Structure-function and regulation of ADAMTS-13 protease

ADAMs and ADAMTSs in cancer

(2016) S.L. Turner et al.   BRITISH JOURNAL OF BIOMEDICAL SCIENCE

Preferential HLA-DRB1*11-dependent presentation of CUB2-derived peptides by ADAMTS13-pulsed dendritic cells

(2013) N. Sorvillo et al.   BLOOD

Indexes of von Willebrand Factor as Biomarkers of Aortic Stenosis Severity (from the Biomarkers of Aortic Stenosis Severity [BASS] Study)

(2012) Joseph L. Blackshear et al.   AMERICAN JOURNAL OF CARDIOLOGY

Genetic Ablation of Adamts13 Gene Dramatically Accelerates the Formation of Early Atherosclerosis in a Murine Model

(2012) Sheng-Yu Jin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Simultaneous Exposure of Sites in von Willebrand Factor for Glycoprotein Ib Binding and ADAMTS13 Cleavage

(2012) Junmei Chen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The macrophage mannose receptor promotes uptake of ADAMTS13 by dendritic cells

(2012) N. Sorvillo et al.   BLOOD

A new mouse model mimicking thrombotic thrombocytopenic purpura: correction of symptoms by recombinant human ADAMTS13

(2012) A. Schiviz et al.   BLOOD

ADAMTS13 meets MR, then what?

(2012) X. L. Zheng   BLOOD

Gain-of-function ADAMTS13 variants that are resistant to autoantibodies against ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura

(2012) C. Jian et al.   BLOOD

Protective anti-inflammatory effect of ADAMTS13 on myocardial ischemia/reperfusion injury in mice

(2012) S. F. De Meyer et al.   BLOOD

ADAMTS13 deficiency exacerbates VWF-dependent acute myocardial ischemia/reperfusion injury in mice

(2012) C. Gandhi et al.   BLOOD

Residual plasmatic activity of ADAMTS13 is correlated with phenotype severity in congenital thrombotic thrombocytopenic purpura

(2012) L. A. Lotta et al.   BLOOD

Light Chain of Factor VIII Is Sufficient for Accelerating Cleavage of von Willebrand Factor by ADAMTS13 Metalloprotease

(2012) Wenjing Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rearranging Exosites in Noncatalytic Domains Can Redirect the Substrate Specificity of ADAMTS Proteases

(2012) Weiqiang Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microfluidic system for simultaneous optical measurement of platelet aggregation at multiple shear rates in whole blood

(2012) Melissa Li et al.   LAB ON A CHIP

ADAMTS13 promotes angiogenesis and modulates VEGF-induced angiogenesis

(2012) Manfai Lee et al.   MICROVASCULAR RESEARCH

ADAMTS13 gene deletion enhances plasma high-mobility group box1 elevation and neuroinflammation in brain ischemia–reperfusion injury

(2012) Masayuki Fujioka et al.   NEUROLOGICAL SCIENCES

Generation and Breakdown of Soluble Ultralarge von Willebrand Factor Multimers

(2012) Nancy Turner et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

ADAMTS13 safeguards the myocardium in a mouse model of acute myocardial infarction

(2012) Masaaki Doi et al.   THROMBOSIS AND HAEMOSTASIS

Essential Domains of A Disintegrin and Metalloprotease With Thrombospondin Type 1 Repeats-13 Metalloprotease Required for Modulation of Arterial Thrombosis

(2011) Juan Xiao et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Von Willebrand Factor and ADAMTS13

(2011) Alain Stepanian et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

High VWF, low ADAMTS13, and oral contraceptives increase the risk of ischemic stroke and myocardial infarction in young women

(2011) H. M. Andersson et al.   BLOOD

ADAMTS13 reduces vascular inflammation and the development of early atherosclerosis in mice

(2011) C. Gandhi et al.   BLOOD

Residues Arg568 and Phe592 contribute to an antigenic surface for anti-ADAMTS13 antibodies in the spacer domain

(2011) W. Pos et al.   HAEMATOLOGICA

Humoral immune response to ADAMTS13 in acquired thrombotic thrombocytopenic purpura

(2011) W. POS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Association of ADAMTS13 polymorphism with cerebral malaria

(2011) Sirima Kraisin et al.   MALARIA JOURNAL

Mechanism of von Willebrand factor scissile bond cleavage by a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13)

(2011) Y. Xiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel recombinant glycosylphosphatidylinositol (GPI)-anchored ADAMTS13 and variants for assessment of anti-ADAMTS13 autoantibodies in patients with thrombotic thrombocytopenic purpura

(2011) Dengju Li et al.   THROMBOSIS AND HAEMOSTASIS

Epitope analysis of autoantibodies to ADAMTS13 in patients with acquired thrombotic thrombocytopenic purpura

(2011) Yusuke Yamaguchi et al.   THROMBOSIS RESEARCH

Analysis of Morphology of Platelet Aggregates Formed on Collagen Under Laminar Blood Flow

(2010) T. Colace et al.   ANNALS OF BIOMEDICAL ENGINEERING

How I treat patients with thrombotic thrombocytopenic purpura: 2010

(2010) J. N. George   BLOOD

Factor IX ectopically expressed in platelets can be stored in  -granules and corrects the phenotype of hemophilia B mice

(2010) G. Zhang et al.   BLOOD

Thrombotic thrombocytopenic purpura directly linked with ADAMTS13 inhibition in the baboon (Papio ursinus)

(2010) H. B. Feys et al.   BLOOD

Amino acid residues Arg659, Arg660, and Tyr661 in the spacer domain of ADAMTS13 are critical for cleavage of von Willebrand factor

(2010) S.-Y. Jin et al.   BLOOD

Shiga toxin B subunits induce VWF secretion by human endothelial cells and thrombotic microangiopathy in ADAMTS13-deficient mice

(2010) J. Huang et al.   BLOOD

Multiple domains of ADAMTS13 are targeted by autoantibodies against ADAMTS13 in patients with acquired idiopathic thrombotic thrombocytopenic purpura

(2010) X. L. Zheng et al.   HAEMATOLOGICA

Registry of 919 Patients with Thrombotic Microangiopathies across Japan: Database of Nara Medical University during 1998-2008

(2010) Yoshihiro Fujimura et al.   INTERNAL MEDICINE

Factor VIII and Platelets Synergistically Accelerate Cleavage of von Willebrand Factor by ADAMTS13 under Fluid Shear Stress

(2010) Christopher G. Skipwith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disulfide bond reduction of von Willebrand factor by ADAMTS-13

(2010) H.-C. YEH et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The distal carboxyterminal domains of murine ADAMTS13 influence proteolysis of platelet-decorated VWF strings in vivo

(2010) B. DE MAEYER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

An autoantibody epitope comprising residues R660, Y661, and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF

(2009) W. Pos et al.   BLOOD

Force-induced cleavage of single VWFA1A2A3 tridomains by ADAMTS-13

(2009) T. Wu et al.   BLOOD

Endothelial cell ADAMTS-13 and VWF: production, release, and VWF string cleavage

(2009) N. A. Turner et al.   BLOOD

von Willebrand factor-cleaving protease ADAMTS13 reduces ischemic brain injury in experimental stroke

(2009) B.-Q. Zhao et al.   BLOOD

A novel binding site for ADAMTS13 constitutively exposed on the surface of globular VWF

(2009) S. Zanardelli et al.   BLOOD

Rapid activation of endothelial cells enables Plasmodium falciparum adhesion to platelet-decorated von Willebrand factor strings

(2009) D. J. Bridges et al.   BLOOD

ADAMTS13mutations and polymorphisms in congenital thrombotic thrombocytopenic purpura

(2009) Luca A. Lotta et al.   HUMAN MUTATION

ADAMTS13 Bound to Endothelial Cells Exhibits Enhanced Cleavage of von Willebrand Factor

(2009) Anthony N. Vomund et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Disintegrin-like and Metalloprotease (Reprolysin-type) with Thrombospondin Type 1 Motif (ADAMTS) Superfamily: Functions and Mechanisms

(2009) Suneel S. Apte   JOURNAL OF BIOLOGICAL CHEMISTRY

von Willebrand factor cleaved from endothelial cells by ADAMTS13 remains ultralarge in size

(2009) S.-Y. JIN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

IgG subclass distribution of anti-ADAMTS13 antibodies in patients with acquired thrombotic thrombocytopenic purpura

(2009) S. FERRARI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Human leukocyte antigen association in idiopathic thrombotic thrombocytopenic purpura: evidence for an immunogenetic link

(2009) M. SCULLY et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Structural specializations of A2, a force-sensing domain in the ultralarge vascular protein von Willebrand factor

(2009) Q. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor

(2009) M. Akiyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanoenzymatic Cleavage of the Ultralarge Vascular Protein von Willebrand Factor

(2009) X. Zhang et al.   SCIENCE

Severe malaria is associated with a deficiency of von Willebrand factor cleaving protease, ADAMTS13

(2009) E. C. Löwenberg et al.   THROMBOSIS AND HAEMOSTASIS

Severe Plasmodium falciparum Malaria Is Associated with Circulating Ultra-Large von Willebrand Multimers and ADAMTS13 Inhibition

(2009) Deirdre Larkin et al.   PLoS Pathogens

Pathogenesis of Thrombotic Microangiopathies

(2008) X. Long Zheng et al.   Annual Review of Pathology-Mechanisms of Disease

Extensive contacts between ADAMTS13 exosites and von Willebrand factor domain A2 contribute to substrate specificity

(2008) W. Gao et al.   BLOOD

A functional calcium-binding site in the metalloprotease domain of ADAMTS13

(2008) M. D. Gardner et al.   BLOOD

Platelet-delivered factor VIII provides limited resistance to anti-factor VIII inhibitors

(2008) J. GEWIRTZ et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

ADAMTS-13 cleaves long von Willebrand factor multimeric strings anchored to endothelial cells in the absence of flow, platelets or conformation-altering chemicals

(2008) N. TURNER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Microfluidic devices for studies of shear-dependent platelet adhesion

(2008) Edgar Gutierrez et al.   LAB ON A CHIP

Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin

(2008) Y. Luan et al.   OSTEOARTHRITIS AND CARTILAGE

Factor VIII accelerates proteolytic cleavage of von Willebrand factor by ADAMTS13

(2008) W. Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-dimensional domain architecture of the ADAM family proteinases

(2008) Soichi Takeda   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Platelet-VWF complexes are preferred substrates of ADAMTS13 under fluid shear stress

(2007) K. Shim et al.   BLOOD