Application of Chitosan, Chitooligosaccharide, and Their Derivatives in the Treatment of Alzheimer’s Disease

Chitosan nanofilm and electrospun nanofiber for quick drug release in the treatment of Alzheimer’s disease: In vitro and in vivo evaluation

(2017) Keshireddy AnjiReddy et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Targeted delivery of rosmarinic acid across the blood–brain barrier for neuronal rescue using polyacrylamide-chitosan-poly(lactide- co -glycolide) nanoparticles with surface cross-reacting material 197 and apolipoprotein E

(2017) Yung-Chih Kuo et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Gossypium herbaceam Extracts Inhibited NF-κB Activation to Attenuate Spatial Memory Impairment and Hippocampal Neurodegeneration Induced by Amyloid-β in Rats

(2017) Chao Ji et al.   JOURNAL OF ALZHEIMERS DISEASE

Copper Abolishes the β-Sheet Secondary Structure of Preformed Amyloid Fibrils of Amyloid-β42

(2017) Emily House et al.   JOURNAL OF ALZHEIMERS DISEASE

Pharmacological, toxicological and neuronal localization assessment of galantamine/chitosan complex nanoparticles in rats: future potential contribution in Alzheimer’s disease management

(2016) Amira S. Hanafy et al.   DRUG DELIVERY

Chitosan oligosaccharides alleviate cognitive deficits in an amyloid-β1–42-induced rat model of Alzheimer's disease

(2016) Shiliang Jia et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Co-encapsulation ofNigella sativaoil and plasmid DNA for enhanced gene therapy of Alzheimer’s disease

(2016) Abd Almonem Doolaanea et al.   JOURNAL OF MICROENCAPSULATION

Thyrotropin-Releasing Hormone Loaded and Chitosan Engineered Polymeric Nanoparticles: Towards Effective Delivery of Neuropeptides

(2016) Sarabjit Kaur et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Neuroprotective Effects of Engineered Polymeric Nasal Microspheres Containing Hydroxypropyl-β-cyclodextrin on β-Amyloid (1-42)–Induced Toxicity

(2016) Ayfer Yalcin et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies

(2016) Vibha Rani et al.   LIFE SCIENCES

Ceria-containing uncoated and coated hydroxyapatite-based galantamine nanocomposites for formidable treatment of Alzheimer's disease in ovariectomized albino-rat model

(2016) Sanaa M.R. Wahba et al.   Materials Science & Engineering C-Materials for Biological Applications

Insights on the pathophysiology of Alzheimer's disease: The crosstalk between amyloid pathology, neuroinflammation and the peripheral immune system

(2016) Sandro Dá Mesquita et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Recombinant pre-miR-29b for Alzheimer´s disease therapeutics

(2016) Patrícia A. Pereira et al.   Scientific Reports

Genipin-crosslinked catechol-chitosan mucoadhesive hydrogels for buccal drug delivery

(2015) Jinke Xu et al.   BIOMATERIALS

Chitosan Oligosaccharides Inhibit/Disaggregate Fibrils and Attenuate Amyloid β-Mediated Neurotoxicity

(2015) Xueling Dai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intranasal Piperine-Loaded Chitosan Nanoparticles as Brain-Targeted Therapy in Alzheimer's Disease: Optimization, Biological Efficacy, and Potential Toxicity

(2015) Yosra S.R. Elnaggar et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The biology of innate lymphoid cells

(2015) David Artis et al.   NATURE

Recent Advances from the Bench Toward the Bedside in Alzheimer's Disease

(2015) Shannon L. Macauley et al.   EBioMedicine

Role of zinc and copper ions in the pathogenetic mechanisms of Alzheimer’s and Parkinson’s diseases

(2014) E. V. Stelmashook et al.   BIOCHEMISTRY-MOSCOW

Stem Cell Treatment for Alzheimer’s Disease

(2014) Ming Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sulfated Chitosan Oligosaccharides Suppress LPS-Induced NO Production via JNK and NF-κB Inactivation

(2014) Jung-Hyun Kim et al.   MOLECULES

Mitogen-activated protein kinase signaling pathways are involved in regulating α7 nicotinic acetylcholine receptor-mediated amyloid-β uptake in SH-SY5Y cells

(2014) W.N. Yang et al.   NEUROSCIENCE

Chitooligosaccharides Attenuate Cu2+-Induced Cellular Oxidative Damage and Cell Apoptosis Involving Nrf2 Activation

(2014) Han-Chang Huang et al.   NEUROTOXICITY RESEARCH

Rationale and clinical data supporting nutritional intervention in Alzheimer’s disease

(2014) S. Engelborghs et al.   ACTA CLINICA BELGICA

Alzheimer’s Disease and Antioxidant Therapy: How Long How Far?

(2013) J. Teixeira et al.   CURRENT MEDICINAL CHEMISTRY

Therapeutics of Alzheimer's disease: Past, present and future

(2013) R. Anand et al.   NEUROPHARMACOLOGY

Chitosan oligosaccharides protect rat primary hippocampal neurons from oligomeric β-amyloid 1-42-induced neurotoxicity

(2013) Xueling Dai et al.   NEUROSCIENCE LETTERS

Anti-amnesic effect of pseudoginsenoside-F11 in two mouse models of Alzheimer's disease

(2013) Chun-Ming Wang et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Nanoparticulate systems for brain delivery of drugs

(2012) Jörg Kreuter   ADVANCED DRUG DELIVERY REVIEWS

Separation of chito-oligomers with several degrees of polymerization and study of their antioxidant activity

(2012) Kecheng Li et al.   CARBOHYDRATE POLYMERS

β-secretase inhibitory activity of phenolic acid conjugated chitooligosaccharides

(2012) Tae-Kil Eom et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Dendritic Degeneration, Neurovascular Defects, and Inflammation Precede Neuronal Loss in a Mouse Model for Tau-Mediated Neurodegeneration

(2011) Tomasz Jaworski et al.   AMERICAN JOURNAL OF PATHOLOGY

A review on coumarins as acetylcholinesterase inhibitors for Alzheimer’s disease

(2011) Preet Anand et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Antioxidant activity of gallate-chitooligosaccharides in mouse macrophage RAW264.7 cells

(2011) Dai-Hung Ngo et al.   CARBOHYDRATE POLYMERS

Protective Effect of Isorhynchophylline Against β-Amyloid-Induced Neurotoxicity in PC12 Cells

(2011) Yan-Fang Xian et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Chitooligosaccharide-mediated neuroprotection is associated with modulation of Hsps expression and reduction of MAPK phosphorylation

(2011) Golsa Joodi et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Protective effects of sulfated chitooligosaccharides against hydrogen peroxide-induced damage in MIN6 cells

(2011) Xiaoyun Lu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Brief update on different roles of tau in neurodegeneration

(2011) Arne Ittner et al.   IUBMB LIFE

The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeutics

(2011) Susanne M. Pritchard et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Targeting Post-translational Modifications on Tau as a Therapeutic Strategy for Alzheimer's Disease

(2011) Jacob Newman Marcus et al.   JOURNAL OF NEUROGENETICS

Chronic IL-1β-Mediated Neuroinflammation Mitigates Amyloid Pathology in a Mouse Model of Alzheimer’s Disease without Inducing Overt Neurodegeneration

(2011) Sarah B. Matousek et al.   Journal of Neuroimmune Pharmacology

Soluble A  Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors

(2011) S. Li et al.   JOURNAL OF NEUROSCIENCE

Recent advances in the multitarget-directed ligands approach for the treatment of Alzheimer's disease

(2011) Rafael León et al.   MEDICINAL RESEARCH REVIEWS

Effects of Chitooligosaccharide Lactate Salt on Sleep Deprivation-Induced Fatigue in Mice

(2010) Si Young Cho et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Chitooligosaccharides protect rat cortical neurons against copper induced damage by attenuating intracellular level of reactive oxygen species

(2010) Wei Xu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

TAU Aggregation is a Therapeutic Target for Alzheimers Disease

(2010) A. Takashima   Current Alzheimer Research

Neuroprotective Properties of Chitosan and Its Derivatives

(2010) Ratih Pangestuti et al.   Marine Drugs

Biomarkers of oxidative and nitrosative damage in Alzheimer's disease and mild cognitive impairment

(2009) Francesca Mangialasche et al.   AGEING RESEARCH REVIEWS

Acetylcholinesterase inhibitory activity of novel chitooligosaccharide derivatives

(2009) Na Young Yoon et al.   CARBOHYDRATE POLYMERS

The serotonin 5-HT6receptor: a viable drug target for treating cognitive deficits in Alzheimer’s disease

(2009) Werner J Geldenhuys et al.   Expert Review of Neurotherapeutics

Separation of chitooligosaccharides and the potent effects on gene expression of cell surface receptor CR3

(2009) Xinlin Wei et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Chitosan solutions and particles: Evaluation of their permeation enhancing potential on MDCK cells used as blood brain barrier model

(2009) Juliane Hombach et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Chitooligosaccharides promote peripheral nerve regeneration in a rabbit common peroneal nerve crush injury model

(2009) Yanpei Gong et al.   MICROSURGERY

Chitosan prevents oxidative stress-induced amyloid β formation and cytotoxicity in NT2 neurons: involvement of transcription factors Nrf2 and NF-κB

(2009) Fariba Khodagholi et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The promotion of peripheral nerve regeneration by chitooligosaccharides in the rat nerve crush injury model

(2009) Maorong Jiang et al.   NEUROSCIENCE LETTERS

Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors

(2008) Francesco Leonetti et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Chitooligosaccharides suppress the level of protein expression and acetylcholinesterase activity induced by Aβ25–35 in PC12 cells

(2008) Sang-Hoon Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of phosphorylated chitosan by novel method and its characterization

(2008) R. Jayakumar et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Marine Derived Polysaccharides for Biomedical Applications: Chemical Modification Approaches

(2008) Giovanna D’Ayala et al.   MOLECULES

MicroRNA regulation of Alzheimer's Amyloid precursor protein expression

(2008) Sébastien S. Hébert et al.   NEUROBIOLOGY OF DISEASE

Astrocytes Protect Against Copper-Catalysed Loss of Extracellular Glutathione

(2008) Simon A. S. Pope et al.   NEUROCHEMICAL RESEARCH

Chitooligosaccharides protect cultured hippocampal neurons against glutamate-induced neurotoxicity

(2008) Songlin Zhou et al.   NEUROSCIENCE LETTERS

Chitosan oligosaccharides attenuate hydrogen peroxide-induced stress injury in human umbilical vein endothelial cells

(2008) Hong-Tao Liu et al.   PHARMACOLOGICAL RESEARCH