay

(2012) Leigh A. Stoddart et al.   CHEMISTRY & BIOLOGY

Persistent cAMP signaling by internalized TSH receptors occurs in thyroid but not in HEK293 cells

(2012) Ruth C. Werthmann et al.   FASEB JOURNAL

Persistent signaling by thyrotropin-releasing hormone receptors correlates with G-protein and receptor levels

(2012) Alisa Boutin et al.   FASEB JOURNAL

Biased signalling and allosteric machines: new vistas and challenges for drug discovery

(2011) Terry P Kenakin   BRITISH JOURNAL OF PHARMACOLOGY

Structural insights into agonist-induced activation of G-protein-coupled receptors

(2011) Xavier Deupi et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

(2011) Søren G. F. Rasmussen et al.   NATURE

Retromer terminates the generation of cAMP by internalized PTH receptors

(2011) Timothy N Feinstein et al.   Nature Chemical Biology

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors--An Update

(2011) B. B. Fredholm et al.   PHARMACOLOGICAL REVIEWS

Two distinct conformations of helix 6 observed in antagonist-bound structures of a  1-adrenergic receptor

(2011) R. Moukhametzianov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of an Agonist-Bound Human A2A Adenosine Receptor

(2011) F. Xu et al.   SCIENCE

Quantitative analysis of neuropeptide Y receptor association with β-arrestin2 measured by bimolecular fluorescence complementation

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Therapeutic potential of β-arrestin- and G protein-biased agonists

(2010) Erin J. Whalen et al.   TRENDS IN MOLECULAR MEDICINE

Bimolecular fluorescence complementation: lighting up seven transmembrane domain receptor signalling networks

(2009) Rachel H Rose et al.   BRITISH JOURNAL OF PHARMACOLOGY

Engineering G protein-coupled receptors to facilitate their structure determination

(2009) Christopher G Tate et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

A Conserved Aromatic Lock for the Tryptophan Rotameric Switch in TM-VI of Seven-transmembrane Receptors

(2009) Birgitte Holst et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformational Toggle Switches Implicated in Basal Constitutive and Agonist-Induced Activated States of 5-Hydroxytryptamine-4 Receptors

(2009) L. P. Pellissier et al.   MOLECULAR PHARMACOLOGY

Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors

(2009) Florian Mullershausen et al.   Nature Chemical Biology

Ligand binding and micro-switches in 7TM receptor structures

(2009) Rie Nygaard et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Agonist-selective, Receptor-specific Interaction of Human P2YReceptors with β-Arrestin-1 and -2

(2008) Carsten Hoffmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Translocation of arrestin induced by human A3 adenosine receptor ligands in an engineered cell line: Comparison with G protein-dependent pathways

(2008) Z GAO et al.   PHARMACOLOGICAL RESEARCH

Distinct conformational changes in  -arrestin report biased agonism at seven-transmembrane receptors

(2008) A. K. Shukla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA