Interactions between the microbiota and innate and innate-like lymphocytes

An Ocular Commensal Protects against Corneal Infection by Driving an Interleukin-17 Response from Mucosal γδ T Cells

(2017) Anthony J. St. Leger et al.   IMMUNITY

The Toll-like receptor 9 signalling pathway regulates MR1-mediated bacterial antigen presentation in B cells

(2017) Jianyun Liu et al.   IMMUNOLOGY

Human circulating group 2 innate lymphoid cells can express CD154 and promote IgE production

(2017) Laura Maggi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Multiple layers of heterogeneity and subset diversity in human MAIT cell responses to distinct microorganisms and to innate cytokines

(2017) Joana Dias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lactobacillus reuteriinduces gut intraepithelial CD4+CD8αα+T cells

(2017) Luisa Cervantes-Barragan et al.   SCIENCE

Intestinal commensal bacteria mediate lung mucosal immunity and promote resistance of newborn mice to infection

(2017) Jerilyn Gray et al.   Science Translational Medicine

The microbiota maintain homeostasis of liver-resident γδT-17 cells in a lipid antigen/CD1d-dependent manner

(2017) Fenglei Li et al.   Nature Communications

Microbiota-activated CD103+ DCs stemming from microbiota adaptation specifically drive γδT17 proliferation and activation

(2017) Chris Fleming et al.   Microbiome

Microbiota-derived butyrate suppresses group 3 innate lymphoid cells in terminal ileal Peyer’s patches

(2017) Sae-Hae Kim et al.   Scientific Reports

Temporal Stability and Composition of the Ocular Surface Microbiome

(2017) Jerome Ozkan et al.   Scientific Reports

The Spectrum and Regulatory Landscape of Intestinal Innate Lymphoid Cells Are Shaped by the Microbiome

(2016) Meital Gury-BenAri et al.   CELL

Temporal Stability of the Human Skin Microbiome

(2016) Julia Oh et al.   CELL

Lymphoid-Tissue-Resident Commensal Bacteria Promote Members of the IL-10 Cytokine Family to Establish Mutualism

(2016) Thomas C. Fung et al.   IMMUNITY

Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8 + T Cell-Mediated Immunity in Colorectal Cancer

(2016) Nupur Bhattacharya et al.   IMMUNITY

Intrinsic functional defects of type 2 innate lymphoid cells impair innate allergic inflammation in promyelocytic leukemia zinc finger (PLZF)–deficient mice

(2016) Philip A. Verhoef et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

NKT Cell–Deficient Mice Harbor an Altered Microbiota That Fuels Intestinal Inflammation during Chemically Induced Colitis

(2016) Thirumahal Selvanantham et al.   JOURNAL OF IMMUNOLOGY

A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage

(2016) Hui-Fern Koay et al.   NATURE IMMUNOLOGY

The microbiome in early life: implications for health outcomes

(2016) Sabrina Tamburini et al.   NATURE MEDICINE

Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδ T cells

(2016) Corinne Benakis et al.   NATURE MEDICINE

The maternal microbiota drives early postnatal innate immune development

(2016) M. Gomez de Aguero et al.   SCIENCE

How colonization by microbiota in early life shapes the immune system

(2016) Thomas Gensollen et al.   SCIENCE

B-1 Cell Heterogeneity and the Regulation of Natural and Antigen-Induced IgM Production

(2016) Nicole Baumgarth   Frontiers in Immunology

Enterogenous bacterial glycolipids are required for the generation of natural killer T cells mediated liver injury

(2016) Yingfeng Wei et al.   Scientific Reports

An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses

(2015) Teruyuki Sano et al.   CELL

Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells

(2015) Koji Atarashi et al.   CELL

Innate Immune Defenses Mediated by Two ILC Subsets Are Critical for Protection against Acute Clostridium difficile Infection

(2015) Michael C. Abt et al.   Cell Host & Microbe

Natural Killer Cell Memory

(2015) Timothy E. O’Sullivan et al.   IMMUNITY

Innate Lymphoid Cells Control Early Colonization Resistance against Intestinal Pathogens through ID2-Dependent Regulation of the Microbiota

(2015) Xiaohuan Guo et al.   IMMUNITY

Recognition of Vitamin B Precursors and Byproducts by Mucosal Associated Invariant T Cells

(2015) Sidonia B. G. Eckle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers

(2015) Azad Rahimpour et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of a Potent Microbial Lipid Antigen for Diverse NKT Cells

(2015) Benjamin J. Wolf et al.   JOURNAL OF IMMUNOLOGY

The biology of innate lymphoid cells

(2015) David Artis et al.   NATURE

The burgeoning family of unconventional T cells

(2015) Dale I Godfrey et al.   NATURE IMMUNOLOGY

Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells

(2015) Claudia U Duerr et al.   NATURE IMMUNOLOGY

PLZF expression maps the early stages of ILC1 lineage development

(2015) Michael G. Constantinides et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4+ T cells

(2015) M. R. Hepworth et al.   SCIENCE

Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis

(2015) Peter Zanvit et al.   Nature Communications

Homeostatic Control of Memory Cell Progenitors in the Natural Killer Cell Lineage

(2015) Yosuke Kamimura et al.   Cell Reports

γδT Cells: First Line of Defense and Beyond

(2014) Yueh-hsiu Chien et al.   Annual Review of Immunology

Sphingolipids from a Symbiotic Microbe Regulate Homeostasis of Host Intestinal Natural Killer T Cells

(2014) Dingding An et al.   CELL

Role of the Microbiota in Immunity and Inflammation

(2014) Yasmine Belkaid et al.   CELL

CD3bright signals on γδ T cells identify IL-17A-producing Vγ6Vδ1+ T cells

(2014) C Paget et al.   IMMUNOLOGY AND CELL BIOLOGY

Oral-resident natural Th17 cells and γδ T cells control opportunisticCandida albicansinfections

(2014) Heather R. Conti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Innate PLZF+CD4+αβ T Cells Develop and Expand in the Absence of Itk

(2014) Amanda L. Prince et al.   JOURNAL OF IMMUNOLOGY

Invariant natural killer T cells developing in the human fetus accumulate and mature in the small intestine

(2014) L Loh et al.   Mucosal Immunology

Rapid fucosylation of intestinal epithelium sustains host–commensal symbiosis in sickness

(2014) Joseph M. Pickard et al.   NATURE

A committed precursor to innate lymphoid cells

(2014) Michael G. Constantinides et al.   NATURE

Polyclonal type II natural killer T cells require PLZF and SAP for their development and contribute to CpG-mediated antitumor response

(2014) J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbiota-Dependent Crosstalk Between Macrophages and ILC3 Promotes Intestinal Homeostasis

(2014) A. Mortha et al.   SCIENCE

Adaptation of Innate Lymphoid Cells to a Micronutrient Deficiency Promotes Type 2 Barrier Immunity

(2014) S. P. Spencer et al.   SCIENCE

Innate lymphoid cells regulate intestinal epithelial cell glycosylation

(2014) Y. Goto et al.   SCIENCE

Acquisition of innate-like microbial reactivity in mucosal tissues during human fetal MAIT-cell development

(2014) Edwin Leeansyah et al.   Nature Communications

Naturally secreted immunoglobulins limit B1 and MZ B-cell numbers through a microbiota-independent mechanism

(2013) A. C. Lino et al.   BLOOD

Transcriptional regulation of the NKT cell lineage

(2013) Michael G Constantinides et al.   CURRENT OPINION IN IMMUNOLOGY

Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22

(2013) Teresa Zelante et al.   IMMUNITY

Intestinal bacteria induce TSLP to promote mutualistic T-cell responses

(2013) I Mosconi et al.   Mucosal Immunology

A T-bet gradient controls the fate and function of CCR6−RORγt+ innate lymphoid cells

(2013) Christoph S. N. Klose et al.   NATURE

Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria

(2013) Matthew R. Hepworth et al.   NATURE

Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells

(2013) You Jeong Lee et al.   NATURE IMMUNOLOGY

Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs

(2013) R. V. V. Tatituri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Long-Term Stability of the Human Gut Microbiota

(2013) J. J. Faith et al.   SCIENCE

The ARNT–STAT3 axis regulates the differentiation of intestinal intraepithelial TCRαβ+CD8αα+ cells

(2013) Kohei Nakajima et al.   Nature Communications

Intestinal Microbes Affect Phenotypes and Functions of Invariant Natural Killer T Cells in Mice

(2012) Gerhard Wingender et al.   GASTROENTEROLOGY

Commensal Bacteria Calibrate the Activation Threshold of Innate Antiviral Immunity

(2012) Michael C. Abt et al.   IMMUNITY

Priming of Natural Killer Cells by Nonmucosal Mononuclear Phagocytes Requires Instructive Signals from Commensal Microbiota

(2012) Stephanie C. Ganal et al.   IMMUNITY

Co-dependents: MR1-restricted MAIT cells and their antimicrobial function

(2012) Marielle C. Gold et al.   NATURE REVIEWS MICROBIOLOGY

Innate Lymphoid Cells Promote Anatomical Containment of Lymphoid-Resident Commensal Bacteria

(2012) G. F. Sonnenberg et al.   SCIENCE

Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function

(2012) T. Olszak et al.   SCIENCE

The Aryl Hydrocarbon Receptor Regulates Gut Immunity through Modulation of Innate Lymphoid Cells

(2011) Ju Qiu et al.   IMMUNITY

Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus

(2011) Laurel A Monticelli et al.   NATURE IMMUNOLOGY

RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota

(2011) Shinichiro Sawa et al.   NATURE IMMUNOLOGY

AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch

(2011) Jacob S Lee et al.   NATURE IMMUNOLOGY

Natural Aryl Hydrocarbon Receptor Ligands Control Organogenesis of Intestinal Lymphoid Follicles

(2011) E. A. Kiss et al.   SCIENCE

Marginal Zone B-Cells, a Gatekeeper of Innate Immunity

(2011) Moncef Zouali et al.   Frontiers in Immunology

Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells

(2010) M. Dusseaux et al.   BLOOD

Microbial Colonization Drives Expansion of IL-1 Receptor 1-Expressing and IL-17-Producing γ/δ T Cells

(2010) Jinyou Duan et al.   Cell Host & Microbe

Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

(2010) Daniel R. Neill et al.   NATURE

Antimicrobial activity of mucosal-associated invariant T cells

(2010) Lionel Le Bourhis et al.   NATURE IMMUNOLOGY

Systemically dispersed innate IL-13-expressing cells in type 2 immunity

(2010) A. E. Price et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lineage Relationship Analysis of RORγt+Innate Lymphoid Cells

(2010) Shinichiro Sawa et al.   SCIENCE

Cd1d-dependent regulation of bacterial colonization in the intestine of mice

(2009) Edward E.S. Nieuwenhuis et al.   JOURNAL OF CLINICAL INVESTIGATION

Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells

(2009) Kazuyo Moro et al.   NATURE

Clostridium difficile infection: new developments in epidemiology and pathogenesis

(2009) Maja Rupnik et al.   NATURE REVIEWS MICROBIOLOGY

TCR-inducible PLZF transcription factor required for innate phenotype of a subset of    T cells with restricted TCR diversity

(2009) T. Kreslavsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resident enteric microbiota and CD8+ T cells shape the abundance of marginal zone B cells

(2008) Bo Wei et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Microbial Flora Drives Interleukin 22 Production in Intestinal NKp46+ Cells that Provide Innate Mucosal Immune Defense

(2008) Naoko Satoh-Takayama et al.   IMMUNITY

The Transcription Factor PLZF Directs the Effector Program of the NKT Cell Lineage

(2008) Adam K. Savage et al.   IMMUNITY

Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis

(2008) Djahida Bouskra et al.   NATURE

RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46+ cells

(2008) Stephanie L Sanos et al.   NATURE IMMUNOLOGY

The BTB–zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions

(2008) Damian Kovalovsky et al.   NATURE IMMUNOLOGY