Thrombomodulin as an intravascular safeguard against inflammatory and thrombotic diseases

Activated protein C: biased for translation

(2015) J. H. Griffin et al.   BLOOD

Recombinant Thrombomodulin Inhibits Lipopolysaccharide-Induced Inflammatory Response by Blocking the Functions of CD14

(2015) Chih-Yuan Ma et al.   JOURNAL OF IMMUNOLOGY

Recombinant soluble thrombomodulin: coagulation takes another chance to reduce sepsis mortality

(2015) M. Levi   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Recombinant human soluble thrombomodulin in severe sepsis: a systematic review and meta-analysis

(2015) K. Yamakawa et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Functional Difference Between Membrane-bound and Soluble Human Thrombomodulin

(2015) Yuko Miwa et al.   TRANSPLANTATION

Recombinant human soluble thrombomodulin and mortality in severe pneumonia patients with sepsis-associated disseminated intravascular coagulation: an observational nationwide study

(2014) T. Tagami et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1

(2013) Yaoming Wang et al.   BRAIN RESEARCH

A Randomized, Double-Blind, Placebo-Controlled, Phase 2b Study to Evaluate the Safety and Efficacy of Recombinant Human Soluble Thrombomodulin, ART-123, in Patients With Sepsis and Suspected Disseminated Intravascular Coagulation*

(2013) Jean-Louis Vincent et al.   CRITICAL CARE MEDICINE

Recombinant human soluble thrombomodulin in sepsis-induced disseminated intravascular coagulation: a multicenter propensity score analysis

(2013) Kazuma Yamakawa et al.   INTENSIVE CARE MEDICINE

A Novel Strategy for Hemolytic Uremic Syndrome: Successful Treatment With Thrombomodulin  

(2013) T. Honda et al.   PEDIATRICS

Recombinant Thrombomodulin Protects Mice against Histone-Induced Lethal Thromboembolism

(2013) Mayumi Nakahara et al.   PLoS One

Lack of the Lectin-like Domain of Thrombomodulin Worsens Shiga Toxin-Associated Hemolytic Uremic Syndrome in Mice

(2012) C. Zoja et al.   JOURNAL OF IMMUNOLOGY

Drotrecogin Alfa (Activated) in Adults with Septic Shock

(2012) V. Marco Ranieri et al.   NEW ENGLAND JOURNAL OF MEDICINE

An Activated Protein C Analog With Reduced Anticoagulant Activity Extends the Therapeutic Window of Tissue Plasminogen Activator for Ischemic Stroke in Rodents

(2012) Yaoming Wang et al.   STROKE

Flow-Dependent Regulation of Krüppel-Like Factor 2 Is Mediated by MicroRNA-92a

(2011) Wei Wu et al.   CIRCULATION

Thrombomodulin: protectorate God of the vasculature in thrombosis and inflammation

(2011) T. ITO et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Thrombomodulin and its role in inflammation

(2011) Edward M. Conway   Seminars in Immunopathology

Age-dependent vulnerability to endotoxemia is associated with reduction of anticoagulant factors activated protein C and thrombomodulin

(2010) M. E. Starr et al.   BLOOD

Recombinant human soluble thrombomodulin decreases the plasma high-mobility group box-1 protein levels, whereas improving the acute liver injury and survival rates in experimental endotoxemia

(2009) Masaru Nagato et al.   CRITICAL CARE MEDICINE

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

Thrombomodulin Mutations in Atypical Hemolytic–Uremic Syndrome

(2009) Mieke Delvaeye et al.   NEW ENGLAND JOURNAL OF MEDICINE

Proteolytic Cleavage of High Mobility Group Box 1 Protein by Thrombin-Thrombomodulin Complexes

(2008) Takashi Ito et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Lectin-like domain of thrombomodulin binds to its specific ligand Lewis Y antigen and neutralizes lipopolysaccharide-induced inflammatory response

(2008) C.-S. Shi et al.   BLOOD

Mechanotransduction in vascular physiology and atherogenesis

(2008) Cornelia Hahn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY