Alternative Splicing Transcripts of Zebrafish LGP2 Gene Differentially Contribute to IFN Antiviral Response

Quantitative microspectroscopic imaging reveals viral and cellular RNA helicase interactions in live cells

(2017) M. J. Corby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PUM1 is a biphasic negative regulator of innate immunity genes by suppressing LGP2

(2017) Yonghong Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Grass Carp Laboratory of Genetics and Physiology 2 Serves As a Negative Regulator in Retinoic Acid-Inducible Gene I- and Melanoma Differentiation-Associated Gene 5-Mediated Antiviral Signaling in Resting State and Early Stage of Grass Carp Reovirus Infection

(2017) Youliang Rao et al.   Frontiers in Immunology

The evolution and functional characterization of miiuy croaker cytosolic gene LGP2 involved in immune response

(2016) Jingjing Han et al.   FISH & SHELLFISH IMMUNOLOGY

Negative regulation of the antiviral response by grouper LGP2 against fish viruses

(2016) Yepin Yu et al.   FISH & SHELLFISH IMMUNOLOGY

LGP2 of black carp plays an important role in the innate immune response against SVCV and GCRV

(2016) Jun Xiao et al.   FISH & SHELLFISH IMMUNOLOGY

Zebrafishfoxo3bNegatively Regulates Antiviral Response through Suppressing the Transactivity ofirf3andirf7

(2016) Xing Liu et al.   JOURNAL OF IMMUNOLOGY

Zebrafish IRF1, IRF3, and IRF7 Differentially Regulate IFNΦ1 and IFNΦ3 Expression through Assembly of Homo- or Heteroprotein Complexes

(2016) Hui Feng et al.   JOURNAL OF IMMUNOLOGY

Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5

(2016) Emiko Uchikawa et al.   MOLECULAR CELL

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

(2016) Qi Chen et al.   NATURE IMMUNOLOGY

LGP2 synergy with MDA5 in RLR-mediated RNA recognition and antiviral signaling

(2015) Annie M. Bruns et al.   CYTOKINE

Virus genomes and virus-host interactions in aquaculture animals

(2015) QiYa Zhang et al.   Science China-Life Sciences

Fish MAVS is involved in RLR pathway-mediated IFN response

(2014) Jun Zhang et al.   FISH & SHELLFISH IMMUNOLOGY

Zebrafish IRF1 Regulates IFN Antiviral Response through Binding to IFNϕ1 and IFNϕ3 Promoters Downstream of MyD88 Signaling

(2014) Hui Feng et al.   JOURNAL OF IMMUNOLOGY

The Innate Immune Sensor LGP2 Activates Antiviral Signaling by Regulating MDA5-RNA Interaction and Filament Assembly

(2014) Annie M. Bruns et al.   MOLECULAR CELL

Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells

(2014) Safia Deddouche et al.   eLife

Lineage-Specific Expansion of IFIT Gene Family: An Insight into Coevolution with IFN Gene Family

(2013) Ying Liu et al.   PLoS One

LGP2 Plays a Critical Role in Sensitizing mda-5 to Activation by Double-Stranded RNA

(2013) Kay S. Childs et al.   PLoS One

Innate immune detection of microbial nucleic acids

(2013) Claudia Gürtler et al.   TRENDS IN MICROBIOLOGY

Molecular regulation of interferon antiviral response in fish

(2012) Yi-Bing Zhang et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

The RIG-I-like Receptor LGP2 Controls CD8+ T Cell Survival and Fitness

(2012) Mehul S. Suthar et al.   IMMUNITY

ATP Hydrolysis Enhances RNA Recognition and Antiviral Signal Transduction by the Innate Immune Sensor, Laboratory of Genetics and Physiology 2 (LGP2)

(2012) Annie M. Bruns et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LGP2 Downregulates Interferon Production during Infection with Seasonal Human Influenza A Viruses That Activate Interferon Regulatory Factor 3

(2012) M. Malur et al.   JOURNAL OF VIROLOGY

Both STING and MAVS Fish Orthologs Contribute to the Induction of Interferon Mediated by RIG-I

(2012) Stéphane Biacchesi et al.   PLoS One

Fish MITA Serves as a Mediator for Distinct Fish IFN Gene Activation Dependent on IRF3 or IRF7

(2011) F. Sun et al.   JOURNAL OF IMMUNOLOGY

Expression and Functional Characterization of the RIG-I-Like Receptors MDA5 and LGP2 in Rainbow Trout (Oncorhynchus mykiss)

(2011) M. Chang et al.   JOURNAL OF VIROLOGY

Cooperative Roles of Fish Protein Kinase Containing Z-DNA Binding Domains and Double-Stranded RNA-Dependent Protein Kinase in Interferon-Mediated Antiviral Response

(2011) T.-K. Liu et al.   JOURNAL OF VIROLOGY

Evolutional Conservation of Molecular Structure and Antiviral Function of a Viral RNA Receptor, LGP2, in Japanese Flounder, Paralichthys olivaceus

(2010) M. Ohtani et al.   JOURNAL OF IMMUNOLOGY

Characterization of Fish IRF3 as an IFN-Inducible Protein Reveals Evolving Regulation of IFN Response in Vertebrates

(2010) F. Sun et al.   JOURNAL OF IMMUNOLOGY

Fish virus-induced interferon exerts antiviral function through Stat1 pathway

(2010) Fei-Fei Yu et al.   MOLECULAR IMMUNOLOGY

LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses

(2010) T. Satoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Signal Transduction by Enzymatically Inactive Antiviral RNA Helicase Proteins MDA5, RIG-I, and LGP2

(2009) Darja Bamming et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Two Groups of Zebrafish Virus-Induced Interferons Signal via Distinct Receptors with Specific and Shared Chains

(2009) D. Aggad et al.   JOURNAL OF IMMUNOLOGY

The regulatory domain of the RIG-I family ATPase LGP2 senses double-stranded RNA

(2009) Diana A. Pippig et al.   NUCLEIC ACIDS RESEARCH

The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

(2008) Bo Zhong et al.   IMMUNITY

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE