Role of negative regulation of immune signaling pathways in neutrophil function

IL-20 promotes epithelial healing of the injured mouse cornea

(2017) Wanyu Zhang et al.   EXPERIMENTAL EYE RESEARCH

IL-20 Signaling in Activated Human Neutrophils Inhibits Neutrophil Migration and Function

(2017) Portia Gough et al.   JOURNAL OF IMMUNOLOGY

Early tyrosine phosphorylation events following adenosine A 2A receptor in human neutrophils: identification of regulated pathways

(2017) Miriam S. Giambelluca et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophil-mediated vascular barrier injury: Role of neutrophil extracellular traps

(2017) Jamie E. Meegan et al.   MICROCIRCULATION

Protein Tyrosine Phosphatase-1B Negatively Impacts Host Defense against Pseudomonas aeruginosa Infection

(2016) Lei Yue et al.   AMERICAN JOURNAL OF PATHOLOGY

Biomarker-guided clinical development of the first-in-class anti-inflammatory FPR2/ALX agonist ACT-389949

(2016) Anna K. Stalder et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Pathobiology of neutrophil-epithelial interactions

(2016) Jennifer C. Brazil et al.   IMMUNOLOGICAL REVIEWS

Regulation of neutrophil functions through inhibitory receptors: an emerging paradigm in health and disease

(2016) Benoit Favier   IMMUNOLOGICAL REVIEWS

Rac GTPase Activating Protein ARHGAP25 Regulates Leukocyte Transendothelial Migration in Mice

(2016) Roland Csépányi-Kömi et al.   JOURNAL OF IMMUNOLOGY

Signal Inhibitory Receptor on Leukocytes-1 Limits the Formation of Neutrophil Extracellular Traps, but Preserves Intracellular Bacterial Killing

(2016) Kristof Van Avondt et al.   JOURNAL OF IMMUNOLOGY

Protein tyrosine phosphatase 1B negatively regulates S100A9-mediated lung damage during respiratory syncytial virus exacerbations

(2016) R F Foronjy et al.   Mucosal Immunology

Preferential Recruitment of Neutrophils into the Cerebellum and Brainstem Contributes to the Atypical Experimental Autoimmune Encephalomyelitis Phenotype

(2015) Yudong Liu et al.   JOURNAL OF IMMUNOLOGY

Host and pathogen hyaluronan signal through human siglec-9 to suppress neutrophil activation

(2015) Ismael Secundino et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Siglec receptors impact mammalian lifespan by modulating oxidative stress

(2015) Flavio Schwarz et al.   eLife

RhoA determines disease progression by controlling neutrophil motility and restricting hyperresponsiveness

(2014) R. T. Jennings et al.   BLOOD

Clec12a Is an Inhibitory Receptor for Uric Acid Crystals that Regulates Inflammation in Response to Cell Death

(2014) Konstantin Neumann et al.   IMMUNITY

Signal Regulatory Protein Alpha Is Present in Several Neutrophil Granule Populations and Is Rapidly Mobilized to the Cell Surface to Negatively Fine-Tune Neutrophil Accumulation in Inflammation

(2014) Åsa Stenberg et al.   Journal of Innate Immunity

Pivotal role of protein tyrosine phosphatase 1B (PTP1B) in the macrophage response to pro-inflammatory and anti-inflammatory challenge

(2014) P G Través et al.   Cell Death & Disease

Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b  2-integrin-dependent signaling

(2013) S. J. McMillan et al.   BLOOD

Distinct Roles for Neutrophils and Dendritic Cells in Inflammation and Autoimmunity in motheaten Mice

(2013) Clare L. Abram et al.   IMMUNITY

Neutrophil cell surface receptors and their intracellular signal transduction pathways

(2013) Krisztina Futosi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Ligation of Signal Inhibitory Receptor on Leukocytes-1 Suppresses the Release of Neutrophil Extracellular Traps in Systemic Lupus Erythematosus

(2013) Kristof Van Avondt et al.   PLoS One

Phosphatase Wip1 negatively regulates neutrophil development through p38 MAPK-STAT1

(2012) G. Liu et al.   BLOOD

Sialoglycoproteins adsorbed by Pseudomonas aeruginosa facilitate their survival by impeding neutrophil extracellular trap through siglec-9

(2012) B. Khatua et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophil infiltration during inflammation is regulated by PILRα via modulation of integrin activation

(2012) Jing Wang et al.   NATURE IMMUNOLOGY

The kinase Btk negatively regulates the production of reactive oxygen species and stimulation-induced apoptosis in human neutrophils

(2012) Fumiko Honda et al.   NATURE IMMUNOLOGY

TIPE2 protein serves as a negative regulator of phagocytosis and oxidative burst during infection

(2012) Z. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CEACAM1 Negatively Regulates IL-1β Production in LPS Activated Neutrophils by Recruiting SHP-1 to a SYK-TLR4-CEACAM1 Complex

(2012) Rongze Lu et al.   PLoS Pathogens

Targeting cytosolic proliferating cell nuclear antigen in neutrophil-dominated inflammation

(2012) Alessia De Chiara et al.   Frontiers in Immunology

Proteins derived from neutrophil extracellular traps may serve as self-antigens and mediate organ damage in autoimmune diseases

(2012) Jason S. Knight et al.   Frontiers in Immunology

Alteration in the Gene Encoding Protein Tyrosine Phosphatase Nonreceptor Type 6 (PTPN6/SHP1) May Contribute to Neutrophilic Dermatoses

(2011) Andrew B. Nesterovitch et al.   AMERICAN JOURNAL OF PATHOLOGY

ARHGAP25, a novel Rac GTPase-activating protein, regulates phagocytosis in human neutrophilic granulocytes

(2011) R. Csepanyi-Komi et al.   BLOOD

The RacGAP ArhGAP15 is a master negative regulator of neutrophil functions

(2011) C. Costa et al.   BLOOD

The GTPase-activating protein ARAP3 regulates chemotaxis and adhesion-dependent processes in neutrophils

(2011) L. Gambardella et al.   BLOOD

Neutrophils, from Marrow to Microbes

(2010) Niels Borregaard   IMMUNITY

CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow

(2010) Kyle J. Eash et al.   JOURNAL OF CLINICAL INVESTIGATION

Anti-Inflammatory Role of the Murine Formyl-Peptide Receptor 2: Ligand-Specific Effects on Leukocyte Responses and Experimental Inflammation

(2010) Neil Dufton et al.   JOURNAL OF IMMUNOLOGY

Neutrophil spontaneous death is mediated by down-regulation of autocrine signaling through GPCR, PI3K , ROS, and actin

(2010) Y. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil function in inflammation and inflammatory diseases

(2010) H. L. Wright et al.   RHEUMATOLOGY

Targeted deletion of tumor suppressor PTEN augments neutrophil function and enhances host defense in neutropenia-associated pneumonia

(2009) Y. Li et al.   BLOOD

Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response

(2009) A. F. Carlin et al.   BLOOD

CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions

(2009) Kyle J. Eash et al.   BLOOD

Regulation of neutrophil apoptosis by modulation of PKB/Akt activation

(2009) Madhavi et al.   Frontiers in Bioscience-Landmark

Group BStreptococcussuppression of phagocyte functions by protein-mediated engagement of human Siglec-5

(2009) Aaron F. Carlin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Myeloid-Specific Deletion of Tumor Suppressor PTEN Augments Neutrophil Transendothelial Migration during Inflammation

(2009) B. Sarraj et al.   JOURNAL OF IMMUNOLOGY

Bcr and Abr Cooperate in Negatively Regulating Acute Inflammatory Responses

(2009) J. M. Cunnick et al.   MOLECULAR AND CELLULAR BIOLOGY

Neutrophil apoptosis and the resolution of infection

(2008) Adam D. Kennedy et al.   IMMUNOLOGIC RESEARCH

The CD300a (IRp60) inhibitory receptor is rapidly up-regulated on human neutrophils in response to inflammatory stimuli and modulates CD32a (FcγRIIa) mediated signaling

(2007) Yelina Alvarez et al.   MOLECULAR IMMUNOLOGY