A critical review of the postulated role of the non-essential amino acid, β-N-methylamino-L-alanine, in neurodegenerative disease in humans

Evidence for Participation of Aluminum in Neurofibrillary Tangle Formation and Growth in Alzheimer's Disease

(2017) J.R. Walton   JOURNAL OF ALZHEIMERS DISEASE

Neurodegeneration with Brain Iron Accumulation

(2016) Susanne A. Schneider   Current Neurology and Neuroscience Reports

A Collaborative Evaluation of LC-MS/MS Based Methods for BMAA Analysis: Soluble Bound BMAA Found to Be an Important Fraction

(2016) Elisabeth Faassen et al.   Marine Drugs

Vervets and macaques: Similarities and differences in their responses to l -BMAA

(2016) P.S. Spencer et al.   NEUROTOXICOLOGY

Dietary exposure to an environmental toxin triggers neurofibrillary tangles and amyloid deposits in the brain

(2016) Paul Alan Cox et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

BMAA detected as neither free nor protein bound amino acid in blue mussels

(2016) Johan Rosén et al.   TOXICON

Cyanobacteria and cyanotoxins are present in drinking water impoundments and groundwater wells in desert environments

(2016) Aspassia D. Chatziefthimiou et al.   TOXICON

Systematic detection of BMAA (β-N-methylamino-l-alanine) and DAB (2,4-diaminobutyric acid) in mollusks collected in shellfish production areas along the French coasts

(2016) Damien Réveillon et al.   TOXICON

Liquid Chromatographic Determination of the Cyanobacterial Toxin β-N-Methylamino-L-Alanine in Algae Food Supplements, Freshwater Fish, and Bottled Water

(2016) PETER M. SCOTT et al.   JOURNAL OF FOOD PROTECTION

BMAA extraction of cyanobacteria samples: which method to choose?

(2015) Sandra Lage et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Assessment of the non-protein amino acid BMAA in Mediterranean mussel Mytilus galloprovincialis after feeding with estuarine cyanobacteria

(2015) Mafalda S. Baptista et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Morphometric and neurochemical alterations found in l-BMAA treated rats

(2015) Estefanía de Munck et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

The persistence of cyanobacterial toxins in desert soils

(2015) Renee Richer et al.   JOURNAL OF ARID ENVIRONMENTS

Neurotoxic amino acids and their isomers in desert environments

(2015) J.S. Metcalf et al.   JOURNAL OF ARID ENVIRONMENTS

Biotransfer of β-N-Methylamino-l-alanine (BMAA) in a Eutrophicated Freshwater Lake

(2015) Sandra Lage et al.   Marine Drugs

β-N-methylamino-l-alanine (BMAA) and isomers: Distribution in different food web compartments of Thau lagoon, French Mediterranean Sea

(2015) Damien Réveillon et al.   MARINE ENVIRONMENTAL RESEARCH

Unknown

(2015)   MOVEMENT DISORDERS

Corrigendum to “Detection of BMAA in the human central nervous system” [Neuroscience 292 (2015) 137–147]

(2015) L. Berntzon et al.   NEUROSCIENCE

Neuroinflammation in Lewy body dementia

(2015) Ajenthan Surendranathan et al.   PARKINSONISM & RELATED DISORDERS

Bacteria do not incorporate β-N-methylamino-l-alanine into their proteins

(2015) Rianita van Onselen et al.   TOXICON

Detection of Cyanotoxins, β-N-methylamino-L-alanine and Microcystins, from a Lake Surrounded by Cases of Amyotrophic Lateral Sclerosis

(2015) Sandra Banack et al.   Toxins

d-serine levels in Alzheimer’s disease: implications for novel biomarker development

(2015) C Madeira et al.   Translational Psychiatry

High Resolution Metabolite Imaging in the Hippocampus Following Neonatal Exposure to the Environmental Toxin BMAA Using ToF-SIMS

(2014) Jörg Hanrieder et al.   ACS Chemical Neuroscience

The natural non-protein amino acid N-β-methylamino-l-alanine (BMAA) is incorporated into protein during synthesis

(2014) W. Broc Glover et al.   AMINO ACIDS

Development of an analytical procedure for quantifying the underivatized neurotoxin β-N-methylamino-l-alanine in brain tissues

(2014) Audrey Combes et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

BMAA in shellfish from two Portuguese transitional water bodies suggests the marine dinoflagellate Gymnodinium catenatum as a potential BMAA source

(2014) Sandra Lage et al.   AQUATIC TOXICOLOGY

Intracellular fibril formation, calcification, and enrichment of chaperones, cytoskeletal, and intermediate filament proteins in the adult hippocampus CA1 following neonatal exposure to the nonprotein amino acid BMAA

(2014) Oskar Karlsson et al.   ARCHIVES OF TOXICOLOGY

The Paths to Neurodegeneration in Genetic Parkinson's Disease

(2014) Omar Abdel-Salam   CNS & Neurological Disorders-Drug Targets

Protein Misfolding and Aggregation in Alzheimer’s Disease and Type 2 Diabetes Mellitus

(2014) Ghulam Ashraf et al.   CNS & Neurological Disorders-Drug Targets

Uptake of a cyanotoxin, β-N-methylamino-l-alanine, by wheat (Triticum aestivum)

(2014) Valeska Contardo-Jara et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

The fate of the cyanobacterial toxin β-N-methylamino-l-alanine in freshwater mussels

(2014) Simoné Downing et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Effects of growth conditions on the production of neurotoxin 2,4-diaminobutyric acid (DAB) in Microcystis aeruginosa and its universal presence in diverse cyanobacteria isolated from freshwater in China

(2014) Hua Fan et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Military Service, Deployments, and Exposures in Relation to Amyotrophic Lateral Sclerosis Etiology and Survival

(2014) J. D. Beard et al.   EPIDEMIOLOGIC REVIEWS

Environmental neurotoxins β-N-methylamino-l-alanine (BMAA) and mercury in shark cartilage dietary supplements

(2014) Kiyo Mondo et al.   FOOD AND CHEMICAL TOXICOLOGY

An amino acid depleted cell-free protein synthesis system for the incorporation of non-canonical amino acid analogs into proteins

(2014) Amrita Singh-Blom et al.   JOURNAL OF BIOTECHNOLOGY

Beta-N-Methylamino-l-Alanine: LC-MS/MS Optimization, Screening of Cyanobacterial Strains and Occurrence in Shellfish from Thau, a French Mediterranean Lagoon

(2014) Damien Réveillon et al.   Marine Drugs

Diatoms: A Novel Source for the Neurotoxin BMAA in Aquatic Environments

(2014) Liying Jiang et al.   PLoS One

Protein association of the neurotoxin and non-protein amino acid BMAA (β-N-methylamino-l-alanine) in the liver and brain following neonatal administration in rats

(2014) Oskar Karlsson et al.   TOXICOLOGY LETTERS

Detection of cyanobacterial neurotoxin β-N-methylamino-l-alanine within shellfish in the diet of an ALS patient in Florida

(2014) Sandra Anne Banack et al.   TOXICON

Environmental modulation of microcystin and β-N-methylamino-l-alanine as a function of nitrogen availability

(2014) L.L. Scott et al.   TOXICON

Quantification of neurotoxin BMAA (β-N-methylamino-L-alanine) in seafood from Swedish markets

(2014) Liying Jiang et al.   Scientific Reports

Presence of the Neurotoxin BMAA in Aquatic Ecosystems: What Do We Really Know?

(2014) Elisabeth Faassen   Toxins

Co-occurrence of the Cyanotoxins BMAA, DABA and Anatoxin-a in Nebraska Reservoirs, Fish, and Aquatic Plants

(2014) Maitham Al-Sammak et al.   Toxins

Mapping amyotrophic lateral sclerosis lake risk factors across northern New England

(2014) Nathan Torbick et al.   International Journal of Health Geographics

Non-standard amino acid incorporation into proteins using Escherichia coli cell-free protein synthesis

(2014) Seok Hoon Hong et al.   Frontiers in Chemistry

β-N-methylamino-l-alanine causes neurological and pathological phenotypes mimicking Amyotrophic Lateral Sclerosis (ALS): The first step towards an experimental model for sporadic ALS

(2013) Estefanía de Munck et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Environmental Characteristics and Oxidative Stress of Inhabitants and Patients with Amyotrophic Lateral Sclerosis in a High-incidence Area on the Kii Peninsula, Japan

(2013) Tameko Kihira et al.   INTERNAL MEDICINE

Neurotoxin-Induced Neuropeptide Perturbations in Striatum of Neonatal Rats

(2013) Oskar Karlsson et al.   JOURNAL OF PROTEOME RESEARCH

Quality Measures of Imaging Mass Spectrometry Aids in Revealing Long-term Striatal Protein Changes Induced by Neonatal Exposure to the Cyanobacterial Toxin β-N-methylamino-L-alanine (BMAA)

(2013) Oskar Karlsson et al.   MOLECULAR & CELLULAR PROTEOMICS

Cerebral uptake and protein incorporation of cyanobacterial toxin β-N-methylamino-L-alanine

(2013) Xiaobin Xie et al.   NEUROREPORT

The Non-Protein Amino Acid BMAA Is Misincorporated into Human Proteins in Place of l-Serine Causing Protein Misfolding and Aggregation

(2013) Rachael Anne Dunlop et al.   PLoS One

Occurrence and transfer of a cyanobacterial neurotoxin β-methylamino-l-alanine within the aquatic food webs of Gonghu Bay (Lake Taihu, China) to evaluate the potential human health risk

(2013) Yiying Jiao et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Linking β-methylamino-l-alanine exposure to sporadic amyotrophic lateral sclerosis in Annapolis, MD

(2013) Nicholas C. Field et al.   TOXICON

Is exposure to cyanobacteria an environmental risk factor for amyotrophic lateral sclerosis and other neurodegenerative diseases?

(2013) Walter G. Bradley et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Spatial clustering of amyotrophic lateral sclerosis and the potential role of BMAA

(2012) Tracie A. Caller et al.   Amyotrophic Lateral Sclerosis

Analytical techniques for the detection of α-amino-β-methylaminopropionic acid

(2012) Steven A. Cohen   ANALYST

Elucidation of matrix effects and performance of solid-phase extraction for LC-MS/MS analysis of β-N-methylamino-l-alanine (BMAA) and 2,4-diaminobutyric acid (DAB) neurotoxins in cyanobacteria

(2012) Aifeng Li et al.   ANALYST

Strategy for quantifying trace levels of BMAA in cyanobacteria by LC/MS/MS

(2012) Liying Jiang et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Amino acid neurotoxins in feathers of the Lesser Flamingo, Phoeniconaias minor

(2012) J.S. Metcalf et al.   CHEMOSPHERE

Effect of β-N-methylamino-l-alanine on oxidative stress of liver and kidney in rat

(2012) Estefanía de Munck et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Cyanobacterial Neurotoxin β-N-Methylamino-L-alanine (BMAA) in Shark Fins

(2012) Kiyo Mondo et al.   Marine Drugs

Aerosolization of cyanobacteria as a risk factor for amyotrophic lateral sclerosis

(2012) Elijah W. Stommel et al.   MEDICAL HYPOTHESES

A Comparative Study on Three Analytical Methods for the Determination of the Neurotoxin BMAA in Cyanobacteria

(2012) Elisabeth J. Faassen et al.   PLoS One

Neonatal Exposure to the Cyanobacterial Toxin BMAA Induces Changes in Protein Expression and Neurodegeneration in Adult Hippocampus

(2012) Oskar Karlsson et al.   TOXICOLOGICAL SCIENCES

L-BMAA Induced ER Stress and Enhanced Caspase 12 Cleavage in Human Neuroblastoma SH-SY5Y Cells at Low Nonexcitotoxic Concentrations

(2012) Oliver Okle et al.   TOXICOLOGICAL SCIENCES

Excitotoxic potential of the cyanotoxin β-methyl-amino-l-alanine (BMAA) in primary human neurons

(2012) Alexander S. Chiu et al.   TOXICON

The non-protein amino acid β-N-methylamino-l-alanine in Portuguese cyanobacterial isolates

(2011) Rosa C. Cervantes Cianca et al.   AMINO ACIDS

Early hippocampal cell death, and late learning and memory deficits in rats exposed to the environmental toxin BMAA (β-N-methylamino-l-alanine) during the neonatal period

(2011) Oskar Karlsson et al.   BEHAVIOURAL BRAIN RESEARCH

Inherited and somatic mitochondrial DNA mutations in Guam amyotrophic lateral sclerosis and parkinsonism-dementia

(2011) Dana M. Reiff et al.   NEUROLOGICAL SCIENCES

The Cycad Genotoxin MAM Modulates Brain Cellular Pathways Involved in Neurodegenerative Disease and Cancer in a DNA Damage-Linked Manner

(2011) Glen E. Kisby et al.   PLoS One

The ALS/PDC syndrome of Guam: Potential biomarkers for an enigmatic disorder

(2011) Patrick L. McGeer et al.   PROGRESS IN NEUROBIOLOGY

Hair analysis for biomonitoring of environmental and occupational exposure to organic pollutants: State of the art, critical review and future needs

(2011) Brice M.R. Appenzeller et al.   TOXICOLOGY LETTERS

Improved sensitivity using liquid chromatography mass spectrometry (LC-MS) for detection of propyl chloroformate derivatised &#946-N-methylamino-L-alanine (BMAA) in cyanobacteria

(2011) M Esterhuizen-Londt et al.   WATER SA

Is Neurodegenerative Disease a Long-Latency Response to Early-Life Genotoxin Exposure?

(2011) Glen E. Kisby et al.   International Journal of Environmental Research and Public Health

Environmental neurotoxin-induced progressive model of parkinsonism in rats

(2010) Wei-Bin Shen et al.   ANNALS OF NEUROLOGY

The Effect of Age upon the Entry of Some Amino Acids into the Brain, and their Incorporation into Cerebral Protein

(2010) Guadalupe Baños et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Cyanobacterial blooms and the occurrence of the neurotoxin, beta-N-methylamino-l-alanine (BMAA), in South Florida aquatic food webs

(2010) Larry E. Brand et al.   HARMFUL ALGAE

Development and application of a comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry method for the analysis of l-β-methylamino-alanine in human tissue

(2010) Laura R. Snyder et al.   JOURNAL OF CHROMATOGRAPHY A

Transfer of a cyanobacterial neurotoxin within a temperate aquatic ecosystem suggests pathways for human exposure

(2010) S. Jonasson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cycas micronesica (Cycadales) plants devoid of endophytic cyanobacteria increase in β-methylamino-l-alanine

(2010) Thomas E. Marler et al.   TOXICON

Cyanobacterial neurotoxin BMAA in ALS and Alzheimer’s disease

(2009) J. Pablo et al.   ACTA NEUROLOGICA SCANDINAVICA

Determination of the neurotoxins BMAA (β-N-methylamino-L-alanine) and DAB (α-,γ-diaminobutyric acid) by LC-MSMS in Dutch urban waters with cyanobacterial blooms

(2009) Elisabeth J. Faassen et al.   Amyotrophic Lateral Sclerosis

Consumption offa cai Nostocsoup: A Potential for BMAA exposure fromNostoccyanobacteria in China?

(2009) Britton R. Roney et al.   Amyotrophic Lateral Sclerosis

Multiple neurotoxic items in the Chamorro diet link BMAA with ALS/PDC

(2009) Sandra Anne Banack et al.   Amyotrophic Lateral Sclerosis

Cyanobacteria and BMAA exposure from desert dust: A possible link to sporadic ALS among Gulf War veterans

(2009) Paul Alan Cox et al.   Amyotrophic Lateral Sclerosis

Human exposure to cyanobacteria and BMAA

(2009) Larry E. Brand   Amyotrophic Lateral Sclerosis

A cluster of amyotrophic lateral sclerosis in New Hampshire: A possible role for toxic cyanobacteria blooms

(2009) Tracie A. Caller et al.   Amyotrophic Lateral Sclerosis

Beyond Guam: The cyanobacteria/BMAA hypothesis of the cause of ALS and other neurodegenerative diseases

(2009) Walter G. Bradley et al.   Amyotrophic Lateral Sclerosis

Analytical protocol for identification of BMAA and DAB in biological samples

(2009) Zdeněk Spáčil et al.   ANALYST

Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options

(2009) A. C. Ludolph et al.   EUROPEAN JOURNAL OF NEUROLOGY

Identification of novel susceptibility loci for Guam neurodegenerative disease: challenges of genome scans in genetic isolates

(2009) Weiva Sieh et al.   HUMAN MOLECULAR GENETICS

LACK OF CEREBRAL BMAA IN HUMAN CEREBRAL CORTEX

(2009) L. R. Snyder et al.   NEUROLOGY

Selective Brain Uptake and Behavioral Effects of the Cyanobacterial Toxin BMAA (β-N-Methylamino-L-alanine) following Neonatal Administration to Rodents

(2009) Oskar Karlsson et al.   TOXICOLOGICAL SCIENCES

Long-term Cognitive Impairments in Adult Rats Treated Neonatally with β-N-Methylamino-L-Alanine

(2009) Oskar Karlsson et al.   TOXICOLOGICAL SCIENCES

LC–MS/MS determination of the isomeric neurotoxins BMAA (β-N-methylamino-l-alanine) and DAB (2,4-diaminobutyric acid) in cyanobacteria and seeds of Cycas revoluta and Lathyrus latifolius

(2009) Thomas Krüger et al.   TOXICON

Enduring involvement of tau, β-amyloid, α-synuclein, ubiquitin and TDP-43 pathology in the amyotrophic lateral sclerosis/parkinsonism–dementia complex of Guam (ALS/PDC)

(2008) Judith Miklossy et al.   ACTA NEUROPATHOLOGICA

Determination of the neurotoxin BMAA (β-N-methylamino-l-alanine) in cycad seed and cyanobacteria by LC-MS/MS (liquid chromatography tandem mass spectrometry)

(2008) Johan Rosén et al.   ANALYST

β-N-methylamino-l-alanine (BMAA) in novel South African cyanobacterial isolates

(2008) M. Esterhuizen et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Co-occurrence of β-N-methylamino-l-alanine, a neurotoxic amino acid with other cyanobacterial toxins in British waterbodies, 1990–2004

(2008) James S. Metcalf et al.   ENVIRONMENTAL MICROBIOLOGY

Misincorporation of amino acid analogues into proteins by biosynthesis

(2008) Kenneth J. Rodgers et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cyanobacteria (Nostoc commune) used as a dietary item in the Peruvian highlands produce the neurotoxic amino acid BMAA

(2008) Holly E. Johnson et al.   JOURNAL OF ETHNOPHARMACOLOGY

Chronic Exposure to Dietary Sterol Glucosides is Neurotoxic to Motor Neurons and Induces an ALS–PDC Phenotype

(2008) R. C. Tabata et al.   NEUROMOLECULAR MEDICINE

Effective determination method for a cyanobacterial neurotoxin, β-N-methylamino-l-alanine

(2008) Takuya Kubo et al.   TOXICON