ADAMTS-13 and von Willebrand factor: a dynamic duo

A model for the conformational activation of the structurally quiescent metalloprotease ADAMTS13 by von Willebrand factor

(2017) Kieron South et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformational quiescence of ADAMTS-13 prevents proteolytic promiscuity: comment

(2017) W. J. Cao et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Conformational quiescence of ADAMTS-13 prevents proteolytic promiscuity: reply

(2017) K. South et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Reduced ADAMTS13 levels in patients with acute and chronic cerebrovascular disease

(2017) Frederik Denorme et al.   PLoS One

Thrombotic thrombocytopenic purpura

(2017) Johanna A. Kremer Hovinga et al.   Nature Reviews Disease Primers

Von Willebrand Factor, ADAMTS13, and the Risk of MortalityHighlights

(2016) Michelle A.H. Sonneveld et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Acquired von Willebrand syndrome associated with left ventricular assist device

(2016) A. Nascimbene et al.   BLOOD

N-linked glycans within the A2 domain of von Willebrand factor modulate macrophage-mediated clearance

(2016) Alain Chion et al.   BLOOD

N-acetylcysteine in preclinical mouse and baboon models of thrombotic thrombocytopenic purpura

(2016) Claudia Tersteeg et al.   BLOOD

N-linked glycan stabilization of the VWF A2 domain

(2016) C. J. Lynch et al.   BLOOD

CD4+ T cells from patients with acquired thrombotic thrombocytopenic purpura recognize CUB2 domain-derived peptides

(2016) F. C. Verbij et al.   BLOOD

Human neutrophil peptides inhibit cleavage of von Willebrand factor by ADAMTS13: a potential link of inflammation to TTP

(2016) Vikram G. Pillai et al.   BLOOD

ADAMTS13-mediated thrombolysis of t-PA-resistant occlusions in ischemic stroke in mice

(2016) F. Denorme et al.   BLOOD

The role of ADAMTS13 in acute myocardial infarction: cause or consequence?

(2016) Elise S. Eerenberg et al.   CARDIOVASCULAR RESEARCH

Update on ADAMTS13 and VWF in cardiovascular and hematological disorders

(2016) Omer Akyol et al.   CLINICA CHIMICA ACTA

Conformational quiescence of ADAMTS-13 prevents proteolytic promiscuity

(2016) K. South et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Caplacizumab for Acquired Thrombotic Thrombocytopenic Purpura

(2016) Flora Peyvandi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Force sensing by the vascular protein von Willebrand factor is tuned by a strong intermonomer interaction

(2016) Jochen P. Müller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thromboinflammation in Stroke Brain Damage

(2016) Simon F. De Meyer et al.   STROKE

Generation of Anti-Murine ADAMTS13 Antibodies and Their Application in a Mouse Model for Acquired Thrombotic Thrombocytopenic Purpura

(2016) Louis Deforche et al.   PLoS One

Potential for Recombinant ADAMTS13 as an Effective Therapy for Acquired Thrombotic Thrombocytopenic PurpuraSignificance

(2015) Claudia Tersteeg et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The role of the ADAMTS13 cysteine-rich domain in VWF binding and proteolysis

(2015) R. de Groot et al.   BLOOD

Low ADAMTS13 activity is associated with an increased risk of ischemic stroke

(2015) M. A. H. Sonneveld et al.   BLOOD

Delayed treatment with ADAMTS13 ameliorates cerebral ischemic injury without hemorrhagic complication

(2015) Takafumi Nakano et al.   BRAIN RESEARCH

ADAMTS13 and von Willebrand factor interactions

(2015) Catherine B. Zander et al.   CURRENT OPINION IN HEMATOLOGY

Acquired thrombotic thrombocytopenic purpura: new therapeutic options and their optimal use

(2015) S. R. Cataland et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Linker regions and flexibility around the metalloprotease domain account for conformational activation of ADAMTS-13

(2015) L. Deforche et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Plasma ADAMTS-13 levels and the risk of myocardial infarction: an individual patient data meta-analysis

(2015) A. Maino et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Probing ADAMTS13 Substrate Specificity using Phage Display

(2015) Karl C. Desch et al.   PLoS One

Massively parallel enzyme kinetics reveals the substrate recognition landscape of the metalloprotease ADAMTS13

(2015) Colin A. Kretz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Von Willebrand factor in relation to coronary plaque characteristics and cardiovascular outcome

(2015) Michelle A. Sonneveld et al.   THROMBOSIS AND HAEMOSTASIS

Pathogenicity of Anti-ADAMTS13 Autoantibodies in Acquired Thrombotic Thrombocytopenic Purpura

(2015) Mari R. Thomas et al.   EBioMedicine

Control of VWF A2 domain stability and ADAMTS13 access to the scissile bond of full-length VWF

(2014) C. J. Lynch et al.   BLOOD

How I treat thrombotic thrombocytopenic purpura and atypical haemolytic uraemic syndrome

(2014) Marie Scully et al.   BRITISH JOURNAL OF HAEMATOLOGY

Plasmin Cleavage of von Willebrand Factor as an Emergency Bypass for ADAMTS13 Deficiency in Thrombotic Microangiopathy

(2014) Claudia Tersteeg et al.   CIRCULATION

Anti-ADAMTS13 IgG autoantibodies present in healthy individuals share linear epitopes with those in patients with thrombotic thrombocytopenic purpura

(2014) R. Grillberger et al.   HAEMATOLOGICA

Allosteric activation of ADAMTS13 by von Willebrand factor

(2014) Joshua Muia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational activation of ADAMTS13

(2014) Kieron South et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Relationship of Von Willebrand Factor with carotid artery and aortic arch calcification in ischemic stroke patients

(2013) Michelle A.H. Sonneveld et al.   ATHEROSCLEROSIS

Mechanisms by which von Willebrand Disease Mutations Destabilize the A2 Domain

(2013) Amy J. Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure and enzymatic activity of an ADAMTS-13 mutant with the East Asian-specific P475S polymorphism

(2013) M. Akiyama et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Structure-function and regulation of ADAMTS-13 protease

(2013) X. L. Zheng   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

ADAMTS13 modulates atherosclerotic plaque progression in mice via a VWF-dependent mechanism

(2013) C. Gandhi et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Recombinant ADAMTS13 reduces tissue plasminogen activator-induced hemorrhage after stroke in mice

(2012) Lixiang Wang et al.   ANNALS OF NEUROLOGY

A new mouse model mimicking thrombotic thrombocytopenic purpura: correction of symptoms by recombinant human ADAMTS13

(2012) A. Schiviz et al.   BLOOD

Unwinding the von Willebrand factor strings puzzle

(2012) K. De Ceunynck et al.   BLOOD

Intersection of mechanisms of type 2A VWD through defects in VWF multimerization, secretion, ADAMTS-13 susceptibility, and regulated storage

(2012) P. M. Jacobi et al.   BLOOD

Gain-of-function ADAMTS13 variants that are resistant to autoantibodies against ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura

(2012) C. Jian et al.   BLOOD

Protective anti-inflammatory effect of ADAMTS13 on myocardial ischemia/reperfusion injury in mice

(2012) S. F. De Meyer et al.   BLOOD

ADAMTS13 deficiency exacerbates VWF-dependent acute myocardial ischemia/reperfusion injury in mice

(2012) C. Gandhi et al.   BLOOD

Sequence and structure relationships within von Willebrand factor

(2012) Y.-F. Zhou et al.   BLOOD

Macrophage LRP1 contributes to the clearance of von Willebrand factor

(2012) G. Rastegarlari et al.   BLOOD

Shear stress is required for the endocytic uptake of the factor VIII-von Willebrand factor complex by macrophages

(2012) L. CASTRO-NÚÑEZ et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Essential Domains of A Disintegrin and Metalloprotease With Thrombospondin Type 1 Repeats-13 Metalloprotease Required for Modulation of Arterial Thrombosis

(2011) Juan Xiao et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Unraveling the scissile bond: how ADAMTS13 recognizes and cleaves von Willebrand factor

(2011) J. T. B. Crawley et al.   BLOOD

High VWF, low ADAMTS13, and oral contraceptives increase the risk of ischemic stroke and myocardial infarction in young women

(2011) H. M. Andersson et al.   BLOOD

Local Elongation of Endothelial Cell-anchored von Willebrand Factor Strings Precedes ADAMTS13 Protein-mediated Proteolysis

(2011) Karen De Ceunynck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of von Willebrand factor scissile bond cleavage by a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13)

(2011) Y. Xiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

von Willebrand Factor

(2011) Simon F. De Meyer et al.   STROKE

Calcium modulates force sensing by the von Willebrand factor A2 domain

(2011) Arjen J. Jakobi et al.   Nature Communications

Unfolding the A2 Domain of Von Willebrand Factor with the Optical Trap

(2010) Junyi Ying et al.   BIOPHYSICAL JOURNAL

Thrombotic thrombocytopenic purpura directly linked with ADAMTS13 inhibition in the baboon (Papio ursinus)

(2010) H. B. Feys et al.   BLOOD

Amino acid residues Arg659, Arg660, and Tyr661 in the spacer domain of ADAMTS13 are critical for cleavage of von Willebrand factor

(2010) S.-Y. Jin et al.   BLOOD

The importance of vicinal cysteines, C1669 and C1670, for von Willebrand factor A2 domain function

(2010) B. M. Luken et al.   BLOOD

Inhibition of von Willebrand factor by ARC1779 in patients with acute thrombotic thrombocytopenic purpura

(2010) Bernd Jilma et al.   THROMBOSIS AND HAEMOSTASIS

Lower levels of ADAMTS13 are associated with cardiovascular disease in young patients

(2009) T.N. Bongers et al.   ATHEROSCLEROSIS

An autoantibody epitope comprising residues R660, Y661, and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF

(2009) W. Pos et al.   BLOOD

Force-induced cleavage of single VWFA1A2A3 tridomains by ADAMTS-13

(2009) T. Wu et al.   BLOOD

von Willebrand factor-cleaving protease ADAMTS13 reduces ischemic brain injury in experimental stroke

(2009) B.-Q. Zhao et al.   BLOOD

A novel binding site for ADAMTS13 constitutively exposed on the surface of globular VWF

(2009) S. Zanardelli et al.   BLOOD

Multi-step binding of ADAMTS-13 to von Willebrand factor

(2009) H. B. FEYS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Structural specializations of A2, a force-sensing domain in the ultralarge vascular protein von Willebrand factor

(2009) Q. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanoenzymatic Cleavage of the Ultralarge Vascular Protein von Willebrand Factor

(2009) X. Zhang et al.   SCIENCE

Extensive contacts between ADAMTS13 exosites and von Willebrand factor domain A2 contribute to substrate specificity

(2008) W. Gao et al.   BLOOD

A functional calcium-binding site in the metalloprotease domain of ADAMTS13

(2008) M. D. Gardner et al.   BLOOD

Von Willebrand factor, ADAMTS13, and thrombotic thrombocytopenic purpura

(2008) J. E. Sadler   BLOOD

Evidence that high von Willebrand factor and low ADAMTS-13 levels independently increase the risk of a non-fatal heart attack

(2008) J. T. B. CRAWLEY et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

VH1-69 germline encoded antibodies directed towards ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura

(2008) W. POS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

N-linked glycosylation of VWF modulates its interaction with ADAMTS13

(2007) T. A. J. McKinnon et al.   BLOOD