A kallikrein-targeting RNA aptamer inhibits the intrinsic pathway of coagulation and reduces bradykinin release

Nucleic acids as cofactors for factor XI and prekallikrein activation: Different roles for high-molecular-weight kininogen

(2017) Ivan Ivanov et al.   THROMBOSIS AND HAEMOSTASIS

Polyphosphate and RNA Differentially Modulate the Contact Pathway of Blood Clotting

(2016) Joshua M. Gajsiewicz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The contact activation and kallikrein/kinin systems: pathophysiologic and physiologic activities

(2016) A. H. Schmaier   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A comparison of the effects of factor XII deficiency and prekallikrein deficiency on thrombus formation

(2016) Yasin Kokoye et al.   THROMBOSIS RESEARCH

Targeting Two Coagulation Cascade Proteases with a Bivalent Aptamer Yields a Potent and Antidote-Controllable Anticoagulant

(2016) Erin E. Soule et al.   Nucleic Acid Therapeutics

Inhibition of Plasma Kallikrein by a Highly Specific Active Site Blocking Antibody

(2014) Jon A. Kenniston et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Factor XIIa Inhibitory Antibody Provides Thromboprotection in Extracorporeal Circulation Without Increasing Bleeding Risk

(2014) M. Larsson et al.   Science Translational Medicine

Inhibiting the intrinsic pathway of coagulation with a factor XII-targeting RNA aptamer

(2013) R. S. Woodruff et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Effects of plasma kallikrein deficiency on haemostasis and thrombosis in mice: Murine Ortholog of the Fletcher Trait

(2013) Patricia Smith et al.   THROMBOSIS AND HAEMOSTASIS

Plasma kallikrein: the bradykinin-producing enzyme

(2013) Jenny Björkqvist et al.   THROMBOSIS AND HAEMOSTASIS

Hereditary angioedema: a bradykinin-mediated swelling disorder

(2013) Jenny Björkqvist et al.   THROMBOSIS AND HAEMOSTASIS

Factor XIIa inhibition by Infestin-4: in vitro mode of action and in vivo antithrombotic benefit

(2013) Yiming Xu et al.   THROMBOSIS AND HAEMOSTASIS

A comparison of blood factor XII autoactivation in buffer, protein cocktail, serum, and plasma solutions

(2012) Avantika Golas et al.   BIOMATERIALS

In vivo roles of factor XII

(2012) T. Renne et al.   BLOOD

Potent Anticoagulant Aptamer Directed against Factor IXa Blocks Macromolecular Substrate Interaction

(2012) Bruce Sullenger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A high affinity, antidote-controllable prothrombin and thrombin-binding RNA aptamer inhibits thrombin generation and thrombin activity

(2012) K. M. BOMPIANI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Thrombotic Events Associated with C1 Esterase Inhibitor Products in Patients with Hereditary Angioedema: Investigation from the United States Food and Drug Administration Adverse Event Reporting System Database

(2012) Pranav K. Gandhi et al.   PHARMACOTHERAPY

Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding

(2011) A. S. Revenko et al.   BLOOD

Hyperglycemia-induced cerebral hematoma expansion is mediated by plasma kallikrein

(2011) Jia Liu et al.   NATURE MEDICINE

The Plasma Contact System 2.0

(2011) Coen Maas et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

An Anticoagulant RNA Aptamer That Inhibits Proteinase-Cofactor Interactions within Prothrombinase

(2009) Sai K. Buddai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of an RNA aptamer bound to thrombin

(2008) S. B. Long et al.   RNA

Assembly, activation, and physiologic influence of the plasma kallikrein/kinin system

(2007) Alvin H. Schmaier   INTERNATIONAL IMMUNOPHARMACOLOGY