Discovery of a new diol-containing polyketide by heterologous expression of a silent biosynthetic gene cluster from Streptomyces lavendulae FRI-5

Identification and characterization of lbpA , an indigoidine biosynthetic gene in the γ-butyrolactone signaling system of Streptomyces lavendulae FRI-5

(2017) Ivy Grace Umadhay Pait et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Streptenols F–I Isolated from the Marine-Derived Streptomyces misionensis BAT-10-03-023

(2017) Guillermo Tarazona et al.   JOURNAL OF NATURAL PRODUCTS

Identification by Genome Mining of a Type I Polyketide Gene Cluster from Streptomyces argillaceus Involved in the Biosynthesis of Pyridine and Piperidine Alkaloids Argimycins P

(2017) Suhui Ye et al.   Frontiers in Microbiology

Domain Organization and Active Site Architecture of a Polyketide Synthase C-methyltransferase

(2016) Meredith A. Skiba et al.   ACS Chemical Biology

Production of a Novel Amide-Containing Polyene by Activating a Cryptic Biosynthetic Gene Cluster inStreptomycessp. MSC090213JE08

(2016) Danyao Du et al.   CHEMBIOCHEM

Gifted microbes for genome mining and natural product discovery

(2016) Richard H. Baltz   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Prospecting for new bacterial metabolites: a glossary of approaches for inducing, activating and upregulating the biosynthesis of bacterial cryptic or silent natural products

(2016) Joseph Scott Zarins-Tutt et al.   NATURAL PRODUCT REPORTS

Mycolic acid-containing bacteria activate heterologous secondary metabolite expression in Streptomyces lividans

(2015) Hiroyasu Onaka et al.   JOURNAL OF ANTIBIOTICS

Novel terpenes generated by heterologous expression of bacterial terpene synthase genes in an engineered Streptomyces host

(2015) Yuuki Yamada et al.   JOURNAL OF ANTIBIOTICS

The Sound of Silence: Activating Silent Biosynthetic Gene Clusters in Marine Microorganisms

(2015) F. Reen et al.   Marine Drugs

Identification of the Polyketide Biosynthetic Machinery for the Indolizidine Alkaloid Cyclizidine

(2015) Wei Huang et al.   ORGANIC LETTERS

Heronamides D–F, Polyketide Macrolactams from the Deep-Sea-Derived Streptomyces sp. SCSIO 03032

(2014) Wenjun Zhang et al.   JOURNAL OF NATURAL PRODUCTS

Terpene synthases are widely distributed in bacteria

(2014) Yuuki Yamada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of a methyltransferase involved in herboxidiene biosynthesis

(2013) Dayu Yu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Activation and Products of the Cryptic Secondary Metabolite Biosynthetic Gene Clusters by Rifampin Resistance (rpoB) Mutations in Actinomycetes

(2013) Y. Tanaka et al.   JOURNAL OF BACTERIOLOGY

Genome mining of the Streptomyces avermitilis genome and development of genome-minimized hosts for heterologous expression of biosynthetic gene clusters

(2013) Haruo Ikeda et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Microbial genome mining for accelerated natural products discovery: is a renaissance in the making?

(2013) Brian O. Bachmann et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

antiSMASH 2.0—a versatile platform for genome mining of secondary metabolite producers

(2013) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

Interspecies Interactions Stimulate Diversification of the Streptomyces coelicolor Secreted Metabolome

(2013) M. F. Traxler et al.   mBio

Engineered Streptomyces avermitilis Host for Heterologous Expression of Biosynthetic Gene Cluster for Secondary Metabolites

(2013) Mamoru Komatsu et al.   ACS Synthetic Biology

New strategies for drug discovery: activation of silent or weakly expressed microbial gene clusters

(2012) Kozo Ochi et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Complete genome sequence of Saccharothrix espanaensis DSM 44229T and comparison to the other completely sequenced Pseudonocardiaceae

(2012) Tina Strobel et al.   BMC GENOMICS

Erratum: Thoughts and facts about antibiotics: Where we are now and where we are heading

(2012) János Bérdy   JOURNAL OF ANTIBIOTICS

Structure and biosynthesis of the unusual polyketide alkaloid coelimycin P1, a metabolic product of the cpk gene cluster of Streptomyces coelicolor M145

(2012) Juan Pablo Gomez-Escribano et al.   Chemical Science

Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens

(2011) L. Laureti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbial metabolites: 45 years of wandering, wondering and discovering

(2011) Satoshi Ōmura   TETRAHEDRON

Reconstitution of the FK228 Biosynthetic Pathway Reveals Cross Talk between Modular Polyketide Synthases and Fatty Acid Synthase

(2010) Shane R. Wesener et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Deletion of a regulatory gene within the cpk gene cluster reveals novel antibacterial activity in Streptomyces coelicolor A3(2)

(2010) M. Gottelt et al.   MICROBIOLOGY-SGM

Biosynthesis of polyketides by trans-AT polyketide synthases

(2010) Jörn Piel   NATURAL PRODUCT REPORTS

Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism

(2010) M. Komatsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of a regulatory gene, aveR, for the biosynthesis of avermectin in Streptomyces avermitilis

(2009) Shigeru Kitani et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Activation of secondary metabolite–biosynthetic gene clusters by generating rsmG mutations in Streptomyces griseus

(2009) Yukinori Tanaka et al.   JOURNAL OF ANTIBIOTICS

Triggering cryptic natural product biosynthesis in microorganisms

(2009) Kirstin Scherlach et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

GenomeMatcher: A graphical user interface for DNA sequence comparison

(2008) Yoshiyuki Ohtsubo et al.   BMC BIOINFORMATICS

Genome Sequence of the Streptomycin-Producing Microorganism Streptomyces griseus IFO 13350

(2008) Y. Ohnishi et al.   JOURNAL OF BACTERIOLOGY

Mining microbial genomes for new natural products and biosynthetic pathways

(2008) G. L. Challis   MICROBIOLOGY-SGM

Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol

(2008) M. Komatsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA