The role of complement inhibitors beyond controlling inflammation

Deficiency of the complement regulatory protein CD59 accelerates the development of diabetes-induced atherosclerosis in mice

(2017) Fengming Liu et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Non-traditional roles of complement in type 2 diabetes: Metabolism, insulin secretion and homeostasis

(2017) Ben C. King et al.   MOLECULAR IMMUNOLOGY

Therapy with eculizumab for patients with CD59 p.Cys89Tyr mutation

(2016) Dror Mevorach et al.   ANNALS OF NEUROLOGY

Complement in removal of the dead - balancing inflammation

(2016) Myriam Martin et al.   IMMUNOLOGICAL REVIEWS

Protection of host cells by complement regulators

(2016) Christoph Q. Schmidt et al.   IMMUNOLOGICAL REVIEWS

CD46 Activation Regulates miR-150–Mediated Control of GLUT1 Expression and Cytokine Secretion in Human CD4+T Cells

(2016) Ben C. King et al.   JOURNAL OF IMMUNOLOGY

Cartilage oligomeric matrix protein contributes to the development and metastasis of breast cancer

(2016) E Englund et al.   ONCOGENE

The human complement inhibitor Sushi Domain-Containing Protein 4 (SUSD4) expression in tumor cells and infiltrating T cells is associated with better prognosis of breast cancer patients

(2015) Emelie Englund et al.   BMC CANCER

Role of Complement and Complement Regulatory Proteins in the Complications of Diabetes

(2015) Pamela Ghosh et al.   ENDOCRINE REVIEWS

Moraxella catarrhalisEvades Host Innate Immunity via Targeting Cartilage Oligomeric Matrix Protein

(2015) Guanghui Liu et al.   JOURNAL OF IMMUNOLOGY

The Complement Inhibitor CD59 Regulates Insulin Secretion by Modulating Exocytotic Events

(2014) Ulrika Krus et al.   Cell Metabolism

Cartilage oligomeric matrix protein and its binding partners in the cartilage extracellular matrix: Interaction, regulation and role in chondrogenesis

(2014) Chitrangada Acharya et al.   MATRIX BIOLOGY

The novel complement inhibitor human CUB and Sushi multiple domains 1 (CSMD1) protein promotes factor I-mediated degradation of C4b and C3b and inhibits the membrane attack complex assembly

(2013) Astrid Escudero-Esparza et al.   FASEB JOURNAL

Sushi domain-containing protein 4 (SUSD4) inhibits complement by disrupting the formation of the classical C3 convertase

(2013) Emelie Holmquist et al.   FASEB JOURNAL

COMP-C3b Complexes in Rheumatoid Arthritis with Severe Extraarticular Manifestations

(2013) K. E. Happonen et al.   JOURNAL OF RHEUMATOLOGY

Neuropsychological Deficits in Mice Depleted of the Schizophrenia Susceptibility Gene CSMD1

(2013) Vidar M. Steen et al.   PLoS One

CSMD1 exhibits antitumor activity in A375 melanoma cells through activation of the Smad pathway

(2012) Ming-Rui Tang et al.   APOPTOSIS

A Thrombospondin-Dependent Pathway for a Protective ER Stress Response

(2012) Jeffrey M. Lynch et al.   CELL

The “quad-partite” synapse: Microglia-synapse interactions in the developing and mature CNS

(2012) Dorothy P. Schafer et al.   GLIA

Interactions of the complement system with molecules of extracellular matrix: Relevance for joint diseases

(2012) Kaisa E. Happonen et al.   IMMUNOBIOLOGY

Transient GPI-anchored protein homodimers are units for raft organization and function

(2012) Kenichi G N Suzuki et al.   Nature Chemical Biology

The CD46-Jagged1 interaction is critical for human TH1 immunity

(2012) Gaëlle Le Friec et al.   NATURE IMMUNOLOGY

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Serum COMP-C3b complexes in rheumatic diseases and relation to anti-TNF-α treatment

(2012) Kaisa E Happonen et al.   ARTHRITIS RESEARCH & THERAPY

The Complement Control-Related Genes CSMD1 and CSMD2 Associate to Schizophrenia

(2011) Bjarte Håvik et al.   BIOLOGICAL PSYCHIATRY

Complement factor I in health and disease

(2011) Sara C. Nilsson et al.   MOLECULAR IMMUNOLOGY

Genome-wide association study identifies five new schizophrenia loci

(2011)   NATURE GENETICS

Thrombospondin-1 Contributes to Mortality in Murine Sepsis through Effects on Innate Immunity

(2011) Sara McMaken et al.   PLoS One

IFN-  and CD46 stimulation are associated with active lupus and skew natural T regulatory cell differentiation to type 1 regulatory T (Tr1) cells

(2011) H. Le Buanec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue Distribution and Functional Analysis of Sushi Domain-Containing Protein 4

(2010) Zhidan Tu et al.   AMERICAN JOURNAL OF PATHOLOGY

Regulation of complement by cartilage oligomeric matrix protein allows for a novel molecular diagnostic principle in rheumatoid arthritis

(2010) Kaisa E. Happonen et al.   ARTHRITIS AND RHEUMATISM

CharacterizationCSMD1in a large set of primary lung, head and neck, breast and skin cancer tissues

(2010) Changqing Ma et al.   CANCER BIOLOGY & THERAPY

Replication of top markers of a genome-wide association study in multiple sclerosis in Spain

(2010) M L Cavanillas et al.   GENES AND IMMUNITY

Complement control protein factor H: The good, the bad, and the inadequate

(2010) Viviana P. Ferreira et al.   MOLECULAR IMMUNOLOGY

Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells

(2010) John Cardone et al.   NATURE IMMUNOLOGY

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Loss of CSMD1 expression is associated with high tumour grade and poor survival in invasive ductal breast carcinoma

(2009) Mohamed Kamal et al.   BREAST CANCER RESEARCH AND TREATMENT

Complement Regulator CD59 Protects Against Atherosclerosis by Restricting the Formation of Complement Membrane Attack Complex

(2009) Gongxiong Wu et al.   CIRCULATION RESEARCH

Cartilage Oligomeric Matrix Protein Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells by Interacting With α 7 β 1 Integrin

(2009) Li Wang et al.   CIRCULATION RESEARCH

Cartilage oligomeric matrix protein promotes cell attachment via two independent mechanisms involving CD47 and αVβ3 integrin

(2009) Matthew J. Rock et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Complement evasion strategies of pathogens—Acquisition of inhibitors and beyond

(2009) Anna M. Blom et al.   MOLECULAR IMMUNOLOGY

Modulation of the antitumor immune response by complement

(2008) Maciej M Markiewski et al.   NATURE IMMUNOLOGY