Review
Hematology
Anna M. Randi, Daisy Jones, Claire Peghaire, Deepa J. Arachchillage
Summary: This review discusses the organotypic differences in the hemostatic profile of endothelial cells, focusing on two major endothelial regulators, von Willebrand factor and thrombomodulin, as examples of transcriptional mechanisms that control heterogeneity.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Biochemistry & Molecular Biology
Chih-Hsien Wu, Yi-Lin Chiu, Chung-Yueh Hsieh, Guo-Shiang Tsung, Lian-Shan Wu, Cheng-Chung Cheng, Tsung-Neng Tsai
Summary: Cilostazol exerts antithrombotic and vasculoprotective effects in endothelial cells by activating KLF2 and SIRT1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Susan Yung, Tak Mao Chan
Summary: Lupus nephritis is a severe manifestation of systemic lupus erythematosus, and early diagnosis and management are crucial. Kidney biopsy remains the gold standard for diagnosis, but it is invasive and cannot be frequently repeated. Current clinical indicators are non-specific, and novel biomarkers are needed for better management.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Vincenzo La Mura, Nicoletta Gagliano, Francesca Arnaboldi, Patrizia Sartori, Patrizia Procacci, Luca Denti, Eleonora Liguori, Niccolo Bitto, Giuseppe Ristagno, Roberto Latini, Daniele Dondossola, Francesco Salerno, Armando Tripodi, Massimo Colombo, Flora Peyvandi
Summary: This study investigated the hemostatic changes induced by endotoxemia and the protective effects of simvastatin on liver vascular microthrombosis. The results showed that simvastatin prevented fibrin deposition and hypo-coagulability caused by endotoxemia, and preserved the antithrombotic properties of sinusoidal endothelial cells. It suggests that simvastatin has potential pharmacological properties to counteract sepsis-associated coagulopathy and hepatic failure.
Review
Biochemistry & Molecular Biology
Mario Bauer
Summary: This review summarizes the consequences of GPR15 signaling, focusing on different cell types expressing GPR15 and its ligands, with a particular emphasis on blood and vasculature.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Michael Hultstrom, Karin Fromell, Anders Larsson, Barbro Persson, Bo Nilsson, Susan E. Quaggin, Christer Betsholtz, Robert Frithiof, Miklos Lipcsey, Marie Jeansson
Summary: Hypercoagulation and endothelial dysfunction play important roles in severe forms of COVID-19 infections. Angiopoietin-2, an inflammatory cytokine and TIE2 receptor antagonist, appears to be involved in the molecular mechanisms underlying COVID-19-associated hypercoagulation. Clinical data, mouse models, and in vitro assays support the hypothesis that Angiopoietin-2 directly inhibits thrombin/thrombomodulin-mediated anticoagulation, leading to increased coagulation in COVID-19 patients.
Article
Multidisciplinary Sciences
Hemant Giri, Sumith R. Panicker, Xiaofeng Cai, Indranil Biswas, Hartmut Weiler, Alireza R. Rezaie
Summary: Deletion of TM in endothelial cells leads to increased basal permeability, enhanced tyrosine phosphorylation of VE-cadherin, reduced F-actin filament polymerization, increased NF-kappa B signaling, expression of inflammatory cell adhesion molecules, von Willebrand factor levels, storage, and release. Reexpression of TM construct normalized the cellular phenotype, suggesting cell-bound TM regulates expression of procoagulant, proinflammatory, and angiogenic molecules in vascular endothelial cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Dentistry, Oral Surgery & Medicine
Feng-Yen Lin, Yi-Ting Tsai, Chun-Yao Huang, Ze-Hao Lai, Chien-Sung Tsai, Chun-Ming Shih, Cheng-Yen Lin, Yi-Wen Lin
Summary: We found that GroEL in Porphyromonas gingivalis promotes tumor growth and increases mortality in tumor-bearing mice by promoting the proangiogenic function of endothelial progenitor cells (EPCs). In this study, we explored the regulatory mechanisms by which GroEL enhances the proangiogenic function of EPCs. Our results showed that GroEL inhibits thrombomodulin (TM) expression by activating specific miRNAs, leading to the activation of PI3K/Akt signaling pathways and increased migration and tube formation of EPCs. The inhibition of proangiogenic properties of EPCs can reduce the effects of GroEL on tumor growth.
MOLECULAR ORAL MICROBIOLOGY
(2023)
Article
Cell Biology
Anton Klersy, Soeren Meyer, Florian Leuschner, Thorsten Kessler, Markus Hecker, Andreas H. Wagner
Summary: This study investigates the association between ADAM17-mediated CD40 shedding and inflammation in CC genotype human endothelial cells. Inhibition of ADAM17 prevented TNF-alpha-induced sCD40 and soluble vascular cell adhesion molecule-1 release, and reinforced CD40 surface abundance. Levels of sCD40 and the inflammatory biomarkers hs-CRP and IL-6 were positively correlated in the plasma of patients with CHD.
Article
Medicine, General & Internal
Taejoon Won, Megan K. Wood, David M. Hughes, Monica Talor, Zexu Ma, Jowaly Schneider, John T. Skinner, Beejan Asady, Erin Goerlich, Marc K. Halushka, Allison G. Hays, Deok-Ho Kim, Chirag R. Parikh, Avi Z. Rosenberg, Isabelle Coppens, Roger A. Johns, Nisha A. Gilotra, Jody E. Hooper, Andrew Pekosz, Daniela Cihakova
Summary: The article explains the copyright ownership and the license agreement it follows.
Article
Cell & Tissue Engineering
Paul Billoir, Adeline Blandinieres, Nicolas Gendron, Richard Chocron, Sven Gunther, Aurelien Philippe, Coralie L. Guerin, Dominique Israel-Biet, David M. Smadja
Summary: This study investigated hypercoagulability states in ECFCs from patients with IPF, finding higher thrombin potential in IPF-ECFCs and decreased expression of anticoagulant proteins on ECFCs membrane. This new finding suggests a potential role of ECFC in IPF pathophysiology and thrombotic-related disorders.
STEM CELL REVIEWS AND REPORTS
(2021)
Article
Peripheral Vascular Disease
Xenia Kraus, Michael Pflaum, Stefanie Thoms, Rebecca Jonczyk, Martin Witt, Thomas Scheper, Cornelia Blume
Summary: The study aimed to develop a standardized pre-conditioning protocol under dynamic conditions to improve the formation of a flow resistant monolayer of ECFCs and enhance the antithrombogenicity of endothelial cells. High shear stress of 20 dyn/cm(2) led to significant orientation and elongation of ECFCs, forming a confluent endothelial cell layer.
MICROVASCULAR RESEARCH
(2021)
Review
Critical Care Medicine
Toshiaki Iba, Julie Helms, Jean Marie Connors, Jerrold H. Levy
Summary: The International Society on Thrombosis and Haemostasis (ISTH) released overt DIC diagnostic criteria in 2001. However, DIC includes early stages with systemic activation in coagulation, and thus the ISTH recently released SIC criteria that can diagnose the compensated-phase of coagulopathy.
JOURNAL OF INTENSIVE CARE
(2023)
Article
Biochemistry & Molecular Biology
Kazufumi Ohmura, Takamasa Kinoshita, Hiroyuki Tomita, Hideshi Okada, Masayoshi Shimizu, Kosuke Mori, Toshiaki Taniguchi, Akio Suzuki, Toru Iwama, Akira Hara
Summary: The study found that Vincristine-induced peripheral neuropathy can be improved by protecting the endothelial glycocalyx. The results suggest that nafamostat may be a potential new drug for the treatment of VIPN.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Review
Medicine, General & Internal
Mohammad Houshmand, Alireza Kazemi, Ali Anjam Najmedini, Muhammad Shahzad Ali, Valentina Gaidano, Alessandro Cignetti, Carmen Fava, Daniela Cilloni, Giuseppe Saglio, Paola Circosta
Summary: The elimination of TKI resistant leukemic stem cells is crucial for achieving long-term treatment free remission in CML patients. Understanding the biology of LSCs and identifying differences from normal HSCs are important steps in designing strategies to target LSCs selectively.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Endocrinology & Metabolism
Svenja Noelting, Nicole Bechmann, David Taieb, Felix Beuschlein, Martin Fassnacht, Matthias Kroiss, Graeme Eisenhofer, Ashley Grossman, Karel Pacak
Summary: Pheochromocytomas/paragangliomas have high heritability, with 70% of patients falling into 3 main molecular clusters with distinct phenotypes and clinical behaviors. Personalized management strategies are essential for accurate diagnosis and effective treatment in different clusters.
Review
Endocrinology & Metabolism
Nicole Bechmann, Graeme Eisenhofer
Summary: Germline or somatic driver mutations are identified in approximately 70% of catecholamine-producing pheochromocytomas and paragangliomas (PPGLs), with mutations in HIF2 alpha leading to a higher risk of metastatic disease. HIF2 alpha mutations result in distinct catecholamine phenotype and contribute to the initiation of invasion and metastasis, highlighting the therapeutic relevance of targeting HIF2 alpha signaling pathways in PPGLs.
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
(2022)
Article
Medical Laboratory Technology
Flaminia Fanelli, Marco Cantu, Anastasia Temchenko, Marco Mezzullo, Johanna M. Lindner, Mirko Peitzsch, James M. Hawley, Stephen Bruce, Pierre-Alain Binz, Mariette T. Ackermans, Annemieke C. Heijboer, Jody Van den Ouweland, Daniel Koeppl, Elena Nardi, Finlay MacKenzie, Manfred Rauh, Graeme Eisenhofer, Brian G. Keevil, Michael Vogeser, Uberto Pagotto
Summary: This study compared LC-MS/MS measurements of cortisol, 17OH-progesterone, and aldosterone from nine European centers and assessed their performance based on external quality assessment (EQA) materials and calibration. The results showed variability in intra-laboratory imprecision and performance with EQA materials, but overall the inter-laboratory performance was mostly within specifications. The adoption of common traceable calibrators and EQA materials determined by a reference measurement procedure (RMP) is beneficial for standardization of LC-MS/MS steroid measurements.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Oncology
Susan Richter, Bei Qiu, Mirthe Ghering, Carola Kunath, Georgiana Constantinescu, Charlotte Luths, Christina Pamporaki, Nicole Bechmann, Leah Meuter, Aleksandra Kwapiszewska, Timo Deutschbein, Svenja Noelting, Mirko Peitzsch, Mercedes Robledo, Aleksander Prejbisz, Karel Pacak, Volker Gudziol, Henri J. L. M. Timmers, Graeme Eisenhofer
Summary: Jugulotympanic HNPGLs have distinct features, primarily occurring in women and having a lower proportion of SDHx mutations. Compared to carotid body and vagal HNPGLs, jugulotympanic HNPGLs are less likely to be bilateral, smaller in size, and have a lower metastatic rate. Patients with HNPGLs have higher plasma concentrations of MTY, while plasma normetanephrine does not differ significantly.
ENDOCRINE-RELATED CANCER
(2022)
Article
Endocrinology & Metabolism
Kristina Berke, Georgiana Constantinescu, Jimmy Masjkur, Otilia Kimpel, Ulrich Dischinger, Mirko Peitzsch, Aleksandra Kwapiszewska, Piotr Dobrowolski, Svenja Nolting, Martin Reincke, Felix Beuschlein, Stefan R. Bornstein, Aleksander Prejbisz, Jacques W. M. Lenders, Martin Fassnacht, Graeme Eisenhofer
Summary: Plasma steroid profiling combined with metanephrines and adrenal tumor size can be used for the differential diagnosis of patients with adrenal incidentaloma. This approach shows high sensitivity and specificity for identifying different types of adrenal tumors.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Georg Pommer, Christina Pamporaki, Mirko Peitzsch, Hanna Remde, Timo Deutschbein, Svenja Noelting, Lisa Marie Mueller, Leah Braun, Sven Gruber, Alessio Pecori, Stephanie Hampson, Eleanor Davies, Anthony Stell, Gian Paolo Rossi, Livia Lenzini, Filippo Ceccato, Henri J. L. M. Timmers, Jaap Deinum, Laurence Amar, Anne Blanchard, Stephanie Baron, Martin Fassnacht, Piotr Dobrowolski, Andrzej Januszewicz, Maria-Christina Zennaro, Aleksander Prejbisz, Graeme Eisenhofer
Summary: This study aimed to identify preanalytical precautions to minimize false-positive results for plasma metanephrines in patients with PPGL. The results showed that outpatient sampling, low temperature, semi-recumbent position, and direct venipuncture were associated with higher plasma concentrations and rates of false-positive results.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Graeme Eisenhofer, Mirko Peitzsch, Nicole Bechmann, Angela Huebner
Summary: Catecholamine-producing tumors of childhood, including neuroblastoma, pheochromocytoma, and paraganglioma, have different diagnostic methods. While biopsy-dependent histopathology is used for neuroblastoma, biochemical tests for catecholamine excess are crucial for the diagnosis of PPGL. However, there are challenges in using these tests in children, and the true prevalence of childhood PPGL may be underestimated. Early identification and accurate diagnosis are important for improving therapeutic outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nikolaos G. Bliziotis, Leo A. J. Kluijtmans, Gerjen H. Tinnevelt, Parminder Reel, Smarti Reel, Katharina Langton, Mercedes Robledo, Christina Pamporaki, Alessio Pecori, Josie Van Kralingen, Martina Tetti, Udo F. H. Engelke, Zoran Erlic, Jasper Engel, Timo Deutschbein, Svenja Noelting, Aleksander Prejbisz, Susan Richter, Jerzy Adamski, Andrzej Januszewicz, Filippo Ceccato, Carla Scaroni, Michael C. Dennedy, Tracy A. Williams, Livia Lenzini, Anne-Paule Gimenez-Roqueplo, Eleanor Davies, Martin Fassnacht, Hanna Remde, Graeme Eisenhofer, Felix Beuschlein, Matthias Kroiss, Emily Jefferson, Maria-Christina Zennaro, Ron A. Wevers, Jeroen J. Jansen, Jaap Deinum, Henri J. L. M. Timmers
Summary: This study aimed to establish signatures for different forms of endocrine hypertension (EHT) and investigate unbiased disease biomarkers. Plasma samples from 13 biobanks across seven countries were analyzed using untargeted NMR metabolomics. While signatures that could differentiate different forms of EHT were found, confounding effects related to sample center and age were also identified. Various approaches were applied to correct these confounding effects, but no biomarkers for differentiating primary hypertension from EHT could be identified.
Article
Medical Laboratory Technology
Flaminia Fanelli, Stephen Bruce, Marco Cantu, Anastasia Temchenko, Marco Mezzullo, Johanna M. Lindner, Mirko Peitzsch, Pierre-Alain Binz, Mariette T. Ackermans, Annemieke C. Heijboer, Jody Van den Ouweland, Daniel Koeppl, Elena Nardi, Manfred Rauh, Michael Vogeser, Graeme Eisenhofer, Uberto Pagotto
Summary: This study aimed to compare the reproducibility of liquid chromatography-tandem mass spectrometry (LC-MS/MS) measurements for diagnosing adrenal cortical diseases among eight European centers and assess the performance after calibration. The results showed variability within and between laboratories, with some laboratories exceeding the acceptable limits of uncertainty. The study suggested that the variability in method uncertainty may be related to the accuracy and specificity of individual methods, and tools for improving accuracy are required for harmonization.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Endocrinology & Metabolism
Minghao Li, Tamara Prodanov, Leah Meuter, Michiel N. Kerstens, Nicole Bechmann, Aleksander Prejbisz, Hanna Remde, Henri J. L. M. Timmers, Svenja Noelting, Sara Talvacchio, Annika M. A. Berends, Stephanie Fliedner, Mercedes Robledo, Jacques W. M. Lenders, Karel Pacak, Graeme Eisenhofer, Christina Pamporaki
Summary: This study found that the prevalence of recurrence in patients with sporadic PPGL is lower than in patients with pathogenic variants, but similar to those with variants that activate kinase pathways. Noradrenergic/dopaminergic phenotype, larger size, and extra-adrenal location of primary tumors were identified as independent predictors of recurrence in sporadic PPGL.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Cardiac & Cardiovascular Systems
Andrzej Januszewicz, Paolo Mulatero, Piotr Dobrowolski, Silvia Monticone, Patricia Van der Niepen, Martin Reincke, Emrush Rexhaj, Graeme Eisenhofer, Magdalena Januszewicz, Alexandros Kasiakogias, Reinhold Kreutz, Jacques W. M. Lenders, Maria Lorenza Muiesan, Alexandre Persu, Enrico Agabiti-Rosei, Rodrigo Soria, Mateusz Spiewak, Aleksander Prejbisz, Franz H. Messerli
Summary: Secondary hypertension carries a higher risk of cardiac morbidity and mortality. Studying cardiac phenotypes in secondary hypertension helps understand the underlying mechanisms affecting the heart. The higher prevalence of heart damage in these patients compared to those with primary hypertension can be attributed to specific clinical and biochemical phenotypes, providing an opportunity for early screening and monitoring of heart damage and personalized treatment.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Geriatrics & Gerontology
Yingxian Pang, Minghao Li, Jingjing Jiang, Xiang Chen, Yan Fu, Cikui Wang, Yao He, Yuanzhe Zhao, Yong Wang, Xiao Guan, Liang Zhang, Xiaowen Xu, Yu Gan, Yalin Liu, Yaoling Xie, Tingyuan Tang, Jing Wang, Bin Xie, Zhihao Liang, Danlei Chen, Haipeng Liu, Changyong Chen, Graeme Eisenhofer, Longfei Liu, Xiaoping Yi, Bihong T. Chen
Summary: This study found that tumor size, catecholamine levels, body composition, and genotype are associated with intraoperative hemodynamics in patients with PPGL. Urine vanillylmandelic acid, tumor size, and Cluster 2 mutations were found to be independent risk factors for intraoperative hemodynamic instability. These findings are important for preventing perioperative complications.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Review
Endocrinology & Metabolism
Georgiana Constantinescu, Cristina Preda, Victor Constantinescu, Timo Siepmann, Stefan R. Bornstein, Jacques W. M. Lenders, Graeme Eisenhofer, Christina Pamporaki
Summary: Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors with diverse clinical presentations and potentially lethal outcomes. The increasing use of imaging studies and surveillance for at-risk patients has led to the diagnosis of these tumors at an early stage, resulting in the term "silent PPGL" becoming commonly used without a clear definition. This analysis provides an overview of the literature and proposes standardized terminology to facilitate scientific communication.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Graeme Eisenhofer, Christina Pamporaki, Jacques W. M. Lenders
Summary: Pheochromocytoma and paraganglioma (PPGL) require prompt consideration and efficient diagnosis and treatment to minimize associated morbidity and mortality. Advances in understanding catecholamine metabolism have clarified why measurements of the O-methylated catecholamine metabolites rather than the catecholamines themselves are important for effective diagnosis.
Article
Endocrinology & Metabolism
Nikolaos G. Bliziotis, Leo A. J. Kluijtmans, Sebastian Soto, Gerjen H. Tinnevelt, Katharina Langton, Mercedes Robledo, Christina Pamporaki, Udo F. H. Engelke, Zoran Erlic, Jasper Engel, Timo Deutschbein, Svenja Noelting, Aleksander Prejbisz, Susan Richter, Cornelia Prehn, Jerzy Adamski, Andrzej Januszewicz, Martin Reincke, Martin Fassnacht, Graeme Eisenhofer, Felix Beuschlein, Matthias Kroiss, Ron A. Wevers, Jeroen J. Jansen, Jaap Deinum, Henri J. L. M. Timmers
Summary: This study characterized the plasma metabolome of PPGL patients using an untargeted approach, finding differences in metabolic profiles before and after surgery, particularly in glucose and ketone body homeostasis pathways. BMI-related metabolite levels were also found to be altered, potentially linking muscle atrophy to PPGL. Patient metabolomes could be discriminated based on their catecholamine phenotype.
Article
Hematology
E. O. Artemenko, S. I. Obydennyi, K. S. Troyanova, G. A. Novichkova, D. Y. Nechipurenko, M. A. Panteleev
Summary: In this study, we investigated the adhesive properties of circulating plasma-derived and platelet-derived microvesicles (MVs) and their potential role in thrombus growth. The results showed that both types of MVs weakly bound fibrinogen but did not stably adhere to immobilized fibrinogen. Moreover, the presence of these MVs did not significantly affect thrombus formation. Therefore, MVs present in the plasma of healthy individuals are unlikely to directly contribute to thrombus formation under arterial flow conditions.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Giuseppe Lippi, Camilla Mattiuzzi, Emmanuel J. Favaloro
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marium Malik, Maha Al-Ghafry, Abraham Haimed, Julia Su, Maribel Lema, Linda Shore-Lessersson, Suchitra S. Acharya
Summary: This study analyzed and evaluated leukemia-associated coagulopathy in newly diagnosed pediatric leukemia patients using CCTs and ROTEM. The results showed that fibrinogen and platelets played a significant role in causing coagulopathies in this population. This suggests the utility of using CCTs and ROTEM in the pediatric population to evaluate hemostatic function and guide blood product replacement.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Mohammad M. Elahi, Alexandra N. Witt, Edward L. G. Pryzdial, Paul B. McBeth
Summary: Thrombotic disease may be underdiagnosed in microgravity conditions, and the underlying factors are still poorly understood. A case of internal jugular vein thrombosis was recently diagnosed in a low-risk female astronaut, and six out of ten additional crew members showed risk factors for jugular venous flow. Observations in space and studies on Earth suggest that microgravity affects blood flow, coagulation, and vascular function.
THROMBOSIS RESEARCH
(2024)
Review
Hematology
Stian Ingemann-Molden, Christina Krogner Caspersen, Nanna Rolving, Anette Arbjerg Hojen, Frederikus A. Klok, Erik L. Grove, Barbara Cristina Brocki, Jane Andreasen
Summary: This study found that no single PROM covered all aspects considered important by PE patients. PROMs recommended in the ICHOM core set covered most aspects, but worrisome thoughts, hypervigilance around symptoms, and uncertainty of illness were not covered.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Haomin Yan, Tsutomu Sasaki, Yasufumi Gon, Kumiko Nishiyama, Hideaki Kanki, Hideki Mochizuki
Summary: The incidence of cancer-associated stroke has increased with the prolonged survival times of cancer patients. In this study, the researchers focused on the driver gene KRAS and found that KRAS mutations exacerbated neurological deficits after stroke and promoted tumor growth. They also identified the upregulation of pro-inflammatory responses and the promotion of STAT3 phosphorylation in mice with KRAS mutations. Additionally, the researchers found that colorectal cancer patients with stroke onset within 3 months after cancer diagnosis had a worse prognosis.
THROMBOSIS RESEARCH
(2024)
Letter
Hematology
Tomoki Togashi, Satomi Nagaya, Makiko Meguro-Horike, Haruto Matsumoto, Yuta Imai, Koichi Yamaguchi, Yoshinari Fujii, Haruka Moriya, Yuika Kikuchi, Ibuki Yasuda, Shin-ichi Horike, Eriko Morishita
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Marta Najarro, Winnifer Briceno, Carmen Rodriguez, Alfonso Muriel, Sara Gonzalez, Ana Castillo, Ignacio Jara, Parth Rali, Catalin Toma, Behnood Bikdeli, David Jimenez
Summary: The CPES score is a useful tool in identifying the risk of hemodynamic deterioration in normotensive patients with acute PE, with acceptable C-statistic, excellent specificity, and low positive predictive value.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Lei Liu, Huifang Xu, Jian Wang, Haiyan Wang, Saisai Ren, Qian Huang, Mingyan Zhang, Hui Zhou, Chunyan Yang, Lu Jia, Yu Huang, Hao Zhang, Yanling Tao, Ying Li, Yanan Min
Summary: This study investigated the gut microbiota metabolites and cytokines, chemokines, and growth factors in patients with ITP and found their association with treatment responsiveness. The findings suggest that imbalanced secretion of cyto(chemo)kins/growth factors and inadequate levels of TMAO are characteristic of patients with ITP.
THROMBOSIS RESEARCH
(2024)
Article
Hematology
Roxanne Mcknight, Mohammad Salameh, Lee Ann Jones, Greta Anton, Lindsay Carter
Summary: This study evaluated the safety of fixed-dose heparin titration boluses in underweight patients with VTE. The results showed that although underweight patients required more frequent holding of heparin, there was no significant increase in bleeding risk.
THROMBOSIS RESEARCH
(2024)