The Role of Brain-Derived Neurotrophic Factor Signaling in Central Nervous System Disease Pathogenesis

Neuroimmune crosstalk through brain-derived neurotrophic factor and its precursor pro-BDNF: New insights into mood disorders

(2022) Xiao-Pei Zhao et al.   World Journal of Psychiatry

ERRγ ligand HPB2 upregulates BDNF-TrkB and enhances dopaminergic neuronal phenotype

(2021) Hyo In Kim et al.   PHARMACOLOGICAL RESEARCH

proBDNF expression induces apoptosis and inhibits synaptic regeneration by regulating the RhoA-JNK pathway in an in vitro post-stroke depression model

(2021) Bangkun Yang et al.   Translational Psychiatry

Calycosin Preserves BDNF/TrkB Signaling and Reduces Post-Stroke Neurological Injury after Cerebral Ischemia by Reducing Accumulation of Hypertrophic and TNF-α-Containing Microglia in Rats

(2020) Chien-Chin Hsu et al.   Journal of Neuroimmune Pharmacology

Abnormalities in the cerebellar levels of trophic factors BDNF and GDNF in pcd and Lurcher cerebellar mutant mice

(2020) Martina Salomova et al.   NEUROSCIENCE LETTERS

Genetics of Anxiety Disorders

(2019) Sandra M. Meier et al.   Current Psychiatry Reports

Therapeutic AAV Gene Transfer to the Nervous System: A Clinical Reality

(2019) Eloise Hudry et al.   NEURON

Peripheral BDNF/TrkB protein expression is decreased in Parkinson’s disease but not in Essential tremor

(2019) Yixian Huang et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Effects of corticosterone on the expression of mature brain-derived neurotrophic factor (mBDNF) and proBDNF in the hippocampal dentate gyrus

(2019) Jianguo Li et al.   BEHAVIOURAL BRAIN RESEARCH

Astrocyte morphogenesis is dependent on BDNF signaling via astrocytic TrkB.T1

(2019) Leanne M Holt et al.   eLife

Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression

(2018) Marion J. F. Levy et al.   PSYCHOPHARMACOLOGY

Hippocampal Membrane-Associated p75NTR Levels are Increased in Alzheimer's Disease

(2018) Balu Chakravarthy et al.   JOURNAL OF ALZHEIMERS DISEASE

Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model

(2018) Se Hoon Choi et al.   SCIENCE

Decreased BDNF Release in Cortical Neurons of a Knock-in Mouse Model of Huntington’s Disease

(2018) Chenglong Yu et al.   Scientific Reports

BDNF Val66Met in preclinical Alzheimer's disease is associated with short-term changes in episodic memory and hippocampal volume but not serum mBDNF

(2017) Yen Ying Lim et al.   INTERNATIONAL PSYCHOGERIATRICS

BDNF at the synapse: why location matters

(2017) M Song et al.   MOLECULAR PSYCHIATRY

Can anxiety damage the brain?

(2016) Linda Mah et al.   CURRENT OPINION IN PSYCHIATRY

The Effects of Acute Exercise on Memory and Brain-Derived Neurotrophic Factor (BDNF)

(2016) Jennifer L. Etnier et al.   JOURNAL OF SPORT & EXERCISE PSYCHOLOGY

Tau downregulates BDNF expression in animal and cellular models of Alzheimer's disease

(2016) Elyse Rosa et al.   NEUROBIOLOGY OF AGING

Higher brainBDNFgene expression is associated with slower cognitive decline in older adults

(2016) Aron S. Buchman et al.   NEUROLOGY

Val66Met BDNF polymorphism is associated with Parkinson's disease cognitive impairment

(2016) Vivian Altmann et al.   NEUROSCIENCE LETTERS

Parkinson’s Disease: New Insights into Pathophysiology and Rehabilitative Approaches

(2016) Vincenza Frisardi et al.   Parkinsons Disease

Targeting the CD80/CD86 costimulatory pathway with CTLA4-Ig directs microglia toward a repair phenotype and promotes axonal outgrowth

(2015) Antoine Louveau et al.   GLIA

The p75 neurotrophin receptor: at the crossroad of neural repair and death

(2015) RickB Meeker et al.   Neural Regeneration Research

Overexpression of brain-derived neurotrophic factor in the hippocampus protects against post-stroke depression

(2015) Xiao-yan Fu et al.   Neural Regeneration Research

Gender and brain regions specific differences in brain derived neurotrophic factor protein levels of depressed individuals who died through suicide

(2015) Shawn Hayley et al.   NEUROSCIENCE LETTERS

Increased cerebellar volume and BDNF level following quadrato motor training

(2014) Tal Dotan Ben-Soussan et al.   SYNAPSE

Sustained Mobilization of Endogenous Neural Progenitors Delays Disease Progression in a Transgenic Model of Huntington’s Disease

(2013) Abdellatif Benraiss et al.   Cell Stem Cell

Upregulation of blood proBDNF and its receptors in major depression

(2013) Li Zhou et al.   JOURNAL OF AFFECTIVE DISORDERS

Emerging roles of astrocytes in neural circuit development

(2013) Laura E. Clarke et al.   NATURE REVIEWS NEUROSCIENCE

The BDNF Val66Met Polymorphism Modulates the Generalization of Cued Fear Responses to a Novel Context

(2013) Andreas Mühlberger et al.   NEUROPSYCHOPHARMACOLOGY

Imbalance of p75NTR/TrkB protein expression in Huntington’s disease: implication for neuroprotective therapies

(2013) V Brito et al.   Cell Death & Disease

BDNF overexpression in mouse hippocampal astrocytes promotes local neurogenesis and elicits anxiolytic-like activities

(2013) G Quesseveur et al.   Translational Psychiatry

p75 neurotrophin receptor signaling in nervous system injury and degeneration: paradox and opportunity

(2012) Carlos F. Ibáñez et al.   TRENDS IN NEUROSCIENCES

Potential therapeutic uses of BDNF in neurological and psychiatric disorders

(2011) Alan H. Nagahara et al.   NATURE REVIEWS DRUG DISCOVERY

Social deprivation stress is a triggering factor for the emergence of anxiety- and depression-like behaviours and leads to reduced brain BDNF levels in C57BL/6J mice

(2011) Alessandra Berry et al.   PSYCHONEUROENDOCRINOLOGY

Overexpression of α-Synuclein Down-Regulates BDNF Expression

(2010) Yuhe Yuan et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

(2009) Alan H Nagahara et al.   NATURE MEDICINE

TrkB Regulates Hippocampal Neurogenesis and Governs Sensitivity to Antidepressive Treatment

(2008) Yun Li et al.   NEURON

Serum Concentrations of Nerve Growth Factor and Brain-Derived Neurotrophic Factor in Depressed Patients before and after Antidepressant Treatment

(2008) R. Hellweg et al.   PHARMACOPSYCHIATRY