Interaction between Multimeric von Willebrand Factor and Complement: A Fresh Look to the Pathophysiology of Microvascular Thrombosis

Human neutrophil peptides and complement factor Bb in pathogenesis of acquired thrombotic thrombocytopenic purpura

(2016) Wenjing Cao et al.   HAEMATOLOGICA

Von Willebrand factor regulates complement on endothelial cells

(2016) Damien G. Noone et al.   KIDNEY INTERNATIONAL

Human neutrophil peptides and complement factor Bb in pathogenesis of acquired thrombotic thrombocytopenic purpura

(2016) Wenjing Cao et al.   HAEMATOLOGICA

Treatment of Congenital Thrombotic Thrombocytopenic Purpura With Eculizumab

(2015) Carmine Pecoraro et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Modified Ham test for atypical hemolytic uremic syndrome

(2015) E. Gavriilaki et al.   BLOOD

ADAMTS13 Secretion and Residual Activity among Patients with Congenital Thrombotic Thrombocytopenic Purpura with and without Renal Impairment

(2015) E. Rurali et al.   Clinical Journal of the American Society of Nephrology

Cell surface levels of endothelial ICAM-1 influence the transcellular or paracellular T-cell diapedesis across the blood-brain barrier

(2015) Michael Abadier et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Complement and platelets: Mutual interference in the immune network

(2015) Cornelia Speth et al.   MOLECULAR IMMUNOLOGY

von Willebrand factor is a cofactor in complement regulation

(2014) S. Feng et al.   BLOOD

Dynamics of complement activation in aHUS and how to monitor eculizumab therapy

(2014) M. Noris et al.   BLOOD

von Willebrand factor, Jedi knight of the bloodstream

(2014) T. A. Springer   BLOOD

Complement Factor B Mutations in Atypical Hemolytic Uremic Syndrome--Disease-Relevant or Benign?

(2014) M. C. Marinozzi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Syndromes of Thrombotic Microangiopathy

(2014) James N. George et al.   NEW ENGLAND JOURNAL OF MEDICINE

ADAMTS13 content in plasma-derived factor VIII/von Willebrand factor concentrates

(2013) Flora Peyvandi et al.   AMERICAN JOURNAL OF HEMATOLOGY

The interaction between factor H and VWF increases factor H cofactor activity and regulates VWF prothrombotic status

(2013) J. Rayes et al.   BLOOD

Potential value of targeting von Willebrand factor in atherosclerotic cardiovascular disease

(2013) Silvia Montoro-García et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Complement Activation Associated with ADAMTS13 Deficiency in Human and Murine Thrombotic Microangiopathy

(2013) R. Tati et al.   JOURNAL OF IMMUNOLOGY

Properdin in complement activation and tissue injury

(2013) Allison M. Lesher et al.   MOLECULAR IMMUNOLOGY

Terminal Complement Inhibitor Eculizumab in Atypical Hemolytic–Uremic Syndrome

(2013) C.M. Legendre et al.   NEW ENGLAND JOURNAL OF MEDICINE

Assembly and Activation of Alternative Complement Components on Endothelial Cell-Anchored Ultra-Large Von Willebrand Factor Links Complement and Hemostasis-Thrombosis

(2013) Nancy A. Turner et al.   PLoS One

Structural basis for the stabilization of the complement alternative pathway C3 convertase by properdin

(2013) M. Alcorlo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overview of Complement Activation and Regulation

(2013) Marina Noris et al.   SEMINARS IN NEPHROLOGY

Crosstalk between platelets and the complement system in immune protection and disease

(2013) Harald F. Langer et al.   THROMBOSIS AND HAEMOSTASIS

The complement receptor 2/factor H fusion protein TT30 protects paroxysmal nocturnal hemoglobinuria erythrocytes from complement-mediated hemolysis and C3 fragment

(2012) A. M. Risitano et al.   BLOOD

Residual plasmatic activity of ADAMTS13 is correlated with phenotype severity in congenital thrombotic thrombocytopenic purpura

(2012) L. A. Lotta et al.   BLOOD

Complement activation in thrombotic microangiopathies

(2012) Shuju Feng et al.   BRITISH JOURNAL OF HAEMATOLOGY

Complement activation in thrombotic thrombocytopenic purpura

(2012) M. RÉTI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

STEC-HUS, atypical HUS and TTP are all diseases of complement activation

(2012) Marina Noris et al.   Nature Reviews Nephrology

Congenital thrombotic thrombocytopenic purpura (cTTP) with two novel mutations

(2012) Timothy D. Prestidge et al.   PEDIATRIC BLOOD & CANCER

Unraveling the scissile bond: how ADAMTS13 recognizes and cleaves von Willebrand factor

(2011) J. T. B. Crawley et al.   BLOOD

Access to the Complement Factor B Scissile Bond Is Facilitated by Association of Factor B with C3b Protein

(2011) Dennis E. Hourcade et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alternative Pathway Activation of Complement by Shiga Toxin Promotes Exuberant C3a Formation That Triggers Microvascular Thrombosis

(2011) M. Morigi et al.   JOURNAL OF IMMUNOLOGY

Thrombomodulin and its role in inflammation

(2011) Edward M. Conway   Seminars in Immunopathology

Relative Role of Genetic Complement Abnormalities in Sporadic and Familial aHUS and Their Impact on Clinical Phenotype

(2010) M. Noris et al.   Clinical Journal of the American Society of Nephrology

Calcium-dependent Conformational Flexibility of a CUB Domain Controls Activation of the Complement Serine Protease C1r

(2010) Balázs Major et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complement activation, endothelial dysfunction, insulin resistance and chronic heart failure

(2010) Mette Bjerre et al.   SCANDINAVIAN CARDIOVASCULAR JOURNAL

Structure and Function of a Recombinant von Willebrand Factor Drug Candidate

(2010) Peter Turecek et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Evaluation of assay methods to measure plasma ADAMTS13 activity in thrombotic microangiopathies

(2010) Carla Valsecchi et al.   THROMBOSIS AND HAEMOSTASIS

Reducing agents induce thrombomodulin shedding in human endothelial cells

(2010) Mario Menschikowski et al.   THROMBOSIS RESEARCH

Hyperfunctional C3 convertase leads to complement deposition on endothelial cells and contributes to atypical hemolytic uremic syndrome

(2009) L. T. Roumenina et al.   BLOOD

Endothelial cell ADAMTS-13 and VWF: production, release, and VWF string cleavage

(2009) N. A. Turner et al.   BLOOD

Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome

(2009) I. Moore et al.   BLOOD

Atypical Hemolytic–Uremic Syndrome

(2009) Marina Noris et al.   NEW ENGLAND JOURNAL OF MEDICINE

3D structure of the C3bB complex provides insights into the activation and regulation of the complement alternative pathway convertase

(2009) Eva Torreira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional basis of protection against age-related macular degeneration conferred by a common polymorphism in complement factor B

(2009) T. Montes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor

(2009) M. Akiyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in complement C3 predispose to development of atypical hemolytic uremic syndrome

(2008) V. Fremeaux-Bacchi et al.   BLOOD

Factor H family proteins and human diseases

(2008) Mihály Józsi et al.   TRENDS IN IMMUNOLOGY