Exploiting virus-like particles as innovative vaccines against emerging viral infections

Molecular pharming — VLPs made in plants

(2016) Johanna Marsian et al.   CURRENT OPINION IN BIOTECHNOLOGY

Yeast as an expression system for producing virus-like particles: what factors do we need to consider?

(2016) H.J. Kim et al.   LETTERS IN APPLIED MICROBIOLOGY

The 2016 Vaccine Development Pipeline: A special issue from the World Health Organization Product Development for Vaccine Advisory Committee (PDVAC)

(2016) Birgitte K. Giersing et al.   VACCINE

Next generation vaccines and vectors: Designing downstream processes for recombinant protein-based virus-like particles

(2015) Christopher Ladd Effio et al.   Biotechnology Journal

Next generation vaccines and vectors: Designing downstream processes for recombinant protein-based virus-like particles

(2015) Christopher Ladd Effio et al.   Biotechnology Journal

Tandem Fusion of Hepatitis B Core Antigen Allows Assembly of Virus-Like Particles in Bacteria and Plants with Enhanced Capacity to Accommodate Foreign Proteins

(2015) Hadrien Peyret et al.   PLoS One

Protein Folding In Vivo Revisited

(2014) Seong Choi et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Virus-Like Display of a Neo-Self Antigen Reverses B Cell Anergy in a B Cell Receptor Transgenic Mouse Model

(2014) Bryce Chackerian et al.   JOURNAL OF IMMUNOLOGY

Energetic Changes Caused by Antigenic Module Insertion in a Virus-Like Particle Revealed by Experiment and Molecular Dynamics Simulations

(2014) Lin Zhang et al.   PLoS One

Plant-based vaccines against viruses

(2014) Edward P Rybicki   Virology Journal

Virus-like particles produced in plants as potential vaccines

(2013) Nunzia Scotti et al.   Expert Review of Vaccines

SV40 virus-like particles as an effective delivery system and its application to a vaccine carrier

(2013) Masaaki Kawano et al.   Expert Review of Vaccines

Insect cells as a production platform of complex virus-like particles

(2013) Fabiana Fernandes et al.   Expert Review of Vaccines

Utilizing Dynamic Light Scattering as a Process Analytical Technology for Protein Folding and Aggregation Monitoring in Vaccine Manufacturing

(2013) Zhou Yu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Molecular Energetics in the Capsomere of Virus-Like Particle Revealed by Molecular Dynamics Simulations

(2013) Lin Zhang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Design of Hybrid Lipid/Retroviral-Like Particle Gene Delivery Vectors

(2013) Rahul K. Keswani et al.   MOLECULAR PHARMACEUTICS

Virus-like particles for enterovirus 71 produced from Saccharomyces cerevisiae potently elicits protective immune responses in mice

(2013) Hao-Yang Li et al.   VACCINE

Virus-induced humoral immunity: on how B cell responses are initiated

(2013) Franziska Zabel et al.   Current Opinion in Virology

Engineered Mutations Change the Structure and Stability of a Virus-Like Particle

(2012) Jason D. Fiedler et al.   BIOMACROMOLECULES

Virus-like particles as universal influenza vaccines

(2012) Sang-Moo Kang et al.   Expert Review of Vaccines

Innate Immunity Mediates Follicular Transport of Particulate but Not Soluble Protein Antigen

(2012) A. Link et al.   JOURNAL OF IMMUNOLOGY

Noroviruses: The Perfect Human Pathogens?

(2012) A. J. Hall   JOURNAL OF INFECTIOUS DISEASES

Purification of norovirus-like particles (VLPs) by ion exchange chromatography

(2012) Tiia Koho et al.   JOURNAL OF VIROLOGICAL METHODS

Protective efficacy of the recombinant, live-attenuated, CYD tetravalent dengue vaccine in Thai schoolchildren: a randomised, controlled phase 2b trial

(2012) Arunee Sabchareon et al.   LANCET

Simultaneous expression of recombinant proteins in the insect cell-baculovirus system: Production of virus-like particles

(2012) Laura A. Palomares et al.   METHODS

Construction and Characterization of Virus-Like Particles: A Review

(2012) Andris Zeltins   MOLECULAR BIOTECHNOLOGY

The Influenza Pandemic of 2009

(2012) Paul Shapshak et al.   Molecular Diagnosis & Therapy

Comparative analysis of recombinant Human Papillomavirus 8 L1 production in plants by a variety of expression systems and purification methods

(2012) Slavica Matić et al.   PLANT BIOTECHNOLOGY JOURNAL

Computer-aided antibody design

(2012) D. Kuroda et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Virus-like particles as a highly efficient vaccine platform: Diversity of targets and production systems and advances in clinical development

(2012) Natasha Kushnir et al.   VACCINE

Disassembly and reassembly of human papillomavirus virus-like particles produces more virion-like antibody reactivity

(2012) Qinjian Zhao et al.   Virology Journal

Plant-derived virus-like particles as vaccines

(2012) Qiang Chen et al.   Human Vaccines & Immunotherapeutics

On the Effect of Thermodynamic Equilibrium on the Assembly Efficiency of Complex Multi-Layered Virus-Like Particles (VLP): the Case of Rotavirus VLP

(2012) António Roldão et al.   PLoS Computational Biology

Cell-Specific Delivery of Diverse Cargos by Bacteriophage MS2 Virus-like Particles

(2011) Carlee E. Ashley et al.   ACS Nano

Human parvovirus B19 virus-like particles: In vitro assembly and stability

(2011) Sandra P. Sánchez-Rodríguez et al.   BIOCHIMIE

Molecular pharming

(2011) Mathew Paul et al.   Human vaccines & immunotherapeutics

Efficient disulfide bond formation in virus-like particles

(2011) Bradley C. Bundy et al.   JOURNAL OF BIOTECHNOLOGY

Management of Accidental Exposure to Ebola Virus in the Biosafety Level 4 Laboratory, Hamburg, Germany

(2011) Stephan Günther et al.   JOURNAL OF INFECTIOUS DISEASES

Molecular and process design for rotavirus-like particle production in Saccharomyces cerevisiae

(2011) William A Rodríguez-Limas et al.   Microbial Cell Factories

Bioprocessing of plant-derived virus-like particles of Norwalk virus capsid protein under current Good Manufacture Practice regulations

(2011) Huafang Lai et al.   PLANT CELL REPORTS

Protein delivery using engineered virus-like particles

(2011) S. J. Kaczmarczyk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A recombinant Hendra virus G glycoprotein-based subunit vaccine protects ferrets from lethal Hendra virus challenge

(2011) Jackie Pallister et al.   VACCINE

Safety and immunogenicity of a recombinant M2e–flagellin influenza vaccine (STF2.4xM2e) in healthy adults

(2011) Christine B. Turley et al.   VACCINE

A comparison of methods for purification and concentration of norovirus GII-4 capsid virus-like particles

(2010) L. Huhti et al.   ARCHIVES OF VIROLOGY

Modeling the competition between aggregation and self-assembly during virus-like particle processing

(2010) Yong Ding et al.   BIOTECHNOLOGY AND BIOENGINEERING

A Lentiviral Strategy for Highly Efficient Retrograde Gene Transfer by Pseudotyping with Fusion Envelope Glycoprotein

(2010) Shigeki Kato et al.   HUMAN GENE THERAPY

Structure of Hepatitis E Virion-sized Particle Reveals an RNA-dependent Viral Assembly Pathway

(2010) Li Xing et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiscaling for systems with a broad continuum of characteristic lengths and times: Structural transitions in nanocomposites

(2010) S. Pankavich et al.   JOURNAL OF MATHEMATICAL PHYSICS

A virus-like particle vaccine for epidemic Chikungunya virus protects nonhuman primates against infection

(2010) Wataru Akahata et al.   NATURE MEDICINE

RNA-mediated chaperone type for de novo protein folding

(2010) Seong Il Choi et al.   RNA Biology

Viral nanoparticles and virus-like particles: platforms for contemporary vaccine design

(2010) Emily M. Plummer et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Influenza Virus Vaccine Based on the Conserved Hemagglutinin Stalk Domain

(2010) J. Steel et al.   mBio

Broadly Protective Monoclonal Antibodies against H3 Influenza Viruses following Sequential Immunization with Different Hemagglutinins

(2010) Taia T. Wang et al.   PLoS Pathogens

Innate signaling regulates cross-priming at the level of DC licensing and not antigen presentation

(2009) Susanne A. Keller et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Use of hepadnavirus core proteins as vaccine platforms

(2009) David C Whitacre et al.   Expert Review of Vaccines

Biological Gene Delivery Vehicles: Beyond Viral Vectors

(2009) Yiqi Seow et al.   MOLECULAR THERAPY

Quality by design for biopharmaceuticals

(2009) Anurag S Rathore et al.   NATURE BIOTECHNOLOGY

Vaccines in a hurry

(2009) Christian Søborg et al.   VACCINE

The coming of age of virus-like particle vaccines

(2008) Gary T. Jennings et al.   BIOLOGICAL CHEMISTRY

Vaccination greatly reduces disease, disability, death and inequity worldwide

(2008) FE Andre et al.   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Nanoparticles target distinct dendritic cell populations according to their size

(2008) Vania Manolova et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Viral vectors for production of recombinant proteins in plants

(2008) Chiara Lico et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Noroviruses: A comprehensive review

(2008) Manish M. Patel et al.   JOURNAL OF CLINICAL VIROLOGY

Physical Stabilization of Norwalk Virus‐Like Particles**The views, opinions and/or findings contained in this report are those of the author(s) and should not be construed as an official Department of the Army position, policy or decision unless so designated by other documentation.

(2008) Julian Kissmann et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

VIPERdb2: an enhanced and web API enabled relational database for structural virology

(2008) M. Carrillo-Tripp et al.   NUCLEIC ACIDS RESEARCH

Protein Solubility and Folding Enhancement by Interaction with RNA

(2008) Seong Il Choi et al.   PLoS One

Escherichia coli-based cell-free synthesis of virus-like particles

(2007) Bradley C. Bundy et al.   BIOTECHNOLOGY AND BIOENGINEERING