Potential value of targeting von Willebrand factor in atherosclerotic cardiovascular disease

Anti-human VWF monoclonal antibody SZ-123 prevents arterial thrombus formation by inhibiting VWF–collagen and VWF–platelet interactions in Rhesus monkeys

(2013) Yi-ming Zhao et al.   BIOCHEMICAL PHARMACOLOGY

Atherosclerotic geometries exacerbate pathological thrombus formation poststenosis in a von Willebrand factor-dependent manner

(2013) Erik Westein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting von Willebrand factor as a novel anti-platelet therapy; Application of ARC1779, an Anti-vWF aptamer, against thrombotic risk

(2012) Ok-Nam Bae   ARCHIVES OF PHARMACAL RESEARCH

Genetic Ablation of Adamts13 Gene Dramatically Accelerates the Formation of Early Atherosclerosis in a Murine Model

(2012) Sheng-Yu Jin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

ARC15105 Is a Potent Antagonist of Von Willebrand Factor Mediated Platelet Activation and Adhesion

(2012) Jolanta M. Siller-Matula et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A murine model to characterize the antithrombotic effect of molecules targeting human von Willebrand factor

(2012) A.-M. Navarrete et al.   BLOOD

Evaluation of efficacy and safety of the anti-VWF Nanobody ALX-0681 in a preclinical baboon model of acquired thrombotic thrombocytopenic purpura

(2012) F. Callewaert et al.   BLOOD

Vascular and platelet responses to aspirin in patients with coronary artery disease

(2012) Andrew D. Blann et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Von Willebrand factor as new noninvasive predictor of portal hypertension, decompensation and mortality in patients with liver cirrhosis

(2012) Monika Ferlitsch et al.   HEPATOLOGY

Calcium stabilizes the von Willebrand factor A2 domain by promoting refolding

(2012) A. J. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Left Atrial Blood Stasis and Von Willebrand Factor–ADAMTS13 Homeostasis in Atrial Fibrillation

(2011) Naser Ammash et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Antithrombotic drug candidate ALX-0081 shows superior preclinical efficacy and safety compared with currently marketed antiplatelet drugs

(2011) H. Ulrichts et al.   BLOOD

Endothelial dysfunction in hypertension in pregnancy: associations between circulating endothelial cells, circulating progenitor cells and plasma von Willebrand factor

(2011) V. J. Karthikeyan et al.   Clinical Research in Cardiology

An observational study of endothelial function in early arthritis

(2011) Will Foster et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Local Elongation of Endothelial Cell-anchored von Willebrand Factor Strings Precedes ADAMTS13 Protein-mediated Proteolysis

(2011) Karen De Ceunynck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasma von Willebrand Factor Levels Are an Independent Risk Factor for Adverse Events Including Mortality and Major Bleeding in Anticoagulated Atrial Fibrillation Patients

(2011) Vanessa Roldán et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Intracardiac expression of markers of endothelial damage/dysfunction, inflammation, thrombosis, and tissue remodeling, and the development of postoperative atrial fibrillation

(2011) D. KAIREVICIUTE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Calcium modulates force sensing by the von Willebrand factor A2 domain

(2011) Arjen J. Jakobi et al.   Nature Communications

von Willebrand factor-mediated platelet adhesion is critical for deep vein thrombosis in mouse models

(2010) A. Brill et al.   BLOOD

Molecular Imaging of Activated von Willebrand Factor to Detect High-Risk Atherosclerotic Phenotype

(2010) Owen J.T. McCarty et al.   JACC-Cardiovascular Imaging

Von Willebrand factor increases endothelial cell adhesiveness for human mesenchymal stem cells by activating p38 mitogen-activated protein kinase

(2010) Irina A Potapova et al.   Stem Cell Research & Therapy

Impaired glucose tolerance and endothelial damage, as assessed by levels of von Willebrand factor and circulating endothelial cells, following acute myocardial infarction

(2009) Shahirose S. Jessani et al.   ANNALS OF MEDICINE

Oxidative modification of von Willebrand factor by neutrophil oxidants inhibits its cleavage by ADAMTS13

(2009) J. Chen et al.   BLOOD

Deficiency of von Willebrand factor protects mice from ischemic stroke

(2009) C. Kleinschnitz et al.   BLOOD

von Willebrand factor to the rescue

(2009) S. F. De Meyer et al.   BLOOD

The glycoprotein Ibα-von Willebrand factor interaction induces platelet apoptosis

(2009) S. LI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Extensive contacts between ADAMTS13 exosites and von Willebrand factor domain A2 contribute to substrate specificity

(2008) W. Gao et al.   BLOOD

Influence of Atrial Fibrillation on Plasma Von Willebrand Factor, Soluble E-Selectin, and N-Terminal Pro B-type Natriuretic Peptide Levels in Systolic Heart Failure

(2008) Bethan Freestone et al.   CHEST

Inflammation-associated ADAMTS13 deficiency promotes formation of ultra-large von Willebrand factor

(2008) C. L. Bockmeyer et al.   HAEMATOLOGICA

Impaired flow mediated dilatation as evidence of endothelial dysfunction in chronic atrial fibrillation:

(2007) Bethan Freestone et al.   THROMBOSIS RESEARCH