Factor XIIa inhibition by Infestin-4: in vitro mode of action and in vivo antithrombotic benefit

Differential profiles of thrombin inhibitors (heparin, hirudin, bivalirudin, and dabigatran) in the thrombin generation assay and thromboelastography in vitro

(2013) Yiming Xu et al.   BLOOD COAGULATION & FIBRINOLYSIS

Development of a Selective Peptide Macrocycle Inhibitor of Coagulation Factor XII toward the Generation of a Safe Antithrombotic Therapy

(2013) Vanessa Baeriswyl et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibiting the intrinsic pathway of coagulation with a factor XII-targeting RNA aptamer

(2013) R. S. Woodruff et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Hereditary angioedema: a bradykinin-mediated swelling disorder

(2013) Jenny Björkqvist et al.   THROMBOSIS AND HAEMOSTASIS

Corn trypsin inhibitor coating attenuates the prothrombotic properties of catheters in vitro and in vivo

(2012) Jonathan W. Yau et al.   Acta Biomaterialia

The Kazal-type inhibitors infestins 1 and 4 differ in specificity but are similar in three-dimensional structure

(2012) I. T. N. Campos et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

In vivo roles of factor XII

(2012) T. Renne et al.   BLOOD

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

(2012) Marie-Luise von Brühl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Selective Factor XIIa Inhibition Attenuates Silent Brain Ischemia

(2012) John W. Chen et al.   JACC-Cardiovascular Imaging

Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding

(2011) A. S. Revenko et al.   BLOOD

Factor XIIa regulates the structure of the fibrin clot independently of thrombin generation through direct interaction with fibrin

(2011) J. Konings et al.   BLOOD

Factor XIIa Inhibitor Recombinant Human Albumin Infestin-4 Abolishes Occlusive Arterial Thrombus Formation Without Affecting Bleeding

(2010) Ina Hagedorn et al.   CIRCULATION

Effect of the Direct Factor Xa Inhibitor Apixaban in Rat Models of Thrombosis and Hemostasis

(2010) William A Schumacher et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Apixaban inhibition of factor Xa: Microscopic rate constants and inhibition mechanism in purified protein systems and in human plasma

(2010) Joseph M. Luettgen et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Platelet Polyphosphates Are Proinflammatory and Procoagulant Mediators In Vivo

(2009) Felicitas Müller et al.   CELL

Favorable therapeutic index of the direct factor Xa inhibitors, apixaban and rivaroxaban, compared with the thrombin inhibitor dabigatran in rabbits

(2009) P. C. WONG et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Novel 3-Carboxamide-coumarins as Potent and Selective FXIIa Inhibitors

(2008) Séverine Robert et al.   JOURNAL OF MEDICINAL CHEMISTRY

Triggers, targets and treatments for thrombosis

(2008) Nigel Mackman   NATURE