Prospecting for new bacterial metabolites: a glossary of approaches for inducing, activating and upregulating the biosynthesis of bacterial cryptic or silent natural products

Structure Elucidation and Activity of Kolossin A, theD-/L-Pentadecapeptide Product of a Giant Nonribosomal Peptide Synthetase

(2015) Helge B. Bode et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Lincomycin at Subinhibitory Concentrations Potentiates Secondary Metabolite Production by Streptomyces spp.

(2015) Yu Imai et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Elicitation of secondary metabolism in actinomycetes

(2015) Usama Ramadan Abdelmohsen et al.   BIOTECHNOLOGY ADVANCES

Simple “On-Demand” Production of Bioactive Natural Products

(2015) Edna Bode et al.   CHEMBIOCHEM

Iterative Mechanism of Macrodiolide Formation in the Anticancer Compound Conglobatin

(2015) Yongjun Zhou et al.   CHEMISTRY & BIOLOGY

Two Master Switch Regulators Trigger A40926 Biosynthesis in Nonomuraea sp. Strain ATCC 39727

(2015) Letizia Lo Grasso et al.   JOURNAL OF BACTERIOLOGY

A new antibiotic kills pathogens without detectable resistance

(2015) Losee L. Ling et al.   NATURE

Minimum Information about a Biosynthetic Gene cluster

(2015) Marnix H Medema et al.   Nature Chemical Biology

Discovery of microbial natural products by activation of silent biosynthetic gene clusters

(2015) Peter J. Rutledge et al.   NATURE REVIEWS MICROBIOLOGY

Activating a Cryptic Ansamycin Biosynthetic Gene Cluster To Produce Three New Naphthalenic Octaketide Ansamycins with n-Pentyl and n-Butyl Side Chains

(2015) Shanren Li et al.   ORGANIC LETTERS

Yeast homologous recombination-based promoter engineering for the activation of silent natural product biosynthetic gene clusters

(2015) Daniel Montiel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exploiting a precise design of universal synthetic modular regulatory elements to unlock the microbial natural products inStreptomyces

(2015) Chaoxian Bai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterologous production of fungal secondary metabolites in Aspergilli

(2015) Diana Chinyere Anyaogu et al.   Frontiers in Microbiology

Microbial communication leading to the activation of silent fungal secondary metabolite gene clusters

(2015) Tina Netzker et al.   Frontiers in Microbiology

Discovery of Clostrubin, an Exceptional Polyphenolic Polyketide Antibiotic from a Strictly Anaerobic Bacterium

(2014) Sacha Pidot et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Spatial and temporal control of fungal natural product synthesis

(2014) Fang Yun Lim et al.   NATURAL PRODUCT REPORTS

An environmental bacterial taxon with a large and distinct metabolic repertoire

(2014) Micheal C. Wilson et al.   NATURE

High-throughput platform for the discovery of elicitors of silent bacterial gene clusters

(2014) M. R. Seyedsayamdost   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A

(2014) Kazuya Yamanaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation and identification of five clusters for secondary metabolites inStreptomyces albus J1074

(2014) Carlos Olano et al.   Microbial Biotechnology

Activation and Products of the Cryptic Secondary Metabolite Biosynthetic Gene Clusters by Rifampin Resistance (rpoB) Mutations in Actinomycetes

(2013) Y. Tanaka et al.   JOURNAL OF BACTERIOLOGY

Exploitation of the Streptomyces coelicolor A3(2) genome sequence for discovery of new natural products and biosynthetic pathways

(2013) Gregory L. Challis   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Bioinformatics tools for genome mining of polyketide and non-ribosomal peptides

(2013) Christopher N. Boddy   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Strategies for mining fungal natural products

(2013) Philipp Wiemann et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

The role of transcription in heterologous expression of polyketides in bacterial hosts

(2013) D. Cole Stevens et al.   NATURAL PRODUCT REPORTS

MS/MS networking guided analysis of molecule and gene cluster families

(2013) D. D. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The antibiotic planosporicin coordinates its own production in the actinomycete Planomonospora alba

(2013) E. J. Sherwood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of a family of γ-aminobutyrate ureas via rational derepression of a silent bacterial gene cluster

(2013) John D. Sidda et al.   Chemical Science

Interspecies Interactions Stimulate Diversification of the Streptomyces coelicolor Secreted Metabolome

(2013) M. F. Traxler et al.   mBio

New strategies for drug discovery: activation of silent or weakly expressed microbial gene clusters

(2012) Kozo Ochi et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Induction of Antifouling Diterpene Production byStreptomyces cinnabarinusPK209 in Co-Culture with Marine-DerivedAlteromonassp. KNS-16

(2012) Ji Young CHO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

The Butenolide Signaling Molecules SRB1 and SRB2 Induce Lankacidin and Lankamycin Production in Streptomyces rochei

(2012) Kenji Arakawa et al.   CHEMBIOCHEM

Finished bacterial genomes from shotgun sequence data

(2012) F. J. Ribeiro et al.   GENOME RESEARCH

Luminmycins A–C, Cryptic Natural Products from Photorhabdus luminescens Identified by Heterologous Expression in Escherichia coli

(2012) Xiaoying Bian et al.   JOURNAL OF NATURAL PRODUCTS

Tetarimycin A, an MRSA-Active Antibiotic Identified through Induced Expression of Environmental DNA Gene Clusters

(2012) Dimitris Kallifidas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A genomic approach to the cryptic secondary metabolome of the anaerobic world

(2012) Anne-Catrin Letzel et al.   NATURAL PRODUCT REPORTS

Regulation of fungal secondary metabolism

(2012) Axel A. Brakhage   NATURE REVIEWS MICROBIOLOGY

Structure and biosynthesis of the unusual polyketide alkaloid coelimycin P1, a metabolic product of the cpk gene cluster of Streptomyces coelicolor M145

(2012) Juan Pablo Gomez-Escribano et al.   Chemical Science

A cryptic antibiotic triggered by monensin

(2011) Sho-ichi Amano et al.   JOURNAL OF ANTIBIOTICS

Chaxamycins A–D, Bioactive Ansamycins from a Hyper-arid DesertStreptomycessp.

(2011) Mostafa E. Rateb et al.   JOURNAL OF NATURAL PRODUCTS

Diverse Metabolic Profiles of aStreptomycesStrain Isolated from a Hyper-arid Environment

(2011) Mostafa E. Rateb et al.   JOURNAL OF NATURAL PRODUCTS

antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences

(2011) Marnix H. Medema et al.   NUCLEIC ACIDS RESEARCH

The Revised Structure, Total Synthesis, and Absolute Configuration of Streptophenazine A

(2011) Zhicai Yang et al.   ORGANIC LETTERS

Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens

(2011) L. Laureti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Avenolide, a Streptomyces hormone controlling antibiotic production in Streptomyces avermitilis

(2011) S. Kitani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting

(2011) F. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative Actions for Antibiotics

(2011) W. C. Ratcliff et al.   SCIENCE

Mycolic Acid-Containing Bacteria Induce Natural-Product Biosynthesis inStreptomycesSpecies

(2010) Hiroyasu Onaka et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The dynamic architecture of the metabolic switch in Streptomyces coelicolor

(2010) Kay Nieselt et al.   BMC GENOMICS

Pacidamycin Biosynthesis: Identification and Heterologous Expression of the First Uridyl Peptide Antibiotic Gene Cluster

(2010) Emma J. Rackham et al.   CHEMBIOCHEM

Fungal secondary metabolites – Strategies to activate silent gene clusters

(2010) Axel A. Brakhage et al.   FUNGAL GENETICS AND BIOLOGY

Promomycin, a polyether promoting antibiotic production in Streptomyces spp.

(2010) Sho-ichi Amano et al.   JOURNAL OF ANTIBIOTICS

Streptomyces and Saccharopolyspora hosts for heterologous expression of secondary metabolite gene clusters

(2010) Richard H. Baltz   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Fluostatins Produced by the Heterologous Expression of a TAR Reassembled Environmental DNA Derived Type II PKS Gene Cluster

(2010) Zhiyang Feng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Induced Biosynthesis of Cryptic Polyketide Metabolites in a Burkholderia thailandensis Quorum Sensing Mutant

(2010) Keishi Ishida et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Deletion of a regulatory gene within the cpk gene cluster reveals novel antibacterial activity in Streptomyces coelicolor A3(2)

(2010) M. Gottelt et al.   MICROBIOLOGY-SGM

SBSPKS: structure based sequence analysis of polyketide synthases

(2010) Swadha Anand et al.   NUCLEIC ACIDS RESEARCH

Identification of the biosynthetic gene cluster for the pacidamycin group of peptidyl nucleoside antibiotics

(2010) W. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism

(2010) M. Komatsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters

(2010) Juan Pablo Gomez-Escribano et al.   Microbial Biotechnology

Myxococcus xanthus induces actinorhodin overproduction and aerial mycelium formation by Streptomyces coelicolor

(2010) Juana Pérez et al.   Microbial Biotechnology

Automated genome mining for natural products

(2009) Michael HT Li et al.   BMC BIOINFORMATICS

Role of sgcR3 in positive regulation of enediyne antibiotic C-1027 production of Streptomyces globisporus C-1027

(2009) Lifei Wang et al.   BMC MICROBIOLOGY

Chemical induction of silent biosynthetic pathway transcription in Aspergillus niger

(2009) K. M. Fisch et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Engineering a platform for photosynthetic isoprene production in cyanobacteria, using Synechocystis as the model organism

(2009) Pia Lindberg et al.   METABOLIC ENGINEERING

Genomic basis for natural product biosynthetic diversity in the actinomycetes

(2009) Markus Nett et al.   NATURAL PRODUCT REPORTS

Epigenome manipulation as a pathway to new natural product scaffolds and their congeners

(2009) Robert H. Cichewicz   NATURAL PRODUCT REPORTS

Triggering cryptic natural product biosynthesis in microorganisms

(2009) Kirstin Scherlach et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Drug Discovery and Natural Products: End of an Era or an Endless Frontier?

(2009) J. W.-H. Li et al.   SCIENCE

Dramatic Activation of Antibiotic Production in Streptomyces coelicolor by Cumulative Drug Resistance Mutations

(2008) G. Wang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The LuxR family members GdmRI and GdmRII are positive regulators of geldanamycin biosynthesis in Streptomyces hygroscopicus 17997

(2008) Weiqing He et al.   ARCHIVES OF MICROBIOLOGY

Elucidation of the Streptomyces coelicolor Pathway to 2-Undecylpyrrole, a Key Intermediate in Undecylprodiginine and Streptorubin B Biosynthesis

(2008) SangJoon Mo et al.   CHEMISTRY & BIOLOGY

Feast or famine: the global regulator DasR links nutrient stress to antibiotic production by Streptomyces

(2008) Sébastien Rigali et al.   EMBO REPORTS

Medical Honey for Wound Care—Still the ‘Latest Resort’?

(2008) Arne Simon et al.   Evidence-based Complementary and Alternative Medicine

Subinhibitory Concentrations of Antibiotics Induce Phenazine Production in a MarineStreptomycessp.

(2008) Maya I. Mitova et al.   JOURNAL OF NATURAL PRODUCTS

Isolation and Structural Characterization of Capistruin, a Lasso Peptide Predicted from the Genome Sequence of Burkholderia thailandensis E264

(2008) Thomas A. Knappe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

ClustScan : an integrated program package for the semi-automatic annotation of modular biosynthetic gene clusters and in silico prediction of novel chemical structures

(2008) Antonio Starcevic et al.   NUCLEIC ACIDS RESEARCH

Epigenetic remodeling of the fungal secondary metabolome

(2008) Russell B. Williams et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

2-Alkyl-4-hydroxymethylfuran-3-carboxylic acids, antibiotic production inducers discovered by Streptomyces coelicolor genome mining

(2008) C. Corre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Manipulating and understanding antibiotic production in Streptomyces coelicolor A3(2) with decoy oligonucleotides

(2008) M. McArthur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A complex role for the γ-butyrolactone SCB1 in regulating antibiotic production in Streptomyces coelicolor A3(2)

(2003) Eriko Takano et al.   MOLECULAR MICROBIOLOGY